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Blood Glucose:ketone Ratio

Glucose Ketone Index Calculator For Cancer Management

Glucose Ketone Index Calculator For Cancer Management

Glucose Ketone Index Calculator For Cancer Management This is a fantastic article statingthe incredible benefits of using ketogenic diet for the metabolic management of cancer. To calculate your index you will need to have a blood glucose monitor and a blood ketone monitor to obtain your Glucose Ketone Index (GKI). Paying attention to the optimal ratio of your glucose and ketones has been scientifically proven to be a powerful tool for the metabolic management of brain tumors (and other aggressive and inoperable cancers). Mary Beauchamp is a Registered Nurse, Therapeutic Nutritionist and Mind Body Specialist. She is a world traveler, food alchemist, and student of ancient healing traditions. She has four beautiful children and two grandchildren. With her knowledge of nutritional science, medical research, plant medicines, ancient super foods and indigenous healing rituals, she formulates food products for the natural foods industry and is a private health coach, specializing in healing the metabolism. Mary works with a team of Naturopathic doctors at Auburn Naturopathic Medicine in northern California. She alsooffers private and group online coaching programs. You can learn more about her work by visiting her website, www.ketogenicdietcoach.com . Mary is passionate about re-educating people about nutrition. She invites you to experience your body as a master communication system and facilitates this sacred encounter within to unlock the bodys innate intelligence to heal and thrive! Continue reading >>

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic Joshua J Meidenbauer, Purna Mukherjee and Thomas N Seyfried Background: Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), w hich i s the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. Methods: A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). Results: The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using Conclusions: The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Keywords: Glucose, Beta-hydroxybutyrate, Calorie restriction, Metabolic therapy, Glioblast Continue reading >>

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

The Glucose Ketone Index Calculator: A Simple Tool To Monitor Therapeutic Efficacy For Metabolic Management Of Brain Cancer

Go to: Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood glucose and elevating blood ketones (β-hydroxybutyrate). Brain tumor cells, unlike normal brain cells, cannot use ketone bodies effectively for energy when glucose becomes limiting. Although plasma levels of glucose and ketone bodies have been used separately to predict the therapeutic success of metabolic therapy, daily glucose levels can fluctuate widely in brain cancer patients. This can create difficulty in linking changes in blood glucose and ketones to efficacy of metabolic therapy. A program was developed (Glucose Ketone Index Calculator, GKIC) that tracks the ratio of blood glucose to ketones as a single value. We have termed this ratio the Glucose Ketone Index (GKI). The GKIC was used to compute the GKI for data published on blood glucose and ketone levels in humans and mice with brain tumors. The results showed a clear relationship between the GKI and therapeutic efficacy using ketogenic diets and calorie restriction. The GKIC is a simple tool that can help monitor the efficacy of metabolic therapy in preclinical animal models and in clinical trials for malignant brain cancer and possibly other cancers that express aerobic fermentation. Electronic supplementary material The online version of this article (doi:10.1186/s12986-015-0009-2) contains supplementary material, which is available to authorized users. Keywords: Glucose, Beta-hydroxybutyrate, Calorie Continue reading >>

Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents

Us20160078782a1 - Glucose Ketone Index For Metabolictherapy - Google Patents

US20160078782A1 - Glucose Ketone Index for MetabolicTherapy - Google Patents Glucose Ketone Index for MetabolicTherapy US20160078782A1 US14854713 US201514854713A US2016078782A1 US 20160078782 A1 US20160078782 A1 US 20160078782A1 US 14854713 US14854713 US 14854713 US 201514854713 A US201514854713 A US 201514854713A US 2016078782 A1 US2016078782 A1 US 2016078782A1 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS G09B19/00Teaching not covered by other main groups of this subclass A61MEDICAL OR VETERINARY SCIENCE; HYGIENE A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement A61MEDICAL OR VETERINARY SCIENCE; H

Tracking The Glucose Ketone Index

Tracking The Glucose Ketone Index

In this post we will examine the “glucose ketone index” as a biomarker for tracking metabolic health. We will also explore some of the primary use cases for tracking the glucose ketone index including cancer treatment, weight loss, metabolic disease management and athletic performance. Lastly, we will demonstrate how you can use Heads Up Health to track the glucose ketone index along with all of your other important health data. If you want to skip ahead, click the button below to create an account with Heads Up and start tracking the glucose-ketone index alongside all of your other health metrics. Or, read on for more information on tracking the glucose ketone index. What is the Glucose Ketone Index? The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. Example: If my fasting blood sugar first thing in the morning is 4.6 mmol/L (82 mg/dL) and my ketone reading is 0.8 mmol/L, I would record a glucose ketone index of 5.75 (4.6 / 0.8). Despite its roots in cancer treatment, the index can also be ver Continue reading >>

It Really Is In Your Blood: Glucose To Ketone Ratios

It Really Is In Your Blood: Glucose To Ketone Ratios

I wrote awhile back about how I felt that I might be going a little mad obsessing over my blood numbers and measuring my blood glucose and ketone levels. This is one of the greatest differences, in my opinion, between people that follow a ketogenic or low carb lifestyle for overall health reasons or weight loss, and those of us who are experimenting with using a ketogenic approach as a specific disease therapy. I’m using the term “therapeutic ketosis” now for this, as you’ll know if you’re a Constant Reader here at Greymadder. I think people in the first category, with weight loss or general health goals, can definitely be helped by measuring ketones, and that this is vital to the success of the approach. However, in my personal experience using this approach to “starve” my brain tumour, I find I can become quite the data junkie, measuring blood levels of both glucose and ketones up to four times a day, because in my mind, the optimal levels of both are perhaps what’s required to have a therapeutic effect. I base this on the book Cancer as a Metabolic Disease by Dr. Thomas Seyfried, in which he advises that there is a window of effectiveness of therapeutic ketosis for cancer that uses a glucose to ketone ratio of 1.0. This essentially means that when measured in mmol/L (“millimolar”), blood glucose and ketones should be equal, or even achieving ketone levels that are higher than the glucose levels may be preferable. There is general agreement between my favourite go-to references (Ellen Davis, Dominic D’Agostino, Miriam Kalamian, all found in my Resources section) that this glucose to ketone ratio of 1.0 is best. Miriam Kalamian, in her ebook Get Started with the Ketogenic Diet for Cancer further notes that it should not be disregarded that a thera Continue reading >>

Gki (glucose To Ketone Index)

Gki (glucose To Ketone Index)

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I posted this in the prediabetes forum and someone there suggested I try my posting in this forum as well. So...here it is; Michael here from Tasmania in Australia. Just briefly, I was obese and prediabetic for an excess of 15 years until I discovered intermittent and longer term fasting. I have now lost in excess of 20 kg and whilst I haven't tested my HbA1c for a while am probably no longer prediabetic. I will test my bloods again soon. When doing longer fasts (up to 21 days) I would regularly test my BSL and ketones. I learned that dividing BSL by ketones gives an index called GKI (glucose to ketone index). This is apparently an accurate way of assessing insulin levels in the blood. A GKI of 1 or less is optimal. This morning (my 7th and last day of my current modified water fast), my BSL was 3.1 and my ketones were 3.4. This gives me a GKI of less than 1. I'm happy with that, have lost just under 5 kg in 7 days (though I'm aware I will regain a couple of kilo in water), have absolutely no signs of hypoglycaemia and I feel good. My question is, does anyone else use GKI? Anyone got any research on the reliability and/or validity of using GKI to assess insulin levels in the blood. What a great forum. Very happy to have come across it. Well so much for my theory @Tassiemike ......... Perhaps you'd have more luck over at reddit or maybe the 2 keto dudes forums? I posted this in the prediabetes forum and someone there suggested I try my posting in this forum as well. So...here it is; Michael here from Tasmania in Australia. Just briefly, I was obese and prediabetic for an excess of 15 years until I discovered intermittent and longer term fasting. I have Continue reading >>

Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?

Glucose Ketone Index (gki) – What Ratio Do I Need For Nutritional Ketosis Benefits?

Generally these blog posts are a result of scratching my own itch (answering my own question), and this post is no different. At the time of writing this, I’m doing a 5-day fast, and wanted to understand the readings I’m getting for my blood glucose and blood ketone levels. Initially I thought that blood ketones were all that mattered, and certainly a lot of people only talk about that reading. But looking at Dr Thomas Seyfried’s paper on treating brain cancer (glioblastomas). It suggests that its important to take into account blood glucose also. In their study, they acheieved optimal results when their patients maintained what they called ‘nutritional ketosis’. And as part of the paper, they included a formula for what this means. The chart below describes visually what they mean by nutritional ketosis, and how it affected the tumour growth. The red is an increase in ketones as a fictional patient goes deeper into ketosis. The black line represents blood glucose, that decreases to a plateau, as carbohydrate sources are removed from the diet, and glycogen stores decrease. So that sweet spot they reach at the end is an optimum level of nutritional ketosis. Now… obviously in our case we are (hopefully) not trying to slow the growth of a glioblastoma. But by getting into ketosis we’re hoping to achieve a number of benefits including: Reduced IGF-1 Immune system rejuvenation (perhaps mainly lymphocytes) Increased cellular autophagy Reduced inflammation (often measured by improved C-reactive protein levels) The extent of these benefits will depend if you’re eating a keto diet, or doing a water fast/fast mimicking diet. But all 3 should improve the biomarkers such that you have a reduced risk of major diseases such as diabetes, cancer and cardiovascular disea Continue reading >>

Going Keto Pt. 2: Preparing For Ketosis

Going Keto Pt. 2: Preparing For Ketosis

Sponsored Content Last month we covered the wide range of fascinating benefits one can expect to see while on a ketogenic diet. The same dietary regimen that can fight all sorts of diseases and metabolic ailments can increase satiety while keeping you so unbelievably cut that people will be offering you band-aids all day. These enticing benefits could have you chomping at the bit to start right here and now, but before taking one bite be sure you're fully prepared if you hope to reap peak results from going keto. #1: IDENTIFY YOUR GOALS It's critical that you've written down clear, measurable goals before embarking on this new lifestyle (trust us, it’s more than just a diet). Depending on whether you're looking to build muscle, stay shredded, improve blood markers, or starve (and potentially prevent) cancer, the type of keto diet you follow will reflect that significantly. A ketogenic diet is technically any diet that causes the body to produce ketone bodies, so watch your macros closely, but get creative when you can. Keto diets will vary from one person’s goals to another… not unlike the wide range of meal plans you'll find in the IIFYM crowd. If you didn’t read Going Keto Pt. 1, go back and read that HERE. A few key things to remember before going forward: for those of you doing keto, it's best to err on the side of higher protein. Excess protein increases the likelihood of ‘gluconeogenesis’ though, which is when the body converts protein into glucose. If this happens, your body won't produce as many ketone bodies (if at all). On the flip side, a 4:1 ketogenic diet is not one you want to remain on indefinitely, either, due to such low protein intake. Commit to a higher fat ratio for a relatively short period of time (one month is great) to maximize endoge Continue reading >>

Keto Katie All Things Ketones

Keto Katie All Things Ketones

The glucose ketone index is a ratiototrack your metabolic state. Dr. Thomas Seyfried suggests in his book, Cancer as a Metabolic Disease ,that you aim for a GKI between 0.7 to 2.o with a goal of 1. Today, Todd hit 1! When fighting cancer with the Ketogenic Diet, the goal is to depletethe supply of sugar/glucoseto thecancer cells and elevate the blood ketone level between 2-5 mmol depending on who you ask. Elevated ketone bodies have a very promising effect on shrinking tumors in lab & case studies. Getting your blood glucose down & ketones elevated can be a challenging task for some. What works for some may not for others. Through trial & error, Todd found out that tomatoes, almonds & too much dairy will kick him out of ketosis . There are many factors that play into the equation of raisingglucose including too much protein to any type of stress on the body. Heres how we got to 1. Precision Xtra monitor measure blood glucose in mg/dl and ketones in mmol so the glucose needs to be converted into mmol. Continue reading >>

Using The Ratio Of Blood Glucose To Ketone Levels To Quantify A Fat Adapted State : Ketoscience

Using The Ratio Of Blood Glucose To Ketone Levels To Quantify A Fat Adapted State : Ketoscience

For better or worse, most of my diet planning and information in the ketogenic diet comes from Stephanie Person- a pretty polarizing figure but, I think most would agree, very knowledgeable. One of her claims, the one that I have been most obsessed with in these last few weeks, is the necessity for measuring blood sugar and ketones with a glucometer. The goal is to demonstrate not only high ketones, but a low blood sugar in the 50-76 range ( ). If both are high then a body is producing ketones, but the brain is still not highly keto adapted. We're still carb burning, and sugar is still the preferred fuel source. I believe this theory is of her own finding from consulting with patients, but I was wondering if people here were familiar with this idea and agreed or disagreed with it and why? While I was doing a ketogenic diet for almost a year I believe I was eating too little fat and, when I did measure, my numbers were usually around .5 - .8. Now I'm really amping up my fat intake (and gaining some weight in the process). My ketones show mostly above 2.0 (sometime as low as 1.4) but my blood sugar is also almost constantly elevated in the 80-90 range. Sometimes it is as high as a 100, rarely it will be in the 76-80 range. Carbs come from spinach and cruciferous sources. I've only been eating this way for about a month, so perhaps I just need to be patient. Continue reading >>

Biohacking: Using The Glucose Ketone Index

Biohacking: Using The Glucose Ketone Index

Looking for a way to measure metabolic health? One technique is to look at the ratio of blood glucose to blood ketones. The idea is to reduce carbohydrate intake which will result in lower blood sugar and higher ketone levels. The chart below explains the ideal ratios. The glucose ketone index is simply a way to measure the relationship between your ketone levels and your glucose levels at any moment in time. It is measured by dividing your blood glucose level (mmol/L) by your blood ketone level (mmol/L). The result is a single number we can use an indicator of one’s metabolic state. The index has its roots in brain cancer treatment, where researchers using metabolic therapy found best results when glucose and ketones maintained a very precise relationship in the patient [1]. Since there are many aspects of daily life (stress, exercise, nutrition etc.) that can upset glucose or ketone levels in the body, thereby throwing off the optimal glucose-ketone ratio, the index was developed to ensure both metrics (glucose and ketones) are maintaining the ideal ratio for optimal treatment outcomes. [ … Read More … ] I tend to stay in a solid level of ketosis most of the day and cycle out for just two hours. Using my numbers from the photo above look like: Convert Blood Glucose – 85 mg/dL / 18 = 4.72 mmol/L Divide Glucose by Ketones – 4.72 mmol/L / 1.6 mmol/L = 2.95 GKI No Comments No comments yet. Sorry, the comment form is closed at this time. Continue reading >>

Optimal Ketone And Blood Sugar Levels For Ketosis

Optimal Ketone And Blood Sugar Levels For Ketosis

A low carb helps reduce blood sugars and insulin levels and helps with the management of many of the diseases of modern civilisation (e.g. diabetes, heart disease, stroke, cancer, Parkinson’s and Alzheimer’s). We become insulin resistant when our body fat can’t store any more energy. Excess energy is then stored in the liver, pancreas, heart, brain and other organs that are more insulin sensitive. We also see increased levels of energy in our blood in the form of glucose, fat and elevated ketone. Endogenous ketosis occurs when we eat less food than we need. Our insulin and blood sugar levels decrease and ketones rise to supply the energy we need. Exogenous ketosis occurs when we eat lots fat and/or take exogenous ketones. Blood ketones rise, but our insulin levels will also rise because we have an excess of energy coming from our diet. Most of the good things associated with ketosis occur due to endogenous ketosis. Most people following a ketogenic diet over the long term have ketone values lower than what some people consider to be “optimal ketosis”. If your goal is blood sugar control, longevity or weight loss then endogenous ketosis with lower blood sugars and lower ketones is likely a better place to be than chasing higher blood ketones. I have seen a lot of interest and confusion recently from people following a ketogenic about ideal ketone and blood sugar levels. In an effort to try to clear this up, this article reviews blood ketone (BHB), breath ketone (acetone) and blood sugar data from a large number of people who are following a low carb or ketogenic diet to understand what “normal” and “optimal” look like. Many people initiate a low carb diet to manage their blood glucose levels, insulin resistance or diabetes. As shown in the chart below, Continue reading >>

The Glucose-ketone Index Approach To Cancer Therapy Some Early Insights

The Glucose-ketone Index Approach To Cancer Therapy Some Early Insights

The Glucose-Ketone Index Approach to Cancer Therapy Some Early Insights Written by Chris on June 01, 2015 No comments This recent article appeared in March 2015. Thomas Seyfried and colleagues came up with a way to monitor the therapeutic efficacy for managing brain cancer by introducing the glucose ketone index. This tool measures the ratio of blood glucose to ketones (BOHB) and its helpful because it outputs a single number that would tell if a patient is predominantly burning ketones or glucose. It would assess whether the patient is successful into implementing a ketogenic dietary approach (or a fasting approach) to managing different pathological conditions. The Glucose Ketone Index (GKI) was created to track the zone of metabolic management for brain tumor management. The GKI is a biomarker that refers to the molar ratio of circulating glucose over -OHB, which is the major circulating ketone body. A mathematical tool called the Glucose Ketone Index Calculator was developed that can calculate the GKI and monitor changes in this parameter on a daily basis. The GKIC generates a single value that can assess the relationship of the major fermentable tumor fuel (glucose) to the non-fermentable fuel (ketone bodies). The formula is quite comprehensive and it can be used with different unit systems and devices: The graphics above show you how you can switch between mg/dL and mM (millimolar). So, far theyve used the calculator to estimate the GKI for mice and humans with brain tumors that were treated with either calorie restriction or ketogenic diets from five previously published reports.[1] They noticed that the optimal results in terms of the efficacy of the treatment would be when GKI was around 1, or lower. I suspect that lower than 1 would be even better. This would Continue reading >>

The Ratio Of Glucose To Ketones

The Ratio Of Glucose To Ketones

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. i was playing around with a ketone meter (not nearly as seriously compared to my glucose meter and monitoring) and heard a podcast reference Dr. Thomas N Seyfried and a paper he wrote tied to this blood glucose vs. ketone ratio and cancer. while I think there were some controversial remarks made related to his take on diabetes, and the GKI is going to be difficult for most folks here to hit (below 1.0), it was nice: to see more studies in this area and more data points strongly connecting cancer and sugar. along with the point that one can have normal blood glucose levels while still having high insulin levels - something folks here already know. nice summary and related blog post: I have made many of these measurements,the lowest ratio I ever got was 0.54 ie 4.0 mmoles/l of BG and 7.4 mmoles/l of betahydroxybutyrate. Indicates very low insulin levels.Its expensive to carry out a lot of these tests. I now use the Ketonix breathyliser to monitor ketones. Hi Orlando! Hey, aren't you one of the military guys on this forum? Interestingly, as I dig up more and more papers, articles, and studies on nutritional ketosis and athletic contexts, I see more and more military application ambition, esp. withexogenousketones. It makes sense, but I'm wondering where that'll end up. Awesome to hear that you've done these measurements and wow, that's a fantastic ratio! Are you a pretty experienced nutritional ketosis guy? Nicely adapted and all? Or was this a temporary thing? And you're right about those strips costing way more than the glucose ones. Wonder why. Heard they're cheaper in Canada, but that doesn' Continue reading >>

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