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Alcoholic Starvation Ketoacidosis

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Postmortem Diagnosis Of Alcoholic Ketoacidosis | Alcohol And Alcoholism | Oxford Academic

Aims: The aim of this article is to review the forensic literature covering the postmortem investigations that are associated with alcoholic ketoacidosis fatalities and report the results of our own analyses. Methods: Eight cases of suspected alcoholic ketoacidosis that had undergone medico-legal investigations in our facility from 2011 to 2013 were retrospectively selected. A series of laboratory parameters were measured in whole femoral blood, postmortem serum from femoral blood, urine and vitreous humor in order to obtain a more general overview on the biochemical and metabolic changes that occur during alcoholic ketoacidosis. Most of the tested parameters were chosen among those that had been described in clinical and forensic literature associated with alcoholic ketoacidosis and its complications. Results: Ketone bodies and carbohydrate-deficient transferrin levels were increased in all cases. Biochemical markers of generalized inflammation, volume depletion and undernourishment showed higher levels. Adaptive endocrine reactions involving insulin, glucagon, cortisol and triiodothyronine were also observed. Conclusions: Metabolic and biochemical disturbances characterizing alc Continue reading >>

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Popular Questions

  1. Janja

    I thought I was finished with these, and I quit taking hormones a year ago without reverting to hot flashes.
    Well, a few days after I started PB (three weeks ago), I started getting them again, many per day, and have been having them ever since. I know that some say it might be a vitamin deficiency, and I've read a few posts online that say people experienced them for the first few weeks of a paleo diet because their bodies were converting from glucose-burning to fat-burning. I don't know if this is pertinent, but I was a faithful follower of the McDougall plan (low-fat, high-carb) for 10 months before I started low-carbing again.
    Does anyone have any thoughts on this?
    Here is a typical day for me:
    B
    Eggs scrambled in bacon fat
    Blueberries
    L
    Large tossed salad with chopped cooked chicken, bacon, and vinaigrette
    S
    Apple wedges with almond butter
    D
    Crumbled grilled hamburger with lettuce (lots), onion, tomato, mayonnaise
    Spinach sauteed in butter

  2. jarnapal

    Originally posted by Janja
    I thought I was finished with these, and I quit taking hormones a year ago without reverting to hot flashes.
    Well, a few days after I started PB (three weeks ago), I started getting them again, many per day, and have been having them ever since. I know that some say it might be a vitamin deficiency, and I've read a few posts online that say people experienced them for the first few weeks of a paleo diet because their bodies were converting from glucose-burning to fat-burning. I don't know if this is pertinent, but I was a faithful follower of the McDougall plan (low-fat, high-carb) for 10 months before I started low-carbing again.
    Does anyone have any thoughts on this?
    Here is a typical day for me:
    B
    Eggs scrambled in bacon fat
    Blueberries
    L
    Large tossed salad with chopped cooked chicken, bacon, and vinaigrette
    S
    Apple wedges with almond butter
    D
    Crumbled grilled hamburger with lettuce (lots), onion, tomato, mayonnaise
    Spinach sauteed in butter Hello Janja.
    Do you experience hot flashes in the face area ? I started to experience hot flashes/extreme bushing after starting to eat primal and low carb. I also thought that it's because of the diet change and body converting from glycose to ketones but after 6 months it couldn't be true anymore. I found out my problem and it was iodine deficiency. I added back my iodized salt (potassium iodide does not help. Find salt or supplement like lugol's with pure iodine) and my heart palpilations and hot flashes dissapeared.

  3. MalPaz

    i get hot flashes and palpiltations too, but im 24 s i hope mine isnt menopausal!
    ill try adding back the normal salt, good idea

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Alcoholic Ketoacidosis

Alcoholic ketoacidosis is a metabolic complication of alcohol use and starvation characterized by hyperketonemia and anion gap metabolic acidosis without significant hyperglycemia. Alcoholic ketoacidosis causes nausea, vomiting, and abdominal pain. Diagnosis is by history and findings of ketoacidosis without hyperglycemia. Treatment is IV saline solution and dextrose infusion. Alcoholic ketoacidosis is attributed to the combined effects of alcohol and starvation on glucose metabolism. Alcohol diminishes hepatic gluconeogenesis and leads to decreased insulin secretion, increased lipolysis, impaired fatty acid oxidation, and subsequent ketogenesis, causing an elevated anion gap metabolic acidosis. Counter-regulatory hormones are increased and may further inhibit insulin secretion. Plasma glucose levels are usually low or normal, but mild hyperglycemia sometimes occurs. Diagnosis requires a high index of suspicion; similar symptoms in an alcoholic patient may result from acute pancreatitis, methanol or ethylene glycol poisoning, or diabetic ketoacidosis (DKA). In patients suspected of having alcoholic ketoacidosis, serum electrolytes (including magnesium), BUN and creatinine, glucose, Continue reading >>

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Popular Questions

  1. William Keating

    For commercial aircraft: mountain wave, changing winds, slow aircraft or pilot response to airspeed fluctuations. It is not necessarily even a serious inspection depending on the amount the limit is exceeded. Exceeding airframe speed limits is rarely the real cause of aircraft incidents.

  2. Ronald Sanders

    I just add one scenario: cruising at maximum operating mach number you get a horizontal windshear and you will momentarily exceed that limit. This is common enough to prompt us to set overspeed warning at a few knots above mmo. Traversing the jet steam or entering strong frontal systems can lead to significant headwind changes.

    112 Views · Answer requested by Faiz Ruslan






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  3. Jason Yap

    Recover from a stall or spin
    Stall or spin will not induct an aircraft to exceed speed limit. With a suitable height, the aircraft is available to spin for a very long time until you intend to recover. In example, you can start to recover above 5000ft so that you will have more time and distance to the ground. In the recovery process, you have to pitch your nose down while spinning adjacent to all and singular three axis, your airspeed will not increase. However, in that point you wish to recover from a stall, an inadequate recovery is taking a risk to exceed the never exceed speed (Vne).
    Spiral dive
    In a spiral dive without adjusting the throttle, the aircraft is pointed into the relative wind, aircraft nose is pitching down and it is in a descending turn. This situation is the phrase where things get complicated. The aircraft will get tighter turns as the nose is dropping lower, speed of the aircraft will go higher. If this situation prolonged, you will exceed the never exceed speed (Vne) and you will have structural damage to your aircraft. You might end up having a land or sea impact if you have insufficient time or height to recover. When you are conducting a coordinated turn, if you don't look out the window or use the instruments, you will not figure out that you are turning, descending or accelerating and that may lead to a spiral dive.

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Insulin Drip In Euglycemic Ketoacidosis - A Tough Nut To Crack!

Abstract: This abstract also was presented at the 15th annual Rachmiel Levine Diabetes and Obesity Symposium on March 2, 2015, Levine Poster Number: 39. Background: Metabolic ketoacidosis has been frequently associated with three major etiologies which include diabetes, alcohol and starvation. Treatment is tailored towards the cause and usually involves crystalloid infusion in alcohol and starvation ketosis and implementation of insulin drip in diabetic ketoacidosis[1]. On the contrary our patient presents with a challenging scenario which warrants further insight to the treatment strategies of metabolic ketoacidosis. Clinical Case: A 59-year-old male with past medical history of diabetes and alcoholism presented to the ER with coffee ground emesis for 3 days. One week prior to admission the patient fell off the stairs and injured his left shoulder. Thereafter he consumed alcohol for pain relief and had not eaten anything. He admits to not taking his insulin for last 2 days. Upon admission vitals were stable. His labs were significant for Hb- 10.4 (n 11.6-16.8) g/dL, INR- 1.0 (n 0.9-1.1), blood glucose- 106 (n 70-115) mg/dL, BUN- 15 (n 6-20) mg/dL, Cr- 0.6 (n 0.7-1.2) mg/dL, Na- 13 Continue reading >>

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Popular Questions

  1. FitCoachTina

    New to Keto & Overheating?

    I've been following a Keto diet (60/35/5) for the last 6 days. Been in ketosis according to Ketostix since the second morning and down 5 lb already (water Im assuming). I'm a 39 yo female @ 188 this a.m and 43% bf (scale not calipers) eating 1500-1800 cal. Here's my question:
    I am hot all the time...almost to the point of breaking a sweat. Is this common? Maybe due to my metabolism speeding up? I noticed it a bit on day 2, by day 4 it was on and off for most of the day and woke up sweating last night w/just a sheet. It's not hot in the house or outside (about 75).
    The other thing I've notice is that I'm still exhausted. I havent had any energy to do any cardio or weights for the last 5 days and I was working out 30-60 min/day (HIIT, weights & MISS cardio). Any ideas when thus should lift?
    Thx for the help!

  2. Blackjack68

    Some people call it "induction flu", and it's pretty common. It's your body adjusting to using the fuel it evolved to use for the first time in your life. Stick with everything, you should be past it very soon, then you'll feel better than ever and your energy will go way up.
    With that said.... sweating is one of the symptoms of being hypoglycemic (nothing to play around with). Any diabetics in the family you could have check your blood glucose levels?

  3. FitCoachTina

    Originally Posted by Blackjack68
    S
    With that said.... sweating is one of the symptoms of being hypoglycemic (nothing to play around with). Any diabetics in the family you could have check your blood glucose levels?

    I was actually diagnosed w/hypoglycemia years ago but never told a cause, no matter which doctor or specialist I saw. Been watching my blood sugars several times a day (which also explains some of the light-headedness at times.) I've been doing really well there, staying between 88-125 (its rare for me to ever go higher than that). This morning it was in the low 60s but it came right up w/coffee and cream. I'll try something w/fat before bed and see if that helps.
    Thanks for the input!

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