Metformin Pros And Cons

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Pros And Cons Of Pioglitazone

Home / Resources / Articles / Pros and Cons of Pioglitazone Should it be used in treating type 2 diabetes? Pioglitazone is an oral anti-hyperglycemic drug in the thiazolidinedione class that improves insulin sensitivity and may lower HbA1c by 1%. It has been used in patients with type 2 diabetes for over a decade. A recent review of the literature gave a breakdown of the pros and cons of pioglitazone use in type 2 diabetes. Pros: Reduction in HbA1c of about 1%, improvement in insulin resistance in type 2 diabetics, and positive effects on insulin secretion and lipid metabolism. Pioglitazone has been shown to cause an increase in HDL cholesterol, as well as a decrease in triglycerides. Although it has been reported to cause a 10-15% increase in LDL cholesterol, this increase is more associated with an increase in the type A LDL particles and a decrease in the type B LDL particles. The type A LDL particles are less atherogenic than their type B LDL counterparts. Cons: Thiazolidinedione drugs, including pioglitazone, have been associated with edema and increased risk of congestive heart failure, and should not be used in patients with heart failure. Additionally, pioglitazone use has Continue reading >>

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  1. Dan360

    The good, the bad and the ugly of metformin

    I have been taking metformin sense the day I was first diagnosed with type 2 diabetes. As you probably know, it is the first-line drug of choice for the treatment of type 2 diabetes and I doubt that there are many of you that do not take metformin. Metformin works by suppressing glucose production by the liver. Evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels and is not associated with weight gain; in some people, it promotes weight loss. Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines.
    One of my first experiences with diabetes was finding that when I worked out my glucose level would actually increase. That was very frustrating sense I was working out to lower levels of glucose. When I told my doctor she put me on a heavier dose of metformin, 1000 mg twice a day. As with most drugs the treatment of one problem often causes another. There is a whole list of side effects associated with metformin: abdominal or stomach discomfort, cough or hoarseness, decreased appetite, diarrhea, fast or shallow breathing, fever or chills, general feeling of discomfort, lower back or side pain, muscle pain or cramping and painful or difficult urination. Other problems metformin may cause which will usually diminish over time is: Acid or sour stomach, belching, bloated, excess air or gas in the stomach or intestines, full feeling, heartburn, indigestion, loss of appetite, metallic taste in the mouth, passing of gas, stomachache, stomach upset or pain and vomiting. I hope this isn’t too much information!
    My latest experience with metformin was excess air or gas in the stomach. I experienced what seem to be a swelling in my throat followed by belching or burping. I cut my dose of metformin in half and the problem went away. Have any of you experienced discomforts with metformin?

  2. govna

    Let me tell you about my awful 3 year journey with metformin! I dealt with all the horrible side affects for a few years Mostly massive pain and intestinal bloating all that goes with it to the point of doctors taking out my gall bladder then on to a colonoscopy and endoscopy and then on to a stress test! All was "just fine" Finally doc said take me off the metformin since a small percentage of people cannot tolerate metformin. Well low and behold I was one of them! After about two weeks most all of the hellish discomfort disappeared! I now take 50 units of toujeo every morning feel great and found a new lease on life energy wise! I am back baby!!!! It is just a shame looking back on how long I suffered needlessly. Not to mention the metformin wasn't even bringing my sugar down anyhow. All it did was make me extremely sick!!!

  3. Scared ****less

    join the club Metformin was a nightmare too the stomach pain was terrible but lucky my dr took me them a week later

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