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Alcohol Lactic Acidosis Mechanism

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Ketoacidosis

GENERAL ketoacidosis is a high anion gap metabolic acidosis due to an excessive blood concentration of ketone bodies (keto-anions). ketone bodies (acetoacetate, beta-hydroxybutyrate, acetone) are released into the blood from the liver when hepatic lipid metabolism has changed to a state of increased ketogenesis. a relative or absolute insulin deficiency is present in all cases. CAUSES The three major types of ketosis are: (i) Starvation ketosis (ii) Alcoholic ketoacidosis (iii) Diabetic ketoacidosis STARVATION KETOSIS when hepatic glycogen stores are exhausted (eg after 12-24 hours of total fasting), the liver produces ketones to provide an energy substrate for peripheral tissues. ketoacidosis can appear after an overnight fast but it typically requires 3 to 14 days of starvation to reach maximal severity. typical keto-anion levels are only 1 to 2 mmol/l and this will usually not alter the anion gap. the acidosis even with quite prolonged fasting is only ever of mild to moderate severity with keto-anion levels up to a maximum of 3 to 5 mmol/l and plasma pH down to 7.3. ketone bodies also stimulate some insulin release from the islets. patients are usually not diabetic. ALCOHOLIC KE Continue reading >>

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Popular Questions

  1. FrankUnderWood

    Hi,
    I have started out for the third and final time on Keto on Monday.
    My weight has dropped 3 pounds in 4 days, but the Keto sticks are not changing colour (only started yesterday using them).
    How long does it take the average person to get into Ketsosis, I know there are a lot of variables to consider but I was wondering what people’s experience is?
    Before when I did this, the sticks were changing colour after 3 days.
    Thanks

    F

  2. VLC.MD

    Focus on the process and the results will happen. Test your urine 2/week

  3. Jacob4Jesus

    FrankUnderWood:
    How long does it take the average person to get into Ketsosis, I know there are a lot of variables to consider but I was wondering what people’s experience is?
    The average person (someone who is insulin sensitive) could be in ketosis when they get up every morning.
    I started casually and it took about 2 days for me to get the first symptoms of carb withdrawal.

    –Jacob

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