Metformin Resistance Over Time

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In Part 1, by Anne Dabrow Woods, MSN, RN, CRNP, ANP-BC, Chief Nurse, Wolters Kluwer Health, Ovid and Lippincott Williams & Wilkins, introduces the principles of Evidence Based Practice.

Metformin: Improving Insulin Sensitivity

Metformin is the only medication in the biguanides category of blood glucose-lowering drugs approved by the U.S. Food and Drug Administration (FDA). Metformin has been available in the United States since the mid-1990s, when it received FDA approval. You may also know it by its brand name when it was under patent, Glucophage. Metformin is now widely available as a relatively inexpensive generic medication. Metformin’s main action is to decrease the overproduction of glucose by the liver, a common problem in prediabetes and type 2 diabetes. The action of metformin helps lower blood sugar levels particularly during the night to keep fasting glucose levels under control, but it also helps control blood glucose throughout the day. Metformin also increases the uptake of glucose by your muscles. Overall, metformin decreases insulin resistance and improves insulin sensitivity, thereby helping the insulin your body still makes work more effectively. People with prediabetes and in the early years of type 2 diabetes often continue to make some insulin, just not enough to control blood sugar levels alone. Metformin is not formally approved for use in prediabetes, and any use to treat predia Continue reading >>

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  1. Cloudlesssky

    I was just wondering how others have coped with Metformin.
    I did the usual gradual introducing over a period of a few weeks, but struggled with the last increase to 4 tablets a day.
    To put "me" into context, I had an emergency admission to hospital in 2010 with pancreatitis which resulted in having my gall bladder removed 10 months later.
    I have had no trouble with this since, but the nurse did wonder if this had been what had kick started the diabetes .... not that is matters because I have it now and so the "why" is less important to me.
    However, after being on the full Metformin dose for a couple of weeks I (don't read on if you're squeamish!) developed the need to visit the loo at least half a dozen times a day in somewhat of a hurry! It was very much like have a nasty bug without any of the pain or stomach cramps!
    After 5 days of not going too far from home (!) I stopped my evening Metformin completely and next day my stomach was virtually back to normal.
    I tried then taking one Metformin in the evening and two in the morning, which is better, but one alternate evenings is better still!
    Sorry to go on, nearly finished!
    What I was wondering is, as my glucose levels have gone down well since September, do you think I should persevere with the Metformin or, as I am still around 9 do you think I should ask about slow release Met, which seems to be better tolerated by some people?
    Thank you for getting to the end of my ramble, and for your thoughts
    Bee Gee

  2. Lazybones

    Not everyone is able to tolerate Metformin, but from what you have said you do seem able to adjust to it given sufficient time. It might be worth asking for the SR version and seeing how you get on with it as many diabetics find it easier to tolerate. The NHS don't usually dish it out unless you ask for it as it costs a little more than the standard Metformin Tablets.
    Having give it a good try out, should things still present you with a problem then there are other diabetic medications that your Dr might consider.
    If you can adjust to Metformin it has many proven advantages particularly as a first line diabetic medication for Type 2 diabetes, so give it a fair trial before ruling it out. Some individuals are known to take many weeks, sometimes months before things finally settle down. did with me and I worked myself through every known side effect in the process.
    Best of luck - Lazybones

  3. Daibell

    Hi. Yes, do ask for Metformin SR (Slow Release) and it should resolve your problems. If it doesn't and you are not overweight I would give up on the Metformin as it only helps a bit anyway with blood sugar. Do keep the carbs down anyway

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Polycystic ovary syndrome or PCOS is the most common problem which causes women to not ovulate. Many women with PCOS have a second problem called insulin resistance. Insulin is the hormone in our bodies which keeps blood sugar low. diabetes, or high blood sugar can be the result of failure to make insulin or more commonly, the failure of insulin to do its job in the body. This latter type is known as insulin resistance. Insulin resistance is known to interfere with ovulation and reducing insulin resistance can improve the chances for ovulation and pregnancy. Methods to reduce insulin resistance include diet, exercise and medication. the most commonly used medication is called metformin. Many studies have found that metformin can help some women with PCOS to ovulate and conceive. If you already ovulate, there is little convincing evidence that metformin will help your fertility. To learn more, subscribe to Infertility TV now or visit our website at IVF1 http://www.ivf1.com http://www.ivf1.com/pcos/ http://www.ivf1.com/insulin-resistance/ Have a topic you would like to see covered? Post a suggestion!

Long-term Effect Of Metformin On Metabolic Parameters In The Polycystic Ovary Syndrome

Go to: Insulin resistance is a central feature of the polycystic ovary syndrome (PCOS) and may increase cardiovascular risk. Due to insulin resistance, the metabolic syndrome is more prevalent in PCOS women compared to normal women. Metformin improves the metabolic profile in PCOS in short-term studies. In this study, we evaluated the long-term effect of metformin on metabolic parameters in PCOS women during routine care without a controlled diet. We performed a retrospective medical chart review of 70 women with PCOS receiving metformin from an academic endocrine clinic. Metabolic risk factors were compared before and after metformin treatment. Time trends of these metabolic parameters were also analyzed. After a mean follow-up of 36.1 months with metformin treatment, improvements were observed for BMI (−1.09±3.48 kg/m2, p=0.0117), diastolic blood pressure (−2.69±10.35 mmHg, p=0.0378), and HDL cholesterol (+5.82±11.02 mg/dL, p<0.0001). The prevalence of metabolic syndrome decreased from 34.3% at baseline to 21.4% (p=0.0495). The course of BMI reduction during metformin treatment was significantly more pronounced in PCOS women with metabolic syndrome at baseline, compared wi Continue reading >>

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    i was diagnosed with PCOS and taking metformin... im losing 1kg every day. ive been taking metformin for 3days now and lose 3kgs. my doctor prescribed me take metformin for 3months... im afraid that ill become underweight..


    Metformin has done some wonderful things for me but weight loss is not one. My endocrinologist did not want to put me on it since I didn't appear to have any metabolic dysfunction. I asked if I could try it anyway. Two years later the calcified cysts on my ovaries are gone and my body pelt has disappeared in some areas or become very fine. My arm hair is normal now. I have been on birth control and spironolactone since 2001 for PCOS symptoms but I wasnt diagnosed until a few years ago. I just had my 6th month blood work done for my endocrinologist and all my levels were good. Its so nice not to have elevated testosterone and be told its because I am fat.


    Metformin helps you lose weight as long as you meet a certain set of conditions. For example, if you're type 1 and have good blood sugar control, Metformin can help you lose weight. If you're type 2 and you don't have good blood sugar control, Metformin will not help you lose weight (though it will help lower your blood sugar). See here for more details: http://www.bootcampforbetics.org/blog/im-u

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Sure, everyone knows that bacon and eggs are a traditional breakfast - but why? Listen in to learn how Freud's nephew invented PR and changed the way America eats breakfast. Learn more at HowStuffWorks.com: http://recipes.howstuffworks.com/baco... Share on Facebook: http://goo.gl/oU943B Share on Twitter: http://goo.gl/0LzXyJ Subscribe: http://goo.gl/ZYI7Gt Visit our site: http://www.brainstuffshow.com Hey internet, its me, Ben. Every day before I head into the studio, I have a healthy, hearty breakfast of eggs, coffee and, of course, bacon. Well, thats not entirely true. Who has their life together enough to eat breakfast every day? Thats crazy talk. Anyway. The point is this: If youre in the States, then you already know that bacon is one of the most popular breakfast foods in civilization right up there with eggs. But this wasnt always the case. For much of American history, breakfast would be something simple like a slice of buttered toast with coffee and orange juice. And, believe it or not, theres one man responsible for changing the way America eats breakfast. His name? Edward Bernays. I know, I know: youre probably wondering how could just one guy sway the minds of millions? Wasnt bacon already around? Yes. Bacon, or cured pork, had been around in European cuisine for hundreds and hundreds of years but it wasnt thought of as a breakfast food. So in 1925, an outfit named the Beech-Nut Packing Company hired Edward Bernays to boost their bacon sales. In a scientific poll, Bernays had a physician ask 5,000 doctors the same loaded question. Is a hearty breakfast [] better than a light breakfast to replace energy lost by the body at night? Because of the way the poll was phrased, most doctors agreed that a hearty breakfast was superior. Bernays reported these scientific results to other doctors across the United States. He also embarked upon a broadcast and print campaign, reporting these results along with advertisements for bacon. This campaign exhibited some brilliant if not exactly ethical - strategies. First, it used the appearance of objective, scientific evidence. Second, this evidence came from trusted authority figures. Third, it sounded like nutritional advice, rather than an ad. Whether you like bacon or not, you cant argue with the results. Beech-Nut profits soared, and today bacon is a major breakfast heavy weight. Each year, people consume more than 1.7 billion pounds of this stuff in the States alone and thats just counting statistics from the food service industry. A little more than half of all US homes keep bacon on hand at all times. SOURCES: https://www.youtube.com/watch?feature... http://baltimorepostexaminer.com/baco... http://www.npr.org/templates/story/st... http://www.apa.org/monitor/2009/12/co... http://www.loveinfographics.com/categ...

Why Is Metformin Considered The Drug Of Choice For Type 2 Diabetes?

Gunda Siska, PharmD, has worked in various fields within the pharmaceutical industry as a licensed pharmacist for more than 20 years. She is currently a staff hospital pharmacist assisting nurses and doctors with drug prescribing, administration, and dispensing, as well as independently monitoring and dosing highly toxic and dangerous drugs. For 2 years, she was concurrently a consultant pharmacist for skilled nursing facilities and nursing homes. Dr. Siska is a member of the New Mexico Society of Health-System Pharmacists and the American Academy of Anti-Aging Medicine. Follow her on Twitter @GundaSiska Metformin is a medication that I believe is underappreciated by the general public. Many people ttell me that their doctor prescribed this drug for them, but they took themselves off of it, but if they knew what I know about metformin, they would have stayed on the medication. This is what I know: metformin extends life. It’s been proven in animal studies1 and in humans. A prospective observational study of nearly 20,000 people with type 2 diabetes mellitus (T2DM) and arteriosclerosis found that metformin use was associated with 24% lower all-cause mortality compared to patients Continue reading >>

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  1. GGrosie

    I have been working since March to get my numbers down and they just slowly keep creeping up. I am now consistently waking up with 120s and spending the entire day never going under 120. I walk my dog three miles in the mornings and often an evening 1-2 mile walk. I run three days a week and do Pilates with weights twice a week . I know it’s not high on the cardio scale but it’s what I can get myself to do consistently.
    I am 5’6” 128 pounds and definitely in perimenopause. Sometimes my sleep is fabulous, but lately I have many periods of wakeful moments during the evening (I’m assuming lack of sleep and hormones aren’t helping my cause). When have people started metformin (I don’t relish the side effects) but would rather not have that diabetes diagnosis quite yet? I met with an edocronologist in May but he wasn't interested in seeing me until I was diabetic, didn't see the reason to test daily, and was rather dismissive. My last A1C was 6.0 and I thought I had been better but it continued to rise from my previous 5.9. I’m guessing my next one will be higher with my recent meter readings and want to have a knowledgeable conversation with the doctor when results come back in.
    My diet consists of 60-80 carbs a day, mostly vegetarian although I’m eating more chicken to increase lower fat protein as I was gaining weight in my efforts.

  2. Goodgirl08

    Hi G, you are a diabetic. If you can not get your number under 120 then you need to see a CDE . She will go over diet and see where it needs to be changed. If that does not work, then you will need Meds. You can see a internist for what you have and everything else.

  3. abill

    With T2 the signal to block the liver releasing 'sugar is messed up. metformin will help the liver not release 'sugar' and 2,000mg may lower your A1c by 0.5 to 1.5%. and I would ask about metformin, because of its many benefits.
    I would think the rise is hormone based and T2 woman of that age may need to greatly reduce the carbs, to reduce the insulin resistance
    the macros use insulin in different amounts, fat uses the least amount and has the least effect on your BG. This is one of the reasons why a lot use the LCHF diet, The fat is burnt for energy
    100% of carbs turn to glucose
    58% of protein turn to glucose
    10% of fat turn to glucose.
    This is one of the reasons why the carb and protein consumption counting is more important than the fat.
    to maintain your weight and blood glucose numbers first is to minimise carbs and insulin/insulin resistance, some need to go down to 50g or even 20g
    protein could be 75g a day
    fat makes up the rest of the calories for energy, you eat till you are satisfied
    when low carbing, once under 50g carb. protein is used to adjust weight, fat is burnt as energy because the body is fat adapted and isn't stored as body fat.
    Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence based using a LCHF diet

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