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Novolog 70/30 Dosing

Novolog Mix 70/30 Suspension For Injection 30-70u Drug Medication Dosage Information

Novolog Mix 70/30 Suspension For Injection 30-70u Drug Medication Dosage Information

*This is an approximate aggregated range of reported side effects from clinical studies performed on this drug. Your experience with this drug may be different. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Class B - Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate and well-controlled studies in pregnant women. OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester. Continue reading >>

Novolog Insulin 70 30 - Medhelp

Novolog Insulin 70 30 - Medhelp

Common Questions and Answers about Novolog insulin 70 30 Unopened insulin may also be stored at room temperature below 86 degrees F ( 30 degrees C), but in that case it must be discarded after 28 days. Once opened, this medication may be stored in the refrigerator or at room temperature below 86 degrees F (30 degrees C). Discard 28 days after opening. Do not freeze. Discard the insulin if it has been frozen. You may need to be changed to an insulin with a different ratio of long acting to short acting insulin (perhaps 70 / 30 will be better for you)3)you are actually dropping low in the middle of the night and your body is bringing you up on its own to keep you safe--this is one you MUST investigate becase if you keep going low, your body gets used to it and eventually stops "alarming " quite as well.Thereis actually no known highest dose allowed of insulin. I switched from lantus to novolog and the doses are different, I then switched to the 70/30 novolin (relion brand from wal mart) as it was much cheaper and the dose once again changed, although I am type 2 and monitor my levels closely, all insulin brands work differently so be careful and consult Dr.I did finally settle on the 70 / 30 mix, you can get the pens but it is much cheaper to just inject yourself, I get the needles that are the same size as the pens..... My father was recently discharged from a nursing home and he takes 2 different kinds of insulin . Novolog 70 / 30 and Novolog Aspart (Sliding Scale). I've heard about sliding scale before but when i brought it up to his pharmacist she did not know much about it (got me concerned). I found this one sliding scale online, listings of how much units to give depending on what his blood sugar level is. THIS HAPPENED WHEN I FIRST STARTED USING NOVOLOG MIX 70 / Continue reading >>

Novolog 70/30 3 Times A Day

Novolog 70/30 3 Times A Day

So I have been on Novolog 70/30 for a few months now. It is working great now that I have made a few adjustments. I started on 5 units in the morning and 4 units at night. I always seemed to be higher than I would like between lunch and dinner. This led me to needing more at night which I was uncomfortable with. I have since adjusted to 4 units in the morning, 4 units at lunch and 3 units at dinner. This has my numbers rock solid. I am never out of the "non-diabetic" range anymore. I still don't eat much carbs and this dosing works for me. The problem is that when I picked up my last set of pens, the pharmacist said they were confused on what the doctor had prescribed as they didn't understand what she had written. I told them what she had prescribed but that I had fine tuned it to what I am at now. The pharmacist was alarmed that I was taking the 70/30 3 times a day. She said the 70/30 should only be taken twice a day and I run a risk of having a hypo using it 3 times a day. I shook my head and said I would talk to my new doctor about it. I understand the pharmacist has a certain training but I would like to hear from the folks here who understand using insulin. I know most will say I need a separate basal/bolus but I am quite happy with the results I am getting now. My BG numbers are quite predictable and I have not had a hypo yet. Closest I have come was a 74. That was because I didn't eat per my schedule. Is there a major risk in using the 70/30 3 times a day? I am not using large amounts. My FBG is always in the 90's. My pre and post are always in the 80's to 90's. I don't see what the problem is. I feel better than ever not having to figure out how to keep my numbers down. Disclaimer: I'm a know-nothing about insulin. But ... one thing I have learned in this jour Continue reading >>

Study On Dual-acting Insulin Analog Novolog® Mix 70/30 Suggests Alternate Approach To Treating Type 2 Diabetes

Study On Dual-acting Insulin Analog Novolog® Mix 70/30 Suggests Alternate Approach To Treating Type 2 Diabetes

NovoLog® Mix 70/30 (70 percent insulin aspart protamine suspension and 30 percent insulin aspart injection, [rDNA origin]), NPH (Neutral Protamine Hagedorn) insulin or biphasic human insulin. The new study, appearing in the current issue of the Journal of Diabetes and its Complications, shows that in people with type 2 diabetes taking the oral antidiabetic drug (OAD) metformin, once-daily dosing of NovoLog® Mix 70/30 controls blood glucose levels as effectively as once-daily dosing of NPH insulin or biphasic human insulin. Typically, NovoLog® Mix 70/30 is administered twice a day, usually just before breakfast and dinner, but participants in the study showed adequate control with just one dinner-time injection per day in combination with metformin. The participants also showed adequate control with a once-daily dinnertime injection of biphasic human insulin or a bedtime (10 p.m.) injection of NPH insulin. "Eventually, many people with type 2 diabetes have to go on insulin to improve blood glucose control — the question is, which insulin should they start with?" said Charles Kilo, M.D., lead author of the study and Professor of Clinical Medicine at Washington University in St. Louis, Missouri. "NovoLog® Mix 70/30 is administered immediately before a meal, and mealtime dosing is convenient for many patients," he said. Study and findings The open-label study included 140 people with type 2 diabetes currently taking metformin with or without an insulin secretagogue. Metformin is an OAD that increases the body's responsiveness to insulin and decreases production of glucose in the liver; insulin secretagogues, such as sulphonylureas and repaglinide, are OADs that increase insulin release from the pancreas. None of the participants had previously been on insulin therapy, Continue reading >>

1-2-3 Study Demonstrates Efficacy Of Novolog Mix 70/30 In Reaching American Diabetes Association A1c Targets With Once-daily Dosing And The Additional Benefit Of Intensifying Therapy

1-2-3 Study Demonstrates Efficacy Of Novolog Mix 70/30 In Reaching American Diabetes Association A1c Targets With Once-daily Dosing And The Additional Benefit Of Intensifying Therapy

1-2-3 Study demonstrates efficacy of NovoLog Mix 70/30 in reaching American Diabetes Association A1C targets with once-daily dosing and the additional benefit of intensifying therapy Study shows 41 percent of participants with type 2 diabetes reached ADA glucose targets with once-daily dosing of NovoLog Mix 70/30 San Diego, CA (June 13, 2005) NovoLog Mix 70/30 (70% insulin aspart protamine suspension and 30 percent insulin aspart injection, [rDNA origin]) enables 77 percent of type 2 diabetes patients to achieve glycemic targets when titrated as the disease progresses, according to the 1-2-3 Study. The findings show that NovoLog Mix 70/30 can be used effectively once and up to three times daily among patients who were unsuccessfully treated with oral antidiabetic agents (OADs) with or without basal insulin therapy. Data from the 1-2-3 Study (278-OR),1 presented yesterday at the 65th annual Scientific Sessions of the American Diabetes Association (ADA), show that 41 percent of the patients enrolled in the trial achieved an A1C target of < 7 percent and 21 percent achieved an A1C level 6.5 percent when receiving just a single daily dose of NovoLog Mix 70/30. "These results are particularly encouraging for patients who are inadequately treated with OADs," said Dr. Garber. "Now physicians can feel comfortable in prescribing a once-daily dose of NovoLog Mix 70/30 to control diabetes. For those patients not controlled with a single dose, our study clearly demonstrates how a physician can then easily transition patients to two doses and occasionally, as necessary, three doses a day of the same insulin to achieve target A1C goals." In a 48-week, multi-center, open-label trial, patients with type 2 diabetes who were not achieving targets on OADs (with or without once-daily basa Continue reading >>

Selected Important Safety Information

Selected Important Safety Information

NovoLog® Mix 70/30 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® Mix 70/30 or one of its excipients. Never Share a NovoLog® Mix 70/30 FlexPen® Between Patients, even if the needle is changed. Patients using NovoLog® Mix 70/30 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. Changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart injectable suspension) 100 U/mL Indications and Usage NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart injectable suspension) 100 U/mL is a mixture of insulin aspart protamine and insulin aspart indicated to improve glycemic control in patients with diabetes mellitus. NovoLog® Mix 70/30 is not recommended for the treatment of diabetic ketoacidosis. The proportions of rapid-acting and long-acting insulins are fixed and do not allow for basal versus prandial dose adjustments. NovoLog® Mix 70/30 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to NovoLog® Mix 70/30 or one of its excipients. Never Share a NovoLog® Mix 70/30 FlexPen® Between Patients, even if the needle is changed. Patients using NovoLog® Mix 70/30 vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or Continue reading >>

What Is Novolog (insulin Aspart)?

What Is Novolog (insulin Aspart)?

Before you receive DARZALEX®, tell your healthcare provider about all of your medical conditions, including if you: have a history of breathing problems have had shingles (herpes zoster) are pregnant or plan to become pregnant. DARZALEX® may harm your unborn baby. Females who are able to become pregnant should use an effective method of birth control during treatment and for at least 3 months after your final dose of DARZALEX®. Talk to your healthcare provider about birth control methods that you can use during this time. are breastfeeding or plan to breastfeed. It is not known if DARZALEX® passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DARZALEX® may be given alone or together with other medicines used to treat multiple myeloma. Your healthcare provider will decide the time between doses as well as how many treatments you will receive. Your healthcare provider will give you medicines before each dose of DARZALEX® and on the first day after each dose of DARZALEX® to help reduce the risk of infusion reactions. If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment. Infusion reactions. Infusion reactions are common with DARZALEX® and can be severe. Your healthcare provider may temporarily stop your infusion or completely stop treatment with DARZALEX® if you have infusion reactions. Tell your healthcare provider right away if you get any of the following symptoms: shortness of breath or trouble breathing dizziness or lightheadedness (hypotension) cough wheezing throat tightness runny or stuffy nose headache itching nausea vomiting chills fever Changes in blood tests. DARZALEX Continue reading >>

Combination Insulins

Combination Insulins

Rapid-Acting Analogues Short-Acting Insulins Intermediate-Acting Insulins Long-Acting Insulins Combination Insulins Novolin® 70/30 - Humulin® 70/30 Novolog® Mix 70/30 Humalog® Mix 75/25 SOLIQUA™ 100/33 (insulin glargine and lixisenatide injection) XULTOPHY® 100/3.6 (insulin degludec and liraglutide injection) --® Onset: 30-60 min Peak: 2-12 hours Duration: 18 - 24 hours Solution: Cloudy Comments: Mixture of 70% NPH, Human Insulin Isophane Suspension and 30% Regular, Human Insulin Injection. Recommended interval between dosing and meal initiation: 30 minutes. Mixing You should not attempt to change the ratio of this product by adding additional NPH or Regular insulin to the vial. If the physician has prescribed insulin mixed in a proportion other than 70% NPH and 30% Regular, you should use the separate insulin formulations (e.g. NPH and Regular insulin ) in the amounts recommended by the physician. All Unopened Novolin 70/30: • Keep all unopened Novolin 70/30 in the refrigerator between 36° to 46°F (2° to 8°C). • Do not freeze. Do not use Novolin 70/30 if it has been frozen. • If refrigeration is not possible, the unopened vial may be kept at room temperature for up to 6 weeks (42 days), as long as it is kept at or below 77°F (25°C). • Keep unopened Novolin 70/30 in the carton to protect from light. Novolin 70/30 in use: Vials • Keep at room temperature below 77°F (25°C) for up to 6 weeks (42 days). • Keep vials away from direct heat or light. • Throw away an opened vial after 6 weeks (42 days) of use, even if there is insulin left in the vial. • Unopened vials can be used until the expiration date on the Novolin 70/30 label, if the medicine has been stored in a refrigerator. Note: double mouse click to return to the top of the page Onset Continue reading >>

Novolog Mix 70/30, Novolog Mix 70/30 Flexpen, Novolog Mix 70/30 Penfill (insulin Aspart And Insulin Aspart Protamine) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

Novolog Mix 70/30, Novolog Mix 70/30 Flexpen, Novolog Mix 70/30 Penfill (insulin Aspart And Insulin Aspart Protamine) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

What happens if I miss a dose (NovoLog Mix 70/30, NovoLog Mix 70/30 FlexPen, Novolog Mix 70/30 PenFill)? Since insulin aspart and insulin aspart protamine is used before meals, you may not be on a timed dosing schedule. Whenever you use this medication, be sure to eat a meal within 15 minutes. Do not use extra insulin aspart and insulin aspart protamine to make up a missed dose. What happens if I overdose (NovoLog Mix 70/30, NovoLog Mix 70/30 FlexPen, Novolog Mix 70/30 PenFill)? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions). What should I avoid while using insulin aspart and insulin aspart protamine (NovoLog Mix 70/30, NovoLog Mix 70/30 FlexPen, Novolog Mix 70/30 PenFill)? Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment. What other drugs will affect insulin aspart and insulin aspart protamine (NovoLog Mix 70/30, NovoLog Mix 70/30 FlexPen, Novolog Mix 70/30 PenFill)? Tell your doctor about all other medications you use, especially: sulfa drugs (Bactrim, Septra, and others). This list is not complete and there are many other medicines that can increase or decrease the effects of insulin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Your pharmacist can provide more information about insulin aspart and insulin aspart protamine. Remember, keep this and all other medicines out of the reach of children, never share your medic Continue reading >>

Novolog Mix 70/30 (insulin Aspart,insulin Aspart Protamine) Dosage, Indication, Interactions, Side Effects | Empr

Novolog Mix 70/30 (insulin Aspart,insulin Aspart Protamine) Dosage, Indication, Interactions, Side Effects | Empr

Do not reuse or share pens between patients; or needles and syringes when using vials. Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Increased risk of hypo- or hyperglycemia if changes in physical activity, meal patterns, renal or hepatic function, insulin regimen and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Hyperglycemia and ketoacidosis due to insulin pump device malfunction: see full labeling. Renal or hepatic impairment. Pregnancy (Cat.B). Nursing mothers. Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by atypical antipsychotics, corticosteroids, isoniazid, niacin, danazol, diuretics, glucagon, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, protease inhibitors. Variable effects with -blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant -blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia. Do not mix with other insulins. Hypoglycemia, hypokalemia, local inj site reactions, lipodystrophy, rash, pruritus, edema, sodium retention, weight gain; hypersensitivity and allergic reactions. Continue reading >>

Starting With Novolog® Mix 70/30

Starting With Novolog® Mix 70/30

Do not share your NovoLog® Mix 70/30 FlexPen® with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them. Who should not take NovoLog® Mix 70/30? Do not take NovoLog® Mix 70/30 if: your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients. Before taking NovoLog® Mix 70/30, tell your healthcare provider about all your medical conditions including, if you are: pregnant, planning to become pregnant, or are breastfeeding. taking new prescription or over-the-counter medicines, including supplements. Talk to your health care provider about how to manage low blood sugar. How should I take NovoLog® Mix 70/30? Read the Instructions for Use and take exactly as directed. NovoLog® Mix 70/30 starts acting fast. If you have type 1 diabetes, inject within 15 minutes before you eat a meal. If you have type 2 diabetes, inject within 15 minutes before or after starting your meal. Do not mix NovoLog® Mix 70/30 with other insulin products or use in an insulin pump. Know the type and strength of your insulin. Do not change your insulin type unless your health care provider tells you to. Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them. Do not reuse or share your needles or syringes with other people. You may give other people a serious infection, or get a serious infection from them. What should I avoid while taking NovoLog® Mix 70/30? Do not drive or operate heavy machinery, until you know how NovoLog® Mix 70/30 affects you. Do not drink alcohol or use medicines that contain alcohol. What are the possible side effects of NovoLog® Mix 70/30? Serious side effects can lead to death, includin Continue reading >>

Buy Novomix 30 Penfill Cartridges Online From Canada - Low Prices

Buy Novomix 30 Penfill Cartridges Online From Canada - Low Prices

Before use inspect your cartridge, its should be uniformly cloudy and white. If it is clear or contains solid particles, do not use it. NovoMix 30 must be re-suspended immediately before use. Re-suspension is easier when the insulin has reached room temperature. This drug is for subcutaneous (under the skin) injection into the buttocks, abdominal region, upper arm or thigh. You should remember to rotate your injection sites from one injection to the next to reduce the chance of getting lipodystrophy. Do not administer it intravenously or use it in insulin infusion pumps. NovoLog Mix 70/30 helps you control your mealtime blood sugar levels and also helps you control your blood sugar levels between meals too. It is usually taken twice-daily, with each dose intended to cover two meals or a meal plus a snack. You should administer your dose within 15 minutes before your meal starts. For treatment of type 2 diabetes the dose may be given after the start your meal. Individual dosing schedules will vary among patients and should be determined by your doctor who is familiar with your eating habits, metabolic needs and other lifestyle variables. With all insulin therapies the action of the insulin can change according to the injection site, dose, temperature, blood flow and your level of physical activity. Your individualized dosage schedule is based on your metabolic needs, blood glucose monitoring results, blood sugar level control goals. Dosage adjustments may be needed if you are switching from another type of insulin, or with any changes in physical activity, meal pattern, kidney or liver function or during sickness. Never share your insulin pen with anyone, even if you have changed the needle. Sharing poses a risk for transmission of infections to others and from them to Continue reading >>

What Is Novolog 70/30?

What Is Novolog 70/30?

QUICK LINKS Insulin aspart protamine and insulin aspart is a combination of a fast-acting insulin and an intermediate-acting type of human insulin. Insulin is used by people with diabetes to help keep blood sugar levels under control. When you have diabetes mellitus, your body cannot make enough or does not use insulin properly. So, you must take additional insulin to regulate your blood sugar and keep your body healthy. This is very important as too much sugar in your blood can be harmful to your health. This medicine is available only with your doctor's prescription. Find big savings at pharmacies near you with GoodRx discount coupons Lowest GoodRx Price $526.00 View All Prices A nurse or other trained health professional may give you this medicine. You may also be taught how to give your medicine at home. This medicine is given as a shot under your skin. Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time. Each package of insulin aspart protamine and insulin aspart combination contains a patient information sheet. Read this sheet carefully before beginning your treatment and each time you refill the medicine for any new information, and make sure you understand: How to prepare the medicine. How to inject the medicine. How to use disposable insulin delivery device. How to dispose of syringes, needles, and injection devices. It is best to use a different place on the body for each injection (eg, under the skin of your abdomen or stomach, thigh, buttocks, or upper arm). If you have qu Continue reading >>

Mix 70/30 Flexpen

Mix 70/30 Flexpen

Please scroll down for Important Safety Information and Prescribing Information. NovoLog® Mix 70/30 is a premixed insulin that works in 2 different ways to lower your A1C. It controls blood sugar in between meals for up to 24 hours and treats blood sugar spikes when you eat. NovoLog® Mix 70/30 is available in 10 mL vials, and in FlexPen®, a discreet, prefilled, dial-a-dose insulin pen. For more information, visit www.novologmix70-30.com. Indications and Usage What is NovoLog® Mix 70/30 (insulin aspart protamine and insulin aspart injectable suspension) 100 U/mL? NovoLog® Mix 70/30 is a man-made insulin used to control high blood sugar in adults with diabetes mellitus. It is not known if NovoLog® Mix 70/30 is safe or effective in children. Important Safety Information Do not share your NovoLog®® with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them. Who should not take NovoLog® Mix 70/30? Do not take NovoLog® Mix 70/30 if: your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients. Before taking NovoLog® Mix 70/30, tell your healthcare provider about all your medical conditions including, if you are: pregnant, planning to become pregnant, or are breastfeeding. taking new prescription or over-the-counter medicines, including supplements. Talk to your health care provider about how to manage low blood sugar. How should I take NovoLog® Mix 70/30? Read the Instructions for Use and take exactly as directed. NovoLog® Mix 70/30 starts acting fast. If you have type 1 diabetes, inject within 15 minutes before you eat a meal. If you have type 2 diabetes, inject within 15 minutes before or after starting your meal. Do not mix NovoLog® Mix 70/30 with othe Continue reading >>

Novolog Mix 70/30 (insulin Aspart Protamine (rdna Origin)/insulin Aspart (rdna Origin)) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Novolog Mix 70/30 (insulin Aspart Protamine (rdna Origin)/insulin Aspart (rdna Origin)) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

NovoLog Mix 70/30 Subcutaneous Inj Susp: 1mL, 30-70U For the treatment of type 1 diabetes mellitus or for type 2 diabetes mellitus inadequately managed by diet, exercise, and oral hypoglycemics. Subcutaneous dosage (insulin aspart 30%; insulin aspart protamine 70% mix) Insulin aspart 30%; insulin aspart protamine 70% is considered equipotent to other insulin mixtures. A common regimen is to give 2 injections per day. Initially, about two-thirds of the daily insulin dose is given before breakfast and about one-third is given before the evening meal. The dosage can be adjusted as necessary based on the patient's blood glucose concentrations. For patients with Type 1 DM, administer the injection within 15 minutes of starting a meal. For patients with Type 2 DM, administer the injection 15 minutes before or after starting a meal. Specific maximum dosage information is not available. Individualize dosage based on careful monitoring of blood glucose and other clinical parameters in all patient populations. Dosage should be modified depending on clinical response and degree of hepatic impairment, but no quantitative recommendations are available. Some studies have noted increased circulating levels of insulin in patients with hepatic failure. Individualize dosage based on blood glucose and other clinical parameters. The pharmacokinetics of insulin are generally unchanged with renal impairment, however, pharmacodynamic differences occur in insulin sensitivity as renal function declines, resulting in increased responses to a given dosage. Individualize dosage based on blood glucose and other clinical parameters. Insulin aspart; insulin aspart protamine mixture is administered by subcutaneous injection only. Do not administer by intravenous or intramuscular injection. Visually i Continue reading >>

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