Insulin-glargine, Injectable Solution
Low blood sugar warning: You may have mild or severe low blood sugar (hypoglycemia) while you’re taking insulin glargine. Severe low blood sugar can be dangerous. It can harm your heart or brain, and cause unconsciousness, seizures, or even be fatal. Low blood sugar can happen very quickly and come on without symptoms. It’s important to check your blood sugar as often as your doctor says to. Symptoms can include: anxiety, irritability, restlessness, trouble concentrating, feeling confused or not like yourself tingling in your hands, feet, lips, or tongue dizziness, lightheadedness, or drowsiness nightmares or trouble sleeping headache blurred vision slurred speech fast heart rate sweating shaking unsteady walking Thiazolidinediones warning: Taking diabetes pills called thiazolidinediones (TZDs) with insulin glargine may cause heart failure. Tell your doctor if you have any new or worsening symptoms of heart failure, including shortness of breath, swelling of your ankles or feet, and sudden weight gain. Your doctor may adjust your TZD dosage if you have these symptoms. Infection warning: You should never share insulin vials, syringes, or prefilled pens with other people. Sharing or reusing needles or syringes with another person puts you and others at risk of various infections. Low potassium levels warning: All insulin products can decrease the amount of potassium in the blood. Low potassium blood levels may increase your risk of irregular heartbeat while taking this drug. To prevent this, your doctor will check your potassium blood levels before you start taking this drug. Insulin glargine is a prescription drug. It comes as an injectable solution. This drug is self-injectable. Insulin glargine is available as the brand-name drugs Lantus, Basaglar, Toujeo, and Soli Continue reading >>
Insulin Glargine (lantus).
Abstract Insulin glargine (Lantus) is a long-acting, human insulin analogue that has been specifically designed to overcome the deficiencies of traditionally available 'intermediate-acting' insulins that are currently used for basal insulin supplementation. In contrast to NPH insulin, subcutaneous insulin glargine injected once daily provides a relatively constant basal level of circulating insulin with no pronounced peak. In patients with type 1 and type 2 diabetes, once-daily insulin glargine achieves equivalent glycaemic control to NPH insulin given once or twice daily In patients with type 1 diabetes, it is associated with significantly lower fasting blood glucose (FBG) levels, especially in those patients previously on twice-daily NPH insulin. Insulin glargine is well tolerated and elicits less hypoglycaemia, especially nocturnal episodes, than NPH insulin, with similar levels of glycaemic control. This benefit is seen in patients with both type 1 and type 2 diabetes, in particular those previously on a once-daily NPH insulin regimen. Patients with type 1 and type 2 diabetes have also reported higher levels of treatment satisfaction when treated with insulin glargine. Insulin glargine provides the opportunity to achieve target blood glucose levels more effectively and safely compared with NPH insulin, due to the reduced risk of hypoglycaemia, especially nocturnal hypoglycaemia. Insulin treatment needs to be individualised, with the dose of insulin glargine adjusted according to the blood glucose level as part of an aggressive regimen in an attempt to achieve near normoglycaemia without incurring episodes of hypoglycaemia. Insulin glargine should be used in combination with short-acting insulin analogues in patients with type 1 diabetes. In patients where oral hypog Continue reading >>
Description And Brand Names
Drug information provided by: Micromedex US Brand Name Basaglar Lantus Lantus SoloStar Toujeo Descriptions Insulin glargine is a long-acting type of insulin that works slowly, over about 24 hours. Insulin is one of many hormones that help the body turn the food we eat into energy. This is done by using the glucose (sugar) in the blood as quick energy. Also, insulin helps us store energy that we can use later. When you have diabetes mellitus, your body cannot make enough insulin or does not use insulin properly. This causes you to have too much sugar in your blood. Like other types of insulin, insulin glargine is used to keep your blood sugar level close to normal. You may have to use insulin glargine in combination with another type of insulin or with a type of oral diabetes medicine to keep your blood sugar under control. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Solution Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Continue reading >>
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Indication BASAGLAR is a long-acting insulin used to control high blood sugar in adults and children with type 1 diabetes and adults with type 2 diabetes. Limitation of Use BASAGLAR is not for treating diabetic ketoacidosis. Important Safety Information Do not take BASAGLAR during episodes of low blood sugar or if you are allergic to insulin glargine or any of the ingredients in BASAGLAR. Do NOT reuse needles or share insulin pens, even if the needle has been changed. Before starting BASAGLAR, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed. BASAGLAR should be taken once a day at the same time every day. Test your blood sugar levels while using insulin. Do not make any changes to your dose or type of insulin without talking to your healthcare provider. Any change of insulin should be made cautiously and only under medical supervision. The most common side effect of insulin, including BASAGLAR, is low blood sugar (hypoglycemia), which may be serious and life threatening. Signs and symptoms may include dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood change, or hunger. Do NOT dilute or mix BASAGLAR with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. BASAGLAR must only be used if the solution is clear and colorless with no particles visible. Always make sure you have the correct insulin before each injection. BASAGLAR may cause serious side effects that can lead to death, such as severe allergic reactions. Get emergency help if you have: Heart fa Continue reading >>
What Do Primary Care Doctors Want Most From Basal Insulin?
All doctors involved in diabetes care want a stable really long acting insulin - so not the by now obsolete (but cheap) NPH insulin of the past, but the newer insulin analogues, Insulin Detemir, Insulin Glargine or the newest and most stable insulin Degludec - that doesn't cause nightly low blood sugars, is stable and has reproducible effects on one's blood sugar in the same patient, and ideally also between patients, keeping the blood sugar levels before meals low without being hypoglycemic when not having eaten for a longer time e.g. nights. This is another study comparing the effects of Insulin Glargine and Insulin Degludec, at present the most stable and longacting insulin available Degludec also has the least intraindividual variability: U300 Glargine is available though, thanks anon for reminding me, although I couldn't find a head to head comparison between the effects of Insuline Degludec and U300 Glargine is seems more stable than U100 Glargine see This overview would be useful to anyone interested: The post-meal blood sugar control is left to the body's own residual insulin production, aided by oral meds e.g. metformin, maybe sulfonylurea derivatives, even injectable Glucagon-like peptide-1 agonist, but that is more for an internist or endocrinologist/diabetologist to prescribe. The effect would be something like this (in this example we inject rapid acting insulin analogues when having a meal as often as one has a meal) At present Novo Nordisk in the US has refiled for FDA approval for their newest long acting insulin analogue Degludec (Tresiba®), in Europe it already is available. So for the US Insulin Glargine seems to be the best available long acting insulin analogue. Continue reading >>
Insulin Glargine Solution
Uses Insulin glargine is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Insulin glargine is a man-made product that is similar to human insulin. It replaces the insulin that your body would normally make. It acts longer than regular insulin, providing a low, steady level of insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. Insulin glargine may be used with a shorter-acting insulin product. It may also be used alone or with other diabetes drugs. How to use Insulin Glargine Solution Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Follow all package directions for proper use/injection/storage of the particular type of device/insulin you are using. Your health care professional will teach you how to properly inject this medication. If any of the information is unclear, consult your doctor or pharmacist. Do not inject cold insulin because this can be painful. The insulin container you are currently using can be kept at room temperature (see also Storage section). Wash your hands before measuring and injecting insulin. Before using, check the product visually for particles, thickening, or clumps. If any are present, discard that container. Insulin glargine should be clear and colorless. To avoid damaging the insulin, do not shake the container. The dosage is based on your medical condition and response t Continue reading >>
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What Is The Best Way To Use Insulin As A Supplement For Gaining Lean Muscle?
If you use insulin, you are basically accepting that you will gain fat at the same time as you are gaining muscle. This is a valid mode of training used by some bodybuilders: first bulk up (both muscle and body fat), then cut (body fat). Adding to what Philip Mikal wrote, if you are looking for the benefits of insulin, the safe way to do it is not through injection but through eating carbs. You might consider the GOMAD (Gallon of Milk a Day) protocol, which is claimed by some bodybuilders as the cheapest and most effective way of increasing muscle mass, even though you will definitely also gain body fat at the same time. Continue reading >>
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Lantus (insulin Glargine)
Tweet Lantus is an analogue insulin produced by Sanofi-Aventis with the medical name insulin glargine. Lantus has been available for pharmaceutical use since the year 2000. Lantus hit the news in June 2009 over concerns that it may lead to the formation of cancer. However, the European Medicines Agency (EMEA) found the evidence suggesting the link to be inconclusive and cleared the drug for further use. What is Lantus? Lantus is an ultralente (long acting) analogue insulin. The medical name for Lantus, insulin glargine, is taken from how the DNA of human insulin is modified to form the analogue. In glargine’s case, glycine and two arginines are part of the genetic recombination that helps to produce the insulin. Who is Lantus prescribed to? Lantus can be prescribed for all types of diabetes. However, it is most commonly prescribed to people with type 1 diabetes. Lantus may be prescribed to people with type 2 diabetes for whom oral hypoglycemic agents have not shown to be sufficiently effective. How do I take Lantus? Lantus is injected, usually once daily at the same time each day. Like all insulins, Lantus should be injected subcutaneously (into the fatty tissue underneath the skin). The specific mode of action of Lantus means that it should never be diluted or mixed with any other insulin before injecting. Benefits of Lantus The mode of action of Lantus allows for a peakless profile. Lantus has become a popularly prescribed insulin as its consistent activity can help to reduce nocturnal hypoglycaemia. Side effects of Lantus Being an insulin, hypoglycemia can be a relatively common side effect of using Lantus, if dosages are too strong. Other side effects include allergic reactions and swelling, itching or pain at the injection site. Lantus and cancer link In June 200 Continue reading >>
Uses Insulin glargine is used with a proper diet and exercise program to control high blood sugar in people with diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Insulin glargine is a man-made product that is similar to human insulin. It replaces the insulin that your body would normally make. It acts longer than regular insulin, providing a low, steady level of insulin. It works by helping blood sugar (glucose) get into cells so your body can use it for energy. Insulin glargine may be used with a shorter-acting insulin product. It may also be used alone or with other diabetes drugs. How to use Lantus Vial Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor, diabetes educator, or pharmacist. Follow all package directions for proper use/injection/storage of the particular type of device/insulin you are using. Your health care professional will teach you how to properly inject this medication. If any of the information is unclear, consult your doctor or pharmacist. Do not inject cold insulin because this can be painful. The insulin container you are currently using can be kept at room temperature (see also Storage section). Wash your hands before measuring and injecting insulin. Before using, check the product visually for particles, thickening, or clumps. If any are present, discard that container. Insulin glargine should be clear and colorless. To avoid damaging the insulin, do not shake the container. The dosage is based on your medical condition and response to treatment. M Continue reading >>
What Is The Best Form Of Insulin For Diabetes? Synthetic Or Human Insulin And Why?
We want to mimic the body's own insulin by injecting insulin of different kinds multiple times a day. First we need a super-stable super-long acting insulin which will be continuously effective over 24+ hours, without troughs and peaks, only the newest synthetic analogues do this, the most stable being Novo Nordisk's new Insulin degludec (Tresiba®), before that we had Aventis' quite acceptable Insulin glargine (Lantus®) and NovoNordisk's Insulin detemir (Levemir®). As you can see the glucose needed to be infused to keep the blood glucose level steady over time after Insulin Degludec is stable, but after 8-10 hours rises, peaking at 14-16 hours and going down a lot at 18-20 hours after Insuline Glargine injection: So Insulin Degludec seems more stable than Insulin Glargine. We also want the effect of an insulin to be consistent (the same after each injection on different days): You can see why the old NPH insulin has had its day, peaking at 8 hours and losing potency after 16 hours: If the pancreas is still making enough insulin to regulate the blood sugar after meals, we only need one usually injection of a super long acting insulin analogue before bedtime to keep the blood sugar levels before meals low so the patient's own pancreas by making its own insulin can regulate the blood sugar levels after meals. When this isn't possible anymore, we would opt for superfast, supershort acting insulin analogues, like Eli Lilly's Insulin lispro (Humalog®), NovoNordisk's Insulin aspart (Novorapid®) and Sanofi Adventis' Insulin glulisine (Apidra®) to be injected at the beginning of each meal (and any snack containing enough carbs) to regulate the after meals blood sugar. The so called regular insulin, which only starts working after 2+ hours (the analogues start working after Continue reading >>
Lantus (insulin Glargine) Side Effects
What Is Lantus (Insulin Glargine)? Lantus is the brand name of insulin glargine, a long-acting insulin used to treat adults and children with type 1 diabetes mellitus and adults with type 2 diabetes mellitus to control high blood sugar. Lantus replaces the insulin that your body no longer produces. Insulin is a natural substance that allows your body to convert dietary sugar into energy and helps store energy for later use. In type 2 diabetes mellitus, your body does not produce enough insulin, or the insulin produced is not used properly, causing a rise in blood sugar. Like other types of insulin, Lantus is used to normalize blood sugar levels. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual dysfunction. Proper control of diabetes has also been shown to reduce your risk of a heart attack or stroke. Lantus is meant to be used alongside a proper diet and exercise program recommended by your doctor. Lantus is manufactured by Sanofi-Aventis. It was approved for use by the Food and Drug Administration (FDA) in 2000 as the first long-acting human insulin administered once a day with a 24-hour sugar-lowering effect. Lantus Warnings You will be taught how to properly inject this medication since that is the only way to use it. Do not inject cold insulin because this can be painful. Always wash your hands before measuring and injecting insulin. Lantus is always clear and colorless; look for cloudy solution or clumps in the container before injecting it. Do not use Lantus to treat diabetic ketoacidosis. A short-acting insulin is used to treat this condition. It is recommended that you take a diabetes education program to learn more about diabetes and how to manage it. Other medical problems may affect the use of this Continue reading >>
Insulin Glargine Safety In Pregnancy
Abstract OBJECTIVE Insulin glargine (Lantus) is an extended-action insulin analog with greater stability and duration of action than regular human insulin. The long duration of action and decreased incidence of hypoglycemia provide potential advantages for its use in pregnancy. However, the placental pharmacokinetics of insulin glargine have not been studied. Therefore, the objective of this study was to determine whether insulin glargine crosses the human placenta using the human perfused placental lobule technique. RESEARCH DESIGN AND METHODS Placentae were obtained with informed consent after elective cesarean section delivery of noncomplicated term pregnancies. Insulin glargine, at a therapeutic concentration of 150 pmol/l (20 μU/ml) was added to the maternal circulation. Additional experiments were carried out at insulin glargine concentrations 1,000-fold higher than therapeutic levels (150, 225, and 300 nmol/l). A subsequent perfusion for which the maternal circuit remained open and insulin glargine was continuously infused at 150 pmol/l was completed for further confirmation of findings. The appearance of insulin glargine in the fetal circulation was analyzed by a chemiluminescence immunoassay. RESULTS Results from perfusions carried out at therapeutic concentrations (150 pmol/l) of insulin glargine showed no detectable insulin glargine in the fetal circuit. After perfusion with very high insulin glargine concentrations of 150, 225, and 300 nmol/l, the rate of transfer remained low at 0.079 ± 0.01, 0.14, and 0.064 pmol · min−1 · g tissue−1, respectively. CONCLUSIONS Insulin glargine, when used at therapeutic concentrations, is not likely to cross the placenta. Several new long-acting insulin analogs, such as glargine and detemir, are currently available f Continue reading >>
What's The Difference Between Insulin Nph And 70/30?
NPH(Neutralized Protamine Hagedorm) aka Protamine Insulin refers to an long acting preparation of Insulin. It has a moderately long duration of action and slower onset as compared to regular insulin. HM 30/70 is a mixture of Regular Insulin with Isophane Insulin in a 30:70 ratio. It is used a simpler alternative for administering the two different forms of insulin to the patient. The point is that goal of any regimen used for insulin based treatment is to replicate the natural curve of insulin concentration seen in the body, Ideally that means giving one very long acting preparation such as Insulin Glargine or Detemir or Degludec at night to meet the basal demands and then following it up with a very short acting preparation such as Insulin Lispro/Aspart/Glulisine just before EVERY meal. This would mean a myriad of inconvenient injections. This regimen is used mainly in Type 1 DM where insulin is necessary for survival. For Type 2 DM, we use HM 30/70 for convenience since it contains a moderately long acting and one intermediate acting insulin so, it is sort of a midway between the two extremes. Regular insulin in this preparation takes care of immediate post prandial hyperglycemia and Isophane Insulin takes care of reactionary hyperglycemia occuring after few hours of meal. Continue reading >>
Why Is Insulin So Expensive?
There have been recent article written just to answer this question. This one time when I approve of what of what the drug companies are doing even although I don’t especially like the prices. When insulin was first discovered and used therapeutically, it was pretty raw stuff. It acted the way that it did, and it was necessary to figure out the way to use it. Later the drug companies, based on their own research, found ways to alter the time course of insulin availability. The new insulins, of course, cost more but they provided new convenience and new improved ability to control blood glucose concentration. By the 1970′s NPH and Regular insulin were available, and these together worked pretty well to provide convenient control blood glucose. There was also a parallel group of insulins referred to as Lente, Semi Lente and Ultra Lente to provide BG control. The NPH and Regular insulins still exist, and because they are now old technology, they are relatively cheap. The drug companies began tinkering with the insulin preparations again, and they created new formulations that had new and exciting capabilities. Some artificial insulins had a very rapid onset of action, others were able to produce a uniform 24 hour long reduction of blood glucose. These insulins were new and even more expensive, but they were potentially easier and possibly safer to use. So, there was always a “new, improved” insulin that was priced as a “new-improved” insulin. The cost of insulin has always represented the newest technology, and it never represented a older, more “mature,” and cheaper product. Remember the NPH and Regular insulin combination. It gives you the best of the 1970’s and works pretty well. It is less convenient to use but much cheaper than the new stuff. I used Continue reading >>
Lantus Patient Information Including Side Effects
Brand Names: Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen Generic Name: insulin glargine (Pronunciation: IN su lin AS part, IN su lin AS part PRO ta meen) What is the most important information I should know about insulin glargine (Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen)? What should I discuss with my healthcare provider before using insulin glargine (Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen)? What is insulin glargine (Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen)? Insulin glargine is a man-made form of a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin glargine is a long-acting form of insulin that is slightly different from other forms of insulin that are not man-made. Insulin glargine is used to treat type 1 or type 2 diabetes. Insulin glargine may also be used for purposes not listed in this medication guide. What are the possible side effects of insulin glargine (Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen)? Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out. Hypoglycemia, or low blood sugar, is the most common side effect of insulin glargine. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar. Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin glargine. This is not a complete list of side effects and others may occur. Call Continue reading >>