Two Photon Polymerization Of Microneedles For Transdermal Drug Delivery
Two Photon Polymerization of Microneedles for Transdermal Drug Delivery Shaun D. Gittard ,1 Aleksandr Ovsianikov ,2 Boris N. Chichkov ,2 Anand Doraiswamy ,3 and Roger J. Narayan 1 1Joint Department of Biomedical Engineering, University of North Carolina Chapel Hill and North Carolina State University, Raleigh, NC, USA 1Joint Department of Biomedical Engineering, University of North Carolina Chapel Hill and North Carolina State University, Raleigh, NC, USA 1Joint Department of Biomedical Engineering, University of North Carolina Chapel Hill and North Carolina State University, Raleigh, NC, USA 2Laser Zentrum Hannover e.V., Hannover, Germany 3Advanced Vision Science, Inc., Goleta, CA, USA Shaun D. Gittard, Address: CB 7115, 2147 Burlington Labs, North Carolina State University, Raleigh, NC, 27695, USA, Academic Qualifications and Job Title: BS, Graduate Student, UNC/NCSU Joint Department of Biomedical, Engineering, Phone: 575-742-8644, Fax: 919-513-3814, ude.uscn@rattigds Aleksandr Ovsianikov, Address: Hollerithallee 8, 30419 Hannover, Germany, Academic Qualifications and Job Title: PhD, Scientist in Nanotechnology Department, Laser Zentrum, Hannover e.V., Phone: ++49-511-2788-233, Fax: ++49-511-2788-100, [email protected] Boris N. Chichkov, Address: Hollerithallee 8, 30419 Hannover, Germany, Academic Qualifications and Job Title: PhD, Head of Nanotechnology Department, Laser Zentrum Hannover, e.V., Phone: +49-(0)511-2788316, Fax: +49-(0)511-2788100, [email protected] Anand Doraiswamy, Address: 5743 Thornwood Dr., Goleta, CA 93117, USA, Academic Qualifications and Job Title: PhD, Research & Development Manager, Advanced Vision Science, Inc. (A Santen Company), Phone: 805-683-3851-247, Fax: 805-964-3065, moc.loisva@ymawsiaroda Roger J. Narayan, Address: CB 7115, 2147 Bu Continue reading >>
Smart Insulin Patches Developed At Unc, Ncsu One Step Closer To Market
Smart insulin patches developed at UNC, NCSU one step closer to market For the 29 million Americans living with diabetes, a less painful and more accurate way to monitor their blood sugar is one step closer to reality. Zhen Gu, whose team ... Get the top news stories delivered directly to your inbox! Smart Car with Hayabusa Turbo Engine! Smart Hayabusa Donuts and Burnout, Brutal Exhaust Sound! Smart Car with Hayabusa Turbo Engine! Smart Hayabusa Donuts and Burnout, Brutal Exhaust Sound! Smart Car with Hayabusa Turbo Engine! Smart Hayabusa Donuts and Burnout, Brutal Exhaust Sound! World\'s most powerful and fastest smart car doing a burnout and donuts. Smart car with hayabusa turbo engine! brutal exhaust sound!Hayabusa Smart Car Smart Car with Hayabusa Turbo Engine! Smart Hayabusa Donuts and Burnout, Brutal Exhaust Sound! World\'s most powerful and fastest smart car doing a burnout and donuts. Smart car with hayabusa turbo engine! brutal exhaust sound!Hayabusa Smart Car 20 SMART COOKING TIPS YOU HAD NO IDEA ABOUT 20 SMART COOKING TIPS YOU HAD NO IDEA ABOUT 20 SMART COOKING TIPS YOU HAD NO IDEA ABOUT I bet you didn\'t know how easily you can peel fruits and vegetables and make canape with a simple syringe! These and many more great ideas in this video!Subscribe to 5-Minute Crafts GIRLY: to 5-Minute Workouts: Social Media:5-Minute Crafts KIDS: you ever seen a talking slime? Here he is Slick Slime Sam: Bright Side of Youtube: Youtube: more videos and articles visit:20 SMART COOKING TIPS YOU HAD NO IDEA ABOUT I bet you didn\'t know how easily you can peel fruits and vegetables and make canape with a simple syringe! These and many more great ideas in this video!Subscribe to 5-Minute Crafts GIRLY: to 5-Minute Workouts: Social Media:5-Minute Crafts KIDS: you ever seen a talkin Continue reading >>
Insulin On Flipboard
Rich Piana's Mysterious Death Raises Questions About Insulin and Bodybuilding The medical examiner's office says it hasn't finalized Piana's cause of deathbut the rumors still point to a dangerous trendAfter collapsing and spending two weeks in a medically induced coma, celebrity bodybuilder Rich Piana died in August at the age of 46.The exact cause of his death has yet to This Common Health Problem May Also Wreck Your Memory Good news is, you have the chance to fix itWant to keep your brain young? To do so, we first need to find out what ages it in the first place. And a new study in the Journal of Alzheimer's Disease has identified one previously overlooked factor: insulin resistance.Insulin-resistant people have Needle-phobes take note: Scientists take steps toward an alternativeStronger erections. Weight loss. Better sleep. Theres a pill for almost everything and everyoneexcept for people who take insulin for diabetes. But that could change within the next few years, according to a new paper from the Continue reading >>
Savvy Updates, 7/8/2017: Novo Nordisk Recall, Nasal Glucagon, Smart Insulin Patch, Smartmat
Savvy Updates, 7/8/2017: Novo Nordisk RECALL, Nasal Glucagon, Smart Insulin Patch, Smartmat Jul 8, 2017 | Featured , Research News | 2 comments Novo Nordisk recalls faulty cartridge holders in insulin pens was announced 5 July 2017. iating a recall of insulin cartridge holders used in some NovoPen Echo insulin pen devices distributed in the United States because the holders may crack or break if exposed to certain chemicals, including certain cleaning agents. Using a device with a cracked or broken cartridge holder could result in delivery of a smaller dose of insulin than expected, the company said. Separately, Novo Nordisk warned of a similar problem with NovoPen Echo and NovoPen 5 devices distributed in Canada. Read more: Novo Nordisk Recalls Cartridge Holders In Certain Novopen Echo Insulin Delivery Devices Nasal Glucagon Fixes Severe Hypoglycemia in Type 1 Diabetes, as reported at the ADA 2017 Scientific Sessions in June, 2017 by researchers at the University of Minnesota School of Medicine. Giving one puff of a dry glucagon powder inside the nose of an adult with type 1 diabetes who was having a moderate to severe hypoglycemic episode was easy for a caregiver to do and led to recovery within 30 minutes in almost all patientsin a phase 3 study. The treated patients recovered from hypoglycemia within a half hour in 96% of cases, and 90% of the caregivers (typically a spouse) found the product easy to use, Elizabeth R Seaquist, MD, University of Minnesota School of Medicine, Minneapolis. Read more: Nasal Glucagon Fixes Severe Hypoglycemia in Type 1 Diabetes Smart insulin patches developed at UNC, NCSU one step closer to market, as published in The News & Observer, 30 June 2017. Zhen Gu, whose team at the UNC-N.C. State Biomedical Engineering Program has been leading Continue reading >>
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Smart Insulin Patch Monitors Blood Sugar And Releases Insulin On Demand
Smart Insulin Patch Monitors Blood Sugar and Releases Insulin on Demand A blood sugar-monitoring smart insulin patch developed through the UNC-N.C. State Biomedical Engineering Program is now a step closer to coming to market following a major investment by the Chinese firm MicroPort Scientific. MicroPort Scientific has invested $5.8 million in Zenomics Inc.,the company formed by Zhen Gu, the lead researcher of the UNC-N.C. State Biomedical Engineering Program. Zenomics will be using the investment to fund the recruitment of new staff and to prepare for the first clinical trials of the patch. The smart insulin patch, which is fixed to the skin, monitors blood sugar levels. When blood sugar levels rise, the patch releases insulin on demand. The patch is about the size of a dime and has 121 microneedles, each of which is capable of delivering small packets of insulin. The needles have a diameter less than a human hair and cause no discomfort. Glucose oxidase in the needles reacts to high glucose levels triggering the release of insulin. There are currently 29 million people in the United States that have diabetes and need to regularly monitor their blood sugar levels and administer insulin. The finger prick tests are painful and insulin doses need to be precisely calculated. A smart insulin patch is much more convenient and reduces to chance of excess insulin being administered. Further, by the time an individual determines that insulin is required, blood glucose levels may already have reached dangerously high levels. In a healthy individual, insulin is released quickly when blood sugar levels start to rise. Even the most advanced monitoring technologies currently being used have a lag of between 5 and 15 minutes. The aim of the smart insulin patch is to mimic the human Continue reading >>
Lytehouse Innovations - Home | Facebook
As I wrote on twitter it is interesting how terms we used to be associated for bad are actually for good. The term Hacking used to be for "nerds" and trying to challenge their knowledge. Often times society thought of it as a bad thing. But, in fact was an innocent attempt to learn. Now we come to the brink of a new industrial revolution now businesses and consumers alike are using it to innovate. But, what really is interesting is that Hacking has been happening since the dawn of humans. The wheel, color tv's, and all things that we considered to be innovations was due to hacking. Not in a computer sense, but, as a technology hack. Hello, Everyone! If you have a Chronic Disease (example Diabetes) and have trouble grocery shopping please fill out my questionnaire so that we can help. At Lythouselabs we are trying to make Good Decisions easier! Most people just go to the grocery store and the only concern they have is, "Do I have enough money for everything on my list?" or "I am on a diet I shouldn't really buy that Chocolate cake (But man does it look awesome!)". But, with some chronic diseases, you have to think about everything that you eat. We are trying to change that and this questionnaire will be one step closer to our mission of making Good decisions easier. (And by the way if it works out it will be a lot easier to buy groceries even if you don't have a chronic disease! So if you would fill it out too please!) Continue reading >>
Are Synthetic Insulin-secreting Cells The Future Of Diabetes Treatment?
2 pictures While treatments for type 1 diabetes are rapidly evolving, even the most recent hi-tech artificial pancreas system still involves glucose monitors and insulin pumps. But a new development from scientists at the University of North Carolina and NC State could do away with the need for injections and glucose monitoring through the use of artificial beta cells that mimic the insulin-secreting function of healthy cells. For patients with type 1 diabetes, and some cases of type 2 diabetes, the pancreas fails to produce effective beta cells, the cells that monitor blood sugar and release insulin to keep glucose levels normalized. Outside of manual monitoring and insulin injections, pancreatic cell treatments are an option, albeit an expensive and time consuming one. In an effort to create synthetic beta cells that can duplicate the behavior of natural beta cells, scientists from the University of North Carolina and NC State cleverly produced artificial cells containing insulin-stuffed vesicles. The vesicles' coating can identify high glucose levels and subsequently release the load of insulin into the surrounding bloodstream. "This is the first demonstration using such a vesicle fusion process for delivering insulin that employs insulin-containing vesicles like those found in a beta cell and can reproduce the beta cell's functions in sensing glucose and responding with insulin 'secretion'," says Zhaowei Chen, lead author on the study. The artificial beta cells were tested in diabetic mice and within an hour of the injection the mice displayed normal blood glucose levels, and they remained at normal levels for up to five days following a single dose of the synthetic cells. The researchers are now looking to develop a specific delivery method for the synthetic cells Continue reading >>
Diabetes: Smart Insulin Patches Developed At Unc, Ncsu A Step Closer To Market | News & Observer
The Joint Department of Biomedical Engineering at UNC-Chapel Hill and N.C. State University was founded in 2003 to bring engineers and medical researchers together to solve pressing healthcare issues. Gu, an associate professor in the department, has been working with his colleagues to remedy the imperfections of current insulin delivery methods. In the healthy body, insulin secretion always quickly follows the blood sugar levels, says Gu. We want to mimic this process in a scientific way ourselves. Their solution is a glucose-responsive smart insulin patch that is worn on the skin and instantaneously releases insulin as needed. Roughly the same size as a dime, the patch contains 121 microneedles, each thinner than a human hair and pre-loaded with tiny packets of insulin and glucose oxidase, an enzyme that immediately responds to high glucose levels and sparks a reaction that releases insulin. If youre a very strict, Type A person who is on an extreme schedule, basically always eats the same thing, has the same activity, and youre really good at math and nutrition, then you might not need this patch. But no one is perfect. Susan Spratt, associate professor of medicine at Duke University The on-demand actions of the insulin patches could help people with diabetes worry less about their glucose levels regardless of their activity levels and food intake while also increasing the accuracy of insulin dosing. Not only would the patch prevent high blood glucose, it also would reduce the chance of taking too much insulin, which can result in dangerously low blood glucose levels. If youre a very strict, Type A person who is on an extreme schedule, basically always eats the same thing, has the same activity, and youre really good at math and nutrition, then you might not need th Continue reading >>
Diabetes Archives - Innovation Toronto
A new kind of quantum bits in two dimensions - Printed Electronics World March 27, 2018 - Towards "Valleytronics". As a next step, the tip of the scanning tunneling microscope could be replaced by a series of nanoelectronic gates. This would allow for exploiting the quantum dot states of graphene on hexagonal boron nitride for scalable ... ... A New Kind Of Quantum Dot... - Compound Semiconductor March 26, 2018 - A shift by a few nanometers allows for changing the energy difference of two neighboring energy levels from minus five to plus ten millielectronvolts with high accuracy a tuning range about fifty times larger than previously possible, explains . ... Combining Two Ultrathin Materials in a New QD Could Enable Widely Tunable Quantum Systems - Photonics.com March 21, 2018 - ... two neighboring energy levels from 5 to +10 meV with high accuracy a tuning range about 50 larger than previously possible, said Libisch. As a next step, researchers say the tip of the scanning tunneling microscope could be replaced by a . ... Continue reading >>
- Consumer Driven Innovation for Continuous Glucose Monitoring in Diabetes Patients
- Remote type 2 education platform selected for NHS Innovation
- American Diabetes Association® Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes
May 2014 By Neal Morgan - Issuu
Students struggle to live upto expectations set by theirolder siblings. pg 10&11 NewsNHS Expands 3Dropouts 4-5Diabetes 6Senior Letters 7Transgender 8-9Living Up to Siblings 10Gay Prom Court 11EntertainmentSenior Pranks 12Senior IssueStrange Addictions 13Dog Shows 14Junior YouTuber 15Restaurant Reviews 16-17 The Omniscient reviewslesser known restaurants inthe Triangle. pg 16&17 Opinion 18-19Sports3A Recap 20-21Gender Equality in Sports 22Mudding 23Super Charged 24 Students describe theirmudding experiences.pg 23 EDITORSAllison DeJongEditor-in-ChiefJessica ClaytonGraphic EditorTaylor MalochSocial Media EditorLauren MerrillSocial Media EditorTori Nothnagel Photo EditorTyler WhiteOnline EditorSTAFF WRITERSByron AguilarFrances BerosetAdrianne ClevenAshlynn DavisJohn DunningArlo EstillMadison FittsKatherine GoodrichJasmine Harris Becca HeilmanEmma KoryntaBreanna LeachKenya LeeMeredith LewisSara LipofskiBill McPhilemyMeredith NormanJamie PalermoKatie RobbinsRachel SipeJack TeagueDana WalkerSkyler WaughGreyson WillardJay WilliamsDonald Yates Neal [email protected](919) 542-4181 The Northwood Omniscient is published byjournalism students at Northwood High School.It aims to present accurate coverage of events ofinterest to our readers, as well as provide an openforum for the opinions of students, faculty and thecommunity.We welcome letters to the editor, which can bedelivered to the advisor in Room 607 or sent tothe schools address. Letters must be signed, andthe staff reserves the right to reject any letter containing libelous statements, to edit for length andto ascertain the truthfulness of the content.Unsigned editorials represent the majority viewof the editorial board. Columns, letters and cartoons represent the views of the authors. Bartholomew acknowledged Continue reading >>
Today's Top Stories In Diabetes News! - Diabetic Nation
Smart insulin patches developed at UNC, NCSU one step closer to market For the 29 million Americans living with diabetes, a less painful and more accurate way to monitor their blood sugar is one step closer to reality. Zhen Gu, whose team at the UNC-N.C. State Biomedical Engineering Program has been leading the effort to develop smart insulin patches for treating diabetes, co-founded a company based in Research Triangle Park two years ago with the idea of delivering his patented diabetes treatment to people around the world. Now his company, Zenomics Inc., has received a $5.8 million investment from Chinese company MicroPort Scientific to help fulfill that goal. (read more) Fitting sweet treats in to a diabetic plan If you have diabetes, managing blood sugar levels is critical. Can sweet treats fit into a diabetic diet? In proper portions, of course. Diabetes or not, health experts recommend reining in added sugars (not the natural type found in milk and fruit). Thats because they contribute excess calories without providing nutrients, which can lead to unwanted weight gain, poor heart health and elevated blood sugar levels. The American Heart Association advises women to limit added sugars to six teaspoons daily and men to cap their intake at nine teaspoons per day. (read more) Continue reading >>
N.c. State/unc Spinout Company Raises $5.8m For Smart Insulin Devices
N.C. State/UNC spinout company raises $5.8M for smart insulin devices Technology invented in a laboratory in the UNC-NC State Joint Biomedical Engineering Program could soon mean painless diabetes testing and insulin injections for the nearly 400 million people with diabetes worldwide. Zenomics, Inc., a Research Triangle Park (RTP) startup co-founded by Zhen Gu, PhD, a scientist in the UNC-NC State Joint Biomedical Engineering Program, recently raised $5.8 million in investment fundraising. The money raised was from MicroPort Scientific Corporation, a biomedical device company that promotes the translation of Gus patented smart insulin technology. The microneedles hundreds of which fit onto the coin-sized patch or other smart device platform feature microscopic storage units for insulin and glucose-sensing components, Gu explained. When blood sugar levels get too high, the microneedles automatically release insulin, combining the testing with the insulin injection in a a pain-free and perfectly timed manner that requires little to no effort by the person wearing the device. If this translates successfully, this technology will enhance the health of patients with diabetes and improve their lives, Gu said. The technology is painless and it also lessens human error, so that you receive a more accurate blood-sugar controlling. With this round of investment funding, Zenomics, Inc., which Gu co-founded in September 2015, will continue furthering this technology, while also recruiting employees to staff its labs. Additional testing will be on large animal models. If the technology were to be effective and efficacious in large animals, clinical trials in humans could follow. This news is exciting for our universities, the state of North Carolina, and the nearly 400 million peo Continue reading >>
N.c. Researchers Develop Smart Insulin Patch | Charlotte Observer
N.C. researchers develop smart insulin patch | Charlotte Observer N.C. researchers develop smart insulin patch For people with advanced diabetes, every day is a balancing act of carefully monitoring their blood sugar and responding by taking insulin through painful injections or cumbersome pumps. New technology under development in the Joint Department of Biomedical Engineering at UNC-Chapel Hill and N.C. State University could render these invasive and imprecise treatments obsolete. The research team has designed what it calls a smart insulin patch. The dime-sized patch, which it tested on mice, would respond to high blood-sugar levels by secreting an appropriate amount of insulin, all without the patient having to prick, or even lift, a finger. The North Carolina team describes its smart insulin patch in a paper published online Monday in the journal Proceedings of the National Academy of Sciences. Sign up today for a free 30 day free trial of unlimited digital access. The patch is an exciting move forward in diabetes treatment, said Susan Spratt, director of Diabetes Services at Duke University Hospital, who was not involved in the study. Diabetes typically occurs when the beta cells of the pancreas stop making insulin, or the insulin they make is somehow insufficient. Without insulin, other cells in the body cant take up glucose from the bloodstream, which they require as an energy source. With current treatments for diabetes, a patients brain must take over the role of the pancreas, Spratt said. Patients must calculate how much insulin to inject and when, depending on what theyre eating and the kind of physical activity they plan to do. Too little insulin and the bodys blood sugar remains high, leading to complications like high blood pressure, stroke, and neuropa Continue reading >>
New Smart Insulin Patches Will Manage Blood Sugar
New Smart Insulin Patches Will Manage Blood Sugar More accurate and less painful wayto monitor blood sugar, 29 million Americans dealing with diabetes are one step closer to this reality. At the UNC-N.C. State Biomedical Engineering Program, Dr. Zhen Gus team has been extending the attempt to produce smart insulin patches for dealing with diabetes. Couple of years ago, he also co-founded a company named Zenomics Inc., which is based in Research Triangle Park with the plan of rendering his registered diabetes intervention to patients around the globe. Now, a Chinese company, MicroPort Scientific hasinvested USD 5.8 million in his company to aidin fulfilling its goal. Balancing and measuring blood glucose levels with insulin shots that hurt and finger pricks are a constant worry for diabetes patients. Each day, they have to track theiractivity and diet, aligning blood glucose level with specificallymeasured doses of insulin down the way. Even though insulin delivery by pumpor injection has turnedinto a routine and efficientmanagement for advanced Type II diabetesandType I, neither option iscomfortableor convenient particularly. There is one more issue, which is timing; blood sugar levels are frequently too high till the time insulin is rendered. Even the most superior methods that use pumps attached with constant glucose monitors may lag behind existent glucose levels by 5 to 15 minutes. To bring medical researchersandengineers togetherto resolvecritical healthcare issues, the combined Department of Biomedical Engineering at UNC-Chapel Hill and N.C. State University was established in the year 2003. Dr. Gu is an associate professor in the department and has been working with his team to repair the drawbacks of existing insulin delivery techniques. Dr. Zhen Gu said that i Continue reading >>
Low Carb Experiences With A Type 1 Kid - Home | Facebook
Just got this link from the low carb teenager, who is on his way from the trainings camp. These low-carb breakfasts will give you energy all day! "The switch from 150 to 200 g of carbohydrates a day to a low carbohydrate diet has been liberating for me. With much more stable blood sugars, I have stopped suffering from the side effects of strong More fluctuations and extreme blood sugar levels: I have fewer headaches, sleep better and am thus more well rested, have more stable energy levels throughout the day and feel satiated for longer (often with less food). The dietary adjustment also allows me to exercise more spontaneously with less of an impact on my BG levels. Having fewer and smaller glycaemic excursions also means that I spend a lot less mental and emotional energy on my diabetes management and am more relaxed and less anxious and frustrated than before." Low carbohydrate diet and improved glycaemic control in a patient with type one diabetes - EDM Case Reports Mirjam Eiswirth1, Ewan Clark2 and Michael Diamond2[1] University of EdinburghEdinburgh, UK[2] University of Edinburgh Health CentreEdinburgh, UK A low-carbohydrate diet (LCD) improves liver fat metabolism in NAFLD patients The LCD promotes rapid shifts in the gut microbiota composition of NAFLD patients The LCD-induced microbial changes are More associated with increased circulating folate The LCD increases folate-dependent one-carbon metabolism gene expression in liver An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans Mardinoglu etal. use multi-omics to investigate the effects of a carbohydrate-restricted diet in obese NAFLD patients. They show that the diet improves liver fat metabolism, promotes rapid shifts in the gut microbi Continue reading >>
