How Does Use Of Insulin Lead To Hypokalemia?

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Hypokalemia And Hyperkalemia

Physiology of Potassium Handling Potassium (K+) is the most abundant cation in the body. About 90% of total body potassium is intracellular and 10% is in extracellular fluid, of which less than 1% is composed of plasma. The ratio of intracellular to extracellular potassium determines neuromuscular and cardiovascular excitability, which is why serum potassium is normally regulated within a narrow range of 3.5 to 5.0 mmol/L. Dietary K+ intake is highly variable, ranging from as low as 40 mmol/day to more than 100 mmol/day.1, 2 Homeostasis is maintained by two systems. One regulates K+ excretion, or external balance through the kidneys and intestines, and the second regulates K+ shifts, or internal balance between intracellular and extracellular fluid compartments. Internal balance is mainly mediated by insulin and catecholamines. Cellular Shifts Ingested K+ is absorbed rapidly and enters the portal circulation, where it stimulates insulin secretion. Insulin increases Na+,K+-ATPase activity and facilitates potassium entry into cells, thereby averting hyperkalemia. β2-Adrenergic stimulation also promotes entry of K+ into cells through increased cyclic adenosine monophosphate (cAMP) ac Continue reading >>

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Popular Questions

  1. cybron

    Can you plz tell me why insulin cuZ hypokalemia???

  2. Master shifu

    Insulin results Hypokalemia just by increasing the activity of H*K ATPase pump. So insulin only shifts the K+ from the extracellular compartment to the intracellular compartment, it doesn't decrease the total K+ content of the body........remember it......that's why during management of Hyperkalemia 1st initial therapy is done by giving Insulin + Glucose combination which usually needs 30 minutes to come into action........Hope it helps

  3. cybron

    Thanks master but i heard there is increase activity of Na/K pump not H/K pump..can u plz clarify??
    If H/K pump increases then acid production also increases??

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