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Insulin Like Growth Factor And Diabetes

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Insulin-like Growth Factors (igfs) And Igf-i Treatment In The Adolescent With Insulin-dependent Diabetes Mellitus

Abstract Insulin-dependent diabetes mellitus (IDDM) during adolescence is associated with complex derangements of the growth hormone (GH)/insulin-like growth factor (IGF) axis. Despite GH hypersecretion, IGF-I levels and IGF bioactivity are reduced. The diabetogenic effects of GH are well established, and GH hypersecretion has been implicated in the deterioration in glycemic control during adolescence and in the development of microangiopathy. Insulin deficiency or reduced portal delivery of insulin plays a central role in the development of these abnormalities, and although continuous subcutaneous insulin delivery may improve plasma IGF-I levels, it does not necessarily suppress GH levels. Recombinant IGF-I has been proposed as an adjunct to conventional insulin therapy, as restoring circulating IGF-I levels might lead to GH suppression. Placebo-controlled studies have shown a consistent reduction in GH secretion and related improvements in insulin sensitivity following a single subcutaneous IGF-I injection (40 μg/kg). Repeated daily subcutaneous IGF-I administration for 1 month resulted in a sustained increase in IGF-I levels, as well as a reduction in GH secretion and insulin r Continue reading >>

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Popular Questions

  1. JD2109

    Hi this is my first post on here .So has anybody heard anything about research into I.G.F and the claims by an American doctor that this treatment is a cure for diabeties ? Type 1 and type 2 he claims can be cured in a 14 day course of treatment , Also he recons that the large pharmisuitical firms know all about I.G.F but are refusing to back the research because it would cost them millions in lost revenue.

  2. noblehead

    Welcome to the forum
    Never heard of the research, but if there was a known cure available it would be more widely known about by now.

  3. Brunneria

    JD2109 said: ↑
    Hi this is my first post on here .So has anybody heard anything about research into I.G.F and the claims by an American doctor that this treatment is a cure for diabeties ? Type 1 and type 2 he claims can be cured in a 14 day course of treatment , Also he recons that the large pharmisuitical firms know all about I.G.F but are refusing to back the research because it would cost them millions in lost revenue. Yes, we have had a couple of other people appearing with similar queries to your own.
    Unless they produce good quality links (no sales pitch, dodgy claims) and they provide clear, verifiable evidence, I just dismiss it as snake oil salesmanship.

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