Designing Pharmaceutical Excellence With Eli Lilly
A decades-long relationship between IDEO and Eli Lilly that has transformed patients' lives and health outcomes Since the time Eli Lilly and IDEO first collaborated in 1990, the partnership has redefined the relationship between patient, health, and treatment. IDEO and Lilly, along with Lilly’s other design, development, and manufacturing partners, have collaborated on more than 250 projects over the last 25 years, taking them from groundbreaking engineering-only design to their evolution as a full-fledged human-centered organization, helping millions of patients in the process. Communication and consistency have been key in maintaining the long-term nature of their partnership. In fact, the relationship has evolved to be more like partners working together than a client and consultant. This not only informs the large-scale projects, but also the smallest details. “We have this kind of consistency, where they feel they can just pick up the phone and say, Can you help us?” said IDEO Design Director Dirk Ahlgrim. “They know we will challenge them, maybe do even more than they asked us to do, because we are more like partners.” This heightened level of communication led to a global research project in which a team of IDEO designers traveled the world to understand how people with diabetes lived with the disease. The results of their findings led to the design of a series of award-winning insulin injection pens like SAVVIO. The new injection pens were personalized to the patient, and crossed over from medical devices to personal devices, completely changing the way patients thought about their condition and their treatment. Lilly and IDEO’s latest collaboration, Trulicity, takes the injection pen as personal device one step further: By ensuring consistent dosage Continue reading >>
Novo Knocks It Out Of The Park With New "echo" Smart Insulin Pen
Three bites into my enchilada my mother asks me, "Did you take your insulin?" My first response is to glare at her. I'm 50 years old fer' God's sake. I don't need to be reminded to take my insulin. My second response is to realize that I'm not sure whether or not I did take my insulin. After all, five to six shots a day, 365 days a year, adds up to something well over 2,000 shots annually. They blend together, one pretty much like the last, and each pretty much like the next. In the past, I'd wrack my brain to remember. But until my blood sugar either shot up or stayed where it belonged, there was no way to know for sure whether or not I'd forgotten my insulin. Now, thanks to a sleek new sleek royal-red insulin pen that hit the market in January, with a swift flick of my thumb have the answer: I took 2.5 units of Novolog minutes ago. It's not an app. It's not a pump. It's a super-pen from Novo Nordisk called the NovoPen Echo, one of which I've been test-driving lately. It's the world's first half-unit dosing pen with a memory. Echo is not unique in delivering half-unit drips of insulin; Lilly makes a half-unit re-fillable pen called the HumaPen Luxura HD, and Novo themselves have made the NovoPen Junior, another half-unit re-fillable pen, for years. A pen with a memory is not a new idea either. Lilly at one time offered the HumaPen Memoir that stored dosing info. But combining half-unit with memory is something entirely new. The Echo is billed as a tool for kids, but there are plenty of adult type 1s like me who take fast-acting insulin from a pen. Why wouldn't we want to be more accurate about it too? {Note: Echo is only new to the USA, it's been use in the rest of the civilized world since 2010.} Quick additional background: Refillable pens have been around since 1985 Continue reading >>
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Insulin Pens
What Are Insulin Pens? Scientists are always looking for new ways to improve on the standards of diabetes treatment. For example, they are continually trying to create better delivery devices for self-administering insulin. The insulin pen is one such device. Insulin cannot be taken in pill form, it has to be injected. Traditionally this required patients to use the vial and syringe method but this is no longer necessary. While the insulin pen does not eliminate the need for a needle, it does have a shorter needle so it looks less scary. The pen also has the added benefit of controlling insulin dosages better. This is important because studies show that as many as 80 percent of patients who self-administer with a syringe alone, administer the incorrect dosage. Now insulin pens offer a more flexible, convenient and safer alternative. Pens either come with an insulin cartridge already inserted (and the pen is discarded once the cartridge is spent) or they are reusable and the cartridge is replaced when it runs out (like an ink cartridge would be). The technique for insulin delivery is similar for both devices. Once a needle has been used it must be disposed and another one screwed on for the next injection. 5 Prostate Warning Signs Top Doctor's Video Reveals the 5 Signals Your Body Sends When Prostate Cancer is Coming Newsmax Health Advantages Of Insulin Pens Over Traditional Syringes 1. They are discreet which makes them more socially acceptable to use in public (this is particularly important for kids). Traditional syringes have a stereotypical association with illicit drug users. 2. They offer more accurate dosages. 3. They are less painful because smaller needles are used. 4. Simpler for older adults, children and pregnant women to use. 5. More flexibility because the Continue reading >>
Insulin Pens: Improving Adherence And Reducing Costs
The advantages offered by insulin pens may help improve patient adherence. Currently 8.3% of the United States adult population, or 25.8 million people, have diabetes. Of these cases, more than 90% are cases of type 2 diabetes mellitus (T2DM) and at least 1 million are estimated to be cases of type 1 diabetes mellitus (T1DM). Although a variety of oral medications are available for patients with diabetes, insulins remain an important component of treatment.1,2 Insulins are the standard therapy in patients with T1DM and are ultimately used in patients with T2DM who do not respond adequately to other treatment modalities. Although in some settings insulins may be administered intravenously (eg, with an insulin pump), the vast majority of insulin administrations are subcutaneous injections.1,2 Available Forms and Administration In the United States, 2 types of insulins are available: recombinant human insulins and insulin analogs. Recombinant human insulin is available from 2 manufacturers (Humulin by Eli Lilly and Novolin by Novo Nordisk); each of these is available in a regular form and in a longer-acting neutral protamine hagedorn (NPH) form. Unlike recombinant human insulins, insulin analogs are structurally modified forms of insulin that are designed to either lower blood sugar rapidly or maintain low blood sugar levels over time. These insulin analogs may be classified as rapid-acting and long-acting insulins. Rapid-acting insulins include insulin lispro, insulin aspart, and insulin glulisine, and long-acting insulins include insulin glargine and insulin detemir. Premixed formulations of insulin are also available.1,2 Regardless of the differences between insulin formulations, all conventional types of insulin can be administered subcutaneously. Subcutaneous injectio Continue reading >>
Insulin Pen Overview
Insulin Pen Overview An insulin pen (or just "pen") is an insulin delivery system that generally looks like a large pen, uses an insulin cartridge rather than a vial, and uses disposable needles. Pens are the predominant insulin delivery system in most of the world, except the United States, where syringes and insulin vials still dominate. Pens are made by Novo Nordisk, Eli Lilly, Disetronic, and Owen Mumford. Disetronic makes pens for other companies, including Aventis. Some pens use replaceable insulin cartridges, and some pens use a non-replaceable cartridge and are disposed of after use. All pens use replaceable needles. Most pens use special pen needles (see discussion below), which can be extremely short and thin. The Disetronic pen, however, uses the same syringe as their DTron insulin pump, which has a traditional syringe leuer lock needle. Pens With Replaceable Cartridges Pens with replaceable cartridges are made by Novo Nordisk, Owen Mumford, and Disetronic. BD used to make pens, including the BD Pen Mini, but they are no longer making pens. Insulin cartridges for pens come in 3.0 ml and 1.5 ml sizes, with 3.0 being the predominant size. The 1.5 ml size is being phased out and availability may be limited. Insulin cartridges are made by Eli Lilly, Novo Nordisk, and Aventis. Prefilled Pens Pens that come with a prefilled insulin cartridge are thrown away when the insulin is used up. Prefilled pens are sold by insulin makers Eli Lilly, Novo Nordisk, and Aventis. Lilly only sells prefilled pens which come with a variety of Lilly insulins, including Humalog, Regular, NPH, and various mixes, including Humalog mixes. Novo Nordisk sells both prefilled pens and pens that take replaceable insulin cartridges with NovoLog and other Novo Nordisk insulins. Aventis sells pre Continue reading >>
Overview Of Insulin And Non-insulin Delivery Devices In The Treatment Of Diabetes
Go to: INSULIN Guidelines from the ADA and the AACE highlight the importance of early and aggressive treatment of diabetes to achieve and maintain glucose levels comparable with those of nondiabetic patients in order to prevent chronic complications. Insulin preparations (Table 1) are currently the most effective treatments for diabetes and the only therapeutic options for patients with T1DM. They may also be used in patients with T2DM who have failed treatment with oral agents or who have hemoglobin A1c (HbA1c) levels greater than 10%.13 Health care providers, however, are reluctant to prescribe insulin because of the need for frequent dose adjustments, the potential for hypoglycemia, and the time required to educate patients regarding insulin administration. Patients, in turn, are often reluctant to use insulin because of their fear of injections, their belief that insulin is difficult to administer, and their perception that insulin preparations have adverse side effects.14 These barriers to treatment may be overcome by the use of insulin-delivery devices. For all patients with T1DM and some with T2DM, an ideal insulin regimen mimics the body’s own insulin-release pattern (basal–bolus dosing).13 Intermediate-acting insulin (i.e., neutral protamine Hagedorn [NPH] insulin) and long-acting insulin analogs (i.e., insulin detemir and insulin glargine) provide basal insulin coverage, whereas short-acting regular human insulin and rapid-acting insulin analogs provide prandial coverage.13 Insulin-Delivery Pens Insulin-delivery pens eliminate the need to draw up insulin, which allows more convenient administration compared with syringes. An insulin pen looks like a large fountain pen. The pen is prefilled with insulin, and the only preparation required is attaching the ne Continue reading >>
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
- Hybrid closed-loop insulin delivery systems for type 1 diabetes come of age
- Lancets & Lancing Devices For Diabetes: Read This Before You Buy
Is An Insulin Pen Right For You?
Thinking About Trying an Insulin Pen? For decades, taking insulin required a syringe and a vial. Another option for taking insulin began about 20 years ago when the first insulin pen hit the market. Insulin pens, which look like oversize ink pens, generally contain 300 units of one type of insulin or a fixed combination of two insulins. The pen is a convenient, accurate, and discreet way to take insulin. The ability to quickly and easily deliver a dose of insulin wherever and whenever you need is the pen's biggest advantage. Also, if you lack dexterity in your fingers, an insulin pen might be easier for you to manage than a vial and syringe. "When a person's health plan will cover pens, I try to prescribe them," says cardiologist Steven Nash, M.D., of Manlius, New York. "I think they're much easier to use than syringes." Insulin pens are also great for traveling because they're small and can be kept at room temperature. "My insulin pen has made taking insulin easier," says Marsha LaClair, 41, of Austin, Texas, who has type 1 diabetes. "I travel frequently, and now packing to manage my diabetes is a breeze." Reusable and Disposable Pens Insulin pens fall into two categories: reusable and disposable. Reusable insulin pens use replaceable cartridges filled with insulin; they usually contain 300 units of insulin each. When the cartridge is empty, or if you've stored your pen and cartridge at room temperature for more than 28 days, the cartridge is discarded and a new one is inserted. The more commonly used disposable pens come prefilled with insulin. When the pen is empty or has been stored at room temperature for more than 28 days, discard the whole pen. However, insulin pens do not come with a needle attached. You need to attach an insulin-pen needle to the end of the pen Continue reading >>
Buy Insulin Diabetes Medications For Injections Online
Browse Prescription Insulin Diabetic Medications Below * 90 Day Maximum Supply. You may order refills after 90 days if your prescription allows refills. ** Flat Rate Shipping. CanadianInsulin.com provides flat rate shipping to anywhere in the United States. Humalog Humalog Vials Humalog Cartridges Humalog Cartridges Mix 25/75 Humalog Cartridges Mix 50/50 Humalog KwikPens Humalog KwikPens Mix 25 Humalog KwikPens Mix 50 Humulin Humulin 30/70 Vials Humulin N Vials Humulin R Vials Humulin N KwikPens Lantus Lantus Vials Lantus Solostar Pens Levemir Levemir FlexTouch Pens Levemir PenFill Cartridges Novolin Novolin ge 30/70 Vials Novolin ge 30/70 PenFill Cartridges Novolin ge 40/60 PenFill Cartridges Novolin ge 50/50 PenFill Cartridges Novolin ge NPH Vials Novolin ge NPH PenFill Cartridges Novolin ge Toronto Vials Novolog (Novorapid) Novolog Vials Novolog FlexPens Novolog Mix 70/30 Cartridges Novolog PenFill Cartridges Apidra Apidra SoloStar Pens Apidra SoloStar Vials What is Insulin? Diabetes is a metabolic disorder characterized by high blood sugar levels that result from a problem with insulin function. Either your body does not produce insulin, which is called Type 1 diabetes, or your body does not properly use the insulin that it does produce, which is called Type 2 diabetes. Type 1 diabetes is also sometimes referred to as insulin-dependent diabetes. Insulin is an important hormone produced in your pancreas that regulates your metabolism by helping your body use the sugar from your food as energy for your body. It is involved in the breakdown of sugars, fats and proteins as well as the control of your blood sugar levels. Insulin balances your blood sugar levels, decreasing them if they become too high. It absorbs sugar from your bloodstream, processes it, and allocates i Continue reading >>
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
- New diabetes treatment could eliminate need for insulin injections
- Smart Insulin Patch Could Replace Painful Injections for Diabetes
Get To Know The Lantus® Solostar® Pen
Do not take Lantus® during episodes of low blood sugar or if you are allergic to insulin or any of the inactive ingredients in Lantus®. Do not share needles, insulin pens, or syringes with others. Do NOT reuse needles. Before starting Lantus®, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breast-feeding or planning to breast-feed. Heart failure can occur if you are taking insulin together with certain medicines called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you already have heart failure, it may get worse while you take TZDs with Lantus®. Your treatment with TZDs and Lantus® may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms of heart failure, including: Sudden weight gain Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, including herbal supplements. Lantus® should be taken once a day at the same time every day. Test your blood sugar levels while using insulin, such as Lantus®. Do not make any changes to your dose or type of insulin without talking to your healthcare provider. Any change of insulin should be made cautiously and only under medical supervision. Do NOT dilute or mix Lantus® with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Lantus® must only be used if the solution is clear and colorless with no particles visible. Always make sure you have the correct insulin before each injection. While using Lantus®, do not drive or operate heavy machinery until Continue reading >>
Eli Lilly Launches Reusable Insulin Pen
New Delhi, Jan. 21: Eli Lilly and Company India aims to be in the top-20 list of pharmaceutical companies in the nation by 2020, Eli Lilly India MD Edgard A. Olaizola told Business Line here on Tuesday. The company will be bringing in all its diabetes products to the country, Olaizola said. It has launched a new reusable insulin pen, the HumaPen Savvio. “India is an important market for us within the emerging markets. In an area like diabetes it is one of the largest markets with about 60 million patients. As a company our vision is to be among the top 20 companies in India by 2020,” Olaizola said. The HumaPen Savvio will be priced at Rs. 1,000 in the retail market. It will also be provided free of cost to physicians for distribution to patients. The pen will be co-promoted by the Lilly-Boehringer Ingelheim alliance in India. According to Olaiza, the USP of this product — which he said resembled an accessory rather than a medical product — is that it allows patients to manage the disease discreetly, besides being smaller and having a shelf-life of up to six years. He added that all the diabetes products launched worldwide will be brought to India also in the next few years. It is estimated that the number of diabetics in India will go up to 100 million in 15 years. “From a market point of view we have been growing in double digits in the past 3-4 years. Lilly India has been growing faster than the market,” he said. The company is also present in segments such as osteoporosis, cardiovascular, oncology and growth hormones. aesha.d[email protected] Continue reading >>
Insulin Pens
Normally, about half of the day's insulin is released as a relatively steady background or basal delivery. When carbs are eaten, a spike or bolus of insulin release occurs from the pancreas. In attempting to mimic the pancreas with a basal/bolus approach that better matches insulin to need, a convenient and precise way to deliver insulin can be very helpful. The best way for many to mimic the pancreas is with an insulin pen. Pens have been available for a quarter century, but their use in the U.S. lags behind the wide popularity they have experienced in Europe. Insulin pens allow discrete injections on a just-in-time basis. There is no need to carry a syringe and bottle of insulin and doses can be conveniently dialed up, making dose errors less likely. An insulin pen looks like a fountain pen and is usually only slightly thicker in size. It has a disposable needle at one end with a cartridge that holds insulin and a dial that is used to select the insulin dose. Pen cartridges hold 150 or 300 units of insulin. Some pens are disposable and thrown away once the insulin is gone, while others are more environmentally-friendly with disposable glass cartridges that are replaced when they become empty. Different pens can deliver insulin in half unit, one unit or two unit increments. Half-unit pens, such as the NovoPen Junior, are particularly well suited for children and adults on low doses, and come in bright graphic designs. Two unit pens, such as the AutoPen from Owen Mumford, are ideal for those with Type 2 diabetes or others who use large doses of insulin. Prefilled cartridges are available for common insulins, such as Apidra, Humalog or Novolog, and Lantus or Levemir. Although we do not recommend them for most people, 70/30 mixtures which contain fixed ratios of 70% longe Continue reading >>
Global Insulin Delivery Pens Market: Reusable Insulin Pens Segment Value To Reach Us$ 9,100 Mn By 2027 – Future Market Insights
VALLEY COTTAGE, New York, Nov. 16, 2017 (GLOBE NEWSWIRE) -- Insulin pens are used as an effective solution for diabetes management. With the current technological advancements, insulin now comes with different variants like reusable pens that can be used by just loading insulin cartridges available in packs. Disposable insulin pens contain a prefilled cartridge and the entire pen is disposed or thrown away providing convenient delivery of insulin. Smart insulin pens are the latest advancement in diabetes management. These smart insulin pens are either Bluetooth enabled wireless devices allowing automatic data sharing or devices that require data sharing with a dedicated USB data cable. These pens also come with a feature incorporating a clinician configured bolus calculator with the ability to deliver multiple insulin doses every day safely and discreetly. A new research report by FMI titled ‘Insulin Delivery Pens Market: Global Industry Analysis (2012-2016) and Opportunity Assessment (2017-2027) gives an overview of the global insulin delivery pens market along with a comprehensive market forecast for the period 2017-2027. Global Insulin Delivery Pens Market: Dynamics Several factors contribute to the growth of the global insulin delivery pens market. One major driver is the move towards value based compensation models for therapies from unit priced payment models that are more commonly used to self-administer treatment for chronic diseases like diabetes. The shift is prominently seen in regions such as U.S. and Europe. This shift, in turn, results in increased demand for technology driven insulin delivery systems with higher levels of accuracy and patient compliance in addition to providing patients with the necessary coaching and education. The demand for smart ins Continue reading >>
Novolog® (insulin Aspart Injection) 100 U/ml Indications And Usage
NovoLog® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® or one of its excipients. Never Share a NovoLog® FlexPen, NovoLog® FlexTouch®, PenFill® Cartridge, or PenFill® Cartridge Device Between Patients, even if the needle is changed. Patients using NovoLog® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. NovoLog® (insulin aspart injection) 100 U/mL is an insulin analog indicated to improve glycemic control in adults and children with diabetes mellitus. NovoLog® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® or one of its excipients. Never Share a NovoLog® FlexPen, NovoLog® FlexTouch®, PenFill® Cartridge, or PenFill® Cartridge Device Between Patients, even if the needle is changed. Patients using NovoLog® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. Hypoglycemia is the most common adverse effect of insulin therapy. The timing of hypoglycemia may reflect the time-action profile of the insulin formulation. Glucose monitoring is re Continue reading >>
Reusable Insulin Pens
Two types of insulin pens are being sold on the market today: disposable insulin pens and reusable insulin pens. While these pens offer a lot of advantages over syringes and bottled insulin, each type of pen provides specific benefits for the user. Which Insulin Pen is Right for You? Whether you’re using either a disposable or reusable insulin pen, it is critical to know how much insulin you need at any particular time, and just how precise your dosage has to be. Insulin pens can deliver incremental doses of one-half, one, or two units. Maximum dose from a single injection can range from 21 up to 80 units. Children, for instance, may require a pen that administers incremental half-unit doses of insulin for mealtime. If you take a daily injection of long-acting basal, you’ll require an insulin pen that can deliver a larger dose. Features of Reusable Insulin Pens Reusable insulin pens use replaceable cartridges that are sold separately. The Pen will last for several years, the cartridges are replaced. Each cartridge holds either 150 or (more commonly) 300 units of insulin. They are most often sold in a box of five cartridges. When the cartridge is empty, you dispose of it and replace it with a new cartridge. Depending on how much insulin you require, a single cartridge may provide you with a week of injections. Needles for Reusable Insulin Pens Both disposable and reusable insulin pens use a pen needle. These needles are a lot cheaper than buying insulin syringes. For every injection, just screw on a new needle, dial in the dose you require, insert the needle into your skin, and press the button to administer the insulin. How to Store Reusable Insulin Pens While the insulin cartridges can be stored in your refrigerator before use, reusable pens should never be kept in Continue reading >>
Insulin Pens
Often the size and shape of a large marker, insulin pens carry insulin in a self-contained cartridge. They are easy to use and growing in popularity. Some users use insulin pens for all their injections, while others carry them when they are "on the go" and rely on less-expensive and more versatile syringes when they are: mixing different insulins taking an insulin that is not available in a pen at home Insulin pens are used with pen needles that are sold separately. A new pen needle should be used each time you inject. Insulin Pen Types While there are a number of different brands and models available, most insulin pens fall into one of two groups: reusable pens and disposable pens. Before using a reusable insulin pen, you must load it with a cartridge of insulin. Depending on the size of your doses, a cartridge may give you enough insulin to last for several days of injections. When the cartridge is empty, you throw it away and load a new cartridge. With good care, a reusable pen can often be used for several years. Disposable insulin pens come filled with insulin and are thrown away when they are empty. Disposable pens are generally more convenient than reusable pens because you do not need to load any cartridges, but they usually cost more to use than reusable pens and cartridges. Pen brands and models differ from one another in many ways. When working with your healthcare team to select a pen, there are many factors to keep in mind, including: The brands and types of insulin that are available for the pen. The number of units of insulin that the pen holds when full. The largest size dose that can be injected with the pen. How finely the dose can be adjusted by the pen. For example, one pen may dose in two-unit increments (2, 4, 6, etc.), another in one-unit increme Continue reading >>
