What Is Your Experience With Stem Cell Transplantation In Type 1 Diabetes Mellitus?
In 2000, Shapiro and colleagues described the successful cure of T1D in a small number of patients using a procedure known as the Edmonton Protocol (Shapiro 2000). In this procedure a large number of islet cells were transplanted in Type 1 diabetic patients combined with the use of glucocorticoid free immunosuppressive drug. The main advantage of islet transplantation includes the achievement of physiologic insulin secretion in those patients who are able to achieve insulin independence. This procedure cannot provide long term treatment and there was complete graft loss 1 year after the final transplantation (Shapiro 2006). In my opinion still extensive research on gene therapy should be required before using in patients and this is only the hope for future therapy. I would like to add for consideration: Stem cells could be useful to regenerate pancreatic islets, BUT the major problem is the autoimmune condition that started the disease in the first place. Until the pathogenic effector cells that destroyed islet beta cells are controlled, it will not matter if islets are replaced. They will simply fail again (due to attacks by the immune system not just as standard tissue rejection, but because ramped up T and B cells are already primed to attack beta cells!). There is data suggesting that controlling the autoimmune inflammation allows some islet regeneration. Stem cells (SC) have the unique function of asymmetric division, i.e., they are capable of self-renewing and the generation of other identical cells. They are undifferentiated cells that perpetuate throughout the body and are responsible for regenerating all tissues in adults and are also responsible for tissue morphogenesis in embryos. Such cells may be obtained from the fetus, the umbilical cord, the bone marro Continue reading >>
Research At Pgimer On Stem Cell Therapy Offers Hope Of Affordable Treatment To Liver Patients
Research at PGIMER on stem cell therapy offers hope of affordable treatment to liver patients Rajeev Khanna | Updated on: 9 February 2018, 19:19 IST Stem cell therapy comes as a new hope for the liver disease patients. Efforts at treating liver cirrhosis and alcoholic hepatitis through this technique at the Chandigarh based Post Graduate Institute of Medical Education and Research (PGIMER), one of the premier public health institutions in India, over the last eight years have yielded path breaking results when it comes to treating liver patients. The outcome of the research carried out here has led to trials being undertaken in the United States of America on the technique adopted at the PGIMER. Professor Virendra Singh of Department of Hepatology at the PGIMER explains, The end treatment for a person with liver cirrhosis has been a liver transplant. In public institutions like ours this is done through the liver donations of brain dead patients. Apart from the donors being difficult to find, the cost of the transplant is very high. In public healthcare facilities like the PGIMER it can range between Rs 10 lakh to Rs 15 lakh while in private sector facilities it is more than Rs 25 lakh. In addition to this the patient has to be put on immuno-suppression drugs, which is a disease in itself. But the stem cell treatment costs peanuts in comparison. It is around Rs 10,000 for multiple courses that we have worked on and Rs 3,000 for a single course. He further said that in case of the stem cell therapy there is no need to put the patients on immuno-suppression drugs since the stem cells have been derived from the patient's body only which is one of the major advantages of this therapy. The patient experiences a temporary side effect of back and bone aches for a few days sin Continue reading >>
Diabetes (type 1)
What is Diabetes Type 1 ? Diabetes is the disease affecting the metabolism of glucose to a great extent. The glucose is required by the cells for energy production and normal functioning. This glucose comes in the blood from the food we eat and carried to the cellular level by an important hormone known as the insulin. Once the meal is consumed by the body, it breaks down into the glucose and other nutrients which are then absorbed in the bloodstream from the gastrointestinal tract. This glucose is then transferred from the blood stream to the cells. The diabetes develops when the body either can’t prepare insulin or can’t respond to the insulin. Diabetes can be mainly differentiated into two broad categories such as Diabetes Type 1 & Diabetes Type 2. Type 1 diabetes also known as insulin dependent diabetes or juvenile diabetes, when the pancreatic ability to produce insulin is reduced. How prevalent is Diabetes Type 1? By the end of 2013, almost 9.3% of the kids are known to be suffering from Juvenile diabetes. In general, diabetes remains the seventh leading cause of death globally. The rates of diagnosed diabetes on the basis of race and ethnic background are 5% Non Hispanic or white adults 0% of Asian Adults 8% of Hispanics 2% of Non Hispanic blacks 9% of American Indians/Alaskan Natives Factors responsible for Juvenile Diabetes Various risk factors for the development of juvenile diabetes such as age, race, sex, geographical location and seasonality have been reviewed and confirmed. Age: – Age is the major risk factor accounting for more than or equal to 85% of all the diabetes cases less than 20 years of age. In general the incidence rate is progressively observed by birth and increase with increasing age. However the increasing incidence of the disease has Continue reading >>
Pgimer, Chandigarh
A public lecture on Diabetes by Dr.Anil Bhansali, Head, Department of Endocrinology, PGIMER will be delivered on 25th March 2006 at 3.00 PM in the APC Auditorium of the campus to address some issues related to the disease. Members of all associations and organizations working for a common cause are requested to inform their colleagues to reap maximum benefit Diabetes is a very common disorder and unfortunately, our country is the diabetic capital of the world. As projected by WHO that India houses around 20 millions diabetic and by 2025 the number will be increased to 57 million. Such a huge number of diabetic population in our country is a challenge to health care providers including doctors and nurses and the society. It is not that our population is more as our population is second largest in the world after China, but China has lesser numb! er of diabetes as compared to us. Diabetes has been said to be a disease influenced by nature and nurture, but many studies show that it is nurture which predominates over nature. The various environmental factors including obesity, sedimentary life style and consumption of junk food and on going stress at work-place or in the family contributes to high incidence of diabetes. Obesity in particular abdominal obesity also called as apple shaped obesity is detrimental for predisposition to diabetes. Otherwise, in the past, abdominal obesity has been considered as a sign of prosperity in our society. But in fact, it is a sign of disease and one should try to achieve a waist line of 90 cm for men and 82 cm for women. Diabetes is usually regarded as a less serious disease in view of its chronicity. However, it should be remembered that it is a sweet killer. It not only affects your eyes, kidney and nerves, but also predisposes for hea Continue reading >>
Bone Marrow Stem Cell Treatment Has No Added Benefit: Study
Bone marrow stem cell treatment has no added benefit: Study Bone marrow stem cell treatment has no added benefit over the conventional treatment in paralysis, also known as stroke, reveals a study conducted by AIIMS. According to the study, people suffering from ischemic stroke should exercise caution while opting for stem cell therapy of any kind until more controlled studies come to the fore. The study financed by the Department of Biotechnology, Ministry of Science and Technology, was conducted over a period of six years between 2008 and 2014 and had sample size of 120 patients, all of whom had suffered from stroke. Of the 120 patients, 60 patients were assigned to receive conventional treatment and the rest were assigned to bone marrow stem cells treatment besides the conventional treatment. While half of the patients underwent conventional treatment, the other half underwent stem cell aspiration from hip bone. Bone marrow cells were infused into the veins of their forearms, the study stated. On an average 28 crore bone marrow cells were injected of which blood forming stem cells were on average 29 lakhs per patient. Later, the patients faced difficulties in using arms and legs. They were assessed at an interval of 3, 6 months and 12 months and the difficulties they experienced doing various activities of daily livings were measured using two scales which revealed that stem cell treatment is safe but there is no added benefits over the conventional treatment method. The study proved that stem cell treatment though safe, has no advantages over the conventional treatment process. Infact, any patient suffering from disabling and incurable diseases, should not go for stem cell treatment without knowing the scientific effects of it. The new paradigm of clinical practice Continue reading >>
Effect Of Mesenchymal Stem Cells Transplantation On Glycaemic Profile & Their Localization In Streptozotocin Induced Diabetic Wistar Rats
Effect of mesenchymal stem cells transplantation on glycaemic profile & their localization in streptozotocin induced diabetic Wistar rats We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Effect of mesenchymal stem cells transplantation on glycaemic profile & their localization in streptozotocin induced diabetic Wistar rats Shobhit Bhansali, Vinod Kumar, [...], and Pinaki Dutta Bone marrow is a rich source of adult stem cells that can differentiate into various cell types. Administration of mesenchymal stem cells (MSCs) in irradiated diabetic rat model has transiently shown to decrease blood glucose level. This study examines the effect of high dose and multiple injections of MSCs on glycemic profile, their localization and regeneration of islet in diabetic Wistar rat. The study was carried out in male Wistar rats categorized into three groups (n=6, in each group): Group 1 as control, group 2 streptozotocin (STZ) (50 mg/kg) induced diabetic group and group 3 experimental group; 5-bromo-2-deoxyuridine (BrdU) labelled allogenic MSCs were injected in the non-irradiated diabetic rat of the experimental group through tail vein. The blood glucose profile was subsequently monitored at regular intervals. Rats were sacrificed on day 45 and pancreas was examined for localization of BrdU labelled stem cells by immunofluorescence and islet-neogenesis by immunohistochemistry. There was a significant reduction in blood glucose level after admin Continue reading >>
Success Of Stem Cell Therapy For Diabetes Depends On Pre-transplant Immune Condition
Success of stem cell therapy for diabetes depends on pre-transplant immune condition An innovative method for treating type 1 diabetes based on the transplantation of hematopoietic stem cells taken from the patient's own bone marrow began undergoing testing in Brazil 13 years ago. The results were highly variable. While some of the volunteers were able to stop self-injecting insulin for more than a decade, others had to resume use of the medication only a few months after receiving the experimental treatment. A possible explanation for this discrepancy in the clinical outcome for the 25 patients included in the study was presented in an article published recently in the journal Frontiers in Immunology. According to the authors, the duration of the therapeutic effect was shorter in the patients whose immune systems had attacked the pancreatic cells more aggressively in the pre-transplantation period. This research was conducted at the Center for Cell-Based Therapy (CTC) in Brazil. Initially led by immunologist Julio Voltarelli, who died in March 2012, it is proceeding under the coordination of researchers Maria Carolina de Oliveira Rodrigues and Belinda Pinto Simes. "Because type 1 diabetes is an autoimmune disease, the aim of the treatment is to 'switch off' the immune system temporarily using chemotherapy drugs and 'restart' it by means of the transplantation of autologous hematopoietic stem cells , which can differentiate into every kind of blood cell," Rodrigues explained. By the time the symptoms of type 1 diabetes appear, she added, around 80 percent of the patient's pancreatic islets have already been damaged. If the autoimmune aggression is interrupted at this point, and the remaining cells are protected, the patient can produce an amount of insulin that is smal Continue reading >>
Type 1 Diabetes Among Children Has Rate Of 5-6%: Pgi Experts
Chandigarh Posted at: Nov 14, 2017, 2:19 AM; last updated: Nov 14, 2017, 2:19 AM (IST) Type 1 diabetes among children has rate of 5-6%: PGI experts Dr Rakesh Kumar (left), additional professor, department of paediatrics, PGI, speaks during a press conference in Chandigarh on Monday. Tribune Photo: Manoj Mahajan The paediatrics department of the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, said that Type 1 diabetes among children has a rate of five to six per cent. Holding a press conference, Dr Rakesh Kumar, additional professor, PGIMER, said that among 100 children, five to six children would be suffering from Type 1 diabetes while Type 2 has a much lower rate, at around one in 100. There is no concrete reason behind Type 1 diabetes, said Dr Kumar. At the PGIMER too, we have conducted studies on lack of Vitamin D and lack of breast feeding as reasons but there has been no connection. It is observed in children in the age-group of five to six years and then in 10-12. There has been a rise of two to three per cent in Type 1 diabetes among children in the world. At the PGIMER, 10 years ago, we had diagnosed 20 patients. At present, we have diagnosed 150-200 patients, he said, adding that life expectancy of such patients decrease by 10 years from normal people. Regarding treatment, Dr Kumar said: It comes as a major shock to parents and they are usually distraught to learn that their child will require life-long insulin injections three to four times a day and the same number of finger pricks per day for checking sugar with a glucose meter. The parents and guardians go through a phase of shock, refusal, anger, anxiety and guilt, he said. Type 1 diabetes is a unique disease in the sense that it is treated and managed by parents or patien Continue reading >>
Stem Cell Treatment Now In Chandigarh
Home / Cities / Stem Cell treatment now in Chandigarh Statesman News Service | Chandigarh | January 19, 2017 11:43 am Representational image (Photo: Getty Images) Patients in Chandigarh will now be able to avail a specialised stem cell treatment which was not there in the entire region. The unique aspect of the stem cell therapy being made available is that it will substitute long and multiple sittings with its single one which too will be painless. Only local anaesthesia would be given to the patient and the entire procedure will be over in four to five hours. This is a very safe treatment as the cells from the patients body are used to treat the same patients disease. Therefore the chances of body not accepting the treatment are rare, Dr Rama Sood, a team member of the Stem Cell Centre that is coming up in New Chandigarh said, told The Statesman. She said the approximate cost for the treatment will be somewhere around Rs.2 lakhs to Rs.2.5 lakhs. Modern medicine and the latest advancements in technology have allowed the physicians to use the patients own bodys stem cells to replenish, repair, and regenerate diseased cells. The primary benefit of stem cell therapy lies in the use of undifferentiated cells that have the ability to differentiate into new tissues, joint cartilage, neurons, and much more, Dr Sood added. Stem Cell therapy has seen a big boom in the last 10 years. This is an option when main stream medicines are not available. Dr Rama spoke about painful knee replacements which makes the patient go through various tests and painful knee operation. In comparison the stem cell treatment takes only a day and is painless. The Stem Cell treatment is effective mainly in curing multiple sclerosis, type 1 Diabetes, Rheumatoid Arthritis, Parkinsons Disease, Osteoarth Continue reading >>
Is Pgimer Chandigarh Best For Cancer Treatment?
Answered Apr 18, 2017 Author has 95 answers and 65.9k answer views PGIMER, Chandigarh is one of the best medical institute in India. It is an institute of nation Interest. This institute doesn't specifically focus on cancer treatment,but it offers wide range of departmental care and treatment. There are some other institutes which primarily focus on cancer treatment like Successful Treatment of cancer depends on various factors. The most important factor is the stage of the disease. PGIMER Chandigarh is one of the best hospitals in the country. However as it is a Government Hospital it is choked with patients from all over the country especially Northern India( I have seen patients from as far as Bihar and West Bengal). This overburdens the staff of the hospital. Treatment of cancer in PGI will be successful if the stage has not become beyond control. The patient and family also have to negotiate with heavy rush of patients in the hospital which means long ques for registration, appointment and other operations related with treatment of the disease such as chemotherapy, radiotherapy, surgery etc. My suggestion will be to go to Rajeev Gandhi Cancer Institute Delhi There are alternative treatments available as well like Ayurveda at Ludhiana, Punjab Dr Yeshi Dhonden at Dharamshala, HP giving Tibetan medicines and he is Awarded Padam Shree Award by Govt of India I decided to get surgery done for my breast cancer and then started medicine from Dr Yeshi Dhonden . I met him on 14/2 and after feeling my pulse and seeing my urine sample , he said I was cancer free as of now but to prevent recurrence he gave me medicine to be taken for 2 years . I will be posting the experience in 4 weeks times as well as when I get my next set of tests . Continue reading >>
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Stem Cell Treatment Diabetes Pgi Chandigarh
CHANDIGARH: Now more shots of stem cells have been found to cure type 2 diabetes. Improvising upon its study Before the stem cell therapy is introduced in the PGI as a regenerative medicine, more work and multicentric trials are required. Manning Had Stem Cell Therapy In Europe Stem Cell Therapy Guidelines Icmr OFEV (nintedanib) Added To Updated International Treatment Guidelines for Idiopathic Pulmonary Fibrosis (IPF) Revised May 5, 2015 For this reason it is important for you to be aware of the treatment of You can read here about gene therapy and stem cell therapy for DCM. Bone marrow stem cell treatment which is the first and largest report on stem cells treatment for stroke has been published in the American Journal Stroke. Apart from AIIMS, SGPGI Lucknow, PGIMER Chandigarh, Armed Forces Medical College After using stem cell therapy in treatment of patients of diabetic foot, the Endocrinology Department of PGI is now planning to start islet cell transplant for treatment of those type I diabetes patients in whom insulin injections cannot control the sugar Autologous bone marrow-derived stem cells in Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no effective treatment. Stem cell therapy may be one of the promising treatment Stem Cell Therapy Guidelines Icmr OFEV (nintedanib) Added To Updated International Treatment Guidelines for Idiopathic Pulmonary Fibrosis (IPF) Revised international treatment guidelines for Idiopathic Stem Cell Therapy At Duke University Stem cell therapy is an optional type of alternative treatment for COPD. But, does it really work? Find out more Continue reading >>
Hope For Diabetes Patients, Regions 1st Pancreas Transplant Done At Pgi
Providing a ray of hope for patients suffering from end-stage diabetes, the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, performed the regions first pancreas transplant on Wednesday. The operations success will only be confirmed once the patient Anju, who is in her 30s and hails from Himachal Pradesh, is discharged from the hospital in about two weeks. The pancreas is an organ, located behind the lower part of the stomach. It produces insulin, one of the main blood hormones that help regulate blood glucose levels. Shortage of insulin, due to any reason, leads to diabetes with fatigue, frequent urination, weight problems and numbness in hands and feet. A living as well as a brain-dead individual could be used to source the organ. The surgery, the first-of-its-kind in north of Delhi, was conducted by a team of surgeons from the department of renal transplant. The team was led by Dr Mukut Minz and Dr Ashish Sharma. The number of such surgeries is low. At the PGI, it costs around Rs 2 lakh, while at other hospitals it costs more than 10 times this amount. PGI officials said the organ was donated by Ashok Kumar (45), a native of Barnala, Punjab. He was admitted to the PGI on Monday in a critical condition in the emergency neurosurgery ward. In spite of the best efforts of a team of experts, the patient could not be saved and was declared brain dead, doctors said. The patients younger sister and the family members gave their consent to donate the organs. The family volunteered to donate liver, pancreas, kidneys and corneas of the deceased. Five patients were saved because of the familys generous act, said a hospital spokesperson. A doctor associated with the surgery said they were hopeful of success. A pancreas transplant can be termed succ Continue reading >>
Pgi Plans To Start Islet Cell Transplant For Treatment Of Type I Diabetes Patients
PGI plans to start islet cell transplant for treatment of type I diabetes patients In type I diabetic patients, the beta cells of the pancreas do not make insulin and a person has to take insulin injections daily to survive. Written by TANBIR DHALIWAL | Chandigrah | Published: November 17, 2014 12:13:58 pm Islets from the pancreas of a deceased organ donor are purified, processed, and then transferred to a diabetic patients liver. Jharkhand: Humiliated by panchayat's fine, rape accused sets minor victim on fire; 15 arrested After using stem cell therapy in treatment of patients of diabetic foot, the Endocrinology Department of PGI is now planning to start islet cell transplant for treatment of those type I diabetes patients in whom insulin injections cannot control the sugar level in blood. Islet cells are tiny clusters of pancreatic cells, including beta cells that produce the hormone insulin which helps in the absorption of glucose from the bloodstream. In type I diabetic patients, the beta cells of the pancreas do not make insulin and a person has to take insulin injections daily to survive. Three or four insulin injections a day are quite normal for diabetic patients. However, in some cases, the glucose level becomes difficult to control and there are wide swings, risking the life of a patient. The goal of pancreatic islet transplantation is to help such diabetic patients achieve normal blood glucose levels without daily injections of insulin. It will be helpful for patients with hypoglycemia (sudden decrease in the blood sugar), which is a dangerous situation, says Dr Rama Walia, endocrinologist from PGI. Islets from the pancreas of a deceased organ donor are purified, processed, and then transferred to a diabetic patients liver. After the transplant, the islets s Continue reading >>
With 5 Procedures, Pgi Shows The Way In Pancreas Transplant
Chandigarh Community Posted at: May 31, 2016, 1:47 AM; last updated: May 31, 2016, 1:47 AM (IST) With 5 procedures, PGI shows the way in pancreas transplant No other medical institution in the country offering facility The PGI, Chandigarh, has become the leading medical institute forpancreas transplant in the country with fivesuccessful procedures so far. The pancreas transplant was started at the PGI in December 2014. None of the other medical institutes in India, including AIIMS, is conducting the pancreas transplant at present. AIIMS had performed a couple of pancreas transplants in 2004. The most recent pancreas transplant at the PGI has been conducted on a 32-year-old diabetes patient from Ludhiana, who had suffered kidney failure. She received the pancreas from a cadaver donor who recently lost his life in a road accident in the city. The woman underwent simultaneous pancreas-kidney transplantation at the PGI that was performed by the department of renal transplant surgery in the lastweek of April. Prof Mukut Minz, head of the department, along with Prof Ashish Sharma, additional professor of the department, anda team of threesurgeons performed the transplant. The patient was a diabetic since the age of 10 and had to take five insulin shots per day. Three years ago, she suffered a kidney failure and was put on dialysis, informed Prof Sharma. He added that the patient has recovered fully and would be discharged from the PGI tomorrow. Prof Sharma also disclosed that currently, the PGI was offering pancreas transplant only to patients who had pancreas-kidney failure and 15 patients werealready listed. But over the coming two years, we endeavour to expand the criteria to diabetes patients who do not require kidney transplant, he informed. Significantly, the number of Continue reading >>
Pgi Comes Up With Cure For Diabetes Type 2
PGI comes up with cure for diabetes type 2 PGI comes up with cure for diabetes type 2 In a path-breaking research, PGI doctors have reportedly found a very effective solution for diabetes type 2 through stem cell transplantation technique. CHANDIGARH: In a path-breaking research, PGI doctors have reportedly found a very effective solution for diabetes type 2 through stem cell transplantation technique. With positive results expected, Defence Research and Development Organization (DRDO) has given its nod to fund the study further. Started by PGIs departments of endocrinology, transfusion medicine and radio diagnosis in December 2006, the paper was published in an international journal, Stem Cells Development, in September 2009. Dr Anil Bhansali, head of endocrinology department, hailed the research as the first in the world, with only Brazil doing a similar study on diabetes in children. The technique involves autologous bone marrow transplantation in which stem cells taken from a patients hipbone can be injected peripherally or targeted at the pancreatic artery with the hope that it will lead to improvement in regeneration of pancreas and decrease insulin requirements, said Bhansali. For the study, 10 diabetic patients, with an average age of 55, were given the therapy, with follow-ups for six months. It was found that insulin intake in seven had decreased manifold, while three stopped its use completely. These patients had been suffering from type 2 diabetes and taking treatment for at least five years. However, three did not respond to the process at all. Besides, all seven patients reportedly lost weight and their quality of life improved. Enthusiastic after the first trial, now doctors plan to carry forward the research on 50 patients with funding from DRDO. Type 2 Continue reading >>
