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How Does Exercise Affect Insulin Sensitivity?

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Insulin Resistance

Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin. The body produces insulin when glucose starts to be released into the bloodstream from the digestion of carbohydrates in the diet. Normally this insulin response triggers glucose being taken into body cells, to be used for energy, and inhibits the body from using fat for energy. The concentration of glucose in the blood decreases as a result, staying within the normal range even when a large amount of carbohydrates is consumed. When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. This often remains undetected and can contribute to the development of type 2 diabetes or latent autoimmune diabetes of adults.[1] Although this type of chronic insulin resistance is harmful, during acute illness it is actually a well-evolved protective mechanism. Recent investigations have revealed that insulin resistance helps to conserve Continue reading >>

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Popular Questions

  1. Graceliu

    Help please!!! PCOS-Metformin and Pregnancy

    Hello everyone, I am so happy to find this group today as I have been desperate for a long time.
    I got my first period at the age of 15, then irregular period till now( 28 years old). Sometimes it is three times a year sometimes it is once a year.So I think I am having PCOS for a very long time.
    Now I am trying to get pregnant so hard. My husband and I did all the test but it seems nothing wrong except my PCOS.
    I followed the doctor's advice and started to take Metformin. First I took Utovlan for 7 days to get my period. Meantime I took the Metformin.About 15 days after period ended, I did the Ovulation test and it was positive so my husband and I had sex during that two days. But now 20 day has passed, I didn't have my period neither get pregnant.I am totally panic! Could anyone tell me what happened? I called my doctor many times but she is on holiday. I stopped Metformin right after I found the positive ovulation result because I read the Metformin leaflet that"Do not take Metformin if you are pregnant, planning to become pregnant---" Now I know I was wrong I should continue with it.
    I restart to take Metformin today.Should I take this meds until I am pregnant? Did anyone have the similar exprience?
    Thank you guys for reading my post. I have been crying a lot these two years for a baby.It kills me that I could't have one---
    Love you all
    Grace

  2. KellyBelly80

    Big Hugs Grace, I know exactly how you are feeling. YES carry on taking it!!!
    I started taking metformin a year ago after going back and forth to the docs telling them something was wrong (hadn't ovulated for a year after losing a baby and AF's were really erratic). Was diagnosed with PCOS (Polycystic Ovary Syndrome) after a scan and given metformin.
    I was told to stop taking it when I got a positive pregnancy test, but I researched a bit on the internet and there is research that suggests metformin actually helps to reduce the rate of miscarriage. I carried on taking it until I was 20 weeks, and was under a consultant who actually stated it doesn't harm the baby at all and it will state not to take if pregnant as it is primarily a diabetic drug. Metformin was really a wonder drug for me, I started taking it on the 4th June 2009 and got my BFP (big fat positive (pregnancy test)) on 5th Sept 09 - and had my beautiful daughter 5 weeks ago.
    I will definately be taking it until I'm at least 14 weeks next time too, good luck, keep on with it and I hope you get your BFP (big fat positive (pregnancy test)) soon.

  3. Melrsa

    Hi, I was on clomid first and had 3 chemical pregnancies and then when I didn't ovulate I was also given metformin, So I took my last cycle of clomid along with the metformin and I got pregnant again, this time it stuck.
    I was also worried about whether to carry on with the metformin and saw that many women had mc after stopping and so I carried on taking it. I told my midwife I was on it and she said it won't effect the baby but to probably stop taking it once I was 12 weeks, which I did and all is fine.
    I really hope it works for you soon and just keep on taking it.

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