How Does Insulin Affect Protein?

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Protein Metabolism In Insulin-dependent Diabetes Mellitus

Protein Metabolism in Insulin-Dependent Diabetes Mellitus Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, MN To whom correspondence should be addressed: Mayo Clinic and Foundation, Eisenberg 3-G, 200 First Street S. W., Rochester, MN 55905. Search for other works by this author on: Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, MN Search for other works by this author on: The Journal of Nutrition, Volume 128, Issue 2, 1 February 1998, Pages 323S327S, Michael Charlton, K. Sreekumaran Nair; Protein Metabolism in Insulin-Dependent Diabetes Mellitus, The Journal of Nutrition, Volume 128, Issue 2, 1 February 1998, Pages 323S327S, Patients with insulin-dependent diabetes are in a catabolic state without insulin replacement. The mechanism of insulin's anticatabolic effect has been investigated in whole-body and regional tracer kinetic studies. Whole-body studies have demonstrated that there are increases in both protein breakdown and protein synthesis during insulin deprivation. Because the magnitude of the increase in protein breakdown is greater than the magnitude of the increase in protein synthesis, there is a net protein loss during insulin deprivati Continue reading >>

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  1. CherryAA

    The FII is not something I've thought about before before, though no doubt there are many on here who have, so any thoughts on this would be much appreciated .
    Insulin load for various foods here
    it seems to help explain two things to me
    a) why processed foods including fats and carbs are worse for you than an equivalent real food - because they need more insulin to process and
    b) why diary foods sometimes need to be limited - because their insulin load is higher than one would predict with skimmed milk being particularly bad
    Any views on the FII would be most helpful

  2. Guzzler

    Can you edit the last bit of your post re 'bad o glucose...' please. I'm not quite following. Ty.

  3. Contralto

    I fail to understand the insulin load and how it is measured.
    The glycemic load is a formal based result dependent on the hundreds of diabetics testing individuals food and weeing when and how those food spike. the formula considers fiber %
    But who is testing what and how for the insulin load?????

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What is ACTION PLAN? What does ACTION PLAN mean? ACTION PLAN meaning - ACTION PLAN definition - ACTION PLAN explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. n action plan is a detailed plan outlining actions needed to reach one or more goals. Alternatively, businessdictionary.com defines an action plan as a "sequence of steps that must be taken, or activities that must be performed well, for a strategy to succeed". Producing an action plan can be beneficial not only for individual basis but also for businesses. For example, it allows project managers or any member of a group to monitor their progress and take each task step-by-step, therefore allowing them to handle the project efficiently. The advantage of doing this is, it allows you to execute a structured plan for the end goal you intend to achieve. Furthermore, it provides the team with appropriate foundations, therefore prioritising the amount of time you spend on each task. This will then prevent any sidetracking that may occur. Lastly, it creates a bond within a team, as each member is aware of their individual role, as well as providing necessary information to ens

Insulin Action On Protein Metabolism

Volume 7, Issue 4 , October 1993, Pages 989-1005 Author links open overlay panel GianniBiolo Robert R.Wolfe Get rights and content On the basis of the preceding observations, the following sequence of events can be postulated during insulin deficiency or excess. The main feature of insulin deficiency is the disruption of protein balance in muscle that rapidly leads to emaciation and wasting. Muscle protein degradation is greatly enhanced while increased amino acid availability maintains protein synthesis. In splanchnic tissues, both degradation and synthesis are increased but with an altered pattern, so that the levels of some proteins are increased (e.g. proteins of the acute-phase response), while those of others are decreased (e.g. albumin). As a result, intracellular protein content in liver is maintained but secretion of plasma proteins is abnormal. In healthy subjects, an acute increase in insulin concentration, as occurs after a meal, leads to a rapid suppression of protein breakdown in the splanchnic area. If hyperinsulinaemia is not supported by an exogenous amino acid supply, as might occur during a protein-free meal or experimentally during euglycaemic hyperinsulinaemic Continue reading >>

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  1. Donna Fritz

    IV insulin

    We are giving IV push insulin on our med-surg units. A procedure was writting for this. I would like your comments on this aspect:
    How do I administer IVP Insulin?
    · Draw up the Insulin in an Insulin syringe, transfer to 3 or 5 cc syringe, dilute with 3-5 cc NS and administer within one minute, utilize needless port closest to the IV access; flush with 10cc NS afterwards, even if there is a running IV.
    · Reason for flushing: Insulin sticks to the IV tubing and it is not clear how much medication passes from the infusion port to the patient.
    I am concerned about transferring from the insulin syringe to a 3-5 cc syringe because of contamination during the process of transfer. Also, what about dilution? Doesn't a slower rate of administration via a NS mainline accomplish the same thing?

  2. lynncrni

    You have good reason to be

    You have good reason to be concerned about a procedure requiring syringe-to-syringe drug transfer. The 2011 INS standards state this should be avoided, see page S60, Practice Criteria I. The reference for this is from ISMP. I would need to know the rationale used by the procedure authors about why they think this is necessary. It could be they only have insulin syringes with a fixed needle that can not be attached to your needleless connectors, but there are insulin syringes with removable needles available. It could also be the old concept of not using any syringe smaller than a 10 mL on any CVC. But you did not say this was only for CVC use. If the catheter is open and patent with flow fluids, assessed with a 10 mL saline filled syringe for absence of resistance and good blood return, then it is appropriate to use a syringe size that is best for the drug volume being given. Transfer to another syringe increases risk of contamination and loss of part of the measured dose.
    Insulin does adhere to the plastic of fluid containers and sets, but there is no evidence that flushing will make any difference. You are correct that the infusion of primary fluid will dilute any drug being given as a push through the line.
    Transferring all drugs between syringes is a dangerous and unnecessary practice, in my opinion. Lynn
    Lynn Hadaway, M.Ed., RN, BC, CRNI
    Lynn Hadaway Associates, Inc.
    126 Main Street, PO Box 10
    Milner, GA 30257
    Website http://www.hadawayassociates.com
    Office Phone 770-358-7861

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Hands or other parts of your body can be involved as well, but much less often 20, uncontrolled blood sugar wreak havoc on diabetics' nervous systems. Nerve damage (diabetic neuropathies) can diabetes cause fatigue, body ache? The chart cnn blogs. High blood sugar levels over a long time can damage your nerves. Diabetic neuropathy pain symptoms & treatments medicinenet. Diabetic neuropathy the doctor will see you now. These aren't benign beliefs and they can cause you to forego everything see all rankings aching calves, burning legs, numbness in the feet pain discomfort muscle function, affect amount of water your body as well. About diabetic nerve pain a rx treatment option. Ringworm (a ring shaped itchy patch), and vaginal infection that causes itching using non narcotic pain relievers consistently throughout the day rather neuropathy can cause a host of different types symptoms, depending on whether nerves in legs, gastrointestinal tract, or elsewhere body are affected 5, this happens around half people with type 2 diabetes. Metformin be a i also am taking metformin twice day 500 mg, for diabetes. Joslin diabetes symptoms common of. It can happen in several ways, and they all se

All About Insulin

What is insulin? Insulin is a peptide hormone secreted by the pancreas in response to increases in blood sugar, usually following a meal. However, you don’t have to eat a meal to secrete insulin. In fact, the pancreas always secretes a low level of insulin. After a meal, the amount of insulin secreted into the blood increases as blood sugar rises. Similarly, as blood sugar falls, insulin secretion by the pancreas decreases. Insulin thus acts as an “anabolic” or storage hormone. In fact, many have called insulin “the most anabolic hormone”. Once insulin is in the blood, it shuttles glucose (carbohydrates), amino acids, and blood fats into the cells of the body. If these nutrients are shuttled primarily into muscle cells, then the muscles grow and body fat is managed. If these nutrients are shuttled primarily into fat cells, then muscle mass is unchanged and body fat is increased. Insulin’s main actions Rapid (seconds) Increases transport of glucose, amino acids (among the amino acids most strongly transported are valine, leucine, isoleucine, tyrosine and phenylalanine), and potassium into insulin-sensitive cells Intermediate (minutes) Stimulates protein synthesis (insuli Continue reading >>

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  1. ugeniac

    I was told that too this summer by a new Endo but went back alter to my usual one and after a C PEPTIDE test it was determined that my pancreas was still making a small amount of insulin.
    Because I now have CKD, stage 3, I am almost entirely dependent upon Insulin,both short acting before meals and Long acting before bedtime. before breakfast I am taking a moderate dosage of Januvia, 50 mg.

  2. Type1Lou

    The C-peptide is a blood test done to determine if the pancreas is producing any insulin at all. If it finds that the pancreas doesn't produce insulin, you are classified as a Type 1 and must use insulin (shots or pump) to manage your diabetes. If the test reveals that you are still producing insulin, you would most likely be categorized as a Type 2 and may have other treatment options (oral meds, diet, exercise or insulin) available to you to manage your diabetes. My pancreas stopped producing insulin when I was 27 because an auto-immune response destroyed the islet cells in the pancreas which is where insulin is produced. It is currently unknown what triggers that auto-immune response.

  3. ugeniac

    CKD is Chronic Kidney Disease and is usually determined by the blood level of Creatinine. The renal Function tests may include urine testing too, to look for protein (usually albumin). My egfr, the Estimated Glucose Filtration Rate, went down since summer of 2010, from 66 to 34 this spring and summer. below 30 means stage 4! Stage 5 is dialysis or transplant or …
    My endocrinologists assumed that my pancreas was not producing Insulin anymore so the C Peptide test was done (just a blood sample needed). It is similar to measuring Insulin Levels,which I had not had done for at least FIVE years!
    In type 2 diabetes, Insulin is either absent or ineffective due to high resistance.

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