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Metformin Resistance Over Time

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Could Metformin Actually Make Insulin Resistance Worse?

Polycystic Ovarian Syndrome, or PCOS, and Insulin Resistance (IR) often occur simultaneously. While the connection between these two conditions is, as of yet, not entirely clear, researchers have determined that IR can lead to PCOS and diabetes.1 Metformin, or Glucophage, is commonly prescribed for both of these disorders, as it is assumed to reduce IR and improve the symptoms associated with it (such as high blood sugar). Understanding the Fine Print Although Metformin claims to reduce IR, current labeling laws do not require pharmaceutical companies to reveal how their products achieve results, they simply must accurately represent what kind of results can be expected from their medications.2 This pharmaceutical, in particular, lowers blood sugar using less insulin, which has been taken to mean that it reduces IR.2 This may not be the case. How Does Metformin Really Work? Diabetes Update, a blog that reviews diabetes medications and treatment options, has published some interesting findings pertaining to how Metformin actually improves diabetes and PCOS. A study conducted on mice has suggested that the drug lowers blood sugar not by reducing IR, but by activating a gene that does Continue reading >>

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  1. Dan360

    The good, the bad and the ugly of metformin

    I have been taking metformin sense the day I was first diagnosed with type 2 diabetes. As you probably know, it is the first-line drug of choice for the treatment of type 2 diabetes and I doubt that there are many of you that do not take metformin. Metformin works by suppressing glucose production by the liver. Evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain; in some people, it promotes weight loss. Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines.
    One of my first experiences with diabetes was finding that when I worked out my glucose level would actually increase. That was very frustrating sense I was working out to lower levels of glucose. When I told my doctor she put me on a heavier dose of metformin, 1000 mg twice a day. As with most drugs the treatment of one problem often causes another. There is a whole list of side effects associated with metformin: abdominal or stomach discomfort, cough or hoarseness, decreased appetite, diarrhea, fast or shallow breathing, fever or chills, general feeling of discomfort, lower back or side pain, muscle pain or cramping and painful or difficult urination. Other problems metformin may cause which will usually diminish over time is: Acid or sour stomach, belching, bloated, excess air or gas in the stomach or intestines, full feeling, heartburn, indigestion, loss of appetite, metallic taste in the mouth, passing of gas, stomachache, stomach upset or pain and vomiting. I hope this isn’t too much information!
    My latest experience with metformin was excess air or gas in the stomach. I experienced what seem to be a swelling in my throat followed by belching or burping. I cut my dose of metformin in half and the problem went away. Have any of you experienced discomforts with metformin?

  2. govna

    Let me tell you about my awful 3 year journey with metformin! I dealt with all the horrible side affects for a few years Mostly massive pain and intestinal bloating all that goes with it to the point of doctors taking out my gall bladder then on to a colonoscopy and endoscopy and then on to a stress test! All was "just fine" Finally doc said take me off the metformin since a small percentage of people cannot tolerate metformin. Well low and behold I was one of them! After about two weeks most all of the hellish discomfort disappeared! I now take 50 units of toujeo every morning feel great and found a new lease on life energy wise! I am back baby!!!! It is just a shame looking back on how long I suffered needlessly. Not to mention the metformin wasn't even bringing my sugar down anyhow. All it did was make me extremely sick!!!

  3. Scared ****less

    join the club Metformin was a nightmare too the stomach pain was terrible but lucky my dr took me them a week later

  4. -> Continue reading
read more close
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Effect Of Pioglitazone Compared With Metformin On Glycemic Control And Indicators Of Insulin Sensitivity In Recently Diagnosed Patients With Type 2 Diabetes

Pioglitazone, a thiazolidinedione, improves glycemic control primarily by increasing peripheral insulin sensitivity in patients with type 2 diabetes, whereas metformin, a biguanide, exerts its effect primarily by decreasing hepatic glucose output. In the first head-to-head, double-blind clinical trial comparing these two oral antihyperglycemic medications (OAMs), we studied the effect of 32-wk monotherapy on glycemic control and insulin sensitivity in 205 patients with recently diagnosed type 2 diabetes who were naive to OAM therapy. Subjects were randomized to either 30 mg pioglitazone or 850 mg metformin daily with titrations upward to 45 mg (77% of pioglitazone patients) and 2550 mg (73% of metformin patients), as indicated, to achieve fasting plasma glucose levels of less than 7.0 mmol/liter (126 mg/dl). Pioglitazone was comparable to metformin in improving glycemic control as measured by hemoglobin A1C and fasting plasma glucose. At endpoint, pioglitazone was significantly more effective than metformin in improving indicators of insulin sensitivity, as determined by reduction of fasting serum insulin (P = 0.003) and by analysis of homeostasis model assessment for insulin sensi Continue reading >>

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Popular Questions

  1. Dan360

    The good, the bad and the ugly of metformin

    I have been taking metformin sense the day I was first diagnosed with type 2 diabetes. As you probably know, it is the first-line drug of choice for the treatment of type 2 diabetes and I doubt that there are many of you that do not take metformin. Metformin works by suppressing glucose production by the liver. Evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain; in some people, it promotes weight loss. Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines.
    One of my first experiences with diabetes was finding that when I worked out my glucose level would actually increase. That was very frustrating sense I was working out to lower levels of glucose. When I told my doctor she put me on a heavier dose of metformin, 1000 mg twice a day. As with most drugs the treatment of one problem often causes another. There is a whole list of side effects associated with metformin: abdominal or stomach discomfort, cough or hoarseness, decreased appetite, diarrhea, fast or shallow breathing, fever or chills, general feeling of discomfort, lower back or side pain, muscle pain or cramping and painful or difficult urination. Other problems metformin may cause which will usually diminish over time is: Acid or sour stomach, belching, bloated, excess air or gas in the stomach or intestines, full feeling, heartburn, indigestion, loss of appetite, metallic taste in the mouth, passing of gas, stomachache, stomach upset or pain and vomiting. I hope this isn’t too much information!
    My latest experience with metformin was excess air or gas in the stomach. I experienced what seem to be a swelling in my throat followed by belching or burping. I cut my dose of metformin in half and the problem went away. Have any of you experienced discomforts with metformin?

  2. govna

    Let me tell you about my awful 3 year journey with metformin! I dealt with all the horrible side affects for a few years Mostly massive pain and intestinal bloating all that goes with it to the point of doctors taking out my gall bladder then on to a colonoscopy and endoscopy and then on to a stress test! All was "just fine" Finally doc said take me off the metformin since a small percentage of people cannot tolerate metformin. Well low and behold I was one of them! After about two weeks most all of the hellish discomfort disappeared! I now take 50 units of toujeo every morning feel great and found a new lease on life energy wise! I am back baby!!!! It is just a shame looking back on how long I suffered needlessly. Not to mention the metformin wasn't even bringing my sugar down anyhow. All it did was make me extremely sick!!!

  3. Scared ****less

    join the club Metformin was a nightmare too the stomach pain was terrible but lucky my dr took me them a week later

  4. -> Continue reading
read more close
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Original Article Addition Of Metformin To A Lifestyle Modification Program In Adolescents With Insulin Resistance

To evaluate whether metformin, when added to a program of personal goal setting, improves weight loss and clinical status in obese adolescents. In a randomized double-blind placebo controlled trial, 85 adolescents with insulin resistance were randomized to receive metformin (70%) or placebo (30%), along with monthly goal setting for diet and exercise modification. Anthropometric measures, fasting blood analysis, and glucose tolerance tests were performed at baseline and 6 months. Results Mean age was 15.7 years. Mean body mass index (BMI) was 39.7 kg/m2. 71% were female, 58% were Hispanic, and 34% were African-American. 76% of participants completed the study. Goal setting alone did not result in significant weight loss. In addition, there were no group differences between metformin and placebo in weight loss or measures of glucose metabolism. However, among females taking metformin, there was a significant decrease in BMI not seen in the placebo group. Furthermore, metformin adherence, when accompanied by lifestyle change, was a predictor of BMI decrease of 5% or more. 60% of 10 subjects who adhered to metformin and decreased portion size decreased BMI by >5%. Conclusions In this Continue reading >>

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Popular Questions

  1. Dan360

    The good, the bad and the ugly of metformin

    I have been taking metformin sense the day I was first diagnosed with type 2 diabetes. As you probably know, it is the first-line drug of choice for the treatment of type 2 diabetes and I doubt that there are many of you that do not take metformin. Metformin works by suppressing glucose production by the liver. Evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain; in some people, it promotes weight loss. Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines.
    One of my first experiences with diabetes was finding that when I worked out my glucose level would actually increase. That was very frustrating sense I was working out to lower levels of glucose. When I told my doctor she put me on a heavier dose of metformin, 1000 mg twice a day. As with most drugs the treatment of one problem often causes another. There is a whole list of side effects associated with metformin: abdominal or stomach discomfort, cough or hoarseness, decreased appetite, diarrhea, fast or shallow breathing, fever or chills, general feeling of discomfort, lower back or side pain, muscle pain or cramping and painful or difficult urination. Other problems metformin may cause which will usually diminish over time is: Acid or sour stomach, belching, bloated, excess air or gas in the stomach or intestines, full feeling, heartburn, indigestion, loss of appetite, metallic taste in the mouth, passing of gas, stomachache, stomach upset or pain and vomiting. I hope this isn’t too much information!
    My latest experience with metformin was excess air or gas in the stomach. I experienced what seem to be a swelling in my throat followed by belching or burping. I cut my dose of metformin in half and the problem went away. Have any of you experienced discomforts with metformin?

  2. govna

    Let me tell you about my awful 3 year journey with metformin! I dealt with all the horrible side affects for a few years Mostly massive pain and intestinal bloating all that goes with it to the point of doctors taking out my gall bladder then on to a colonoscopy and endoscopy and then on to a stress test! All was "just fine" Finally doc said take me off the metformin since a small percentage of people cannot tolerate metformin. Well low and behold I was one of them! After about two weeks most all of the hellish discomfort disappeared! I now take 50 units of toujeo every morning feel great and found a new lease on life energy wise! I am back baby!!!! It is just a shame looking back on how long I suffered needlessly. Not to mention the metformin wasn't even bringing my sugar down anyhow. All it did was make me extremely sick!!!

  3. Scared ****less

    join the club Metformin was a nightmare too the stomach pain was terrible but lucky my dr took me them a week later

  4. -> Continue reading
read more close

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