Needle-free Injection Of Insulin Powder: Delivery Efficiency And Skin Irritation Assessment*
AAC are expressed as meanSD (n=6). AAC: area above the blood glucose curve; RDE: relative delivery efficiency; ADE: absolute delivery efficiency In this study, we made a significant advance in PNI of insulin, achieving a relative delivery efficiency of 72.25% via a newly designed PNI device and insulin powder. Previously, the commercial application of PNI has been restricted by trying to balance high bioavailability with the limitations imposed by skin lesions. The de Laval nozzle is the most important part for producing supersonic gas flow. The new PNI device uses a de Laval nozzle with an enlarged throat, where the cross-sectional area through the nozzle is minimal. The enlarged throat allows more gas flow and drug powder to pass through, and consequently is more efficient at accelerating drug powder to high velocity. Our previous PNI device with a small throat size could achieve only 34.9% of relative delivery efficiency (Wang et al., 2007 ), markedly lower than that of the present device. The previously reported PowderJect injector was also designed with a small throat in the de Laval nozzle and its delivery efficiency was only 33% (Sarphie et al., 1997 ). Therefore, we consider that the enlargement of the de Laval nozzle throat is important to ensure a high delivery efficiency of PNI. Apart from the de Laval nozzle, another improvement of the new PNI device is the valve system. In our preliminary studies, we found that the ventilation capability of the valve determines the delivery efficiency of the PNI device. A larger valve diameter permits more ventilation of the gas flow. A large valve diameter is necessary to match up with an enlarged de Laval nozzle. So we used a global valve with a normal diameter of 4 mm. To facilitate use of the device, we designed an aut Continue reading >>
How To Use
Application Needle-free jet injections constitute an important method of drug delivery, especially for insulin. Many diabetics have been successfully treated with needle-free jet injectors, which are effective in enhancing compliance with therapy, particularly when multiple doses of insulin are required. Clinical Evaluation Comfort-inTM has been proven in this test of Diabetes Control and Complications Trial to more effectively reduce hyperglycemic peaks after meals than insulin pen without increase or sudden decrease in hyperglycemic episodes. How to use Clinical Research and Publications for Jet Injection - Cross-matches for bioequivalence evaluation division using needle-free jet injector (Comfort-In) and conventional pen type syringe Continue reading >>
Diabetes Treatment With Needle-free Device
Will Needle-Less Device Make Life Easier for People with Diabetes? Written by Ginger Vieira on December 19, 2017 An MIT start-up company gets ready to distribute an injection device it says will reduce the pain of diabetes treatment. Experts say theyve seen this before. If a fear of needles is the obstacle preventing many people with diabetes from adhering to their medication protocol, a needle-free injection device may be a game changer. For conditions requiring multiple daily injections of precise doses, however, it may be a redundant attempt at technology that has already failed in the past, especially in the diabetes industry. Portal Instruments, an MIT start-up company, has secured a commercial deal for their jet-injection device with hopes of reducing the pain and anxiety many patients experience with injections, according to a company press release. The device works by delivering a rapid, high-pressure stream of medicine, as thin as a strand of hair through the skin, the press release states. The jet comes out at about Mach 0.7, so almost the cruising speed of an average commercial airliner, said Patrick Anquetil, PhD, Portal co-founder and chief executive officer. Company officials say the device causes little or no pain. It communicates with a cell phone app that records administered doses. Patients can also make notes, including whether the dose was effective in reducing their arthritis pain. Portal Instruments hopes to sell the device in combination with a variety of drugs so it is an option for a variety of conditions. Providing a needle-free injector containing different types of insulin would tap into the ever-growing diabetes industry. However, experts in the diabetes field whove also lived with the condition for decades say theyve already seen similar d Continue reading >>
Meet The Insujet™.
The insulin-jet administration system. The InsuJet™ system is developed for people with diabetes and is used to administer insulin. A special, needle-free nozzle is the key feature of the system. By pressing insulin through the nozzle orifice, a fine stream of insulin is created that easily penetrates the skin. Subsequently, the insulin follows the path of least resistance, spreading evenly in the subcutaneous layer. No needle, no worries The absence of a needle has obvious advantages. There are no needle disposal issues, nor any risk of needle prick accidents. So, don't worry about the kids if you accidentally left the device within their reach! Clinical advantages More importantly, research has shown that jet administration is a highly effective manner to administer insulin. It improves the absorption, as well as the action. faster absorption & action of insulin Portable, all-in-one design Re-usable Virtually pain free No needle disposal issues No risk of needle stick injuries How does it work? The InsuJet™ operation principle is based on pressure. By means of a spring system, the insulin is pressed at high speed through a small orifice in the nozzle, creating a fine stream of insulin that easily penetrates the skin. Directly under the skin the insulin diffuses in the subcutaneous tissue. To secure a safe and convenient administration, the InsuJet™ is equipped with a unique safety mechanism that ensures that the contact area between the nozzle and administration site is not breached during injection. InsuJet™ compared to needle injection in 30 seconds Continue reading >>
(pdf) The Needle-free Injection Technology
Mohd.Tosif Khan, Hemant Tiwari, Tahrun Nisha (B.Pharm.Final yr.) The Needle-free injection (NFI) systems are novel ways to introduce various medicines. The needle injection has many complications like anxiety, fever, avoidance, disgust and needle stick injuries. Therefore NFI systems are used to overcome these complications. In NFI's a jet of fluid is accelerated to high speed providing it significant penetrating power through a fine diameter nozzle when placed against skin. Energy sources such as spring, gas cartridge and electricity can be used. The transmission of diseases is prevented, it has a take home option and since, we can also deliver solid dosage form through it, can be used to overcome the stability factor encountered in liquid dosage form. The NFIs have many emerging applications some of which are like its use in diabetes by giving regulated and user friendly insulin injections, its use in treating hemophilia, for giving local anesthetics etc. Excessive prices relative to those of standard syringes is a disadvantage. However, there appears to be tremendous opportunity for needle-free technology to have major impact in the industry. It is likely that dramatic change may occur only when a large pharmaceutical company adopts needle-free technology and demonstrates its versatility, acceptance and value in major therapeutic area. The main goal for the delivery of any drug therapy is oral administration with once or twice daily dosing. However, there are large numbers of therapies, particularly protein-based, gene-based, vaccine-based that cannot be delivered by this route for example insulin, growth hormones and other similar biologics. Therefore the needle free injection is becoming a very interesting subject of study. Although the concept of needle free inje Continue reading >>
Needle-free Injection Device Moves Closer To Market
2 pictures Needles are usually seen as a necessary evil, but maybe they don't have to be. Plenty of painless alternatives are in the works, like microneedle patches, a laser-based device that pushes drugs through the skin as microjets of liquid, and a refined hypodermic design based on a mosquito's proboscis. Now, a pain-free jet-injection device has emerged from development limbo with a commercialization deal that should see it soon hit the market. The device is called PRIME, and it was born out of years of research at MIT. The technology proved successful enough that a company called Portal Instruments was spun out of the university in 2012 to continue working on it. Now Portal has reached a deal with Japanese pharmaceutical company Takeda to further develop PRIME and bring it to market. Rather than jam a sharp metal tube through a patient's skin, PRIME delivers its drug payload painlessly, in the form of a high-pressure stream of liquid. First, a vessel of the desired drug is loaded into the device, which is about the size of an electric razor. These single-use vessels can be potentially loaded up with a range of biologics (drugs made from biological sources like proteins), to deliver hormone treatments, insulin and vaccines. To administer the shot, a linear electromagnetic actuator squeezes the vessel, which pressurizes the drug and forces it out through a tiny nozzle that's placed against the skin. The drug exits the device at about 200 m (656 ft) per second as a jet of liquid no thicker than a hair, penetrating the skin and tissue. That method is not only painless but fast, delivering a 1 ml dose in half a second, which is much more appealing than the 10 to 20 seconds a hypodermic needle needs to stay under a patient's skin. Other jet-injection devices are availab Continue reading >>
Putting up with needle pricks to avoid the complications of diabetes may seem a small price to pay. But injections can be daunting for children and those newly diagnosed with diabetes - and can be simply terrifying for those with a phobia of needles. Injecting using modern day needles is relatively painless, but some still find it unpleasant. And there can be side-effects. There can be bruising or bleeding from the injection sites. And patients are advised to rotate where they inject because repeated jabs can cause noticeable lumps and dips in underlying fatty tissue, known as lipohypertrophy and lipoatrophy. With medical advances that bring us treatments for the previously incurable, surely there must be a better way. Needle-free insulin delivery is the Holy Grail of diabetes treatment that scientists have been seeking for at least the last 60 years. And with more than 220 million people diagnosed with diabetes worldwide, it's a lucrative business. Some new approaches have reached the market, and others are not far behind. Others remain in the laboratory, but promise to revolutionise diabetes management. Needle-free Alternatives Oral insulin Insulin needs to reach the bloodstream to work. Swallowing insulin in a tablet is not currently an option because the digestive juices would break it down in the stomach, rendering the drug useless. A solution would be to create a tablet that can withstand stomach acid and pass through the gut lining to safely deliver the insulin to where it is needed. Researchers are working on prototypes and some are being tested in clinical trials. Other scientists are looking at whether insulin could instead be absorbed through the lining of the mouth and are developing insulin sprays. Sprays As well as mouth sprays, investigators are testin Continue reading >>
Insujet Needle Free Insulin Device
Add to cart Please contact Customer Services. InsuJet is a needle free insulin device that was developed for people who require insulin treatment for their diabetes but have a needle phobia, fear of self-injecting (FSI), or would prefer not to inject themselves with a needle. It is also an alternative for carers in the home, and in health care environments such as nursing homes, as there is no risk of needle-stick injury,Please discuss InsuJet with your Diabetes Health Care Professional to ensure it is suitable for you, and that the use of InsuJet is under their supervision. Before purchasing InsuJet, refer to the "How to Use" section below to watch the videos and read the manual. For more information or to discuss the purchase process call our helpful team at Customer Support on 0800 45 82 67 Insulin is drawn manually into the InsuJet nozzle and then, via an optimised spring in the device, is pressurised through a small hole in the nozzle which creates a high speed jet This insulin jet penetrates the skin for delivery of insulin beneath the skin The diameter of the jet stream produced by InsuJet is very small (0.15mm) InsuJet has been designed so that administration takes place only at a predetermined pressure on the skin. InsuJet has a dose range of 440 international units of U100 insulin (doses greater than this will require more than one administration). InsuJet is suitable for use with all brands and types of insulin. Studies have shown administration of insulinaspartby InsuJet compares well to delivery by needle pen.1 InsuJet does not affect the structure of long acting insulins.2 InsuJet was developed by the European Pharma Group (EPG). Press here to visit their website Reutens AT, Balkau B, Cohen N. A Pilot Study to Examine the Tolerability and Device Preferenc Continue reading >>
Needle-free Diabetes? European Medtech Inventions Which Painlessly Measure Blood Glucose!
Will the daily routine of finger pricking to monitor blood glucose levels finally come to an end for the millions worldwide living with diabetes? Diabetes mellitus is a chronic metabolic disease that affects over 422 million people worldwide. It is the major cause of blindness, kidney failure, heart attack and stroke. The World Health Organization (WHO) considers it an epidemic and predicts it will become the 7th biggest cause of death worldwide by 2030. To monitor blood glucose levels, millions of diabetics have to test their blood sugar close to 10 times a day by pricking their finger with a lancet to obtain a small blood sample. But some companies in Europe are trying to find a pain-free alternative that removes the need for needles – here are three startups revolutionizing blood sugar testing. GlucoSense (London, UK) GlucoSense is a spin-out of the University of Leeds funded by NetScientific that is developing a non-invasive device based on photonics technology. Its basic component is a nano-engineered silica glass with ions that fluoresce in the infrared region when stimulated by a low power laser. When the glass is in contact with the user’s skin, the reflected fluorescence signal varies based on the concentration of glucose in their blood and one can acquire the glucose concentration measurement in less than 30 seconds. NovioSense (Nijmegen, the Netherlands) NovioSense is a Dutch startup working on an implantable glucose sensor that uses tear fluid to measure glucose levels. The device consists of a 15 mm-long metal coil coated with a hydrophilic gel. Its flexible form allows the device to bend to conform to the surface of the lower eye lid, where the sensor is placed. The coil moves to the correct place in the eye and the gel coating swells to increase conta Continue reading >>
Needle-free Insulin Injection Specifically Designed For People With Diabetes. Now Available In Australia
- A fear of needles can be barrier to managing diabetes with insulin injections - For a number of the 1.5 million Australians living with diabetes, the fear of needles can inhibit or seriously delay the management of the condition, when insulin injections are their only treatment option 1, 2. People who do not manage their insulin-dependent diabetes adequately are at much higher risk of heart attack, stroke, eyesight problems as well as peripheral vascular disease - a major cause of amputation, warns Associate Professor Neale Cohen, General Manager of Diabetes Services at Baker IDI Heart and Diabetes Institute. InsuJet™, a needle-free device is specifically designed for people with diabetes whom require insulin, and is now available in Australia. InsuJet™ uses jet technology to deliver insulin, without a needle. (Figure 1).3 Figure 1: InsuJet™ uses jet technology, instead of a needle, to deliver insulin. InsuJet creates a high speed insulin jet which crosses the skin into the subcutaneous tissue. "InsuJet™ provides a new option for those people with diabetes who have been taking daily insulin injections, and are now looking for an alternative option to insulin injections that is needle free," said Associate Professor Cohen, who recently published a clinical pilot study looking at InsuJet™ needle-free insulin delivery.4 "Needle-free technology is also a welcome solution for those living with diabetes who struggle to start injecting insulin because of their fear or strong dislike of needles," said Professor Cohen. One of the first to begin using InsuJet™ in Australia was John Moore. With his oral medication failing, and certain he would never take needles, despite needing insulin for several years, John actively searched for a needle-free alternative. John sai Continue reading >>
Needle Free Insulin Injections For People With Diabetes
Nobody likes needles. Whether you are a tough guy or a little kid. Needle free insulin injections are a safe and pain-free solution for people with diabetes and are simple for both adults and children to use. With the Comfort-in™, the insulin is pushed through a micro-orifice into the superficial skin cells to the tissue below. This is achieved by using a precise measurement of pressure at a fraction of a second without the pain and fear associated with needles. Discomfort or even anxiety related to regular insulin injections by needles belong to the past now. Irrespective of whether you are changing from an oral dose of medication to insulin therapy or have had to inject insulin several times a day for a long time, with the Comfort-in™ you can inject insulin in a tissue preserving way and avoid possible scar formation from daily needle injections. With this reusable injector, the insulin is pushed through a micro-orifice with precisely measured pressure between the superficial skin cells into the tissue below, in a fraction of a second. And this method is virtually painless, tissue preserving and without the risk of injury. Infections resulting from needle stick injuries are likewise ruled out. The use of needle-free injections constitutes an important method of delivery for medicine and other injections. Many diabetics have been successfully treated with needle-free jet injectors, which are effective in enhancing compliance with therapy, particularly when multiple doses of insulin are required. Clinical Evaluation Comfort-in™ has been proven in this test of Diabetes Control and Complications Trial to more effectively reduce hyperglycemic peaks after meals than an insulin pen without increase or sudden decrease in hyperglycemic episodes. Clinical Research and Pub Continue reading >>
- Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE)
- Needle-Free Diabetes? European MedTech Inventions which Painlessly Measure Blood Glucose!
- To Mark World Diabetes Day, Israeli Company Promotes Needle-Free Glucose Test
A Needle-free Injection For Diabetics
A needle-free injection will soon be available to thousands of diabetics. A British company has designed a £120 gadget that could free diabetics from the daily trauma of painful injections. It works by forcing insulin under the skin at high pressure. Instead of a needle prick, it gives a sensation rather like being slapped on the thigh. More than 1.4 million people in the UK have been diagnosed with diabetes, but experts believe another million are unaware they have it. Of those diagnosed, 20,000 are under the age of 20. Nearly 600,000 people inject themselves daily with the hormone, which regulates levels of glucose (sugar) in the blood. The hand-held device, called the mhi-500, is based on a gadget which has been introduced in America. It uses jet pressure to force a fine stream of insulin at high speed through the skin. It is expected to bring relief to the one in 20 people afraid of needles. The device will also dramatically reduce the risk of infection caused by cross-contamination using conventional injections. The Sheffield-based Medical House has applied to the Medical Devices Agency for permission to market the invention. Its chief executive, Ian Townsend, says: 'The mhi-500 can deliver the insulin in only 300 milliseconds, compared with a syringe which takes six seconds.' The company is also working on another needle-free system for insulin users who need a lower dose. This should be available by the end of 2002. Dr Harry Brown, a family GP in Leeds and adviser to the company, says: 'The first thing every person diagnosed with diabetes asks is whether they will have to give themselves injections. The thought that, for the rest of your life, you will be sticking needles into yourself is traumatic. 'The fact that jet injectors offer an alternative is very excit Continue reading >>
Will Needle-less Devices Revolutionise The Treatment Of Diabetes?
/ Will needle-less devices revolutionise the treatment of diabetes? Will needle-less devices revolutionise the treatment of diabetes? Needle-free injectors will go a long way in reducing the number of diabetics non-compliant to insulin therapy. Mansi Kohli | Updated: February 5, 2018 1:56 pm Tags: Blood sugar level Diabetes injection Insulin Insulin injections Diabetes is a chronic lifestyle disease, and the incidence is ever increasing. The number of projected diabetics in India alone will be 109 million people by 2035. Approximately 30-40% of all diabetics eventually require insulin supplementation. However, only 10-15% actually use insulin . The most common excuse for not taking insulin for diabetics is the fear of getting injected. Hence, according to Dr Harsh Sheth, Fellow Fellow, Advance Minimal Access Surgery, Digestive Health Institute by Dr Muffi, needle-free injectors will go a long way in reducing the number of diabetics non-compliant to insulin therapy. But even though various needle free injectors are available overseas, however, none of these companies have started retailing in India yet. Many diabetics have to draw blood and test their blood glucose levels for multiple times in a day, but instead they can now scan the sensor and get a reading in less than a second. Most diabetics with well-controlled blood glucose levels need not constantly prick themselves to test their glucose levels very often. The most accurate estimate of glucose levels is from blood drawn from veins. Glucose monitoring systems use a sensor placed over the skin which pairs with a device and estimates glucose levels in the blood. There are two types of sensors, one, which is implanted under the skin, and another, which is placed over the skin. Both these devices arent as accurate as Continue reading >>
Scientists Develop Device For Needle-less Injection
Scientists develop device for needle-less injection Every year, approximately 16 million injections are administered to patients to deliver vital medications and vaccinations. However, new research from Massachusetts Institute of Technology (MIT) is promising to change the way we view injections by removing the need for needles. The MIT team, led by Professor Ian Hunter, has developed a new way to inject medicine without a needle. The device uses a high-pressure jet to deliver medicine through the skin. A Lorentz-force actuator, which is comprised of a small, powerful magnet surrounded by a coil of wire, is connected to a piston which ejects the drug at a pressure and velocity strong enough to get through skin. Although the skin is still punctured, similar to a needle system, the diameter of the stream is much smaller than a standard needle, about the quarter of the size or about the diameter of human hair. As a result the system is supposed to be less painful, feeling no worse than a mosquito bite. Needle-free injection devices have been available since the 1930s, with similar devices being used for mass vaccination programs for over 50 years. The older devices relied on mechanical compression, such as compressed gas, to generate pressure to deliver medications through skin. As a result the set-up required made many of these devices cost-prohibitive outside of large programs. This new device however, is much smaller and could be available for personal use. A personal needle-free system could be of great benefit to the hundreds of thousands of individuals who require daily injections of medications. For instance, those with insulin-dependent diabetes need multiple injections of insulin every day. Unfortunately, this means multiple painful needle sticks. A device of thi Continue reading >>
Needle-free Injections Making Their Point
Using jet pressure and only taking 300 milliseconds, could needle-free injectors be the answer to ‘needle phobia’? A patient’s fear of a visit to the doctors or dentists often stems from one thing – needles. To overcome this ‘needle phobia’ and other issues relating to needle injections, one area that has received considerable attention over the past few years is the needle-free injection. As the name suggests, the technology has been developed to alleviate the need for a needle to inject medications through the skin. Needle-free injectors also offer an important choice to those people who have to face injecting themselves on a regular basis. Some people with diabetes have to inject themselves up to four times a day with needles to deliver insulin into the subcutaneous tissue where it can be absorbed into the body. Sheffield-based company The Medical House (TMH) are at the forefront of developing needle-free injections. They began this year with an announcement of a £4.3 million agreement with global biotechnology leader Serono. A state of the art needle-free injector is being developed by TMH with development costs of £435,000 to be contributed by Serono. Under the five-year contract, TMH will manufacture and supply a reusable needle-free device, the GH-1, which will be used to deliver human growth hormone. In February TMH licensed the GH-1 for the delivery of Biopartners human growth hormone product Valtropin. Needle-free injections began life for TMH in April 2001 when an agreement was signed with US company Bioject to develop and manufacture a new version of Bioject’s existing reusable needle-free drug delivery system, Vitajet, which has been marketed worldwide for 20 years. The result of that development was the mhi-500, which in November 2002 was l Continue reading >>