Effects Of Exogenous Ketone Supplementation On Blood Ketone, Glucose, Triglyceride, And Lipoprotein Levels In Sprague–dawley Rats
Go to: Background Emerging evidence supports the therapeutic potential of the ketogenic diet (KD) for a variety of disease states, leading investigators to research methods of harnessing the benefits of nutritional ketosis without the dietary restrictions. The KD has been used as an effective non-pharmacological therapy for pediatric intractable seizures since the 1920s [1–3]. In addition to epilepsy, the ketogenic diet has elicited significant therapeutic effects for weight loss and type-2 diabetes (T2D) . Several studies have shown significant weight loss on a high fat, low carbohydrate diet without significant elevations of serum cholesterol [5–12]. Another study demonstrated the safety and benefits of long-term application of the KD in T2D patients. Patients exhibited significant weight loss, reduction of blood glucose, and improvement of lipid markers after eating a well-formulated KD for 56 weeks . Recently, researchers have begun to investigate the use of the KD as a treatment for acne, polycystic ovary syndrome (PCOS), cancer, amyotrophic lateral sclerosis (ALS), traumatic brain injury (TBI) and Alzheimer’s disease (AD) with promising preliminary results [14–26]. The classical KD consists of a 4:1 ratio of fat to protein and carbohydrate, with 80–90 % of total calories derived from fat . The macronutrient ratio of the KD induces a metabolic shift towards fatty acid oxidation and hepatic ketogenesis, elevating the ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) in the blood. Acetone, generated by decarboxylation of AcAc, has been shown to have anticonvulsant properties [28–32]. Ketone bodies are naturally elevated to serve as alternative metabolic substrates for extra-hepatic tissues during the prolonged reduction of glucose Continue reading >>
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- For the love of exogenous ketones!
Avoid This Ketogenic Rip-off
The Truth About Exogenous Ketones Ketones are all the rage among low carbers. And like most things in nutrition and performance, we've found a way to get them in supplement form so we don't have to do any actual work. What are ketones? They're a byproduct of ketosis caused by the process of converting fat to fuel. Your body makes them when it's in a calorie or carb restricted state. What do they do? The body and brain can use them as fuel without the presence of glucose in the blood. And now, you can take ketone supplements (salts and esters), known as exogenous ketones, without actually restricting anything. According to those promoting this nasty-tasting supplement, that means you can have a brain and body fuelled by ketones, along with all of the supposed health benefits that come with running on fat. Well, don't fall for it. Exogenous Ketones = Endogenous Fat Storage? The problem with ketone supplementation (EXOgenous) is that it's not even close to the same thing as being in ketosis (ENDOgenous ketone production). And just like the butter-blended-into-coffee trend, it's a farce. Ketones may be depressing dieters' hunger and giving them a hit of energy and cognitive enhancement, but it's INHIBITING their ability to burn fat, providing zero nourishment, and doing nothing for their metabolic health. There's an assortment of evidence suggesting that it's probably making things worse. Think of exogenous ketones kind of like alcohol. When they're consumed, everything is stored and nothing else is burned. So any lipolysis (fat burning) that would be taking place is halted; any glucose and fatty acids in your blood that were circulating are stored; and the ingested ketones are burned until there aren't any left. More importantly, this clearance of alternative fuels (glucos Continue reading >>
Keto Os Review
Created by Prüvit, Keto OS, which stands for Ketone Operating System, is a “revolutionary drink mix based on a proprietary ketone energy technology. It delivers advanced macro nutritionals and promotes optimized cellular regeneration, energy and longevity.”  Also known as the keto diet, KETO OS is a line of supplements that promise to turbocharge your metabolism and send your body into ketosis without resorting to the draconian no-carb, all-fat diet. The History of Ketones Known for centuries, it wasn’t until a hundred years ago that ketones (Beta-hydroxybutyrate) were used to treat seizures in kids with epilepsy. A “neuroprotective effect” was produced, which calms the nervous system. Soon researchers were exploring an expanded use of ketones to help with mental, emotional and cognitive health, according to Prüvit spokesperson Andra “Dr. Andy” Campitelli , a naturopathic doctor. She says ketone use was expanded as a tool to enhance athletic performance. Ketones result when the body burns fat for fuel.  Prüvit on Better Business Bureau There are two Prüvit profiles on the Better Business Bureau site, one in Indiana and one in Texas. Both sell Prüvit products, but have no website link. The Texas profile has an F rating, mostly for lack of response to customer complaints about return issues. The Indiana profile has an A rating, but no reviews or complaints, and it’s only been open a year. Neither profile lists the CEO the same as the website. There is no phone contact on either the Prüvit website or the Texas BBB profile, only an “Ask a Question” form that goes via email. The Indiana profile does have a phone number: (812) 631-4282.    What Keto OS Does? So Prüvit claims Keto OS supplementation helps shed fat, build a better body Continue reading >>
Tracking Blood Ketones: Behind The Scenes Data On The Ketogenic Diet
Tracking Blood Ketones: Behind the Scenes Data on the Ketogenic Diet I’ve tried a lot of diets. I first went vegetarian, then slow carb, then gluten-free, then Paleo. I even did a 28-day Chipotle diet, which is exactly as awesome as it sounds. Eventually I found the Ketogenic diet. For me, like for many people in our communities, this all started with a health concern. I was born with a heart condition. It never impacted my life, but it was there, lingering. When I was a junior in college, a few classmates and I were out enjoying late night pizza. Out of nowhere, one classmate suddenly jolted upright and fell off his stool. He died. I found out the next morning it was from a lingering heart condition, not too unlike my own. I started to think about my health a lot more after that. I read about nutrition and started exploring the confusing world of diets. As I learned more and as I became more involved in Quantified Self, I found myself wanting to quantify these diets. That’s what drew me to Keto. It’s the most measurable diet. Quick Summary of the Ketogenic Diet Keto is a high-fat, very-low-carb diet, usually with 70% of calories coming from fat. The idea is to switch your body from using glucose as its primary energy to breaking down fats into ketones for energy. You can measure the macros that you eat and you can measure the ketones in your urine, breath, and blood. In 2013, I did my first experiment with the ketogenic diet. In that experiment, I tracked everything I ate in MyFitnessPal and compared it to other data I was collecting. I found my energy increased, my sleep quality went up (according to my Zeo data), my cholesterol levels improved, and my food cravings went away. However, I also found that measuring everything I ate was a pain, I didn’t really kn Continue reading >>
Pruvit Keto Os Now In Canada
Pruvit Canada is shipping Keto OS in Canada! Keto OS Canada! No more cross border duties, high shipping prices etc. Pruvit recognized the demand for Keto//OS in Canada, so they now are shipping Keto OS, and all their products directly from their warehouse in Toronto, Ontario Canada! Here is the link to order from within Canada I live in the Toronto, ON Canada and since they opened up the warehouse my shipping times have been much faster (2 days sometimes), and obviously much cheaper than before. An average order of Keto OS shipped in Ontario, Canada is around $5-$7 and across Canada only $12-$15. (based on my experience) TIP: HOW TO GET 22% OFF KETO OS ALWAYS! Ordering from me above? Well here is how you can save 22% using our “SmartShip” option (monthly autoship which you can cancel anytime). By selecting TODAY + SMARTSHIP when ordering Keto OS. You will get a shipment sent out today to you (paying only for that order) and will be setup for NEXT MONTHS autoship order which will ship out next month (you get charged next month when it ships), that one will be discounted 22% and always be 22% off as long as you keep your smartship! You can change flavors monthly! and cancel anytime without penalty! The Savings are AMAZING! What Is Keto OS? How does it work? This video shows how ketosis happens in the body, and how it burns fat. As well the benefits of using Keto OS. Keto OS Canada | Products Available to Buy Prior, Pruvit in the USA had more Keto OS products available than we did here in Canada. But since we have a warehouse here now – that is not the case. Pruvit Canada has the same products available as in the USA! Below are the Canadian Keto OS products you can buy. As well I explain the benefits of each product, so you can select the right product for you. EXCLU Continue reading >>
Can Ketone Supplementation Mitigate Migraine Attacks?
A new study, not yet published, suggests that taking ketone supplementation might help reduce the frequency of migraine attacks. An improvement of migraine problems is a common experience on a keto diet. Preliminary evidence indicates that a daily dietary supplement providing ketones can reduce the frequency of migraine headaches with no adverse effects. Increasing evidence suggests an energy deficit disorder exists in migraine, the researchers note. By supplying ketones as an alternative fuel to glucose, several deleterious components of the deficit may be avoided. Medscape: Dietary supplement with ketones may mitigate migraine attacks Don’t miss the interview below with PhD student Elena Gross who conducted the study. Video with Elena Gross Top videos about ketosis Earlier “She finally feels good and it warms my heart” Continue reading >>
The 7 Best Keto Supplements For The Ketogenic Diet
Ketogenic Diets (more specifically, Cyclic Ketogenic Diets) are the most effective diets for achieving rapid, ultra low bodyfat levels with maximum muscle retention. Now, as with all such general statements there are circumstantial exceptions. But done right – which they rarely are – the fat loss achievable on a ketogenic diet is nothing short of staggering. And despite what people might tell you, you will also enjoy incredible high energy and overall sense of well being. The Perception Despite these promises, more bodybuilders/shapers have had negative experiences than have seen positive results. The main criticisms are: Chronic lethargy Unbearable hunger Massive decrease in gym performance Severe muscle loss All of these criticisms result from a failure to heed the caveat above: Ketogenic Diets must be done right. It must be realised that they are an entirely unique metabolic modality that adheres to none of the previously accepted ‘rules’ of dieting. And there is no going half-way; 50 grams of carbs per day plus high protein intake is NOT ketogenic. So how are ketogenic diets ‘done right’? Let’s take a quick look at how they work. Overview of Ketosis Simply put our body, organs, muscles and brain can use either glucose or ketones for fuel. It is the function of the liver and pancreas (primarily) to regulate that fuel supply and they show a strong bias toward sticking with glucose. Glucose is the ‘preferred’ fuel because it is derived in abundance from the diet and readily available readily from liver and muscle stores. Ketones have to be deliberately synthesised by the liver; but the liver can easily synthesise glucose (a process known as ‘gluconeogenesis’ that uses amino acids (protein) or other metabolic intermediaries) too. We don’t get bet Continue reading >>
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Exogenous Ketones: The Best Supplements, Benefits And Side Effects
It’s amazing how much of an effect ketosis can have on weight loss. However, modern lifestyle is intertwined with the heavy intake of carbs, and for many people – it’s very hard to go full keto. Enter exogenous ketones. Ketones are extremely beneficial when it comes to our health. By following a ketogenic die t, you will reach ketosis, which is a state of our body producing a lot of ketones, and they are very good if you have high blood sugar. Another great “feature” of ketones is that, if they are consumed too much, leading to an excess amount – you probably won’t gain fat through it. The reason for this is that excess ketones are eliminated from our body very quickly, especially by the help of the kidneys; they throw them out with urine, instead of sending them into tissues. Of course, if you take incredibly high amounts of ketones – you risk gaining weight, but the chances for that are much, much lower, which is what makes ketones amazing nutrients. But first of all... What are ketones? And what are exogenous ketones? Ketones are organic compounds which are used by our body to generate energy. There are three different types of ketones which are produced in the liver: acetone acetoacetic acid and beta-hydroxybutyric acid. When we’re on a low-carb diet, then our body uses stored fat as its primary source of energy, and it doesn’t rely on glucose at all. The direct result of this is fat burning i.e. weight loss. Ketones are produced naturally in our body, but the term exogenous refers to those ketones which are taken through supplements. Here’s a good word of advice: don’t get confused if you end up looking at BHB products (beta-hydroxybutyrate), because the supplements of today are mostly distributed as BHB salts. The reason for this lies in th Continue reading >>
Breakthrough New Ketone Supplement!
A Breakthrough New Ketone Supplement For the last two years I have been living and breathing everything keto, and also reading every book and research out there about ketosis and the benefits of keto adaptation. I have also assisted many conferences, and it was last year at AHS14 that I met Dr. DiAgostino. Dr. DiAgostino is one of the leading researches working with cancer and ketosis at the University of South Florida. Is also one of the first researchers to study the effects of exogenous ketone supplementation. He is the first person who talked to me about ketone supplements, and he really spiked my curiosity, mentioning all the amazing benefits of supplementing with BHB. Here is a great article that explains more about his work. So I decided to try a ketone supplement on myself. Unfortunately what was on the market a year ago was a very unpalatable pure ketone salt (KetoForce), which worked on elevating my ketosis but also gave me very bad stomach upset and nausea. Needless to say I did not continue taking it, and forgot all about ketone supplements. A quick look at ketones and how they work. As you might already know ketones are metabolites with cellular structure quite similar to glucose and they are produced in the liver out of fatty acids, in order to feed the body with energy, when glucose is low or absent. That is why ketosis is induced by restricting carbs and not by adding fat to your diet!! Unfortunately not every body is equally able to convert fat into ketones or getting in ketosis would be much easier! In my clinical experience I learned that every time your liver is not functioning perfectly or is congested, you will have a harder time producing those desired ketones and keeping a high level of nutritional ketosis. That is why weight loss stalls and you Continue reading >>
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Everything You Should Know About The Ketogenic Diet
Recently I had a client tell me that she and her husband were eating more than 2 pounds of bacon a week—usually three strips for breakfast and one or two with a salad for dinner. I’ve been a dietitian for almost 20 years. Few things surprise me. But I had to ask: “Why?” She told me that her husband had heard about a new diet on TV, the keto diet, and they decided to try it. Six months and countless packages of bacon later, her husband had lost 20 pounds and said he felt more energetic. I’m beginning to hear more and more people lecture me about the benefits of the ketogenic diet. “Keto burns fat fast! It turbo-charges your energy! It fights disease! You can eat all the bacon you want!” But as is so often the case with diets, underneath all the initial excitement, there’s a gut check. Here’s everything you should know about the ketogenic diet and whether or not you should try it for yourself. Ketogenesis has existed as long as humans have. If you eat a very low amount of carbohydrates, you starve your brain of glucose, its main fuel source. Your body still needs fuel to function, so your brain signals it to tap its reserve of ketones. It’s like a hybrid car that runs out of gas and reverts to pure electricity. Okay, but what are ketones? They’re compounds created by your liver from your fat stores when blood insulin is low. “Your liver produces ketones all the time, but the rate depends on carbohydrate and protein intake,” says Jeff Volek, Ph.D., R.D., a professor of human sciences at Ohio State University. Eat a normal amount of carbs and protein, and ketogenesis idles. Cut carbs and protein back, and you push to half throttle. This takes about three days to induce. A ketogenic diet requires that fat comprise 60 to 80 percent of your total calo Continue reading >>
What Everybody Ought To Know About Ketosis
Recently I wanted to explore the world of Ketosis. I thought I knew a little bit about ketosis, but after doing some research I soon realised how wrong I was. 3 months later, after reading numerous books, listening to countless podcasts and experimenting with various diets I know have a sound understanding of ketosis. This resource is built as a reference guide for those looking to explore the fascinating world of ketosis. It is a resource that I wish I had 3 months ago. As you will soon see, a lot of the content below is not mine, instead I have linked to referenced to experts who have a greater understanding of this topic than I ever will. I hope this helps and if there is something that I have missed please leave a comment below so that I can update this. Also, as this is a rather long document, I have split it into various sections. You can click the headline below to be sent straight to the section that interests you. For those that are really time poor I have created a useful ketosis cheat sheet guide. This guide covers all the essential information you should know about ketosis. It can be downloaded HERE. Alternatively, if you're looking for a natural and sustainable way to improve health and lose weight head to this page - What is Ketosis? What Are The Benefits from being in Ketosis? Isn’t Ketosis Dangerous? Ketoacidosis vs Ketosis What Is The Difference Between a Low Carb Diet and a Ketogenic Diet? Types of Ketosis: The Difference Between Nutritional, Therapeutic & MCT Ketogenic Diets Is The Ketogenic Diet Safe? Long Term Effects Thyroid and Ketosis - What You May Want To Know What is a Typical Diet/Macro Breakdown for a Ketogenic Diet? Do I Need to Eat Carbs? What do I Eat On a Ketogenic Diet? What Do I Avoid Eating on a Ketogenic Diet? Protein Consumption a Continue reading >>
The Top 5 Best Exogenous Ketone Supplements
Ketogenic diets have been around for at least a century in one form or another, but they have really grown in popularity over the last few years. The idea is that you follow a diet with virtually no carbohydrates in it whatsoever. This is not a low carb diet, this is a very low carb diet (less than 20g per day). After following this for 24 hours your body should be almost completely void of glycogen, the main fuel source (that comes from carbohydrates). When this happens the body goes into a process known as ketosis – where it uses stored body fat to convert to ketones, which can be used for energy as a replacement for glycogen. Exogenous ketones are ones that are not produced in the body. They are taken as nutritional supplements, to 1) help a person enter ketosis faster, and 2) to increase the benefits of doing so. Supplementing with ketones can have physical and mental benefits – improving endurance, reducing appetite (great for people on diets), and increasing cognitive performance (short term memory, decision making, focus). In this article we are going to take a brief look at five of the best exogenous ketone supplements that are currently available to buy. Starting with the best first. 1. Perfect Keto Perfect Keto are a supplement company dedicated to selling exogenous ketones, they have two base products: Chocolate Sea Salt flavour and Peaches & Cream flavour. They use stevia leaf as a sweetener which helps keep calories (and carbs) down to an absolute minimum and each serving contains 11.38g of Beta Hydroxybutyrate (BHB) – which is the main form of exogenous ketone. They have spent a lot of time ensuring that their product tastes delicious which sets them apart from most companies (exogenous ketones have a reputation for tasting disgusting). Order Perfect Continue reading >>
Best Exogenous Ketone Supplements
Exogenous ketones are a very new and exciting health food supplement that offers numerous health benefits to those who use them regularly. They’ve only been on the market since 2014, but ketones themselves have been studied extensively throughout the last several decades. Ketones are made in the liver from stored fat cells, providing us with energy in times when the body doesn’t have available glucose or “glycogen” to burn. Examples include when you’re pushing the body hard physically and burn off all your stored sugar energy (glycogen/blood glucose), or during times of famine when food is scarce. Exogenous ketones are exactly the same as ketones as far as the body is concerned. “Exogenous” simply means that the ketones are derived from sources outside the body, whereas ketones manufactured by the liver from fat stores are referred to as “endogenous” ketones. The Human Body Isn’t Meant to Run on Sugar All the Time Ketones are now recognized by science as the preferred energy source for both the brain and heart, while our biological power-source inside the body, the mitochondria, also thrive when fueled by ketone bodies instead of glucose. Mitochondria are the sole driving force behind aging in the body, as they help kill aged and/or malformed cells (eg., cancer), form new healthy cells, and in general help keep the body vital and full of energy. Several studies where exogenous ketones have been administered show boundless improvements in athletic performance, cancer treatment, Alzheimer’s, dementia, inflammatory diseases, and genetic disorders of all kinds. Exogenous ketones aren’t to be compared with the hyped-up raspberry ketones that are so popular for weight loss these days. Raspberry ketones are somewhat similar on a molecular level, but are Continue reading >>
Raspberry Ketones — Do They Really Help With Weight Loss?
Raspberry ketones are chemicals from red raspberries that are thought to help you lose weight fast. Ketones are natural chemicals that give raspberries their enticing aroma, and they also occur in blackberries and cranberries. When ketones are taken from raspberries, they can be used to add fragrance and flavor to foods and products, such as colas, ice cream and cosmetics. The raspberry ketone is actually one of the most expensive products used in the food industry — the natural compound can cost as much as $20,000 per kilogram. That’s why supplement companies use synthetic raspberry ketone, which is much cheaper. Some research in rodents or in test tubes shows that raspberry ketones might increase measures of metabolism and affect a hormone in the body called adiponectin, which regulates metabolism. Raspberry ketones are claimed to cause the fat within cells to be broken down more effectively, which helps the body burn fat faster. The big issue here is that these claims are not supported with human research, as there is no reliable scientific evidence that proves raspberry ketones improve weight loss when taken by people. Are raspberry ketones another common unhealthy way to lose weight? Studies Involving Raspberry Ketones A 2005 study published in Life Sciences evaluated whether or not raspberry ketones help prevent obesity and activate lipid metabolism in rodents. The study involved two groups of mice — one that was fed a high-fat diet and took raspberry ketone doses for 10 weeks and another group that was given a high-fat diet for six weeks first and then began receiving raspberry ketone doses for the remaining five weeks, along with the high-fat diet. The results of the study suggest that raspberry ketones prevent the high-fat-diet-induced elevations in body Continue reading >>
Pruvit Keto-os – The Ketone Operating System
Pruvit is a trusted health and wellness company with highly known ketone supplements and nutritional products. Their most popular formula is Keto-OS, which stands for Ketone Operating System and it’s a powdered weight-loss ketone drink. The company describes Keto-OS as a powder that you mix with 8-10 oz. of water and within 15-30 minutes it puts the body in a state of Ketosis. Exogenous Ketone supplements are commonly used for weight loss and to enhance physical performance because of their unique properties. When the body lacks glucose, sugars and starchy foods for energy, it burns stored fats instead; this creates a beneficial build-up of acids within the body called ketones. According to multiple studies the benefits of ketones ranges from weight loss, to athletic performance, appetite control and other positive side effects that come from getting the body in a state of Ketosis. When we contacted Pruvit for a quote about their supplements and what they do, here is what they said: Keto-OS is your “ketone operating system” it’is the First Therapeutic Ketone Supplement on the market. The proprietary blend is owned by Prüvit and is Dr. Approved, Lab Tested, University backed and the technology in Keto-OS is patent pending, developed by one of the most world renown Dr.’s and experts on Ketosis. Prüvit was the first company approved by University of South Florida to acquire the sub-license rights to use this patent pending technology. Keto-OS is a powder that you mix with 8=10 oz. of water. Within 15-30 minutes it puts your body into Ketosis. Keto-OS. Keto-OS has a certificate of analysis for purity, consistence and efficacy. Over the past 5 years, Keto-OS has solidified itself as one of the most well known and used ketone supplements. We asked Pruvit why someo Continue reading >>