Bears Hibernation Ketosis

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Access the mini course here: http://defeatkidneydisease.com/FreeMi... Hi, my name is David. A friend of mine was diagnosed with Stage 3 Chronic Kidney Disease (CKD) recently. He was shocked - he had not felt that bad and was there for a routine check-up. He was told that there were 5 CKD stages and that all he could do is try and slow the descent down to Stage 5 - Kidney failure. I am guessing if you are watching this video then you or a loved one has had a similar experience. My personal experience with Western medicine is that it can be very useful, life saving for many. But it can take a rather narrow view to what is possible. So for my friends sake, I went out to find the truth for myself. I learned about the CKD stages which I tell you about in the video. But in the course of my searches I came across Duncan, a second generation naturopath who was leading the world in the natural healing of kidneys. He has many patients who have reversed their Kidney disease, moving from Stage 3 to Stage 2 as an example. Knowing how severe the lower CKD stages are I asked Duncan if he would put together a course I could provide people like you and me who are looking to heal kidney disease. He

5 Stages Of Activity And Hibernation

The annual cycle of black bear activity and hibernation has five stages: The stages differ in biochemistry, physiology, appetite, and level of activity. The onset and duration of the stages are genetically programmed to fit regional norms of food availability, which differ across America. When people defined hibernation simply in terms of temperature reduction, bears were not considered hibernators. However, when biologists discovered the many metabolic changes that let black and grizzly bears hibernate up to 7 ½ months without eating, drinking, urinating, or defecating, they realized that body temperature was only a small part of hibernation. They redefined mammalian hibernation as a specialized, seasonal reduction in metabolism concurrent with scarce food and cold weather (Watts et al. 1981). Black bears are now considered highly efficient hibernators. Before researchers from the Wildlife Research Institute videotaped 3-year-old June digging this den in Eagles Nest Township, Minnesota, they had no idea some bears made dens so early—July 19, 2004. It was the first time researchers watched a bear dig a den. The most interesting part happened when she encountered a 68-pound rock. Continue reading >>

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  1. RawNut

    Humans are unique in their remarkable ability to enter ketosis. They’re also situated near the top of the food chain. Coincidence?
    During starvation, humans rapidly enter ketosis; they do this better than king penguins, and bears don’t do it at all.
    Starvation ketosis
    Humans maintain a high level of functionality during starvation. We can still hunt & plan; some would even argue it’s a more finely tuned state, cognitively. And that’s important, because if we became progressively weaker and slower, chances of acquiring food would rapidly decline.
    Perhaps this is why fasting bears just sleep most of the time: no ketones = no bueno..?
    Observation: chronic ketosis is relatively rare in nature. Angelo Coppola interpreted that to mean animals may have evolved a protective mechanism against ketosis (if you were following along, please let me know if this is a misrepresentation).
    But I think that is misguided. Animals with a low brain/carcass weight ratio (ie, small brain) don’t need it. Babies and children have a higher brain/carcass weight ratio, so they develop ketosis more rapidly than adults. Is this a harmful process? No! It’s an evolutionary adaptation which supports the brain.
    The brain of newborn babies consumes a huge amount of total daily energy, and nearly half comes from ketones. A week or so later, even after the carbohydrate content of breast milk increases, they still don’t get “kicked out of ketosis” (Bourneres et al., 1986). If this were a harmful state, why would Nature have done this? …and all those anecdotes, like babies learn at incredibly rapid rates… coincidence? Maybe they’re myths. Maybe not.
    Ketosis in the animal kingdom
    Imagine a hibernating bear: huge adipose tissue but small brain fuel requirement relative to body size and total energy expenditure. No ketosis, because brain accounts for less than 5% of total metabolism. In adult humans, this is around 19-23%, and babies are much higher (eg, Cahill and Veech, 2003 & Hayes et al., 2012).
    A possible exception to this is ruminant ketosis, but that’s for a different reason. They become ketotic because: 1) their gut turns much of what they eat into a ketogenic diet; and 2) this frequently happens during lactation, which combines very high energy expenditure and an enhanced draw on the oxaloacetate pool to make lactose.
    Whales? Nope. Despite eating for like, 1 month out of the year, they don’t develop ketosis.
    Snakes will enter ketosis, not due to high brain needs per se, but likely because even though small brain, total energy expenditure is so low that brain metabolism easily surpasses the [theoretical] 5% threshold (McCue 2006):
    Fasting baby elephant seals get ketotic, because their babies (Castellini and Costa, 1990):
    Hypercarnivores (eg, cats) don’t develop ketosis on very low carb diets, like humans would, which seems to be due to their inability to down regulate protein catabolism (urea cycle takes care of the nitrogen; gluconeogenesis the carbon)… but they will do so readily during starvation because of relatively big brains (Blanchard et al., 2002):
    Similar to cats, dolphins are carnivorous and also exhibit what appears to be a pathological inability to reduce protein catabolism when necessary. However, unlike cats, dolphins fail to develop ketosis of any sort, whether it’s on their typical low carb diet of fatty fish, or even complete starvation!
    Dolphins are the exception to a lot of rules. I don’t know why. Most animals with big brains have the ability to enter ketosis, but none do it as well as humans.
    Historically, while intermittent or cyclical ketosis was likely more common than nutritional [chronic] ketosis in humans, this doesn’t mean one form is better than another. Common =/= optimal.
    Starvation ketosis isn’t nutritional ketosis, but much of what we know about the latter stems from our understanding of the former… this is getting better, with more and more studies of longer and longer durations being published regularly. And hint: chronic ketosis doesn’t dissolve bones, deteriorate cognitive function, or break your metabolism.
    Are ketones the brain’s preferred fuel?
    Well, let’s just say this: when there are more ketones than glucose, brain uses more ketones than glucose. This happens in both starvation and nutritional ketosis.
    Ketosis proportionately spares glucose utilization in the brain (Zhang et al., 2013)
    If ketones were harmful, Nature would’ve surely devised a way to protect the brain!
    Disclosure: I’m not keto, not even very low carb in the summer really, so this obviously isn’t some sort of confirmation bias or logic fail or whatever you call it. I don’t practice what I preach. Sue me.
    Most of the time, I advocate a plant-based low-carb Paleo-like diet for health; keto if obese insulin resistant. High[ish] protein for all (ymmv). Seasonal when possible.
    Impact of ketones on cognition
    Would our ability to plan and set traps to acquire food, or quickly devise a strategy to escape predation have been negatively impacted during periods of intermittent or cyclical ketosis? I think not; more likely the opposite. And while I [still] believe the physical feats required to do these is not hindered after ketoadaptation, I also [still] believe it’s because we *out-smarted* them, not out-ran them. Compared to many other species, humans suck at speed.
    Some evidence:
    1. acute: in patients with moderate cognitive impairment or Alzheimer’s disease, given 40 mL MCTs to bolster ketoneshttp://ir-na.amazon-adsystem.com/e/...=1&a=B0019LRY8A: cognitive performance improved roughly in parallel with increasing ketones (Reger et al., 2004).
    2. chronic: 20 grams of Axona (purified MCTs) daily for 90 days improved cognition in people with age-associated memory impairment (Constantini et al., 2008).
    3. cruel and unusual: expose a group of type 1 diabetic patients to experimental hypoglycemia and give half 40 grams of coconut oilhttp://ir-na.amazon-adsystem.com/e/...=1&a=B003OGKCDC (which is like a longer-chained version of MCTs) (Page et al., 2009). Result? Hypoglycemia impairs cognition; however, this is largely offset by increasing ketones with coconut oil. This group experienced improved: 1) verbal memory; 2) delayed verbal memory; and 3) verbal memory recognition.
    4. nutritional ketosis: 6 weeks of a bona fide ketogenic diet in patients with mild cognitive impairment = improved verbal memory performance, and this positively correlated with ketones (Krikorian et al., 2012).
    Optimal, harmful, or somewhere in between? You decide (but if you choose harmful, please provide a link! or at least explain why, very clearly…)
    Hint: nutritional ketosis isn’t harmful. FOR. FIVE. YEARS… 1) that’s not cyclical or intermittent ketosis; and 2) five years is probably much longer than the diet you’re following has been tested for “safety.”
    Ketones in evolution
    Without our ability to rapidly enter a robust state of ketosis, we wouldn’t be here, or we’d be some weaker subhuman species. But ketones have been around for a while… some bacteria store energy in the form of poly-beta-hydroxybutyrate. Some prokaryotes use ketones instead of triacylglycerols. Archaea also use ketones; and they’ve been around for billions of years… it’s estimated that we’ve been doing it for quite a long time, too (from evidence on when our brain would’ve surpassed the [theoretical] threshold). I’d cite a study by George Cahill here, and maybe you’d read it. But you should really read all of the studies by George Cahill (it’s not a-whole-lot). Sorry, I know that sounds ‘preachy.’
    Would ketosis have hindered our ability to hunt prey and avoid predation? My thoughts on our ability to perform high intensity physical activity after ketoadaptation have been thoroughly expressed in the past. And ketosis clearly doesn’t hinder cognitive functioning.
    So, from both a mental and physical perspective, ketosis, chronic or otherwise, did not stop us from becoming who we are. Indeed, it probably contributed to how we did so. Well, that and seafood.

  2. keith v

    Wow thanks Rawnut, that was very interesting.
    It especially makes mouse studies suspect due to the mouses small brain

  3. teaser

    An aspect to this that I find interesting is the idea that ketones spare fat. An animal like an elephant seal with its relatively smaller brain and larger fat mass can afford to fuel its glucose cycle from glycerol almost exclusively. If we wanted to do the same trick, and needed 100-125 grams of glucose a day to fuel our brains--at around ten percent of triglyceride calories as glycerol, we'd have to burn through 4000-5000 calories of fat a day during complete starvation, obviously not a good strategy for a person with what used to be "normal" fat stores.

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For Educational Use Only - Fair Use - It s free and it fits in the palm of your hand u2014 Jillian shares her secret for au00a0beach-ready bod rn

Slim By Summer, Secrets Of Ketosis

30day Fat Burning Diet Program: Lose Weight, Secrets of Ketosis Listen to the sweet sounds. The birds are singing. The lawn mower motors are rumbling. Children are outside playing and squealing with delight. Are you smiling? Maybe not. You may just feel stressed because you added pounds like a hibernating bear over the winter and these changes mean it’s time for shorts and halter tops. 30day Physician-Designed Fat Burning Diet Program Fear not. Take action now. You can lose more than 10 pounds in 30 days with an effective (& healthy) combination of high fiber, lean protein and healthy carbs. You can follow this diet without counting calories, counting carbs or counting points. It’s heart-healthy, diabetic-friendly and easy. 30day Diet Program – Phase One Here’s the scoop on this 3-step 30day physician-designed fat burning diet program. The first phase will jump-start your weight loss. You should lose 8-13 pounds over the first two weeks. Most of what you shed will be from your mid-section. During this time, your blood sugar levels will stabilize and you will eliminate your cravings for sugary foods and refined starches. You will do this with a good balance of nutrient-dense Continue reading >>

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  1. coreycorndog

    I posted to r/askscience for the hell of it but really this answer is all I needed.

  2. tinkan

    I think it's a pretty straight-forward yes. There is no other energy source other than stored fat and metabolic processes are conserved amongst all animals. The bear must rely on metabolizing the fat stores and that will involve ketosis (the brain likes ketones, it doesn't/can't use FFA - this is why people say the brain prefers glucose but it's really a misnomer. There are no lipid stores in the brain and free fatty acids are not soluble enough in the blood nor are they going to be able to cross the blood brain barrier. This physical barrier means brain cells can not rely on FFA for energy. Thus, FFA are converted in a more blood soluble fat energy molecule, the ketone. In short, the brain does not "require" glucose to function. It just needs time to adapt to ketone usage.)
    Just be forewarned AskScience harbors some anti-keto sentiments that we know to be false (such as loving to bring up the ketoacidosis reason or kidney troubles). But they would probably give you a better answer than us.

  3. Sporkfortuna

    IIRC, Bear recycles his urine during the long winter months.
    "Stuck in a cave, better..."

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http://prostatesupplementsreview.com/... - Constant Urge To Urinate And Lower Back Pain - What Causes Constant Urge To Urinate And Lower Back Pain In Men? The kidneys are bean-shaped organs located in your lower back. They filter your blood and release waste products via your urine. Problems that affect the kidneys can cause lower back pain. For example, pyelonephritis is a kidney infection that can result in back pain. In addition to frequent urination, your urine may be cloudy and/or foul smelling. A urinary tract infection, kidney stones, or bladder stones can also cause these symptoms. Prostate gland inflammation can also cause back pain and frequent urination, along with flu-like symptoms. If you're taking Enlarged Prostate prescription drugs like Flomax, Proscar, Cardura or Avodart and you have not read this Amazing information concerning Prostate Enlargement treatment yet, then by all means get your hands on this right away. The NEW Enlarged Prostate Healing Discovery! " The $1.49 100% NATURAL Prostate Enlargement & E.D. Cure Your Doctors Hope You'll NEVER FIND OUT ". If You're Looking for a natural treatment for swollen prostate that work, then we advise you to check out Vi

Do Hibernating Bears Urinate?

And now for a discussion of a burning nephrology question: what happens to a bear's renal function when it goes into hibernation? (Thank my brother for raising the question while he was a medical student.) The simple answer to the headline question is: no, they do not. The details behind what does happen to renal function and nitrogenous waste disposal in hibernating bears is unfortunately not fully worked out yet, but what is known is a fascinating example of adaptive physiology. Bears hibernate in spans of a few weeks to several months, depending on the species, the weather, and available food stores. During that period, their metabolism drops to about a third of normal. There is a shift away from protein and carbohydrate metabolism toward fat breakdown. These processes result in a few notable changes in renal function: creatinine rises (from an average of 1-1.5 mg/dL to 3 mg/dL, thought to be due to decreased renal perfusion), and urea:creatinine ratio falls (as a result of decreased protein metabolism). A small amount of urine, about 100 mL, is produced, and the water and nitrogenous breakdown products are reabsorbed through the bladder. How does this happen? No idea. Urea is d Continue reading >>

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  1. Clare

    Does anyone else find that they get motivated to declutter their home while on a fast?!
    This was recently discussed on a Facebook group I'm in, I find the whole idea of 'body' and 'home' autophagy fascinating.......
    I wonder if anyone else experiences the same urge to declutter when fasting or in deep ketosis?
    Maybe its something to do with having that boost in energy that fasting brings plus the extra time that the lack of food prep and eating offers?!
    Anyone else noticed this correlation?

    ***Apologies to admin if I have posted this in the wrong category.

  2. leenie

    Personally, I feel empowered when I'm on a Keto high. My brain is laser focused and overall I move at a much quicker pace and on top of that I don't tire. It's crazy how much I get accomplished when I have high ketones! I do find I go out of my way to clean and straighten up more than usual when I'm feeling wonderful.

  3. Clare

    Yep me too!
    Im thinking it's like we have physiologically evolved to have more energy available when carbs are low, or scarce.
    In temperate climates, during Autumn/winter it seems like we naturally hibernate and conserve energy, and those times are when we have more access to fruits and root vegetables.
    Ketones seem to boost energy levels and during lean times this would give us the energy required. Is it a coincidence that we 'Spring'clean when food would have naturally been scarce?!

    Just something I'm pondering...... lol

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