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Why Insulin Resistance

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Hypertension And Insulin Resistance

For years, doctors have been telling their patients with high blood pressure to cut down on sodium. And for those who are salt sensitive—about 50 percent of those affected with hypertension—this is great advice. In these individuals, even small amounts of sodium can trigger rises in blood pressure. But sodium isn’t the only dietary factor in blood pressure. I want to focus on an aspect of hypertension that is largely ignored by conventional physicians: insulin resistance. The Case for Insulin Resistance Insulin is the hormone that ushers glucose and other nutrients into the cells. When there is insufficient insulin or when the cells are resistant to insulin’s attempts to let glucose in, blood sugar levels climb and you have diabetes. In type 2 (insulin-resistant) diabetes the body responds by producing even more insulin, resulting in elevated levels of both glucose and insulin. More than 20 million Americans have type 2 diabetes caused by insulin resistance. However, millions more—an estimated 25 to 40 percent of the entire population—have earlier stages of insulin resistance. In these individuals, glucose levels are not elevated, but their high insulin levels cause oth Continue reading >>

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  1. Chirag Motwani

    Rapamycin (pharmaceutical)

    Insulin Resistance

    Insulin

    Diabetes



    Why does rapamycin increase insulin resistance?




    1 Answer







    Rapamycin is a drug known for increasing the longevity but at the same time it increases the insulin resistance and impairs glycemic status.
    Rapamycin acts on two complexes of proteins, namely: mTORC1 and mTORC2. Drugging mTORC1 leads to increased longevity and drugging mTORC2 leads to insulin resistance.
    Since, there’s yet to be developed a drug that exclusively acts on the mTORC1 complex, rapamycin will continue to be a drug of choice although it has diabetes as its side effect.
    More on this here: The two faces of rapamycin – why a life-extending drug also increases risk of diabetes - Not Exactly Rocket Science
    If you find this article helpful please Upvote and appreciate!

    DiabeticsToday

    243 Views · 2 Upvotes








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    Related Questions



    Why do beta-blockers increase insulin resistance?


    Do BCAA's increase insulin resistance?


    What is insulin resistance?


    What causes insulin resistance?


    Are there any foods or supplements scientifically proven to reverse insulin resistance/increase insulin sensitivity?


    Does chromium cure insulin resistance?


    Why does insulin resistance persist?


    Does Clenbuterol reduce insulin resistance?


    What is the biochemistry of insulin resistance?


    Does Truvada cause insulin resistance?
    Ask New Question

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