Lack Of Hypoglycemic Symptoms And Decreased Beta-adrenergic Sensitivity Ininsulin-dependent Diabetic Patients.
1. J Clin Endocrinol Metab. 1988 Feb;66(2):273-8. Lack of hypoglycemic symptoms and decreased beta-adrenergic sensitivity ininsulin-dependent diabetic patients. Berlin I(1), Grimaldi A, Landault C, Zoghbi F, Thervet F, Puech AJ, Legrand JC. (1)Department of Clinical Pharmacology, Hpital Piti-Salptrire, Paris, France. Plasma epinephrine, norepinephrine, and dopamine responses were studied ininsulin-dependent diabetic patients at rest, on standing and duringinsulin-induced hypoglycemia. beta-Adrenergic sensitivity was evaluated by theisoproterenol sensitivity test. Five men who had adrenergic symptoms duringhypoglycemia and no severe hypoglycemic accidents (coma, seizures) (group A) and five men who had repeated severe hypoglycemic accidents but lack of adrenergicsymptoms of hypoglycemia (group B) were studied. The mean resting plasmaepinephrine was lower in group B (147 +/- 22 pmol/L, SEM) than in group A (398+/- 98 pmol/L, P less than 0.02). On standing plasma epinephrine increasedsignificantly in both groups. During hypoglycemia blood glucose decreasedidentically in the two groups; plasma epinephrine and norepinephrine increasedsignificantly and to the same extent in both groups; Continue reading >>