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An Analysis Of Dosing Equivalence Of Insulin Detemir And Insulin Glargine: More Evidence?

Current guidelines for the management of type 2 diabetes call for the use of basal insulin when glycemic targets are not achieved, despite the use of oral antihyperglycemic medications.1,2 Controversy remains in the medical literature regarding the comparative efficacy of insulin detemir and insulin glargine, both of which have demonstrated superiority over neutral protamine Hagedorn insulin. While two published studies have demonstrated noninferiority of insulin detemir and insulin glargine, both studies were designed to dose insulin detemir twice daily if predinner glucose levels were elevated, whereas insulin glargine was only dosed once daily regardless of predinner glucose levels.3,4 A third study is underway with a similar design,5 but does not address the comparative efficacy of once-daily administration of these two basal insulins. In this issue of Journal of Diabetes Science and Technology, Dr. Allen King provides further important details of his previously published trial that provides important data in addressing this issue.6,7In this randomized, double-blinded, crossover trial, once-daily insulin detemir was compared with insulin glargine in 29 patients with type 2 diab Continue reading >>

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Popular Questions

  1. daisy707

    Switching from Lantus to Levemir?

    Hi all,
    I am posting because my insurance plan changed and it might not be covering my Lantus any longer, but the letter I received says it will cover Tresiba, Levemir, or Basaglar.
    I know nothing at all about Tresiba or Basaglar, but do know of Levemir as my mother uses it.
    The letter also says that I can ask my doctor for generic prescriptions, but I am unfamiliar with any generics for Lantus, does anyone know if there is one? I am reading up on all of this tonight by the way, but I am always first to post here because you all make it less stressful!
    I take 15u of Lantus at midnight before bed, and that's it, I don't split my dosage, so I just wanted to see what the experiences were switching to another insulin for others.
    Has anyone switched from Lantus to Levemir? What were the differences if any? Was the transition smooth? How did you calculate your dosage/did it change at all (one single dose to a split dose)?
    Has anyone switched from Lantus to either of the other two insulins? I haven't read anything on them so I will have to just to see, but because I am familiar with Levemir I figured it would be my first to look into.
    Just another hoop and a jump-skip to go through at the beginning of the year with insurance But I'm sure I will figure things out! Thanks for the help all!!

  2. daisy707

    And as soon as I posted this I see that Basaglar is very similar to Lantus! GOOD TO KNOW! I know that it's easy to Google things, but I still like hearing everyone's feedback

  3. Lloyd

    Lantus lasts from 18 to 26 hours. Levemir lasts from 12 to 16 hours. So, depending on your needs, a split dosage might be in order.

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