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Antidote For Metformin

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Dept.of GI, Obesity & Metabolic Surgery

Metformin-related Acidosis In A Woman While Performing Haj: A Conservative Approach Ansari Rs, Mady Af, Qutub Ho, Althomaly E, Alzayer Za, Moulana Aa - Saudi J Kidney Dis Transpl

Metformin is a biguanide that enhances the release of glucose from the liver and the insulin effect on peripheral tissues thus decreasing the blood glucose. The most serious sideeffect of metformin is lactic acidosis due to inhibition of hepatic gluconeogenesis and/or reduction of conversion of lactic acid, pyruvic acid or alanine to glucose. The yearly incidence of lactic acidosis in previous reports was less than five episodes in every 100,000 treated individuals. Still, there is no particular antidote for metformin-induced lactic acidosis and its treatment mainly involves the correction of acidemia. [1] Considerable efficacy has been observed in the use of hemodialysis to treat the metformin-induced lactic acidosis. Hemodialysis application is currently recommended in patients with severe metabolic acidosis (pH < 7.1) and renal failure. It has been shown that plasma metformin concentrations are only slightly increased when the estimated glomerular filtration rate is 30 mL/ min/1.73 m2. [2] We present a case of successful management of metformin-associated metabolic acidosis, treated simply with intravenous sodium bicarbonate and aggressive hydration and intensive monitoring. Ou Continue reading >>

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Popular Questions

  1. acratus

    Hi. I've been on Keto for three weeks as of yesterday. Admittedly, my potassium and sodium haven't been where they should have been. (I've been eating green leafies, taking pills, and supplementing with beef broth, only to figure out I've been getting half or less potassium and sodium of what I need.) I have been drinking tons of water.
    Today, my sides are tender where my kidneys are and I have an upset stomach. These are warning signs. I don't want to experiment with things to see how they work, I DON'T WANT A FUCKING KIDNEY STONE. If you can calm me down, please try to do so, otherwise I'm going to get a rice bowl from Chipotle after work.

  2. anbeav

    Go to a doctor if you're concerned! Just FYI you don't grow a kidney stone in 3 weeks nor would rice change your symptoms. Drink some water call a doctor. Keto doesn't increase the risk of stones, it can make a stone symptomatic in those more susceptible to stones who don't drink enough water

  3. acratus

    This was the most helpful comment and you've helped me calm down a good bit. Thank you.

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WATCH FULL VIDEO: https://goo.gl/APNPrA?32717

1322: Prolonged Hemodialysis-an Antidote For Metformin Induced Lactic Acidosis

Introduction: A 60 year old Hispanic man with Type 2 diabetes mellitus and on Metformin was brought to the Emergency Department with vomiting and diarrhea of two days duration. On physical examination, he was noted to be hypothermic, hypotensive and confused. Laboratory work-up revealed severe life threatening high anion gap metabolic acidosis,hyperlactatemia and markedly elevated creatinine of 9 mg/dl (normal 0.6-1.2 mg/dl) without prior laboratory data. Patient was intubated, vasopressor and sodium bicarbonate intravenous drips initiated and arrangement made for urgent hemodialysis based on a high index of suspicion for metformin poisoning. After 4 hours of hemodialysis, there was marked improvement in the laboratory parameters post hemodialysis. He was given another session of hemodialysis with the same hemodialysis prescription next day for 6 hours with further improvement. Initial metformin levels were found to be 46 mg/l (therapeutic levels < 2 mg/l),later confirming the diagnosis. On the 3rd day, renal function started to improve with further reduction of serum metformin level to 1.5 mg/l. He was extubated on day 5 and subsequently discharged after making a complete recover Continue reading >>

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Popular Questions

  1. kellyrae

    Hi, This may sound daft and ive had diabetes for 25 years and probably really should know more of these abbreviations, Ive been reading lots of posts and come across quite alot of them that i have had to look up.....so i now know DKA=Diabetic Ketoacidosis.....obviously i know what it is, just didnt know the DKA part, anyone got any more they can share

  2. glucosegirl

    These are some DAFNE abbreviations that drive me mad. I've never been on a DAFNE course but I learnt these terms from others on this forum:
    BI =background/basal insulin
    QA =quick acting insulin
    CP =carbohydrate portion (10g carbs)
    Some other non-DAFNE terms that I know are:
    hypo= hypoglycemia
    bg = blood glucose
    bgl blood glucose level
    bs = blood sugar
    bsl = blood sugar level
    and the one that has been annoying me since I was diagnosed until I looked it up last week:
    BM - basically used instead of the term bg for example his BM before bed last night was 5.4mmol/l or make sure you check your BM before lunch today
    BM stands for Boehringer Mannheim, now called Roche, who produced test strips called 'BM-test'

  3. kellyrae

    glucosegirl said:
    These are some DAFNE abbreviations that drive me mad. I've never been on a DAFNE course but I learnt these terms from others on this forum:
    BI =background/basal insulin
    QA =quick acting insulin
    CP =carbohydrate portion (10g carbs)
    Some other non-DAFNE terms that I know are:
    hypo= hypoglycemia
    bg = blood glucose
    bgl blood glucose level
    bs = blood sugar
    bsl = blood sugar level
    and the one that has been annoying me since I was diagnosed until I looked it up last week:
    BM - basically used instead of the term bg for example his BM before bed last night was 5.4mmol/l or make sure you check your BM before lunch today
    This is great!!!! Thankyou very much
    BM stands for Boehringer Mannheim, now called Roche, who produced test strips called 'BM-test'
    Click to expand...

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If you think this video some information of medicine or treatment so please like, positive comments, shares and subscribe this channel. Related social media Site more information: https://www.facebook.com/profile.php?... https://twitter.com/jarirose4210 https://www.reddit.com/user/jarirose4... https://vk.com/id212361804 https://www.pinterest.com/jarirose/ https://www.instagram.com/jarirose4210/ http://www.inceptapharma.com/view-pro... Keyword medicine online medicine medicine online medication prescription drugs health and medicine medicine list unani medicine medication list medicine journal health medicine medicine information medicine app online medicine app medicine search medicine name and use drug information drug names medicine names buy medicine online medical journals medicine details journal medicine drug list drug index medical journals online medicine sites medicine information app medicine website medicine and drugs drugs and medicines medicine science web medicine prescription drugs online medicine online shopping medicine for health drug search medical websites online pharmacy online prescription drugs medicine buy science medicine medical school medicine information

Toxicology Case Of The Month: Oral Hypoglycaemic Overdose

Toxicology case of the month: oral hypoglycaemic overdose J Soderstrom, L Murray, M Little, Sir Charles Gairdner Hospital, Perth, WA, Australia L Murray, F F S Daly, M Little, University of Western Australia, Perth, WA, Australia L Murray, F F S Daly, M Little, New South Wales Poison Information Centre, New Children's Hospital, Westmead, NSW, Australia F F S Daly, Royal Perth Hospital, Perth, WA, Australia Copyright 2006 Emergency Medicine Journal. This article has been cited by other articles in PMC. A teenager ingests 375 mg of glipizide and 14.5 g of melformin intentionally in a small country town. She presents to the local medical facility with symptoms and signs of hypoglycaemia. Using a risk assessment based approach, the management of suiphonylurea and metformin overdose is discussed. Sulphonylurea overdose invariably results in profound hypoglycaemia that requires resuscitation with IV dextrose and the use of octreotide as an antidote. Metfonnin overdose rarely causes problems. Keywords: glipizide, hypoglycaemia, lactic acidosis, metformin, overdose This is the first in a series of cases presented by the Western Australian Toxicology Service. The cases are selected for the Continue reading >>

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Popular Questions

  1. Alisonjane10

    Hello folks
    I've been following a low carb diet, moderate fat intake for 2 months now. After asking tons of questions on this marvellous forum, I've learnt how this way of eating works. Via testing, I know I am consistently in nutritional ketosis. I am currently losing about a 1LB a day in weight...which is great. But, is it normal? I'm aware other members have achieved huge weight loss whilst eating LCHF. But I'm unsure of the overall timescale. Recent blood screening shows I don't have thyroid problems. All advice gratefully received.
    Ali. X

  2. jack412

    do you want to slow it down?
    how are you feeling, do you see any diet like symptoms?
    how much more weight do you want to lose?
    it is a lot a week and twice that is recommended
    www.youtube.com/watch?v=2KYYnEAYCGk

  3. AndBreathe

    Alisonjane10 said: ↑
    Hello folks
    I've been following a low carb diet, moderate fat intake for 2 months now. After asking tons of questions on this marvellous forum, I've learnt how this way of eating works. Via testing, I know I am consistently in nutritional ketosis. I am currently losing about a 1LB a day in weight...which is great. But, is it normal? I'm aware other members have achieved huge weight loss whilst eating LCHF. But I'm unsure of the overall timescale. Recent blood screening shows I don't have thyroid problems. All advice gratefully received.
    Ali. X
    Click to expand... So, in two months you have lost 4 stones? At the outset, how much did you have to lose, and how close are you now to your target?

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