Have Researchers Found A Way To Reverse Type 1 Diabetes? Common Heart Drug Found To Work In Mice And Set For Human Trial
UAB scientists have proved through years of research that high blood sugar causes the body to overproduce a protein called TXNIP, which is increased within the beta cells in response to diabetes, but had never previously been known to be important in beta cell biology. Too much TXNIP in the pancreatic beta cells leads to their deaths and thwarts the body's efforts to produce insulin, thereby contributing to the progression of diabetes. Diabetes, which is the nation's seventh-leading cause of death, raises risks for heart attacks, blindness, kidney disease and limb amputation. Recent federal government statistics show that 12.3 percent of Americans 20 and older have diabetes, either diagnosed or undiagnosed. Another 37 percent have pre-diabetes, a condition marked by higher-than-normal blood sugar, up from 27 percent a decade ago. While a new report in the Journal of the American Medical Association showed rates at which new cases are accumulating have slowed in recent years, the numbers remain high and are still increasing overall, with 8.3 percent of adults diagnosed with the disease as of 2012. And no slowing of the disease has been seen in new cases among blacks and Hispanics or in overall rates among people with high school educations or less. Plus, the annual cost to treat the disease is exorbitant and rising. The American Diabetes Association reports that the disease cost the nation $245 billion in 2013. But UAB scientists have also uncovered that the drug verapamil, which is widely used to treat high blood pressure, irregular heartbeat and migraine headaches, can lower TXNIP levels in these beta cells to the point that, when mouse models with established diabetes and blood sugars above 300 milligrams per deciliter were treated with verapamil, the disease was era Continue reading >>
Atg-gcsf: Reversing Type 1 Diabetes After It Is Established
ATG-GCSF: Reversing type 1 diabetes after it is established A pilot safety and feasibility study of Thymoglobulin and Neulasta in established type 1 diabetes Principal Investigator: Peter Gottlieb, MD The combination therapy of Thymoglobulin and Neulasta is being tested in this clinical trial. Thymoglobulin is immunosuppressant drug that affects the cells that are thought to be involved in the development of type 1 diabetes. Neulasta is a medicine that increases the number of white blood cells. This trial is designed to investigate the effect the study drug therapy on preserving beta cell function and to determine if it will help slow the progression of type 1 diabetes. Diagnosis of Type 1 Diabetes Mellitus > than 4 months, but within 2 years Positive for at least one diabetes- related autoantibody Serologic evidence of prior EBV infection C-peptide level 0.1 pmol/ml (0.3ng/mL) when measured during a mixed meal tolerance test (MMTT), conducted at least 4 months from diagnosis of diabetes following a mixed meal tolerance test (MMTT) You will be assessed for general health and diabetes care If you are eligible and enroll you will be assigned to either a treatment or placebo group (2:1) You will receive two days of infusions with Thymoglobulin through an IV You will then receive 6 Subcutaneous Injections over a 10 week period, the first immediately following the last day of infusion You will be required to come in for follow up visits for the duration of this 2- year study Who should I call with questions or to schedule an appointment? Lisa Meyers (Enrollment Coordinator): 303-724-6893 or [email protected] Jenna Lungaro (Study Coordinator): 303-724-6758 or [email protected] Continue reading >>
Ucsf Diabetes Trial: Reversing Type 1 Diabetes After It Is Established
This study is in progress, not accepting new patients Reversing Type 1 Diabetes After it is Established The primary purpose of this study is to determine if giving the combination therapy consisting of Thymoglobulin (ATG) and Neulasta (GCSF) to patients with established Type 1 Diabetes (T1D) is safe and secondarily, if the ATG and GCSF will preserve insulin production. Reversing Type 1 Diabetes After it is Established: A Pilot Safety and Feasibility Study of Anti-Thymocyte Globulin (Thymoglobulin)and Pegylated GCSF (Neulasta) in Established Type 1 Diabetes This is a randomized, placebo controlled, phase I/II trial. Potential subjects will be screened via a 4 hour mixed meal tolerance test to assess residual beta cell (C-peptide) function. If the C-peptide level at any time is 0.1 pmol/ml, and the subject meets the additional inclusion and exclusion criteria, they will be eligible for randomization and enrollment. The study will be randomized 2:1 such that 17 subjects will receive active therapy and 8 will receive placebo. Subjects must receive Thymoglobulin/ Neulasta or placebo within 8 weeks of randomization. Thymoglobulin (2.5mg/kg)/placebo will be given as 0.5 mg/kg IV on day 1 and 2 mg/kg on day 2. Six doses of Neulasta (6mg/dose)/placebo will be given as standard of care every 2 weeks, with the first dose given prior to discharge after the Thymoglobulin infusion. Complete metabolic panel (CMP) and complete blood count (CBC) will be done at the screening visit, just prior to study drug initiation, daily during the Thymoglobulin infusion admission, and at follow up visits. Following discharge, daily phone calls will be made to the subjects during the first 5 days of therapy and weekly thereafter. In addition, weekly phone calls for the month following completion of Continue reading >>
Prevention And Reversal Of Type 1 Diabetes—past Challenges And Future Opportunities
Over the past three decades there have been a number of clinical trials directed at interdicting the type 1 diabetes (T1D) disease process in an attempt to prevent the development of the disease in those at increased risk or to stabilize—potentially even reverse—the disease in people with T1D, usually of recent onset. Unfortunately, to date there has been no prevention trial that has resulted in delay or prevention of T1D. And, trials in people with T1D have had mixed results with some showing promise with at least transient improvement in β-cell function compared with randomized control groups, while others have failed to slow the decline in β-cell function when compared with placebo. This Perspective will assess the past and present challenges in this effort and provide an outline for potential future opportunities. The first randomized, double-masked, controlled trials with sufficient statistical power to give confidence for the outcome were conducted in the mid-1980s with cyclosporine (1,2). Two large studies were conducted—the French cyclosporine study that included 122 patients with type 1 diabetes (T1D) aged 15–40 years who had been symptomatic for 6 months or less and were on insulin therapy for 2 months or less (1) and the Canadian-European cyclosporine study that included 188 subjects aged 9–35 years who had been symptomatic for 14 weeks or less and were on insulin therapy for 6 weeks or less (2). Both trials used as their primary outcome the achievement of remission defined two ways. First, “complete remission” was defined as good metabolic control (fasting glucose <140 mg/dL [7.8 mmol/L], postprandial glucose <200 mg/dL [11.1 mmol/L], HbA1c ≤7.5%) in the absence of insulin treatment. Second, “partial remission” was defined as good metab Continue reading >>
Turmeric Extract May Prevent, Even Reverse Diabetes (type 1 And 2)
Leave your drugs in the chemist's pot if you can cure the patient with food." -Hippocrates, 420 BC Slowly but surely the world is waking up to the reality that diabetes is not only a preventable but a reversible condition, and that the drug-based model of symptom suppression and disease management has fatal flaws. For instance, some of the drugs used to treat type 2 diabetes actually increase the risk of death, with a recent study showing GMO insulin given to type 2 diabetics may lead to the development of so-called "double diabetes": type 2 and type 1 diabetes, together. Clearly, if medicine can't at least abide by its founding principle to "do no harm," it must seek the answer somewhere other than from the "chemist's pot." As the pharmaceutically-driven medical paradigm continues to lose adherents by the droves, and the public seeks a system that identifies and resolves the root causes of disease, interest is growing in the use of natural substances and lifestyle modifications to prevent and treat blood sugar disorders. And unlike a few decades ago, where most of the evidence for "natural healing" was anecdotal, there are now thousands of studies on hundreds of natural substances and therapeutic activities that may ameliorate blood sugar disorders and their complications. You can check out a good portion of the relevant research on the topic on GreenMedInfo.com's blood sugar disorder database. While plants like cinnamon and gymnema sylvestre have received plenty of attention for diabetes over the years, one special plant extract that is beginning to stand out from the crowd as being exceptionally valuable as an anti-diabetic agent is turmeric. There are, in fact, 21 articles on turmeric's value in type 2 diabetes on our database alone. Turmeric's primary polyphenol cu Continue reading >>
Reversing Type 1 Diabetes After It Is Established
You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Reversing Type 1 Diabetes After it is Established The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT01106157 Recruitment Status : Active, not recruiting The Leona M. and Harry B. Helmsley Charitable Trust Information provided by (Responsible Party): Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information The primary purpose of this study is to determine if giving the combination therapy consisting of Thymoglobulin (ATG) and Neulasta (GCSF) to patients with established Type 1 Diabetes (T1D) is safe and secondarily, if the ATG and GCSF will preserve insulin production. Drug: Anti-Thymocyte Globin (ATG) Drug: Placebo Drug: Pegylated GCSF This is a randomized, placebo controlled, phase I/II trial. Potential subjects will be screened via a 4 hour mixed meal tolerance test to assess residual beta cell (C-peptide) function. If the C-peptide level at any time is 0.1 pmol/ml, and the subject meets the additional inclusion and exclusion criteria, they will be eligible for randomization and enrollment. The study will be randomized 2:1 such that 17 subjects will receive active therapy and 8 will receive placebo. Subjects must receive Thymoglobulin/ Neulasta or placebo within 8 weeks of randomization. Thymoglobulin (2.5mg/kg)/placebo will be given as 0.5 mg/kg IV on day 1 and 2 mg/kg on day 2. Six doses of Neulasta (6mg/dose)/placebo will be given as standard of care every 2 weeks, with Continue reading >>
Reversing Type 1 Diabetes: New Research From Boston Children’s Hospital
Researchers at Boston Children’s Hospital recently published the results of research that could ultimately lead to a cure for Type 1 diabetes. The strategy behind the study is based on the knowledge that Type 1 diabetes occurs when T-cells from the immune system attack beta cells in the pancreas — the cells that produce insulin. Previously, one method researchers have used in an attempt to neutralize this attack is to reboot a patient’s own immune system by infusing that patient with his or her own blood stem cells through what’s known as an autologous bone marrow transplant. The problem has been that the blood stem cells of people with diabetes tend to be defective, which can promote inflammation. Researchers at Boston Children’s Hospital, however, said they found a way to fix the defect in the patient’s blood stem cells. They do this by treating the blood stem cells with small molecules or with gene therapy. The treatment stimulates the cells to produce more of a protein called PD-L1, which has a strong anti-inflammatory effect. Then, when they’re introduced into the pancreas, the treated cells bind to receptors on the T-cells. The T-cells either die or become inactive. According to Paolo Fiorina, MD, senior investigator on the study, “There’s really a reshaping of the immune system when you inject these cells.” Researchers tested the procedure on mice and reported they reversed Type 1 diabetes in the animals. All mice were cured of diabetes temporarily, and one-third of them were cured for the rest of their lives. The next step, of course, is to try the treatment on people with diabetes. Accordingly, Boston Children’s researchers are partnering with a California therapeutics firm to refine the procedure for modifying the blood stem cells and the Continue reading >>
How 6 People Reversed Their Diabetes In 30 Days
There’s a good chance you know someone with diabetes give how common it is today, and I think it’s important people start getting to know what others have been doing to treat and cure their diabetes so people can find out if these solutions can work for them. When I think of diabetes, I don’t just think of people who already have the condition, but I also think of preventing it. What if we could not only prevent diabetes before it happened, but also reverse it once it shows up? Diabetes is one of the most rampant diseases of our time. According to the American Diabetes Association, in 2012 29.1 million Americans, or 9.3% of the population, had diabetes. [1] In fact, diabetes is growing at a fairly fast rate. A study completed by the CDC & Research Triangle Institute concluded that If recent trends in diabetes prevalence rates continue linearly over the next 50 years, future changes in the size and demographic characteristics of the U.S. population will lead to dramatic increases in the number of Americans with diagnosed diabetes. [2] According to the current mainstream approach, the major goal in treating diabetes is to minimize any elevation of blood sugar (glucose) without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with insulin, exercise, and a diabetic diet. Type 2 diabetes is treated first with weight reduction, a diabetic diet, and exercise. [3] Currently the belief is “Diabetes is a chronic disease that has no cure.” – The American Diabetes Association. 6 Test Subjects Reverse Diabetes In 30 Days In the film, Simply Raw: Reversing Diabetes in 30 Days, six test subjects were used, all of whom had varying lifestyles and conditions but were all diabetic – five were type 2 and one was type 1. Each subject was taking insulin. Continue reading >>
Type 1 Diabetes Successfully Reversed With Antibody Therapy; Could There Soon Be A Cure?
Type 1 Diabetes Successfully Reversed With Antibody Therapy; Could There Soon Be A Cure? Researchers have identified an antibody that can reverse the onset of type 1 diabetes in mice models, even after they begin showing signs of it. Now, researchers are trying to determine how to develop the therapy into a successful cure for type 1 diabetes in humans. The study, led by Dr. William Ridgway of theUniversity of Cincinnati,was presented on Saturday at the American Diabetes Association's 74th Scientific Sessions in San Francisco, according to a press release . Type 1 diabetes , which is also known as juvenile diabetes, usually affects children and young adults. It's caused by the body's inability to produce insulin, a hormone needed to break down sugars and starches and transform them into energy. The bodys inability to produce insulin arises from an autoimmune response to insulin-producing beta cells in the pancreas. Typical symptoms include frequent urination, increased thirst, and severe weight loss, in spite of regular diets. The exact cause of type 1 diabetes is unknown, but genetics and exposure to certain viruses are thought to be contributing factors. Still, it's the rarer form of diabetes, with only five percent of people having the chronic condition, which requires continuous administration of insulin. In certain cases, lack of proper care may lead to severe complications like heart disease, stroke, and kidney failure. It is believed that the incidence of type 1 diabetes, and autoimmune diseases in general, have increased in the amount of cases due to under-stimulation of innate immune systems, which trigger autoimmunity in children and young adults. Unlike type 2 diabetes , in which a a person is unable to respond to insulin, type 1 diabetes occurs when the bod Continue reading >>
- Type 2 diabetes REVERSED: Removing bread and pasta from diets could be cure
- There’s Now More Evidence That Type 2 Diabetes Can Actually Be Reversed
- Get off your backside! It's madness for the NHS to spend millions fighting type 2 diabetes when the simple cure is exercise, says DR MICHAEL MOSLEY, who reversed HIS own diabetes
Reverse Vaccination And Treatment Of Type 1 Diabetes Using Plant-produced Autoantigens And Anti-inflammatory Cytokines
Type 1 diabetes (T1D) is an autoimmune form of diabetes mellitus that accounts for about 10% of all diabetes cases and occurs predominantly during childhood or adolescence. The disease initiates when most of the insulinproducing -cells in the pancreas are destroyed by autoimmune cells, including T-helper 1 cells, cytotoxic lymphocytes and dendritic cells. The major autoantigens in T1D are insulin, glutamic acid decarboxylase, and insulinoma antigen. At-risk individuals with underlying islet inflammation can be identified by the presence of circulating autoantibodies to these specific islet antigens many years before the clinical onset of T1D, thus, providing a window for prevention strategies. Currently, there is no definitive cure for T1D; therefore, more effective therapeutic interventions for prevention of diabetes onset and progression are urgently needed. Vaccination with autoantigens to promote selfantigen- specific tolerance represents the most specific and safest means of preventing autoimmune diseases. Autoantigens administered by the mucosal route, which is tolerogenic by nature, is the most effective way to prevent or treat autoimmune diseases. However, the two major drawbacks of oral vaccination with autoantigens are the large quantities required to induce significant tolerance, presumably because the protein is partially degraded in the stomach, and the high cost of producing recombinant autoantigens using the conventional cell culture-based platforms. The expression of autoantigens in plants and the oral delivery of the plant tissue expressing the target antigen offer a potential solution for these two drawbacks. The goal of this review is to outline novel diabetes vaccine strategies based on -cell autoantigens with a focus on the advantages and potential Continue reading >>
Type I Diabetes Reversal - Medically Documented
Click here to get L-Arginine MAX. Sometimes wonderful news arrives in unique packages. I am a registered nurse, and I study alternative health measures and nutrition. My husband and I have six precious children. The story behind our impressive news began in January of 2008. I thought our youngest child, Gabriel, possibly had a bladder infection. What started out to be a somewhat routine doctor visit ended up with disturbing news. Our family doctor said he suspected Gabriel had Type 1 Diabetes. Shock hit me as I tried to absorb the news. We had no family history of Diabetes, and overall our family had been very healthy. The extensive tests taken the next day revealed that our six-year-old son would probably be insulin-dependent within six months. Our pediatric endocrinologist insisted that there was nothing we could do to prevent the onset of Diabetes. He said that no dietary changes were needed or would help. After scouring all known resources and a lot of prayers, I discovered Dr. Youngs research. Dr. Young graciously invited us to a microscopy class to observe, learn and have a look at both the live and dried blood of Gabriel. We thought Gabriel had been on a reasonably healthy diet, but as we would come to realize, it was far too acidic with way too many carbohydrates. We chose to dive head-first into the pH Miracle program. Immediately his blood sugar levels came to within normal ranges. His weak body soon returned to its previous vigor. Our story took a twist in the road when only four months later our ten year old son, Nathan, was also diagnosed with Type 1 Diabetes. At the same time, a blood test revealed that Gabriel had no measurable insulin left in his blood. Although we were thankful that Gabriel was maintaining normal blood sugar levels, we grieved at what Continue reading >>
Has A British Man Really Been Cured Of Type 1 Diabetes?
I have been living with type 1 diabetes for 25 years now. The relentlessness of type 1, and the fact that I will probably live with this non-preventable condition for the rest of my life never goes away, but I have almost made peace with it. A few days ago, I saw something that gave me pause. “British man with type 1 diabetes to receive tests after coming off insulin,” read Diabetes.co.uk’s headline. The article goes onto say that, “Daniel Darkes, from Daventy in Northamptonshire, was diagnosed with type 1 diabetes seven years ago. But his recent tests have baffled doctors as his pancreas has shown signs of working properly again.” My first thoughts upon reading this were, “this can’t be true,” and “what’s the real explanation here?” There are many types of diabetes including type 2, LADA, and monogenic. Maybe he actually had one of those types instead of type 1. Usually, tests can determine this quickly though, so why was it not the case with Dan? I live in the UK and I wanted to get to the bottom of things. I managed to get in touch with ‘Miracle Dan’, as he’s been called by his friends. Although he is saving the specific details of his recent test results from the U.S. for an upcoming exclusive interview with another media outlet, he spoke to me and answered some of my questions about everything that has been happening. Please tell us a bit about yourself and your diabetes. When were you diagnosed? I was diagnosed with type 1 diabetes back in February 2011 at the age of 23, after just leaving the army. I started a new engineering job and within two weeks of starting, I noticed the traditional symptoms of type 1 diabetes: thirst, weight loss, blurry vision, and a lot of vomiting. I collapsed and was taken by ambulance to hospital where I wa Continue reading >>
Harvard And Mit Close To Cure For Type 1 Diabetes Which Will End Daily Injections
Harvard and MIT close to cure for Type 1 diabetes which will end daily injections Sufferes of type 1 and type 2 diabetes may have to inject insulin dailyCredit:Alamy A cure for type 1 diabetes is closer than ever after scientists showed they can switch off the disease for six months in animals which would equate to several years in humans. In 2014, researchers at Harvard University discovered how to make huge quantities of insulin-producing cells , in a breakthrough hailed as significant as antibiotics. Now a team at MIT has proven that planting the cells into mice can completely restore insulin function for a long time. "These treatments aim to effectively establish long-term insulin independence and eliminate the daily burden of managing the disease for months, possibly years, at a time" Julia Greenstein JDRF, the type 1 diabetes research charity It could mean the end of daily insulin injections for the 400,000 people in Britain living with Type 1 diabetes. Instead they would simply need a transfusion of engineered cells every few years. Researchers say human trials are just a few years away. We are excited by these results, and are working hard to advance this technology to the clinic, said Dr Daniel Anderson, professor of applied biology at MIT. These results lay the groundwork for future human studies using these formulations with the goal of achieving long-term replacement therapy for type one diabetes. We believe (the cells) have the potential to provide insulin independence for patients suffering from this disease. "It has the potential to provide diabetics with a new pancreas that is protected from the immune system, which would allow them to control their blood sugar without taking drugs. Thats the dream. Type 1 diabetes is an autoimmune condition that causes Continue reading >>
Reversing Type 1 Diabetes Without Insulin Replacement
Project Researcher: Subhadra Gunawardana, Ph.D. – Washington University, St. Louis Project Description Type 1 diabetes (T1D) is a serious disease affecting 3 million Americans, with over 15,000 children being diagnosed each year (1). Traditional treatments involve insulin replacement, either directly or via islet/pancreas transplantation, and have numerous limitations. Exogenous insulin administration is obviously inconvenient, and can be dangerous due to potentially fatal dips in blood glucose. Pancreas transplantation, the only available long-term remedy, requires major invasive surgery. Islet transplantation is safer but less effective, as patients return to diabetes in the long term. Both islet and pancreas transplantation are limited by the availability of donor tissue and the need for life-long immunosuppression. Thus there is an ongoing need for better therapies. The ultimate goal in treating T1D is to restore blood glucose control. We recently demonstrated an entirely novel approach to restore normal blood glucose without insulin, thereby avoiding the aforementioned complications. Transplanting healthy embryonic brown adipose tissue (BAT) under the skin of type 1 diabetic mice results in dramatic restoration of glucose control and reversal of diabetes, with no contribution from insulin. While insulin remains low as is typical with T1D, BAT transplant recipients show progressive weight gain and reversal of all clinical signs of diabetes, accompanied by an increase in healthy fat (adipose tissue) content in the body. Adipose tissue is a versatile endocrine organ which secretes hundreds of hormones affecting all body systems, and exerts a profound influence on blood glucose regulation. Healthy adipose tissue is a powerful asset, which helps improve overall metabo Continue reading >>
Type 1 Diabetes . . . Cured?
Carrie posted this wonderfully thought-provoking comment about her diabetic son: My 13 yr old son was diagnosed over a year ago with Type 1 [diabetes]. Before his diagnosis, I was very ‘green’ — bought organic foods, bought meat from free-range, grass-fed local farms, cleaned my house with products I made myself from vinegar and natural products. But we did follow the low-fat, low-calorie, high-fiber, healthy whole grain diet. We were told “eat whatever you want” — just dose for it [with insulin] and be healthy (yep: low-fat, high-fiber, etc.) I didn’t think so: If he has a carb problem, then limit carbs! We immediately went low-carb, causing us to remove a lot of wheat products, but didn’t know about the damages of gluten then. His last two A1Cs [hemoglobin A1c’s, a 60-90 day reflection of blood sugar fluctuations] have been 5.3% [normal range]. He was taken off his basal insulin and his bolus, continuing to less and less. Today, he is OFF insulin! YES, he is a Type 1 diabetic: They double-checked for the antibodies in case he was misdiagnosed–they are there. Even without insulin, his blood sugars are better than me or his dad, or even sister (we all check now). And all this while growing over 5 inches in one year, going through puberty and the stomach flu with no problems (scary for Type 1 diabetics). His doctors are amazed. We all still did not know how he was this way, until someone shared with me Wheat Belly. We are all going completely gluten-free now and staying low-carb. Maybe my asthma will be gone and my daughter’s horrible itchy rash all over her arms will finally leave! Absolutely wonderful book, thank you! Wow. We know that consumption of modern wheat is associated with causing type 1 diabetes in children, average age of onset 4 years Continue reading >>
