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Where Are Insulin Receptors Located

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Quantitative Determination Of Human Insulin Receptor

NEW PRODUCT Human Insu l in Receptor EL ISA High sensitivity (0.173 ng/ml) Excellent analytical characteristics Validated for human serum and plasma (EDTA, citrate, heparin) samples Preliminary population data DIABE TOLOGY ONCOLOGY HUMAN INSULIN RECEPTOR ELISA Insulin receptor (IR) is an α2β2-disulfide linked tetrameric tyrosin kinase receptor located in the plasma membrane of target cells [1]. This glycoprotein is composed of two extracellular α-subunits (731 amino acids; 135 kDa) containing the insulin binding site and two transmembrane β-subunits (620 amino acids; 95kDa) that possess intrinsic tyrosine kinase activity in their intracellular domains and transduce the insulin signal into the cell interior [1,2]. The human insulin receptor is involved on glucose homeostasis, cell growth and differentiation [3]. Binding of insulin leads to a conformational change of the receptor, resulting in ATP binding, autophosphorylation, and subsequent phosphorylation of insulin receptor substrate proteins that are linked to the action of two main signalling pathways. The PI3-K/Akt pathway is involved in the glucose transport to the cell, induction of proliferation or inhibition of Continue reading >>

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Popular Questions

  1. Trevor Brothers

    The problem is that sensory systems take up space, energy, and nutrients which could be used for other purposes. Our fingers are already densely packed with sensory fibers to detect shape and texture, and adding tastes fibers would mean less accurate sensations of touch. This is the same reason why we don't have ten sets of eyeballs scattered all over our body, they'd be difficult to grow and keep care of and only a marginal improvement over simply turning our heads around.
    Additionally, lots of flavors need to be dissolved in a solution before they can be detected by our taste receptors, and it would probably suck to have slobbery fingertips all the time.

  2. Alex Moore

    There isn't any benefit to tasting food before you bring it to your mouth (at least for humans). Anything you want to taste can easily be brought to the lips.
    Also tastes have to be dissolved in saliva to be detected.

  3. Name

    Gustducin is a taste receptor located in the stomach. Some taste receptors are located further down the GI tract as well. I must have taste receptors located in my fingers because as soon as I touch a Krispy Kreme donut my mouth waters.

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