diabetestalk.net

Insulin Antibodies Treatment

Share on facebook

Insulin Resistance: Definition And Clinical Spectrum

INTRODUCTION Insulin resistance can be broadly defined as a subnormal biological response to normal insulin concentrations. By this definition, it may pertain to many biological actions of insulin in many tissues of the body. Typically, however, in clinical practice, insulin resistance refers to a state in which a given concentration of insulin is associated with a subnormal glucose response [1]. The term first came into use several years after the introduction of insulin therapy in 1922 to describe occasional diabetic patients who required increasingly large doses of insulin to control hyperglycemia. Most of these patients developed insulin resistance secondary to antibodies directed against the therapeutic insulin, which at that time was both impure and derived from non-human species [2]. Antiinsulin antibodies are rare in patients treated with recombinant human insulin, and the spectrum of clinical disorders in which insulin resistance plays a major role has changed markedly. Insulin resistance, rather than being a rare complication of the treatment of diabetes, is now recognized as a component of several disorders, including the following (table 1): Extreme insulin-resistance s Continue reading >>

Share on facebook

Popular Questions

  1. hsa04930

    DRUG: Insulin human

    Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
    A ALIMENTARY TRACT AND METABOLISM
    A10 DRUGS USED IN DIABETES
    A10A INSULINS AND ANALOGUES
    A10AB Insulins and analogues for injection, fast-acting
    A10AB01 Insulin (human)
    D03230 Insulin human (USP/INN)
    A10AC Insulins and analogues for injection, intermediate-acting
    A10AC01 Insulin (human)
    D03230 Insulin human (USP/INN)
    A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
    A10AD01 Insulin (human)
    D03230 Insulin human (USP/INN)
    A10AE Insulins and analogues for injection, long-acting
    A10AE01 Insulin (human)
    D03230 Insulin human (USP/INN)
    A10AF Insulins and analogues for inhalation
    A10AF01 Insulin (human)
    D03230 Insulin human (USP/INN)
    USP drug classification [BR:br08302]
    Blood Glucose Regulators
    Insulins
    Insulin human (regular)
    D03230 Insulin human (USP/INN)
    Therapeutic category of drugs in Japan [BR:br08301]
    2 Agents affecting individual organs
    24 Hormones
    249 Miscellaneous
    2492 Pancreatic hormones
    D03230 Insulin human (USP/INN); Insulin human (genetical recombination) (JP17); Insulin human (genetical recombination) injection (JP17); Insulin human (biosynthesis) (JAN); Insulin human (synthesis) (JAN)
    Target-based classification of drugs [BR:br08310]
    Cytokine receptors
    Receptor tyrosine kinase
    RTK class II (Insulin receptor family)
    insulin receptor
    Insulin (human)
    D03230 Insulin human (USP/INN)
    Cytochrome P450 interactions [BR:br08309]
    CYP inducers
    CYP1A2
    Insulin (human)
    D03230 Insulin human (USP/INN)
    Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
    Chemicals
    D03230 Insulin human (genetical recombination)
    D03230 Insulin human (genetical recombination) injection
    Antidiabetics [br08361.html]
    D03230
    New drug approvals in Europe [br08329.html]
    European public assessment reports (EPAR) authorised medicine
    D03230

  2. -> Continue reading
read more close

Related Articles

Popular Articles

More in insulin