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Mixtard Insulin

Human Mixtard Injection

Human Mixtard Injection

Human Mixtard Injection is used for Diabetes , Anti-diabetic and other conditions. Human Mixtard Injection may also be used for purposes not listed in this medication guide. Human Mixtard Injection contains Insulin and Insulin as active ingredients. Human Mixtard Injection works by replacing the normal production of insulin and by helping transfer sugar from the blood into other body tissues; replacing the normal production of insulin and by helping transfer sugar from the blood into other body tissues; Abbott Health manufactures Human Mixtard Injection. Detailed information related to Human Mixtard Injection's uses, composition, dosage, side effects and reviews is listed below. Human Mixtard Injection is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: Human Mixtard Injection may also be used for purposes not listed here. Human Mixtard Injection Working, Mechanism of Action and Pharmacology Human Mixtard Injection improves the patient's condition by performing the following functions: Replacing the normal production of insulin and by helping transfer sugar from the blood into other body tissues. Human Mixtard Injection - Composition and Active Ingredients Human Mixtard Injection is composed of the following active ingredients (salts) Please note that this medicine may be available in various strengths for each active ingredient listed above. The following is a list of possible side-effects that may occur from all constituting ingredients of Human Mixtard Injection . This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away Continue reading >>

Novo Nordisk Withdraw Insulin Mixtard 30

Novo Nordisk Withdraw Insulin Mixtard 30

Around 90,000 people with diabetes in the UK who use the insulin Mixtard 30 have until 31 December 2010 to change their treatment before the medication is withdrawn by manufacturer Novo Nordisk. There are several other similar insulin treatments available for people currently prescribed Mixtard 30, and Diabetes UK is advising people affected to consult with their GP, hospital consultant, practice nurse or diabetes specialist nurse to help them decide which option is best for them. Douglas Smallwood, Diabetes UK Chief Executive, said: While there is no need to panic, as there is time, it is important for those affected not to wait until December. You will need to see your doctor or nurse as soon as possible to ensure you are changed to an alternative treatment. Both Novo Nordisk and Diabetes UK have notified healthcare professionals of the alternative treatments. Not in the best interests of people with diabetes We are very disappointed about this withdrawal as it is not in the best interests of people with diabetes. We think this is wrong and asked Novo Nordisk to reconsider their decision, considering the 90,000 or so people currently using Mixtard 30, but they argued they are committed to withdrawing all older types of human insulin over time. We then asked for a longer withdrawal period to ensure a properly co-ordinated response to this, but that proposal was also turned down. Need advice? Call the Novo Nordisk helpline People with any questions about the withdrawal of Mixtard 30 are asked to call the. Continue reading >>

Mixtard 30 40 Iu/ml Suspension For Injection In A Vial

Mixtard 30 40 Iu/ml Suspension For Injection In A Vial

Mixtard 30 40 IU/ml suspension for injection in a vial Mixtard is human insulin to treat diabetes. Mixtard is a mixture of fast-acting insulin and long-acting insulin. This means that it will start to lower your blood sugar about half an hour after you take it, and the effect will last for approximately 24 hours. What do you have to consider before using it? If you are allergic hypersensitive to this insulin product, metacresol or any of the other ingredients see 7 Further information. Look out for the signs of allergy in 5 Possible side effects If you feel a hypo coming on a hypo is short for a hypoglycaemic reaction and is a symptom of low blood sugar. See 4 What to do in an emergency for more about hypos. If you have trouble with your kidneys or liver, or with your adrenal, pituitary or thyroid glands If you are drinking alcohol watch for signs of a hypo and never drink alcohol on an empty stomach If you are exercising more than usual or if you want to change your usual diet If you are ill carry on taking your insulin If you are going abroad travelling over time zones may affect your insulin needs and the timing of your injections. Many medicines affect the way glucose works in your body and they may influence your insulin dose. Listed below are the most common medicines which may affect your insulin treatment. Talk to your doctor or pharmacist if you take or have recently taken any other medicines, even those not prescribed. Your need for insulin may change if you also take: oral antidiabetic products; monoamine oxidase inhibitors (MAOI); beta-blockers; ACE-inhibitors; acetylsalicylic acid; anabolic steroids; sulphonamides; oral contraceptives; thiazides; glucocorticoids; thyroid hormone therapy; beta-sympathomimetics; growth hormone; danazol; octreotide or lanreot Continue reading >>

Comparison Of Thrice Daily Biphasic Human Insulin (30/70) Versus Basal Detemir & Bolus Aspart In Patients With Poorly Controlled Type 2 Diabetes Mellitus – A Pilot Study

Comparison Of Thrice Daily Biphasic Human Insulin (30/70) Versus Basal Detemir & Bolus Aspart In Patients With Poorly Controlled Type 2 Diabetes Mellitus – A Pilot Study

Go to: Abstract Conventionally, biphasic human insulin (30/70, BHI) is used twice daily for the management of patients with diabetes. However, this regimen is suboptimal to control post-lunch and/or pre-dinner hyperglycaemia in some patients. This study was undertaken to compare the efficacy and safety of thrice-daily biphasic human insulin (30/70, BHI) versus basal detemir and bolus aspart (BB) in patients with poorly controlled type 2 diabetes mellitus (T2DM). In this open labelled randomized pilot study, 50 patients with uncontrolled T2DM on twice-daily BHI and insulin sensitizers were randomized either to BHI thrice-daily or BB regimen. HbA1c, six point plasma glucose profile, increment in insulin dose, weight gain, hypoglycaemic episodes and cost were compared between the two treatment groups at the end of 12 wk. Mean HbAlc (±SD) decreased from 9.0±0.9 per cent at randomization to 7.9±0.8 per cent in BHI (P<0.001) and from 9.4±1.3 to 8.2±1.0 per cent in BB regimen (P<0.001) after 12 wk of treatment. The mean (±SEM) weight gain in patients in the BHI regimen was 1.5±0.33 kg compared to 1.4±0.34 kg in the BB regimen. Insulin dose increment at 12 wk was significantly more in the BB regimen 0.46±0.32 U/kg/day compared to 0.15±0.21 U/kg/day in the BHI regimen (P<0.001). The incidence of major as well as minor hypoglycaemic episodes was not different in both the regimen. The BB regimen was more expensive than the BHI regimen (P<0.001). Interpretation & conclusions: The thrice daily biphasic human insulin regimen is non-inferior to the basal bolus insulin analogue regimen in terms efficacy and safety in patients with poorly controlled T2DM. However, these data require further substantiation in large long term prospective studies. Keywords: Biphasic human insulin Continue reading >>

Humulin70/30, Novolin 70/30 (insulin Isophane Human/insulin Regular Human) Dosing, Indications, Interactions, Adverse Effects, And More

Humulin70/30, Novolin 70/30 (insulin Isophane Human/insulin Regular Human) Dosing, Indications, Interactions, Adverse Effects, And More

insulin isophane human/insulin regular human Ketones moderate or less: 0.5 U/kg/day SC Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1 Suggested guidelines for beginning dose; adjust according to blood glucose levels Initial dose: 0.5-1 units/kg/day in divided doses Typically, 50-75% of total daily dose is given as intermediate- or long-acting insulin May use this combination product if the dosage ratio of NPH (isophane) to regular is 2:1 Ratio of regular insulin to NPH (isophane) insulin 1:2 Administer within 15 min before a meal or immediately after a meal Store unopened vials/pens refrigerated; do not freeze Opened (in-use) product may be stored at ambient room temperature (below 86F [30C]) and away from heat and light Dosage of human insulin, which is always expressed in USP units, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing (See Dosage Adjustment Strategies) Adjust to achieve appropriate glucose control Look for consistent pattern in blood sugars for >3 days Compare blood glucose for same time each day For each time of day: calculate blood glucose range Consider eating and activity patterns during day If all blood sugars are high (within 2.75 mmol/L [50 mg/dL]): correct morning fasting blood glucose 1st Many sliding scales exist to determine exact insulin dose based on frequent blood glucose monitoring - Commonly written for q4hr blood glucose test - Sliding scale coverage usually begins after blood glucose >11 mmol/L (200 mg/dL) - If coverage is needed q4hr x 24 hr, then base insulin dose is adjusted Continue reading >>

Mixtard 30/70 Penfill 3 Ml Injection

Mixtard 30/70 Penfill 3 Ml Injection

Insulin, neutral (rys); Insulin, isophane (rys) Insulin, neutral (rys); Insulin, isophane (rys) Consumer medicine information (CMI) leaflet Please read this leaflet carefully before you start using Mixtard 30/70 Penfill 3 mL Injection. While you are using human insulin Penfill This leaflet answers some common questions about human insulin Penfill. It does not contain all the available information. It does not take the place of talking to your doctor, diabetes education nurse or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using human insulin against the benefits they expect it will have for you. If you have any concerns about using this medicine, ask your doctor, diabetes education nurse or pharmacist. Human insulin is used to treat diabetes mellitus. Diabetes mellitus is a condition where your pancreas does not produce enough insulin to control your blood sugar (glucose) level. Extra insulin is therefore needed. There are two types of diabetes mellitus: Type 1 diabetes also called juvenile onset diabetes Type 2 diabetes also called maturity onset diabetes Patients with type 1 diabetes always require insulin to control their blood sugar levels. Some patients with type 2 diabetes may also require insulin after initial treatment with diet, exercise and tablets. Human insulin lowers your blood sugar level after injection. Each of the following human insulins is available in Penfill, a 3mL glass cartridge designed to be used with Novo Nordisk insulin delivery devices such as NovoPen: Actrapid is Neutral Insulin Injection, a fast-acting insulin. This means that it will start to lower your blood sugar level about half an hour after you inject it, and the effect will last for approximately 8 hours. Actrapid is often used in combi Continue reading >>

Mixtard 30/70 Penfill | Healthdirect

Mixtard 30/70 Penfill | Healthdirect

Mixtard 30/70 Penfill is a medicine containing the active ingredient(s) insulin isophane human + insulin neutral human. On this page you will find out more about Mixtard 30/70 Penfill, including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS) You should seek medical advice in relation to medicines and use only as directed by a healthcare professional. Always read the label. If symptoms persist see your healthcare professional. healthdirect medicines information is not intended for use in an emergency. If you are suffering an acute illness, overdose, or emergency condition, call triple zero (000) and ask for an ambulance. Reasonable care has been taken to provide accurate information at the time of creation. This information is not intended to substitute medical advice, diagnosis or treatment and should not be exclusively relied on to manage or diagnose a medical condition. Please refer to our terms and conditions . Continue reading >>

Mixtard 30 (discontinued In The Uk - December 2010)

Mixtard 30 (discontinued In The Uk - December 2010)

What is it used for? How does it work? Mixtard 30 penfill cartridges (for use with Novopen devices), preloaded pens (Innolet) and vials all contain human biphasic isophane insulin. They are used to treat diabetes. People with diabetes have a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar (glucose) in the blood. People with type one diabetes need to have injections of insulin to control the amount of glucose in their bloodstream. Insulin injections act as a replacement for natural insulin, and allow people with diabetes to achieve normal blood glucose levels. The insulin works in the same way as natural insulin, by binding to insulin receptors on cells in the body. Insulin causes cells in the liver, muscle and fat tissue to increase their uptake of glucose form the bloodstream. It also decreases the production of glucose by the liver, and has various other effects that lower the amount of glucose in the blood. Mixtard 30 contains a mixture of two types of insulin, soluble insulin and isophane insulin. Together, the combination of insulins is called biphasic isophane insulin. The soluble insulin is a short acting insulin. It works rapidly, within 30 to 60 minutes, and its effects last for about eight hours. The isophane insulin is known as an intermediate acting insulin. It takes longer to act, but its duration of action is longer. The pre-mixed combination provides a rapid initial blood glucose lowering effect, followed by a prolonged effect that controls blood glucose throughout the day. It is usually injected under the skin approximately 30 minutes before a meal or snack, and this initially controls the increasing blood glucose levels after eating. It is important to monit Continue reading >>

Human

Human

Please read this carefully before you start to take your insulin. This leaflet provides a summary of the information available on your insulin. If you have any questions or are not sure about anything, ask your doctor or pharmacist. The name of your insulin is: Human Mixtard 30 Pen (Biphasic Isophane Insulin Injection 30/70 BP) This preparation contains insulin [Human insulin (pyr)] which is identical to the insulin produced by the human pancreas. Insulin preparations supplement or replace the insulin that your own pancreas produced before you developed diabetes. They allow your body to continue converting the carbohydrates you eat into energy. Things to remember about Human Mixtard 30 as directed by your doctor and read the instructions below* , your doctor may have prescribed more than one type. More detailed information about Human Mixtard 30 Pen is given below. Human Mixtard 30 Pen is used for the treatment of insulin-requiring diabetics. It is a disposable dial-a-dose insulin delivery device able to deliver 2-78 units in increments of 2 units and containing a mixture of soluble and isophane human insulin (pyr) in the ratio 30:70. The insulin preparation in this device (Biphasic Isophane Insulin Injection BP) is an intermediate-acting insulin (due to the isophane insulin component) with a strong initial effect; the ratio of soluble to isophane insulin gives a measure of the intensity of the initial effect (eg 10/90 low, 50/50 high). Human Mixtard 30 Pen is a suspension which appears white and cloudy when shaken. Before taking your insulin, be sure you do not have hypoglycaemia, i.e. low blood sugar or 'hypo'. You must not take insulin if you have hypoglycaemia (see **Possible Problems). Be sure your insulin is the same as usual; changes in type of insulin without y Continue reading >>

Humulin 30/70

Humulin 30/70

How does this medication work? What will it do for me? Insulin is a naturally occurring hormone made by the pancreas that helps our body use or store blood glucose (sugar) it gets from food. For people with diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels. There are many different types of insulin that are absorbed at different rates and work for varying periods of time. This type of premixed insulin contains a mixture of fast-acting insulin (insulin regular) and intermediate-acting insulin (insulin NPH). This premixed insulin is used by people with diabetes who have their blood glucose under control and have found a particular ratio of fast-acting to intermediate-acting insulin that works best for them. This premixed insulin starts working 30 to 60 minutes after injection, has its maximum effect between 2 and 8 hours, and stops working after about 18 to 24 hours. Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it. What form(s) does this medication come in? Vial Each mL contains 100 Continue reading >>

Mixtard-30 Hm From Novo Nordisk, Insulin - Actrapid To Human Prodica | Drugsupdate India

Mixtard-30 Hm From Novo Nordisk, Insulin - Actrapid To Human Prodica | Drugsupdate India

Mixtard-30 HM from Novo Nordisk contains Insulin Below are some of the details of Insulin(generic) Insulin is a hormone that is central to regulating energy and glucose metabolism in the body. Insulin causes cells in the liver, muscle, and fat tissue to take up glucose from the blood, storing it as glycogen in the liver and muscle. Insulin stops the use of fat as an energy source. When insulin is absent, glucose is not taken up by body cells and the body begins to use fat as an energy source, for example, by transfer of lipids from adipose tissue to the liver for mobilization as an energy source. As its level is a central metabolic control mechanism, its status is also used as a control signal to other body systems (such as amino acid uptake by body cells). In addition, it has several other anabolic effects throughout the body. When control of insulin levels fails, diabetes mellitus will result. As a consequence, insulin is used medically to treat some forms of diabetes mellitus. Patients with Type 1 diabetes mellitus depend on external insulin (most commonly injected subcutaneously) for their survival because the hormone is no longer produced internally. Patients with Type 2 diabetes mellitus are insulin resistant, and because of such resistance, may suffer from a relative insulin deficiency. Some patients with Type 2 diabetes may eventually require insulin if other medications fail to control blood glucose levels adequately, though this is somewhat uncommon. Insulin also influences other body functions, such as vascular compliance and cognition. Once insulin enters the human brain, it enhances learning and memory and in particular benefits verbal memory. Insulin is a peptide hormone composed of 51 amino acids and has a molecular weight of 5808 Da. It is produced in t Continue reading >>

Insulin (medication)

Insulin (medication)

"Insulin therapy" redirects here. For the psychiatric treatment, see Insulin shock therapy. Insulin is used as a medication to treat high blood sugar.[3] This includes in diabetes mellitus type 1, diabetes mellitus type 2, gestational diabetes, and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states.[3] It is also used along with glucose to treat high blood potassium levels.[4] Typically it is given by injection under the skin, but some forms may also be used by injection into a vein or muscle.[3] The common side effect is low blood sugar.[3] Other side effects may include pain or skin changes at the sites of injection, low blood potassium, and allergic reactions.[3] Use during pregnancy is relatively safe for the baby.[3] Insulin can be made from the pancreas of pigs or cows.[5] Human versions can be made either by modifying pig versions or recombinant technology.[5] It comes in three main types short–acting (such as regular insulin), intermediate–acting (such as NPH insulin), and longer-acting (such as insulin glargine).[5] Insulin was first used as a medication in Canada by Charles Best and Frederick Banting in 1922.[6] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[7] The wholesale cost in the developing world is about US$2.39 to $10.61 per 1,000 iu of regular insulin and $2.23 to $10.35 per 1,000 iu of NPH insulin.[8][9] In the United Kingdom 1,000 iu of regular or NPH insulin costs the NHS 7.48 pounds, while this amount of insulin glargine costs 30.68 pounds.[5] Medical uses[edit] Giving insulin with an insulin pen. Insulin is used to treat a number of diseases including diabetes and its acute complications such as diabetic ketoacid Continue reading >>

Mixtard - European Drugs Reference Encyclopedia

Mixtard - European Drugs Reference Encyclopedia

Mixtard is a range of insulin suspensions for injection. Mixtard is supplied in vials, cartridges (PenFill) or pre-filled pens (NovoLet, FlexPen or InnoLet). Mixtard contains the active substance insulin human (rDNA). Mixtard contains both fast-acting (soluble) and long-acting (isophane) insulin: Mixtard 10: soluble insulin 10% and isophane insulin 90%, Mixtard 20: soluble insulin 20% and isophane insulin 80%, Mixtard 30: soluble insulin 30% and isophane insulin 70%, Mixtard 40: soluble insulin 40% and isophane insulin 60%, Mixtard 50: soluble insulin 50% and isophane insulin 50%. Mixtard is used in patients with diabetes. The medicine can only be obtained with a prescription. Mixtard is given subcutaneously (under the skin) by injection, usually in the abdominal wall (tummy). If convenient it may also be given in the gluteal region (buttocks) or the deltoid region (shoulder). The patient's blood glucose (sugar) should be tested regularly to find the lowest effective dose. The usual dose is between 0.3 and 1.0 international units (IU) per kilogram body weight per day. Mixtard is usually given once or twice a day when a rapid initial effect together with a more long-lasting effect is needed. Diabetes is a disease in which the body does not produce enough insulin to control the blood glucose. Mixtard is a replacement insulin which is identical to the insulin made by the pancreas. The active substance in Mixtard, insulin human (rDNA), is produced by a method known as recombinant technology: the insulin is made by a yeast that has received a gene (DNA), which makes it able to produce insulin. Mixtard contains insulin in two forms: the soluble form, which acts quickly (within 30 minutes of injection) and the isophane form which is absorbed much more slowly during the day. T Continue reading >>

Mixtard 30 Hm Penfill Insulin Treatment In Selected Young Insulin-dependent Diabetes Mellitus Patients. Romanian Young Diabetics Study Team (rydst).

Mixtard 30 Hm Penfill Insulin Treatment In Selected Young Insulin-dependent Diabetes Mellitus Patients. Romanian Young Diabetics Study Team (rydst).

Mixtard 30 HM Penfill insulin treatment in selected young insulin-dependent diabetes mellitus patients. Romanian Young Diabetics Study Team (RYDST). [No authors listed] Rom J Intern Med. 1997 Jan-Dec. Rom J Intern Med. 1997 Jan-Dec;35(1-4):99-113. Twelve Romanian centers investigated the validity of a two daily insulin regimen using premixed biosynthetic human insulin Mixtard 30 HM Penfill (ratio: 30% rapid, 70% intermediate NPH-insulin) injected by NovoPen II in IDDM patients. Duration of the study was 16 weeks. A total of 159 patients aged 6 to 18 years were analyzed. Before study started, patients were educated about diabetes management and received strips for home blood glucose monitoring. After a 4-week run-in period on previous treatment (mainly two daily injections of self-mixed highly purified monocomponent porcine or human insulin given by conventional syringes), patients were transferred to two daily injections of Mixtard 30 HM Penfill insulin administered by NovoPen II. From transfer to study end (12 weeks) total daily insulin dose (mean +/- SD: 32.6 +/- 12.1 vs 33.9 +/- 12.2 IU) increased (p < 0.001), four-point blood glucose mean values decreased as well as HbA1 (11.4 +/- 2.2% vs 10.5 +/- 2.2%, p < 0.001), without a significant increase in the number of hypoglycemic events. NovoPen II was well accepted and preferred by patients. Achieved results might be ascribed to the use of Mixtard 30 HM Penfill treatment as well as to blood glucose monitoring and a better education. Follow-up measurement of HbA1 one year after transfer showed no statistically significant differences as compared to the values measured at the end of the study. Continue reading >>

Mixtard 30 Insulin Human For Treatment Of Diabetes Mellitus

Mixtard 30 Insulin Human For Treatment Of Diabetes Mellitus

Mixtard 30 insulin human for treatment of diabetes mellitus Qualitative and quantitative composition : Insulin human, rDNA (produced by recombinant DNA technology in Saccharomyces cerevisiae). 1 vial contains 10 ml equivalent to 400 IU. One IU (International Unit) corresponds to 0.035 mg of anhydrous human insulin. Mixtard is a mixture of dissolved insulin and isophane (NPH) insulin. Mixtard 30 consists of 30% dissolved insulin and 70% isophane insulin. Mixtard is a dual-acting insulin. It is a biphasic formulation containing both fast-acting and long-acting insulin. Premixed insulin products are usually given once or twice daily when a rapid Initial effect together with a more prolonged effect is desired. Dosage is individual and determined. in accordance with the needs of the patient. The individual insulin requirement is usually between 0.3 and 1.0 IU/kg/day. The daily insulin requirement may be higher in patients with insulin resistance (e.g. during puberty or due to obesity) and lower in patients with residual, endogenous insulin production. An injection should be followed within 30 minutes by a meal or snack containing carbohydrates. Concomitant illness, especially infections and feverish conditions, usually increases the patients insulin requirement. Concomitant diseases in the kidney, liver or affecting the adrenal. pituitary or thyroid gland can require changes in the insulin dose. Adjustment of dosage may also be necessary if patients change physical activity or their usual diet. Dosage adjustment may be necessary when transferring patients from one insulin preparation to another. For subcutaneous use. Insulin suspensions are never to be administered intravenously. Mixtard is administered subcutaneously in the thigh or abdominal wall. If convenient, the glute Continue reading >>

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