What Is The Fastest Acting Insulin

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A Newer, Faster-acting Insulin? (faster Than Novolog!)

New findings from phase 3a trials show that a faster-acting insulin aspart by Novo Nordisk reduced A1c levels and improved after meal blood sugars in people with type 1 and 2 diabetes compared with NovoLog. These findings were presented at the 76th annual Scientific Sessions of the American Diabetes Association (ADA) in New Orleans. Novolog (also marketed as Novorapid) is a fast-acting insulin aspart. The trial involves 2,100 people with type 1 and 2 diabetes and an even faster-acting insulin aspart. The trial consisted of 26 weeks of randomized therapy using a faster-acting insulin aspart which showed statistically significantly improved A1c in adults with type 1 diabetes when dosed at mealtime compared with Novolog. A similar result in A1c improvement was found when the insulin aspart was dosed 20 minutes after a meal compared with Novolog. What is Faster-Acting Insulin Aspart? Faster-acting insulin aspart is a fast acting bolus or mealtime insulin in investigation stages developed by Novo Nordisk. It is also insulin aspart like Novolog (or Novorapid) but in a new formulation which includes a vitamin and an amino acid intended to increase the initial absorption rate and provide a Continue reading >>

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  1. Nick1962

    Injected steroids and blood glucose. What I learned this week.

    I haven’t seen this topic in a while, but I went through something this week that may be of interest. Many types of steroids (inhaled, ingested, creams) can raise your BG levels. Injected steroids really do a number on them. Steroids like corticosteroids and glucocorticoids are a potent class that are known to raise blood glucose levels, often quite significantly. Now many of you that are on steroids for things like arthritis or pain management probably already know this, but I’m sure there are a bunch of folks that have been taking them and quite frustrated with their levels without knowing why. Additionally each steroid may react differently with any diabetes meds you are already taking. It pays to ask your pharmacist.
    Yesterday I had to go in for a spinal steroid/nerve deadener shot to hopefully help with my newly diagnosed case of moderate to severe spinal stenosis. I was pre-warned in the literature that this could raise my levels significantly, and in fact brittle diabetics could not have this done. This isn’t my first time getting injected, but it was the first time in my spine and I knew I’d be a little queasy about it, so about 2-1/2 hours prior I ate two hot dogs (w/ buns) to get something substantial in my stomach. Not my usual lunch, but fairly balanced protein and carbs. We didn’t test me before hand (but I knew I had to be running about 100-110). We did test afterward – 138. Not bad we thought, considering the nurse monitoring me said she had sent patients directly to the hospital a few times with high readings. She also informed me of something called “steroid induced diabetes” which sounded a lot like gestational diabetes.
    Well, it took me an hour to drive back home and the whole procedure went really well. Pretty painless except when he actually found the problem nerve and injected it. Yeah, that hurt, but not much worse than the pain I’d already been experiencing. I got home and tested again – 85. Cool I though, no side effects. Two hours later after a nice nap, I sat down to a dinner of a lettuce and cuke salad and two grilled bologna and cheese “sandwiches” which were made on those little cocktail breads that are maybe 1/8 inch thick and 2 inches square - in reality, maybe less than half a sandwich. Looked pretty dinky in the pan and I flipped them with a salad fork. Tasty though, and I was in some pain so the comfort food was welcome, diabetes be damned.
    Two hours later I tested again figuring I’d be at maybe 125. It was 195! Higher than I’ve been in years even after a pig fest on pizza and beer. I freaked, followed my own advice and tested again – still 195, and yet a third time, 195. I looked back in my discharge literature, and they told me if I hit 300 to call my doctor. Whew, still had some room.
    Two hours later (before bed) I tested again, and STILL 195. I went to bed thinking if I do happen to get up in the middle of the night, I’d test, but since the shot was doing its trick, I slept a good comfortable 8 hours. My fasting this morning was 110 (about 15-20 points higher than normal), and I topped out at 150 after lunch. By about 6:30 tonight, I was back at 85.
    Now, about an hour after a dinner of beef and bean soup (broth style) and crackers – about 30 carbs total meal – I’m up again at 185. This is way high for me (now) and I’ll feel this in the form of headaches mostly as long as it stays high.
    I’m told this side effect (for injections) can last three weeks (creams and inhaled steroids much less). I’m scheduled to have at least one more injection, but with this side effect, I may just settle for what I’ve got so far. The spinal stenosis, thank heavens is not a diabetic complication, but more related to injury, long term obesity (both describe me), arthritis and other factors.
    Why do steroids jack up glucose levels? They increase insulin resistance, causing your own to work less effectively in the body and glucose levels build up in your blood. Second, steroids can trigger your liver to release extra glucose, again, leading to high blood glucose levels. So, if you have to take them, for any reason, here’s what the experts say:
    You’ll probably need to check your blood glucose levels more often than you usually do—four or more times a day isn’t uncommon.
    If you take insulin, you’ll likely need to increase your dose, for example, by up to 20% (often called a sick-day booster), depending on your glucose levels.
    If you take pills, you may need to increase the dose, add another type of pill, or possibly even take insulin, temporarily. Again, this all is dependent upon the level of your blood glucose.
    Call your health-care provider or diabetes educator if your blood glucose levels increase while you’re on steroids and your medication dose isn’t enough to bring them down.
    Carry treatment for hypoglycemia (glucose tablets, juice, candy) with you in case your glucose levels drop suddenly.
    Thankfully, this is only a temporary situation for me (I hope), because this will drive me nuts, but hopefully to it puts some education out there to someone who might go through this in the future that hasn’t had as good luck with control as I have. Don’t want to see anyone go into the hospital.

  2. Lady.Grantham

    I just came across your post and I have the issue with it causing insulin resistance, I have rheumatoid arthritis since 2000 and ankylosing spondylitis since 2011 I have been on steroids since 2000 well now that I have been on Humira rather successfully ( cross your fingers ) for the last 8 month) they have been trying to taper me off all has been going well except for the last month. December came around and I started crashing left and right up to 6 times a day and now my doc is trying to do this ACTH test next week she moved me back up to 5mg of prednisone just to keep me somewhat stable but I can't eat I feel sick and I still get close to the low 70 . I am for the first time scared cause now she said my adrenal glands might possible shot … I have always had this easy going attitude about everything I have been dealing with this since I was 17 I am now 44 so yeah a long time . The thing is nothing could ever bring me down but I think this time it is different cause I don't know ! Thanks for listening !!!

  3. Nick1962

    Its posts like yours here that let me know I’m not alone. Sorry to hear about all you’re going through. I can kind of understand how you feel. I’ve spent a lot of my life in poor shape, so I guess I shouldn’t expect that not to catch up with me. I spent the last 5 years getting healthy, losing a ton of weight, getting my diabetes under control, and really changing my attitude then BAM! Spinal stenosis, degenerative disks, onset of arthritis, and like you onset of ankylosing all at the same time. I’ve always tried to remain positive and upbeat, but yeah, I know what you mean, there’s days I really feel defeated.
    Surgery is pretty much decided at this point if I want to avoid disability, but even that is only going to stave off the inevitable. Don’t want to take the steroidal drugs because they mess with my numbers, so I’m kind of stuck. Well, for now I’m pretty much trying to experience as much as I can, and as well as the pain killers will allow. I try to remain positive because it does help. Hope you can find that within yourself to do the same because each morning you’re allowed to open your eyes is another chance things will get better.

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Fiasp® (insulin Aspart Injection) 100 U/ml Indications And Usage

Fiasp® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Fiasp® or one of its excipients. Never share a Fiasp® FlexTouch® Pen between patients, even if the needle is changed. Patients using Fiasp® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. Fiasp® (insulin aspart injection) 100 U/mL is a rapid-acting insulin analog indicated to improve glycemic control in adults with diabetes mellitus. Fiasp® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Fiasp® or one of its excipients. Never share a Fiasp® FlexTouch® Pen between patients, even if the needle is changed. Patients using Fiasp® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, Continue reading >>

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  1. shadowwolf508

    What is the difference between NovoLog 70/30 and Novolin 70/30 insulins>

    This is a very important question, so I'm glad you asked.
    Before the new "insulin pens" came out, there were four types of insulin: rapid-acting, short-acting, intermediate-acting, and long-acting.
    When it comes to the pre-mixed insulins, like Novolog 70/30, there are fewer differences between the brands (for example, Novolog versus Novolin).
    Whether contained in a bottle or in a pen, the premixed insulins all contain a combination of both an intermediate-acting insulin and a short-acting insulin. The numbers on the bottle or pen refer to the percentage of each type of insulin contained in the mixture. That means both Novolin 70/30 and Novolog 70/30 contain a mixture that is 70% intermediate-acting insulin with 30% short-acting insulin.
    However, Novolin 70/30 takes slightly longer to begin working than Novolog 70/30, which has a rapid onset. Both Novolin 70/30 and Novolog 70/30 may last up to 24 hours in the system.
    No matter what kind of insulin you've been prescribed, it's crucial you understand how to use it correctly. Using any insulin incorrectly can cause serious side effects. If you don't understand how to use your insulin, please consult a pharmacist as soon as possible.
    Hope this helps!
    This answer should not be considered medical advice...
    Posted: November 25, 2012 | Report This
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    503 of 549 found this helpful

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Fda Approves Novo Nordisk Fast-acting Insulin Fiasp

(Reuters) - The U.S. Food and Drug Administration on Friday approved Novo Nordisk’s fast-acting insulin to treat diabetes. The product, known as Fiasp, is designed to help diabetics control post-meal spikes in blood sugar. It is already approved in Canada and Europe. Fiasp, or faster acting insulin asparte, is designed to work faster than existing fast-acting insulin such as Eli Lilly and Co’s Humalog and Novo Nordisk’s own NovoLog, known as NovoRapid outside the United States. Last year the FDA declined to approve the product and requested additional information. Continue reading >>

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  1. Snowdawgy

    New to Humalog, questions on dosages?

    I am learning now how to use Humalog, I am insulin resistant, and was given a simple sliding scale to figure out dosages. The issue is I am finding the scale is not accurately reducing my BG according to the chart, but from what I have been reading the basic scale is just that basic, and I need to learn how much I need for me and adjust my scale accordingly. Is this correct? I find if the scale says for 6-8mmol use 4 units I need to add about 2 units to get it correct so my personal scale should read for 6-8mmol use 6 units. So this scale has to be fine tuned to the individual, and then carb counting is figuring out how many carbs I am eating and what that will impact my BG and then adding that to the shot to get a good number correct. So if I am at 6-8mmol and I am using 6 units (adjusted for me) and I will eat 30g carbs which normally will bring up my BG to 12mmol using my adjusted scale 10-15mmol is 10 units, that should be my injection dose. I think I have this all correct as the doc was in a bit of a hurry and explained it quickly as he knows I do my homework and would check to see that I am doing it right and probably ask others for help as I am doing here

  2. Stump86

    Most people who carb count use two different ratios for determining proper bolus amount, rather than a sliding scale.
    There is your insulin to carb ratio (I:C) which tells you how many carbs you can cover with a unit of insulin. You use this number to determine how much insulin to take in response to a given amount of carbs.
    The second ratio, the insulin sensitivity factor (ISF) or correction factor is how much your BG will decrease on one unit of insulin. This factor is used for correcting high BGs, similarly to the sliding scale.
    The difference with the example you have is that you don't need to estimate how much you think you will rise, you base it on how much you are going to eat. Likewise, you will only ever really need a correction bolus if you are high for whatever reason.

  3. Richard157

    I have never used a sliding scale. I use the insulin:carb ratio and insulin sensitivity factor as explained by Shaun. That gives much better control than a sliding scale. A CDE (certified diabetes educator) can instruct you in carb counting and all the features for this kind of diabetes management. A CDE can usually be found in the diabetes education center at many hospitals.
    It should be noted that the carb ratio and insulin sensitivity can vary throughout the day. I use a 1:4 ratio at breakfast (i unit of insulin for every 4 carbs), and 1:6 the rest of the day. For optimum control you can use trial and error and fine tune until you get the numbers you need. Tweaking until you get this going smoothly should cut down on the number of highs and lows and give you a smaller standard deviation.

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