How Many Amino Acids Are There In Insulin?

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Study Group Discussion: Largest Protein And The Smallest Protein In The Human Body

How many amino acids make up a protein ? Which protein is smallest in the human body? Thyroid releasing hormone or TRH should be the smallest protein in the human body, with 234 amino acids. (> 100 amino acids is a protein.) Smallest polypeptide in the human body should be insulin, with 54 amino acids. (10-100 amino acids is a polypeptide.) Smallest peptide in the human body should be glutathione, with 3 amino acids. (<10 amino acids is a peptide.) I concluded these on what I found on Google. Correct me if I'm wrong. Largest protein is titin in the human body! Interesting virology fact:- The largest viruses as Poxviruses measuring 300nm are as large as the smallest bacteria (mycoplasma). The smallest viruses as Parvovirus measuring about 20nm are nearly as small as one of the largest protein molecule, hemocyanin. Continue reading >>

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  1. K. M.

    How many amino acids do the insulin protein of apes and chimanpzees compose of?!

  2. alec_djinn

    On the Ensembl website you can find an easy way to compare genetic sequences of the available genome references, including the one of several primates.
    Here a query example: http://www.ensembl.org/Homo_sapiens/Gene/Compara_Alignments?align=822&db=core&g=ENSG00000254647&r=11%3A2159779-2161341
    For protein sequences, check the Uniprot website. For insulin, this is the page you are looking for http://www.uniprot.org/uniprot/P01308 Check the paragraph "Similar proteins", there you will find all the links to retreive the insulin sequence from all the species for which we have sequencing data.

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