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Should Insulin Be Kept Cold

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How Long Should Insulin Be Used Once A Vial Is Started?

Editor’s comment: The commentary by Dr. Grajower has such important clinical relevance that responses were invited from the three pharmaceutical companies that supply insulin in the U.S. and the American Diabetes Association, and all of these combined in this commentary. The commenting letter and individual responses were authored separately and are completely independent of each other. Diabetic patients treated with insulin, whether for type 1 or type 2 diabetes, are prone to often unexplained swings in their blood glucose. These swings can vary from dangerously low to persistently high levels. Most diabetic patients, and most physicians, will adjust insulin regimens so as to avoid hypoglycemia at the expense of hyperglycemia. Among the “textbook” reasons for variable glucose responses to any given insulin regimen are 1) site of administration, 2) exercise, 3) bottles not adequately mixed before drawing the insulin (for NPH, Lente, or Ultralente), and 4) duration of treatment with insulin (1). A new insulin was marketed by Aventis Pharmaceuticals about 1 year ago, insulin glargine (Lantus). The manufacturer seemed to stress that patients not use a started bottle of this insu Continue reading >>

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Popular Questions

  1. cz_dave

    I am in Italy now and it gets very hot during the day. The temperature in my room easily reaches 30 degrees C and sometimes exceeds it. I put the insulin I use in a fridge I have in my room. I am not sure this is a good practice: putting the insulin I have stored in rooom temperature back into a fridge. I also have a frio with me but have not used it yet.
    I suppose I should use the frio. But has anyone seen any detrimental effects to NovoRapid or Levemir if you put it back to fridge after having been stored at room room tempreature?
    Thanks.

  2. noblehead

    Once the insulin has been out of the fridge and at room temperature it should be used up within 4 weeks, that is the manufacturers advice and says so in the patient leaflet.

  3. cz_dave

    noblehead said: ↑
    Once the insulin has been out of the fridge and at room temperature it should be used up within 4 weeks, that is the manufacturers advice and says so in the patient leaflet. Ok. So as long as I do not exceed the 4 weeks, I can keep storing it at room temperature and in the fridge interchangeably without any problems.

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