The Placebo Effect The placebo effect is one of the strangest and least understood phenomenons found in human physiology and psychology. The placebo effect happens when you decide a therapy will make you better and your belief makes it so. But is the placebo effect real or is it in your head? Make sure to SUBSCRIBE! http://bit.ly/18A7Qki SHARE THIS VIDEO - http://on.fb.me/1lrtzYv Check out our website - http://plethrons.com Like us on Facebook - https://www.facebook.com/PlethronsCha... Follow us on Twitter - https://twitter.com/plethrons - - - - - - - - - - - Check out The Factiod - http://bit.ly/1l7Yqnt
Long-term Treatment With Metformin In Obese, Insulin-resistant Adolescents: Results Of A Randomized Double-blinded Placebo-controlled Trial
As adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used. In this study, the long-term efficacy and safety of metformin versus placebo in adolescents with obesity and insulin resistance is studied. In a randomized placebo-controlled double-blinded trial, 62 adolescents with obesity aged 10–16 years old with insulin resistance received 2000 mg of metformin or placebo daily and physical training twice weekly over 18 months. Primary end points were change in body mass index (BMI) and insulin resistance measured by the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Secondary end points were safety and tolerability of metformin. Other end points were body fat percentage and HbA1c. Forty-two participants completed the 18-month study (66% girls, median age 13 (12–15) years, BMI 30.0 (28.3 to 35.0) kg m−2 and HOMA-IR 4.08 (2.40 to 5.88)). Median ΔBMI was +0.2 (−2.9 to 1.3) kg m−2 (metformin) versus +1.2 (−0.3 to 2.4) kg m−2 (placebo) (P=0.015). No significant difference was observed for HOMA-IR. No serious adverse events were reported. Median change in fa
What is INSULIN RESISTANCE? What does INSULIN RESISTANCE mean? INSULIN RESISTANCE meaning - INSULIN RESISTANCE definition - INSULIN RESISTANCE explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin. The body produces insulin when glucose starts to be released into the bloodstream from the digestion of carbohydrates in the diet. Normally this insulin response triggers glucose being taken into body cells, to be used for energy, and inhibits the body from using fat for energy. The concentration of glucose in the blood decreases as a result, staying within the normal range even when a large amount of carbohydrates is consumed. When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. This often remains undetected and can contribute to a diagnosis of type 2 diabetes or latent autoimmune diabetes of adults. Although this type of chronic insulin resistance is harmful, during acute illness it is actually a well-evolved protective mechanism. Recent investigations have revealed that insulin resistance helps to conserve the brain's glucose supply by preventing muscles from taking up excessive glucose. Insulin resistance should even be strengthened under harsh metabolic conditions such as pregnancy, during which the expanding fetal brain demands more glucose. People who develop type 2 diabetes usually pass through earlier stages of insulin resistance and prediabetes, although those often go undiagnosed. Insulin resistance is a syndrome (a set of signs and symptoms) resulting from reduced insulin action; it is also part of a larger constellation of symptoms called the metabolic syndrome. Insulin resistance may also develop in patients who have recently experienced abdominal or bariatric procedures. This acute form of insulin resistance that may result post-operatively tends to increase over the short-term with sensitivity to insulin typically returning to patients after about five days.
Pro/con: Metformin For Pediatric Patients With Insulin Resistance
Is metformin a much-needed treatment for pediatric patients or an ineffective substitute for lifestyle intervention? Although metformin is widely-used as a treatment for adults with diabetes and insulin resistance, its use in pediatric patients is somewhat controversial. At the Pediatric Academic Societies’ 2006 Annual Meeting, held recently in San Francisco, two leading physicians debated the use of metformin as a treatment for insulin resistance in pediatric patients. Michael Freemark, MD, chief of the division of endocrinology and diabetes in the pediatrics department of Duke University Medical Center, said he supports metformin treatment in pediatric patients. In contrast, Philip Scott Zeitler, MD, PhD, associate professor of pediatrics at the University of Colorado School of Medicine, was opposed to metformin treatment in this population, saying lifestyle interventions should be encouraged for these patients. A needed treatment? Freemark said metformin can and should be used to treat selected pediatric patients with insulin resistance. “We are dealing with a very serious problem,” he said. “This can be seen in the recent surges in the complications of obesity and insul
In order to run cool on those hot summer days, your engine needs to have a consistent flow of coolant supplied from the radiator throughout the engine. The water pump is the primary component responsible for maintaining this flow. When it works properly, your car will maintain a consistent operating temperature, run smoothly, and take you anywhere you need to travel. When the water pump fails or is beginning to wear out, it can lead to complete engine failure. When the water cooled (as opposed to air cooled) engine was introduced, many automotive experts believed that the water pump circulating coolant through the engine block was just as critical to engine protection as oil. This philosophy holds true even as technology has improved over the years to create more efficient cooling systems in today's modern cars. Your cars water pump is the key to making the entire system work. It is an impeller pump and is usually buried under the timing belt cover on the side of the engine. The pump is operated by the engines drive belt as the belt turns, the pump turns. Blades on the pump force coolant to flow through the engine and back to the radiator to be cooled by a forced air cooling fan. Although the water pumps in most modern cars, trucks, and SUVs will last a long time, they are by no means indestructible. Like any other mechanical device, they will produce a few warning signs that they are wearing out, so that car owners can contact a local ASE certified mechanic to replace the water pump before additional engine components are damaged. 1. Coolant leak at the front-center of your car The water pump is comprised of multiple gaskets and seals that keep coolant contained and ensure that consistent flow of coolant is delivered from the radiator to the engine. Eventually, these gaskets and seals will wear out, dry up, crack or break entirely. When this happens, coolant will leak from the water pump and drop to the ground, typically in the front of your car and in the center of the motor's location. If you notice that there is a leak of coolant (which will appear to be green or sometimes red in color) under the center of your car, truck or SUV, contact a professional mechanic to inspect this problem. More often than not, it's a leak from the water pump that can be repaired before it gets worse. 2. Water pump pulley is loose and making whining sounds From time to time you might hear a high pitched sound that comes from the front of the motor. This is typically caused by a loose belt that creates a harmonic buzzing or whining sound as it circulates. The loose belt is commonly caused by a pulley that has become loose or that the bearings that operate the water pump assembly are wearing out. Once the bearings fail inside the water pump, it means the unit cannot be repaired and will need to be replaced entirely. If you notice that there is a loud whining sound coming from the front of your motor that increases in volume as you accelerate, contact a mechanic as soon as possible to inspect your vehicle. 3. Engine is overheating When the water pump fails completely, it will not be able to circulate coolant through the engine block. This results in an overheating situation and if not repaired or replaced quickly, can cause additional engine damage like cracked cylinder heads, pushed head gaskets, or burnt pistons. More About BundysGarage: https://goo.gl/qv3Wzc Questions, Comments, Concerns: [email protected] Twitter: https://twitter.com/bundysgarage @bundysgarage On The Web: http://www.bundysgarage.com Music by Randall Kent: As seen on NCIS https://youtu.be/iYwsjia4GtI All Rights Reserved 2018 Copyright 2018 Bundys Garage All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part with out the express written permission. Contact: [email protected] DISCLAIMER - DISCLAIMER - DISCLAIMER Due to factors beyond the control of BundysGarage, it cannot guarantee against unauthorized modifications of this information, or improper use of this information. BundysGarage assumes no liability for property damage or injury incurred as a result of any of the information contained in this video. BundysGarage recommends safe practices when working with power tools, automotive lifts, lifting tools, jack stands, electrical equipment, blunt instruments, chemicals, lubricants, or any other tools or equipment seen or implied in this video. Due to factors beyond the control of BundysGarage, no information contained in this video shall create any express or implied warranty or guarantee of any particular result. Any injury, damage or loss that may result from improper use of these tools, equipment, or the information contained in this video is the sole responsibility of the end user and not BundysGarage nor any of its subsidiaries.
Effects Of Metformin On Insulin Resistance And Metabolic Disorders Intumor-bearing Rats With Advanced Cachexia.
1. Can J Physiol Pharmacol. 2018 Jan 5:1-8. doi: 10.1139/cjpp-2017-0171. [Epub aheadof print] Effects of metformin on insulin resistance and metabolic disorders intumor-bearing rats with advanced cachexia. de Fatima Silva F(1), Ortiz-Silva M(1), Galia WBS(1), Cassolla P(1), da SilvaFG(2), Graciano MFR(1), Carpinelli AR(2), de Souza HM(1). (1)a Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil. (2)b Department of Physiology and Biophysics, University of So Paulo, 05508-900, So Paulo, SP, Brazil. Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistanceand metabolic disorders associated with cancer cachexia is not established. Weinvestigated the MET effects, isolated or associated with INS, on INS resistance and metabolic changes induced by Walker-256 tumor in rats with advanced cachexia.MET (500 mgkg-1, oral) and MET + INS (1.0 IUkg-1, s.c.) were administered for12 days, starting on the day of tumor cell inoculation. Tumor-bearing rats showedadipose and muscle mass wasting, body mass loss, anorexia, decreased Aktphosphorylation i
by Ruchi Mathur, MD, FRCPC Dr. Mathur is Assistant Professor of Medicine, Cedars Sinai Medical Center, University of California, Los Angeles, California. Bariatric Times. 2011;8(1):10–12 Abstract Metformin is a widely perscribed drug for the treatment of diabetes and is often used off label for the treatment of prediabetes and insulin resistance. In addition to its primary use, metformin has often been cited as having weight loss benefits. This ...
How effective is Victoza for Insulin Resistance Syndrome (Insulin resistance) ? 13 Victoza users have rated its effectiveness for Insulin resistance syndrome. Overall ratings: 2.8/5 Long term ratings: 0/5 This is a reivew of how effective Victoza (liraglutide) is for Insulin resistance syndrome and for what kind of people. The study is created by eHealthMe and is updated continuously. On eHealthMe you can find out what patients like me (same gen ...
Six-Month Clinical Trial Reveals Addition of Metformin Fails to Improve Glycemic Control in Adolescents Living with Type 1 Diabetes Showed improvements to cardiovascular risks—reduced weight, BMI, total daily insulin usage BOSTON, December 1, 2015––Six months of adjunctive metformin therapy does not improve glycemic outcomes in obese adolescents with type 1 diabetes, according to new research from T1D Exchange and funded by the JDRF. Howeve ...
Metformin is the top of the line medication option for Pre-Diabetes and Type 2 Diabetes. If you must start taking medication for your newly diagnosed condition, it is then likely that your healthcare provider will prescribe this medication. Taking care of beta cells is an important thing. If you help to shield them from demise, they will keep your blood sugar down. This medication is important for your beta cell safety if you have Type 2 Diabetes ...
Polycystic Ovarian Syndrome, or PCOS, and Insulin Resistance (IR) often occur simultaneously. While the connection between these two conditions is, as of yet, not entirely clear, researchers have determined that IR can lead to PCOS and diabetes.1 Metformin, or Glucophage, is commonly prescribed for both of these disorders, as it is assumed to reduce IR and improve the symptoms associated with it (such as high blood sugar). Understanding the Fine ...
Managing insulin resistance: role of liraglutide 1Department of Endocrinology, Bharti Hospital, Karnal, India 2Department of Clinical Operations, Excel Life Sciences, Noida, India Correspondence: Sanjay Kalra, Bharti Hospital, Kunjpura Road, Karnal-132001, India, Tel +91 921 5848555, Fax +91 184 4046554, Email [email protected] Author information Copyright and License information Disclaimer Copyright 2010 Kalra et al, publisher and licensee Dov ...