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Acidosis Effects

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Effects Of Acidosis On Ventricular Muscle From Adult And Neonatal Rats.

Effects of acidosis on ventricular muscle from adult and neonatal rats. Department of Physiology, University College London, England. We compared the response of ventricular muscle from adult and neonatal rats to hypercapnic acidosis. In adult muscle, acidosis caused an initial rapid fall of developed tension to 30 +/- 5% of control (mean +/- SEM, n = 6). However, tension recovered slowly to a steady state that was 56 +/- 6% of control. In neonatal muscle, acidosis caused a significantly smaller initial fall in tension to 43 +/- 3% (n = 8, p less than 0.05), but the tension then showed a subsequent slower fall to a steady state that was 29 +/- 4% of control, significantly less than in the adult (p less than 0.01). We have attempted to identify the mechanisms underlying these differences in response. In detergent-skinned myofibrils, reducing the pH from 7.0 to 6.5 caused a reduction in the pCa50 of 0.61 units in the adult muscle, but only 0.27 units in the neonatal ventricular muscle. Myofibrillar Ca2+ sensitivity in neonatal ventricular muscle is thus less susceptible to the effects of acidic pH than that of adult muscle. Since intracellular pH decreases rapidly on application of Continue reading >>

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  1. bpeterson2

    > ultra low carbing and depression/anxiety

    Hi-
    been low carbing since aug '03. started off on south beach, had great, fast results (down 10 pounds, with 15-pound goal) and found it easy to follow. what i noticed is that I stayed on a very, very restrictive version, eating little or no breads, pastas, vegetables, and fruits. I didn't exclude them, just really did embrace them. I guess I was enjoying the weight loss and wanted it to continue. with the exception of a bowl of granola-like cereal and some fruit, I pretty muhc avoided all carbs.
    My question - looking back, i noticed that within a month or so of starting the diet, I began suffering pretty good anxiety. yes, my life grew more stressful, but I felt that i was becoming easily overwhelmed. generally, i felt jittery, nervous with little reason why. this lasted for more than a year, when I entered into a kiund of full-blown anxiety. I am currently in therapy and take an anti-dpressant, which has given me a lot of reliet. However, I'm still not me. the one constant has been my ultra low carb diet. this last week i began eating complex carbs and feel so much better. Anyone else had this kind of reaction to very low carb dieting?
    Thanks,
    Brent

  2. Nancy LC

    I'm glad you're eating more healthily! Get those veggies, and fruits if you're so inclined, back into the diet. Some people just don't do well on extremely low-carb. You might be one of them!

  3. Nancy LC

    Wow, you sure posted this same thing in a lot of places.

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Effects Of Acidosis On Brain Capillary Endothelial Cells And Cholinergic Neurons: Relevance To Vascular Dementia And Alzheimer's Disease.

Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: relevance to vascular dementia and Alzheimer's disease. Laboratory of Experimental Alzheimer's Research, Department of General Psychiatry, Innsbruck Medical University, Austria. Alzheimer's disease is a progressive brain disorder which is neuropathologically characterized by an increased number of beta-amyloid plaques, tau pathology and synapse loss. Recent research suggests that vascular pathology may be also important for the development and progression of Alzheimer's disease. It is still unknown whether there is a relation between damage of brain capillary endothelial cells (BCEC) and subsequent cholinergic cell death. The aim of this study was to examine the effects of acidosis on cell death of BCEC and cholinergic neurons in an organotypic brain slice model. We show that BCEC were heavily damaged in medium at pH<6.6. Cholinergic neurons incubated in medium pH 6.0 degenerated within 2-3 days and were not rescued by nerve growth factor (NGF). Lactate did not affect the survival of BCEC or cholinergic neurons. Both BCEC and cholinergic cells were not affected at pH 7.4, 7.0 or 6.6. It is concluded Continue reading >>

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  1. metalmd06

    Does acute DKA cause hyperkalemia, or is the potassium normal or low due to osmotic diuresis? I get the acute affect of metabolic acidosis on potassium (K+ shifts from intracellular to extracellular compartments). According to MedEssentials, the initial response (<24 hours) is increased serum potassium. The chronic effect occuring within 24 hours is a compensatory increase in Aldosterone that normalizes or ultimatley decreases the serum K+. Then it says on another page that because of osmotic diuresis, there is K+ wasting with DKA. On top of that, I had a question about a diabetic patient in DKA with signs of hyperkalemia. Needless to say, I'm a bit confused. Any help is appreciated.

  2. FutureDoc4

    I remember this being a tricky point:
    1) DKA leads to a decreased TOTAL body K+ (due to diuresis) (increase urine flow, increase K+ loss)
    2) Like you said, during DKA, acidosis causes an exchange of H+/K+ leading to hyperkalemia.
    So, TOTAL body K+ is low, but the patient presents with hyperkalemia. Why is this important? Give, insulin, pushes the K+ back into the cells and can quickly precipitate hypokalemia and (which we all know is bad). Hope that is helpful.

  3. Cooolguy

    DKA-->Anion gap M. Acidosis-->K+ shift to extracellular component--> hyperkalemia-->symptoms and signs
    DKA--> increased osmoles-->Osmotic diuresis-->loss of K+ in urine-->decreased total body K+ (because more has been seeped from the cells)
    --dont confuse total body K+ with EC K+
    Note: osmotic diuresis also causes polyuria, ketonuria, glycosuria, and loss of Na+ in urine--> Hyponatremia
    DKA tx: Insulin (helps put K+ back into cells), and K+ (to replenish the low total potassium
    Hope it helps

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The Effects Of Extracellular Acidosis On Neurons And Glia In Vitro.

1. J Cereb Blood Flow Metab. 1989 Aug;9(4):471-7. The effects of extracellular acidosis on neurons and glia in vitro. Goldman SA(1), Pulsinelli WA, Clarke WY, Kraig RP, Plum F. (1)Department of Neurology, Cornell University Medical College, New York 10021. Cerebral lactic acid, a product of ischemic anaerobic glycolysis, may directlycontribute to ischemic brain damage in vivo. In this study we evaluated theeffects of extracellular acid exposure on 7-day-old cultures of embryonic ratforebrain. Mixed neuronal and glial cultures were exposed to either lactic orhydrochloric acid to compare the toxicities of relatively permeable andimpermeable acids. Neurons were relatively resistant to extra-cellular HClacidosis, often surviving 10-min exposures to pH 3.8. In the same cultures,immunochemically defined astrocytes survived 10-min HCl exposures to a maximumacidity of pH 4.2. Similarly, axonal bundles defasciculated in HCl-titrated mediabelow pH 4.4, although their constituent fibers often survived pH 3.8. Cell deathoccurred at higher pH in cultures subjected to lactic acidosis than in thoseexposed to HCl. Over half of forebrain neurons and glia subjected for 10 min tolactic acidification Continue reading >>

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  1. msmum1977

    > spotting b/t TOM helP ladies!

    I know that a lot of people check whether or not they're in ketosis by testing their urine, but I have another problem.
    Usually when I get into Ketosis I start spotting between TOM...I'm on the bc pill...i shouldn't have bleeding (i never did between TOM when I ate carbs). Could someone provide some info :help:

  2. paisleylin

    I also spot when in ketosis! It is really throwing off my schedule; I think it is my TOM but later realize only spotted. Maybe our hormones are adjusting to the diet? I did some research on Atkins site but no answers there. If I find out any info, I will gladly post it for you. Maybe your gyn. could explain why it is happening?

  3. msmum1977

    that's what I was thinking paisleylin, but I'm on the pill...my hormones should be pretty regulated. I want to ask my gyn, but you know how the doctors are about Atkins. Sigh. All I know is that it is a pain in the butt because I was sooo regular with no spotting when I was eating carbs

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