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How Long Can Insulin Be Stored At Room Temperature

Can Insulin Go Back In The Fridge?

Can Insulin Go Back In The Fridge?

After removing insulin glargine (Lantus) from the refrigerator for use, can it be refrigerated over and over again after having warmed to room temperature, or does this degrade it? Continue reading >>

How Do I Store Unopened Insulin Bottles?

How Do I Store Unopened Insulin Bottles?

Store newly purchased, unopened bottles of insulin in the refrigerator in their original carton to keep them clean and protected from light. When you're ready to use a bottle of insulin, you can remove it from the fridge and generally keep it at room temperature (below 86 degrees F) for up to one month. But the sterility and potency of an opened bottle of insulin are affected by the number of insulin injections per day, the volume of insulin remaining in the bottle and exposure to light and agitation. For this reason, it's important to discuss your insulin dosage and storage—and review patient information available on the insulin manufacturer’s website—with the doctor treating your diabetes. You should also check opened bottles of insulin carefully for discoloration or particles. Never store insulin in the freezer or in direct sunlight and always be sure to check the expiration date. By Joyce A. Generali, M.S. FASHP, R.Ph., director of the University of Kansas Drug Information Center and the author of The Pharmacy Technician’s Pocket Drug Reference From our sister publication, Diabetes Focus, Summer 2011 Publication Review By: the Editorial Staff at HealthCommunities.com Last Modified: 11 Sep 2015 Continue reading >>

Insulin Use Tips

Insulin Use Tips

Before each use, take a moment to inspect the insulin prior to drawing it into the syringe; clear insulins should appear not discolored and clear; suspended insulins should be uniform in their cloudiness. [1][2] Do not use the insulin if: The bottle looks frosted. [3][4][5][6][7][8] Clear insulin that looks discolored or has turned cloudy, contains particles or haze. [9] Cloudy insulin that appears yellowish or remains lumpy or clotted after mixing. [10][8] See Insulin problems for more information about "bad" insulin. Damaged Insulin: Insulin that is getting too old, or has been dropped or shaken or mishandled, or exposed to a lot of light or heat, will be less effective than before. Freezing [11] destroys the molecules of ANY insulin; any that has either been frozen or is suspected of having been frozen should not be used. Insulin which has been frozen will not be able to do an effective job of controlling blood glucose. [12] Check for discoloration or floating objects in the insulin -- it may also be contaminated. It's also possible that the new or newer vial from the pharmacy may be flawed. If you've recently started it and are having problems, this might be the case. Taking down the lot number and getting a new vial that has a different batch/lot number should take care of this. Frosted insulin: If insulin is subjected to temperature extremes, such as freezing or overheating, the insulin can precipitate [13] on the vial's walls, giving it a frosty or frosted appearance.[5] Another term used to describe this is flocculation. [7][14] In the photo above, the insulin vial on the right is a visual example of what a frosted vial would look like. You can see the precipitated insulin clinging to the sides of it. The problem seems to be a particular one with R-DNA/GE/GM NPH Continue reading >>

Thermometers + Insulin

Thermometers + Insulin

Sometimes diabetes pushes us to our limits. Sometimes it feels like we are pushing our diabetes tools to their limits. If you’ve ever wondered how long was too long to keep that vial of insulin in your desk drawer at work, or if you’ve accidentally left the pharmacy bag in the front seat of the car overnight (in winter or summer), check out this guide to learn the effects of temperature on insulin. At what temperature should insulin be kept? When keeping insulin in your fridge at home for long-term storage, the MedAngel team recommends storing it on a center shelf. This helps avoid the back of the fridge, where it could freeze, and the door — even though the butter shelf makes for a handy insulin shelf — where insulin can get too warm due to opening and closing. “We recommend storing it in a Tupperware box or airtight container, mostly the center shelf,” says Laura Krämer, a pharmacist at MedAngel. “[Storing it in] a fridge that is used less is even better because opening it frequently changes the temperature. Typically you get quarterly or half-year prescriptions, so you have meds in the fridge for at least three months. It’s important to get that right.” Do I really need to keep a thermometer with my insulin? If you want to know for sure what your fridge is doing to your medications, because as is the case with other aspects of diabetes, knowledge is power. Laura warns, “There’s a temperature monitor in every warehouse, ship, plane, and truck that stores medications. If there is a slight deviation from the norm, the distributor needs to call the manufacturer and consult based on documentation [to determine] if the product is still good for sale. But then, medicines stay at our house and travel with us for months.” Without a thermometer, Laura Continue reading >>

Storage

Storage

NovoLog® Storage Home or Away, NovoLog® Goes With You NovoLog® lasts up to 28 days without refrigeration after first use, so it can be taken almost anywhere. Once in use, NovoLog® FlexPen® must be kept at room temperature below 86°F for up to 28 days. Its ability to stand up to heat is equal to, or better than, other major fast-acting insulin brands. Here is a quick guide to NovoLog® storage: Storage for NovoLog® FlexPen® 3 mL PenFill® cartridge,a and 10mL vial: Temperature Use up to In useb,c (opened) Room temperature: up to 86°F 28 days Not in use (unopened) Room temperature: up to 86°F 28 days Not in use (unopened) Refrigerated: 36°F to 46°F Expiration date a3 mL PenFill® cartridge is available for NovoPen Echo®. bFlexPen® and PenFill® cartridges in use (opened) must NOT be stored in the refrigerator. cIn use vials (opened) may be stored in the refrigerator. Do's: Don'ts: Do store unused NovoLog® in a refrigerator between 36° to 46°F (2° and 8°C) Don’t store NovoLog® in the freezer or directly adjacent to the refrigerator cooling element Don’t freeze NovoLog® or use NovoLog® if it has been frozen Don’t draw NovoLog® into a syringe and store for later use Do keep vials at temperatures below 86°F (30°C) for up to 28 days after initial use. Opened vials may be refrigerated Do use unpunctured vials until the expiration date printed on the label if they are stored in a refrigerator Do keep unused vials in the carton so they will stay clean and protected from light Don’t expose vials to excessive heat or light Do keep NovoLog® FlexPen® at temperatures below 86°F (30°C) for up to 28 days once it is punctured Don’t store in use NovoLog® FlexPen® in the refrigerator Do keep NovoLog® FlexPen® and all PenFill® cartridges away from Continue reading >>

Storage Of Insulin In Rural Areas

Storage Of Insulin In Rural Areas

Sanjay Kalra1, Bharti Kalra2 1 Department of Endocrinology, Bharti Hospital, Bharti Research Institute of Diabetes and Endocrinology, Karnal, Haryana, India 2 Department of Gynaecology, Bharti Hospital, Bharti Research Institute of Diabetes and Endocrinology, Karnal, Haryana, India Correspondence Address: Bharti Hospital, Kunjpura Road, Karnal - 132001, Haryana India Source of Support: None, Conflict of Interest: None DOI: 10.4103/2249-4855.118669 Sir, It is well-known that many drugs, biological products, and vaccines are temperature-sensitive. One life-saving drug, which needs to be stored under temperature-regulated condition, is insulin. [1] Insulin is a life-saving product used for the management of all type 1, and many type 2 diabetes patients. It is a polypeptide, produced by recombinant DNA technology, using either E. coli or Saccharomyces sp. [2] Insulin analogs or modern insulins are also available, which are produced by changing the chemical structure of the insulin molecule. Insulin can be classified as rapid or fasting acting, e.g., human insulin, aspart insulin, lispro insulin, and glulisine insulin; pre-mixed e.g., pre-mixed human insulin, aspart and lispro; intermediate- acting, e.g., NPH insulin, and long acting, e.g., detemir and glargine insulin. For optimal effect, insulin need to be stored under refrigerated conditions, between 2 and 8°C, and be protected from light when vials or pens are unopened. [3] Pens or vials in use may be kept at room temperature, protected from sunlight, up to 25°C. Exposure to higher temperatures during storage and use may degrade insulin by hydrolysis, or transform it to higher molecular weight components. [4] A study performed in Puducherry, India, showed that storage of regular and biphasic insulin at 32°C and 37°C Continue reading >>

Storing Insulin And Prefilling Syringes

Storing Insulin And Prefilling Syringes

Insulin can become damaged and ineffective if it is not stored properly. Unopened insulin that is packaged in small glass bottles (vials) should be stored in the refrigerator. Liquid insulin that is packaged in small cartridges (containing several doses) is more stable. These cartridges are used in pen-shaped devices (insulin pens) with attached disposable needles. Keep unopened pens and cartridges in the refrigerator. After you open them, store them at room temperature. Powdered insulin cartridges are packaged in blocks of three on cards sealed in foil. Keep unopened foil packages in the refrigerator. After you open a foil package, use the contents within 10 days. And after you tear off and open a block of three, discard any unused insulin after 3 days. Always read the insulin package information that tells the best way to store your insulin. You can keep open bottles with you if you keep them in a dark place. The bottles should not be exposed to temperatures below36F (2.2C) or above86F (30C). Never leave insulin in the sun or in your hot car, because sunlight and heat reduce the strength of the insulin. Avoid shaking insulin bottles and liquid insulin cartridges too much to prevent loss of medicine strength and to prevent clumping, frosting, or particles settling out. Follow the storage information provided by the manufacturer. The first time you use an insulin bottle, write the date on the bottle label. Always store an extra bottle of each type of your insulin in the refrigerator. If you cannot prepare an insulin dose but can give the injection, you may need someone to prepare your insulin dose for you. A family member, friend, or health professional can prefill insulin syringes for you. If you prefill syringes: Store the prefilled syringes in the refrigerator with Continue reading >>

How Long Should Insulin Be Used Once A Vial Is Started?

How Long Should Insulin Be Used Once A Vial Is Started?

Editor’s comment: The commentary by Dr. Grajower has such important clinical relevance that responses were invited from the three pharmaceutical companies that supply insulin in the U.S. and the American Diabetes Association, and all of these combined in this commentary. The commenting letter and individual responses were authored separately and are completely independent of each other. Diabetic patients treated with insulin, whether for type 1 or type 2 diabetes, are prone to often unexplained swings in their blood glucose. These swings can vary from dangerously low to persistently high levels. Most diabetic patients, and most physicians, will adjust insulin regimens so as to avoid hypoglycemia at the expense of hyperglycemia. Among the “textbook” reasons for variable glucose responses to any given insulin regimen are 1) site of administration, 2) exercise, 3) bottles not adequately mixed before drawing the insulin (for NPH, Lente, or Ultralente), and 4) duration of treatment with insulin (1). A new insulin was marketed by Aventis Pharmaceuticals about 1 year ago, insulin glargine (Lantus). The manufacturer seemed to stress that patients not use a started bottle of this insulin for >28 days (2). Two patients of mine highlighted this point. L.K. is a 76-year-old woman with type 2 diabetes, diagnosed at 55 years of age, and treated with insulin since age 56. Her insulin regimen was changed to Lantus at night together with Novolog before meals. She monitors her blood glucose four times a day. She used a bottle of Lantus until it ran out; therefore, a bottle lasted for 2 months. Her recent HbA1c was 7.6%. I retrospectively analyzed her home glucose readings by averaging her fasting blood glucose levels for the first 15 days of a new bottle and the last 15 days of tha Continue reading >>

Must Insulin Be Stored In The Refrigerator?

Must Insulin Be Stored In The Refrigerator?

I have a newly diagnosed diabetic dog on NPH insulin, whose owner has not been refrigerating the insulin (Novolin N). I instructed him to store the open insulin vial in the refrigerator. However, the pharmacy where he purchased the insulin put a sticker on the vial that says it can be left at room temperature. The owner also claims he looked it up online and says it doesn't have to be refrigerated. I have always been taught that insulin must remain in the refrigerator or it loses it's "potency." I did look up the FDA Patient Package Insert online, which says the following: All Unopened Novolin N: Keep all unopened Novolin N in the refrigerator between 36° to 46°F (2° to 8°C). Do not freeze. Do not use Novolin N if it has been frozen. If refrigeration is not possible, the unopened vial may be kept at room temperature for up to 6 weeks (42 days), as long as it is kept at or below 77°F (25°C). Keep unopened Novolin N in the carton to protect from light. Opened Novolin N Vials: Keep at room temperature below 77°F (25°C) for up to 6 weeks (42 days). Keep vials away from direct heat or light. Throw away an opened vial after 6 weeks (42 days) of use, even if there is insulin left in the vial. Unopened vials can be used until the expiration date on the Novolin N label, if the medicine has been stored in a refrigerator. So, is it okay for this man to leave the opened insulin at room temperature? This owner has been doing so for several weeks now but we still haven't gotten the dog regulated! My Response: Yes, it is fine to leave an opened NPH insulin vial at room temperature, but if left out of the refrigerator, we should discard it after 6 weeks (1-3). In extremely hot climates, it has been recommended that the vial be replaced even more frequently if left unrefrigerate Continue reading >>

How To Store Your Insulin

How To Store Your Insulin

Check the expiration date first. Do not use insulin past expiration. Keeping your ‘current’ insulin (i.e., a few days or a week’s supply) at room temperature can help alleviate injection discomfort. Insulin available in vials can usually be stored at room temperature for about a month. Insulin in a pen should be stored at room temperature once in use. Expiration date of insulin pens can vary depending upon the type of insulin. For disposable pens, the entire device is discarded when empty or when expiration date is reached. Store extra insulin (2-3 week supply or more) in the refrigerator. Do not expose insulin to excessive cold (e.g., in a freezer) or heat (e.g., in direct sunlight). Continue reading >>

Information Regarding Insulin Storage And Switching Between Products In An Emergency

Information Regarding Insulin Storage And Switching Between Products In An Emergency

en Español Insulin Storage and Effectiveness Insulin for Injection Insulin from various manufacturers is often made available to patients in an emergency and may be different from a patient's usual insulin. After a disaster, patients in the affected area may not have access to refrigeration. According to the product labels from all three U.S. insulin manufacturers, it is recommended that insulin be stored in a refrigerator at approximately 36°F to 46°F. Unopened and stored in this manner, these products maintain potency until the expiration date on the package. Insulin products contained in vials or cartridges supplied by the manufacturers (opened or unopened) may be left unrefrigerated at a temperature between 59°F and 86°F for up to 28 days and continue to work. However, an insulin product that has been altered for the purpose of dilution or by removal from the manufacturer’s original vial should be discarded within two weeks. Note: Insulin loses some effectiveness when exposed to extreme temperatures. The longer the exposure to extreme temperatures, the less effective the insulin becomes. This can result in loss of blood glucose control over time. Under emergency conditions, you might still need to use insulin that has been stored above 86°F. You should try to keep insulin as cool as possible. If you are using ice, avoid freezing the insulin. Do not use insulin that has been frozen. Keep insulin away from direct heat and out of direct sunlight. When properly stored insulin becomes available again, the insulin vials that have been exposed to these extreme conditions should be discarded and replaced as soon as possible. If patients or healthcare providers have specific questions about the suitability of their insulin, they may call the respective manufacturer a Continue reading >>

Tracking Insulin's Health In The Summer Heat

Tracking Insulin's Health In The Summer Heat

Sunscreen: check. Water bottle: check. Beach ball: check. Insulin cooler....? Yep. For those of us who use insulin, summer heat creates an extra level of complexity and worry. The real question we all ask ourselves in the heat of the summer is whether our fun-in-the-sun will cook our insulin and leave us having-not-so-much-fun in an air conditioned ICU unit? There's a whole industry of solutions dedicated to helping us keep our insulin cool, ranging from cooling packs such as the ReliOn and others, to portable fridges, to high tech cooling crystals. Hell, we're even running a Giveaway contest this week in which our readers can win some of these products! With much of the U.S. suffering under a stifling drought-baked summer, the question of just how hot insulin can get is on all our minds. But you have to wonder if these products are serving an important need or just preying on our fears. To find out, we asked the manufacturers themselves, some leading insulin experts, and the American Diabetes Association — and guess what? The answer isn't as clear as you might like. Not Your Grandma's Insulin First, a bit of history: Didn't grandma keep her insulin in the fridge all the time? Well, only if she read the label. The original pork and beef insulin formulations were supposed to be kept cold all the time. As cold insulin stings like hell to inject, the move to being able to keep the newer human insulin and later analogs at room temperature was a great victory (!) for those of us who are human pin cushions. But wait a minute... whose room temperature are we talking about? My father used to get annoyed with me when I'd shovel ice cubes into my glass of red wine. "Wine is supposed to be consumed at room temperature," he'd huff. "Yeah, in the frickin' French Alps,where room te Continue reading >>

How Long Can Insulin Stay Out Of Fridge Temps.

How Long Can Insulin Stay Out Of Fridge Temps.

How long can insulin stay out of fridge temps. Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. How long can insulin stay out of fridge temps. How long is it ok to keep insulin at normal room temperatures and maybe warmer for? I'm concerned about my 8 hour flight next week to NY. My 4 months insulin suply will be with me in my hand-lugage for whole 2 days before i will be able to refrigerate it. I don't usually keep my pens in the fridge at all, just the insulin I haven't opened, my pens are usually ok for a week. I'm just concerned about my hwole 4 months suply getting too warm Laura Lu, Your insulin should fare just fine for your eight hour flight. Keeping it in your hand luggage is smart. The planes are kept at a comfortable temp for insulin. Refrigerate it when you arrive and you will be just fine. If you feel so inclined you can get freezer packs, but you will have to do some fancy explaining at the gate. Usually, you can get your packs through the inspection if you have adequate reason. KGM managed to get her freezer packs through hand luggage inspection by claiming she needed to keep her insulin cool. All they can do is make you throw it out. Yea,for 8 hours insuline is ok....!!!but be careful,if insuline dosen't work buy new package of insuline... My insulin was fine when I flew from NY to Ireland a few years ago. I had to keep it in my luggage in a hostel for a WEEK before i finally found a flat and could use the refrigerator. I was a little nervous about the whole 6 month supply going bad, but it was fine. This was, however, in Ireland in winter. During those 2 days will you be in airports / airplanes and hotels that have a/c for Continue reading >>

How To Store Insulin

How To Store Insulin

If you need to take insulin to manage diabetes, your first concern may be when and how to give yourself injections. But learning how to properly store insulin should also be a priority. That's because insulin is sensitive to changes in temperature and will become useless if not handled properly. "Insulin is a small protein, and as such it can be denatured at a very high or very low temperature," says George Grunberger, MD, chairman of the Grunberger Diabetes Institute in Bloomfield Hills, Mich., a clinical professor of internal medicine and molecular medicine and genetics at Wayne State University School of Medicine in Detroit, and vice president of the American Association of Clinical Endocrinologists. "Extreme temperatures can destroy it." Some people become so worried about how to store insulin that they allow the medication to rule their lives. "I know people who haven't taken a vacation in 30 years because they don't have a refrigerator in their car," Dr. Grunberger says. But in truth, storing insulin is relatively simple, especially when you understand how to care for it properly. How to Store Insulin In general, store any unopened vials or pens of insulin in a refrigerator to protect the insulin from spoiling. Never store insulin in a freezer because the extreme cold will damage the medication. Be sure to never use insulin that has been frozen, even after it has been thawed. You can store insulin at room temperature once you've opened it for use, as long as you keep it away from direct sunlight and other sources of heat. Some people store opened insulin in a refrigerator, but Grunberger says that creates unnecessary discomfort because injecting cold insulin often stings. Once opened, insulin is good for only about a month before it should be thrown away, whether Continue reading >>

Insulin Pens Are Welcome Back To The Fridge!

Insulin Pens Are Welcome Back To The Fridge!

We all know that unopened insulin must be kept in the refrigerator. But once in use can we put it back in the fridge to protect it from excessive heat? The answer to this simple question is not as easy as one might think. All manufacturers explicitly recommend to ‘Not refrigerate’ insulin pens in use. This guideline that causes confusion among users is now being revoked by one manufacturer. Let’s try to understand the reasoning behind it and what it means for users now. What? I shouldn’t put my insulin pen back in the refrigerator? When it comes to storing medications, it is recommended you follow the leaflet or packaging instructions. For insulin in particular, there are two different situations: storing and in-use. · Before Opening: When insulin is to be stored long-term and has not been opened, keeping it in the fridge ensures it lasts until expiration date. · During Use: Once a vial, a cartridge or a new disposable pen are used for the first time, the insulin can be kept at room temperature. But it needs to be used within weeks. It makes sense: higher temperatures and an open product mean a shorter shelf life. But there is one extra sentence on insulin pens packages, which has caused quite some confusion: Pens in use — ‘Do not refrigerate.’ What does ‘do not refrigerate’ mean for users? Let’s take a trip back to 2003, when the recommendation to not refrigerate opened insulin first appeared. Take Lilly’s Humalog for example, for which the label was first altered 14-years ago: What was the reason behind this? People started to speculate this warning was a result of preventing any kind of temperature extremes from affecting the insulin once it is in use. Many insulin users know from experience that high temperature can lower the effectiveness of Continue reading >>

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