diabetestalk.net

Pros And Cons Of Metformin

Share on facebook

Metformin (glucophage)

Metformin has a really interesting story. Structurally metformin is a biguanide and its chemical structure is related to guanidine. Guanidine-like compounds are extracted from the medicinal herb Galega officinalis (Goats rue). The glucose-lowering properties of guanidine where recognized early in the 20th century. Galega officinalis extracts were used to treat diabetes in the 1920s but had prohibitive gastrointestinal side effects. Metformin itself was first prepared in 1922 by the Dublin chemists Emil A. Werner and James Bell. In 1929, Slotta and Tschesche discovered its sugar-lowering action was the most potent of the biguanide analogs they studied. However, the discovery of the action of metformin was soon overshadowed by insulin. Under the suggestive name of flumamine, the guanidine analogue was used by Eusebio Y. Garcia (an eminent Philippine specialist in infectious diseases) for the treatment of viral influenza in 1949 1 , 2 . He noted sugar-lowering properties of the drug. The publication 1 from the Philippines, mentioning glucose lowering effects of biguanidines, stimulated Jean Stern, a French researcher and diabetologist, in 1957 to try "flumamine" for diabetics. Thus J Continue reading >>

Share on facebook

Popular Questions

  1. Dan360

    The good, the bad and the ugly of metformin

    I have been taking metformin sense the day I was first diagnosed with type 2 diabetes. As you probably know, it is the first-line drug of choice for the treatment of type 2 diabetes and I doubt that there are many of you that do not take metformin. Metformin works by suppressing glucose production by the liver. Evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain; in some people, it promotes weight loss. Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines.
    One of my first experiences with diabetes was finding that when I worked out my glucose level would actually increase. That was very frustrating sense I was working out to lower levels of glucose. When I told my doctor she put me on a heavier dose of metformin, 1000 mg twice a day. As with most drugs the treatment of one problem often causes another. There is a whole list of side effects associated with metformin: abdominal or stomach discomfort, cough or hoarseness, decreased appetite, diarrhea, fast or shallow breathing, fever or chills, general feeling of discomfort, lower back or side pain, muscle pain or cramping and painful or difficult urination. Other problems metformin may cause which will usually diminish over time is: Acid or sour stomach, belching, bloated, excess air or gas in the stomach or intestines, full feeling, heartburn, indigestion, loss of appetite, metallic taste in the mouth, passing of gas, stomachache, stomach upset or pain and vomiting. I hope this isn’t too much information!
    My latest experience with metformin was excess air or gas in the stomach. I experienced what seem to be a swelling in my throat followed by belching or burping. I cut my dose of metformin in half and the problem went away. Have any of you experienced discomforts with metformin?

  2. govna

    Let me tell you about my awful 3 year journey with metformin! I dealt with all the horrible side affects for a few years Mostly massive pain and intestinal bloating all that goes with it to the point of doctors taking out my gall bladder then on to a colonoscopy and endoscopy and then on to a stress test! All was "just fine" Finally doc said take me off the metformin since a small percentage of people cannot tolerate metformin. Well low and behold I was one of them! After about two weeks most all of the hellish discomfort disappeared! I now take 50 units of toujeo every morning feel great and found a new lease on life energy wise! I am back baby!!!! It is just a shame looking back on how long I suffered needlessly. Not to mention the metformin wasn't even bringing my sugar down anyhow. All it did was make me extremely sick!!!

  3. Scared ****less

    join the club Metformin was a nightmare too the stomach pain was terrible but lucky my dr took me them a week later

  4. -> Continue reading
read more close

Related Articles

Popular Articles

More in diabetes