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Why Insulin After Heart Surgery

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The Effects Of Open Heart Surgery On Growth Hormone, Cortisol And Insulin Levels In Man. Hormone Levels During Open Heart Surgery

Abstract Plasma growth hormone, cortisol, insulin and blood glucose concentrations were measured intra- and postoperatively in ten patients who underwent open heart surgery with moderate hypothermia. Diazepam-ketamine anaesthesia for 10-20 min failed to precipitate any significant alterations in the levels of measured hormones and blood glucose. In the pre-bypass period of surgery, an increase in cortisol and a slight elevation in growth hormone levels was observed; insulin level showed no change in spite of marked hyperglycaemia. The bypass period, including hypothermia and haemodilution, was accompanied by unchanged cortisol and elevated growth hormone levels, while insulin demonstrated a slight rise which did not correspond with the degree of hyperglycaemia. The post-bypass period with rewarming the restoring spontaneous circulation was characterized by further marked increase in cortisol and growth hormone levels and, in spite of decreasing levels of blood glucose, by a paradoxical elevation in plasma insulin. It is suggested that hypothermia, haemodilution, reduced tissue perfusion affecting endocrine glands, as well as denaturation of some hormones in the oxygenator, particip Continue reading >>

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Popular Questions

  1. Greenie93

    Okay, so I'll keep it short and sweet, but I'm almost four months out from my heart surgery, and I'm still getting high blood sugar readings.
    I actually had no prior history of blood sugar issues or diabetes, but ever since the surgery, my levels have been running insanely high.
    Overall, it's really depressing. /: I already had enough issues to need an aneurysm repair and aortic valve replacement two months short of my 19th birthday, but if I've actually got diabetes now, I don't know how to handle that too.
    Did anyone else run into this problem? Did it ever clear up for you? I'm just... I'm frustrated and upset, honestly.
    Like I said, living with the heart problems was already hard enough.

  2. escargome

    Hi,
    A few questions - Did you run high blood sugars while you were in the hospital? If so were you discharged with either insulin (with injection instructions) or with oral diabetes medication? What do you test your blood sugars with?
    Since you are 4 months out from surgery, has your doctor given you the go ahead to resume your normal activities? Are you a sedadentary person or active. Increase in activity plus a balanced diet with an appropriate amount of carbs should lower your blood sugars.
    I hope that things clear up for you soon.

  3. ElectLive

    Elevated blood sugar is very common after heart surgery, for anyone, but the severity and duration can vary a lot. For most non-diabetics, though, it seems to usually resolve before discharge, but certainly not always. Some may not even be aware it is even happening. On the other side of the spectrum, for already Type 1 diabetics such as me, I found the effect to last many months, certainly as long as you are experiencing. It did resolve with time.
    I think probably the most important thing is how it is evolving. In other words, has it been improving any over time? Always happening or only after meals, etc? Are you positive you didn't have any prior history?
    I understand your frustration, but just so know, assuming for the sake of discussion that the worst case is actually true and you might by chance even be a late onset Type 1 diabetic, it is very manageable with education and experience. Heck...kids like me were doing it in elementary school 30 years ago, so it couldn't be that hard, right? :biggrin2: Anyway, I don't mean to make light of the situation, nor do I want to imply I think this is a definite possibility, but obviously as one who has both conditions, just wanted to pass a long a little reassurance just in case. Do monitor and stay on top of it, with endocrinologist oversight if need be, and here's hoping the situation improves, as may certainly be possible. Best wishes to you.

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