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Insulin Overdose Antidote

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Members of my hospital pharmacy academy have access to my masterclass training on High Dose Insulin Euglycemia For CCB / Beta Blocker OD which covers the background, use, and weaning of high dose insulin as well as a sample protocol. To access this and over 30 other trainings go to pharmacyjoe.com/academy.

Treatment Of Calcium-channel–blocker Intoxication With Insulin Infusion

To the Editor: Overdose of calcium-channel blockers remains an important cause of fatal poisoning.1 Conventional therapy, consisting of intravenous fluids, calcium, dopamine, dobutamine, norepinephrine, and glucagon, often fails to improve hemodynamic function in intoxicated patients.2 Recent recommendations for treatment of intoxication with calcium-channel blockers include induction of hyperinsulinemia and euglycemia as adjunctive therapy.3 We report two cases of overdose of calcium-channel blockers in which a striking benefit was achieved with hyperinsulinemia–euglycemia therapy. A 34-year-old nondiabetic woman with hypertension and renal failure ingested 12 extended-release tablets containing 2.5 mg of amlodipine each. Hypotension and bradycardia developed. Because of her history of renal failure, the treating physicians did not administer calcium and instead provided intravenous fluids, vasopressors, and glucagon. A 48-year-old nondiabetic man with hypertension, chronic obstructive pulmonary disease, congestive heart failure, and depression was witnessed ingesting an unknown amount of extended-release diltiazem. He became hemodynamically unstable in the emergency department Continue reading >>

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  1. loveofrn

    we do not assignment for students without them trying to use google or their textbook to find the answers.

  2. loveofrn

    do you mean magnesium sulfate?

  3. ButterflyRN90, ASN, LPN

    Quote from cwebb
    Can anyone please tell me where I can find out about Insulin antidotes and where & why my professor's answer is D10 & D50? Also the antidote for heparin sodium, and the antidote for Morphine Sulfate (Ms Contin)? To find the answer, figure out what D10 and D50 are. Also, you must know what insulin is and does. Once you find that out,you'll be able to answer.

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Management Of Sulfonylurea Overdose

Introduction There are multiple oral agents available for the treatment of diabetes. These include several pharmacological classes: the sulfonylureas, biguanides, a-glucosidase inhibitors, thiolidinediones, and metglitinides. The biguaniudes, glycosidase inhibitors, and glitazones do not increase insulin secretion and are therefore unlikely to lead to hypoglycemia in overdose. In the U.S., the sulfonylureas and metformin (the only available biguanide) are by far the most widely prescribed oral antidiabetic agents. Consequently sulfonylureas are involved in the vast majority of oral hypoglycemic toxicity. Untreated, overdose of sulfonylurea medications may cause significant morbidity or mortality. Furthermore, these agents may be particularly dangerous for pediatric patients, as even small doses (1-2 pills) may produce deadly effects in a toddler. This article will focus on the pathophysiology, recognition, and treatment of acute sulfonylurea overdose. Case presentation A 2 year-old male is brought to the emergency department by his parents approximately 30 minutes after being found playing with his grandfather’s medication bottles. Most of the containers in question were child-re Continue reading >>

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Popular Questions

  1. loveofrn

    we do not assignment for students without them trying to use google or their textbook to find the answers.

  2. loveofrn

    do you mean magnesium sulfate?

  3. ButterflyRN90, ASN, LPN

    Quote from cwebb
    Can anyone please tell me where I can find out about Insulin antidotes and where & why my professor's answer is D10 & D50? Also the antidote for heparin sodium, and the antidote for Morphine Sulfate (Ms Contin)? To find the answer, figure out what D10 and D50 are. Also, you must know what insulin is and does. Once you find that out,you'll be able to answer.

  4. -> Continue reading
read more
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FULL VIDEO: https://goo.gl/J51NC9?87146

Treatment Of Sulfonylurea And Insulin Overdose

Abstract The most common toxicity associated with sulfonylureas and insulin is hypoglycaemia. The article reviews existing evidence to better guide hypoglycaemia management. Sulfonylureas and insulin have narrow therapeutic indices; small doses can cause hypoglycaemia, which may be delayed and persistent. All children and adults with intentional overdoses need to be referred for medical assessment and treatment. Unintentional supratherapeutic ingestions can be initially managed at home but if symptomatic or experience persistent hypoglycaemia require medical referral. Patients often require intensive care and prolonged observation periods. Blood glucose concentrations should be assessed frequently. Asymptomatic children with unintentional sulfonylurea ingestions should be observed for 12 hours, except if this would lead to discharge at night when they should be kept until the morning. Prophylactic intravenous dextrose is not recommended. The goal of therapy is to restore and maintain euglycaemia for the duration of the drug's toxic effect. Enteral feeding is recommended in patients who are alert and able to tolerate oral intake. Once insulin or sulfonylurea-induced hypoglycaemia ha Continue reading >>

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Popular Questions

  1. loveofrn

    we do not assignment for students without them trying to use google or their textbook to find the answers.

  2. loveofrn

    do you mean magnesium sulfate?

  3. ButterflyRN90, ASN, LPN

    Quote from cwebb
    Can anyone please tell me where I can find out about Insulin antidotes and where & why my professor's answer is D10 & D50? Also the antidote for heparin sodium, and the antidote for Morphine Sulfate (Ms Contin)? To find the answer, figure out what D10 and D50 are. Also, you must know what insulin is and does. Once you find that out,you'll be able to answer.

  4. -> Continue reading
read more

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