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Ultra-fast Acting Insulin Analogues.

Abstract Insulin analogues are a major improvement in diabetes pharmacotherapy. Rapid acting insulins have certain advantages over regular insulin, but there is a need to develop even faster acting insulin preparations, which mimic physiological insulin release in a better manner. This review discusses recent developments and patents in the field of Ultra- fast acting insulins. It classifies various approaches towards creation of an Ultra-fast acting insulin profile based upon the method used to achieve a faster onset of action. These include change in formulation of insulin, addition of excipients to insulin, and utilization of novel insulin sites or delivery methods. It examines the current state of evidence, and the developments in the field of newer insulin analogues & delivery methods. Continue reading >>

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  1. Kirnesh Pandey

    There can't be one value that can be put up as an answer to this question.
    In a person with normal sensitivity 1 unit of insulin decreases about 50 mg /dl of glucose . Having said that , it is important to realize that this will differ from person to person and even in a same person will vary at different points in a day and on various factors.
    Insulin sensitivity generally increases in the night but again dips in morning due to surge of steroid and sex hormone in the morning. Exercise will also serve to increase insulin sensitivity. Stresses such as infection and drugs like steroid serves to increase insulin demand . People with Type 2 Diabetes have insulin resistance and require more insulin. Those with Type 1 diabetes have higher insulin requirement during puberty or when sick.
    So for each patient Physician attempts to determine dose of insulin at each meal and to achieve that various methods are used in practice.
    This is a good patient resource :
    Diabetes Education Online

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  2. Giovanni Converti

    If you are a diabetic patient you should find out yourself in this simple way
    Test your blood glucose before lunch
    Do your regular insulin as you normally do for that type of lunch and glucose level
    Test after 2h
    See the result and if it is the same as before lunch you know how many carbs gram 1 unit of insulin takes down by dividing the carbs with the insulin units (if glucose level is not the same try again the next day)
    The next day at lunch (if you are at an high glucose level, say 250)try to figure out the insulin quantity needed for what you eat but do your regular insulin like you didn’t know how much is needed for the carbs
    Test after 2 hours

    If glucose has lowered down now check how many units of insulin you should have injected for the carbs, then calculate the difference on the glucose before and after lunch and the difference on the units you have injected compared to the ones exclusively for carbs. Then divide the glucose difference by the insulin units and you have the exact tollerance to insulin per unit of your body
    Great, now you have the result you wanted, plus you know how much carbs a unit of insulin absorbs so you won’t ever figure out insuline “blindely”
    Note: the results for lunch don't work for breakfast or dinner so you have to repeat the test for every meal of the day

    Note II: try to keep regular meals when you do this test

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