Lantus Solostar Storage

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Lantus (insulin Glargine) Dose, Indications, Adverse Effects, Interactions... From Pdr.net

Hormone secreted by pancreatic beta-cells of the islets of Langerhans and essential for the metabolism and homeostasis of carbohydrate, fat, and protein. Insulin glargine is a once-daily basal insulin analog without pronounced peaks. BASAGLAR, Lantus, Lantus SoloStar, Toujeo SoloStar BASAGLAR/Lantus/Lantus SoloStar/Toujeo SoloStar Subcutaneous Inj Sol: 1mL, 100U, 300U For the treatment of type 1 diabetes mellitus and type 2 diabetes mellitus. For the treatment of type 1 diabetes mellitus. Subcutaneous dosage (100 units/mL, i.e., Lantus, Basaglar) Initially, administer one-third of the total daily insulin requirements/dose subcutaneously once daily. Titrate dosage to achieve blood glucose control and A1C goals in conjunction with a short-acting insulin. Give the dose at the same time every day, at any time. Administration in the morning may avoid nocturnal hypoglycemia. When transferring from once daily NPH insulin, the dose is usually not changed. However, when transferring from twice-daily NPH insulin to insulin glargine, the total daily dose of NPH insulin (or other twice daily basal insulin) should be reduced by 20% and administered as single dose once daily. When transferring Continue reading >>

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Popular Questions

  1. stefani&toonces

    I got a question from a rescue group today that prompted me to look up Sanofi-Aventis' online infomation about shelf life and storage of lantus.
    I was shocked to see the instructions emphatically said NOT to refrigerate the solostar pens. I always have done that.
    Does anyone know why they say this? Do those of you who use the solostar pens refrigerate them or not?
    BTW, what prompted me to look this up was my need to prove that lantus is supposed to be discarded after 28 days. Sadly, a woman who contacted the rescue and reported that her cat had recently died from "diabetes and cancer" was offering her left over lantus for use. When I told the rescue lady it would do me no good if it was over 28 days old, the owner of the deceased cat responded that her veterinarian told her the loss of potency after 28 days applies only to humans, not animals, and he advised her to keep using the same vial for up to 6 months. This may explain why diabetic complications played a role in teh cats demise.
    This is the second vet I've heard of tell a pet owner they could keep using lantus until it is all used up. A guy came on this list that I went to coach on home testing (Randall and Sheba) and the vet at the shelter clinic (which is well reputed) told him he could keep using the lantus vial until it was gone. No surprise, all of a sudden his cat was showing symptoms of not responding to treatment. I think he had a hard time believing my word over that of a vet.
    How can vets be so stuipid that they think loss of drug potency wouldn't apply to cats? Is there any document on this that I can anonymously send to these vets? I am sure they are still telling people they can use a vial up!

  2. Frip&Grip

    My pharmacist told me NOT to refrigerate the solostar pen. I'm new to this but I have not refrigerate mine.
    According to the instructions, it must be kept between 15-30 C once opened (important these past few days, it’s hot around here above 30 C (if you don’t have AC), I’ve been checking temperature 3-4 times a day where I keep it just to make sure it's OK. Sure would be easier to keep in the fridge.
    She also told me it could be used up to 3 months or until I notice it doesn’t seem effective. I kept the first one 30 days…

  3. Sienne and Gabby (GA)

    There's been considerable discussion here (both new and old board) and I also think there was a thread in Think Tank about this topic.
    There's a statement in the Tilly Protocol about the shelf life of Lantus once opened.
    Tight Regulation Protocol said:
    • members of the German Diabetes-Katzen Forum buy 3 ml Lantus/Levemir cartridges, refrigerate them after opening and routinely use them for 6 months or more - when refrigerated, opened cartridges of these insulins are extraordinarily stable FWIW, when I've bought Lantus from a chain pharmacy, university medical center, or on-line through Canada, the boxes have always been refrigerated. Likewise, I've always kept the unopened and opened pens refrigerated. That said, I believe Monique pointed out that the packaging of Lantus in pens and their not requiring refrigeration was innovative. It gave human diabetics a great deal more flexibility with travel since their medication did not require refrigeration. It should also be noted that humans use more insulin per shot and they would finish a pen much sooner than we do with our cats.
    The 28 day issue is one which I was curious enough about that I called the pharmacy at the U of IL vet school and spoke with one of the veterinary pharmacists. She could not find anything in the pharmacology literature about why there is a 28 day duration. She was intrigued enough to post on a vet pharmacy listserv. No one had a clear explanation as to why there was a 28 day shelf life. It is the manufacturers recommendation and ostensibly, the 28-day period had to be approved by the FDA. That said, no one seems to be able to find a justification. The pharmacist did say, though, that she would not recommend using Lantus beyond the 28 days recommended by the manufacturer. From the standpoint of the drug company, if a human used Lantus beyond 28 days and developed DKA, the person could not claim it was the fault of the drug. (Also keep in mind, there is no veterinary indication for Lantus. It is only approved for human use.)
    There are many people here who get longer than 28 days from their Lantus providing they don't shake, rattle or roll the vial or pen. On the other hand, I know I find that Gabby's numbers will get wonky if I don't discard my pens at around the 28 day point. The two times I went a week or more beyond that point, Gabby's numbers suffered. I do tend to think some cats are more sensitive to some of the potency issues than other cats.

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