Glucagon And Insulin Are Antagonists Of Each Other Justify The Statement

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How Insulin And Glucagon Work

Insulin and glucagon are hormones that help regulate the levels of blood glucose, or sugar, in your body. Glucose, which comes from the food you eat, moves through your bloodstream to help fuel your body. Insulin and glucagon work together to balance your blood sugar levels, keeping them in the narrow range that your body requires. These hormones are like the yin and yang of blood glucose maintenance. Read on to learn more about how they function and what can happen when they don’t work well. Insulin and glucagon work in what’s called a negative feedback loop. During this process, one event triggers another, which triggers another, and so on, to keep your blood sugar levels balanced. How insulin works During digestion, foods that contain carbohydrates are converted into glucose. Most of this glucose is sent into your bloodstream, causing a rise in blood glucose levels. This increase in blood glucose signals your pancreas to produce insulin. The insulin tells cells throughout your body to take in glucose from your bloodstream. As the glucose moves into your cells, your blood glucose levels go down. Some cells use the glucose as energy. Other cells, such as in your liver and musc Continue reading >>

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Popular Questions

  1. ForEverYoung

    Originally Posted by Stump86
    I don't think insulin is a direct input to the pancreas. There is nothing in the pancreas that says "the insulin level is X." But does the pancreas produce more glucagon when insulin levels are low and more insulin when glucagon levels are low, absolutely. That doesn't make sense. If that were the case then it would be in all the medical books, what you're talking about would have profound effects on bg levels and the medical community would mention it.
    If that were the case then if a person lost phase one response or there was not enough insulin to bring bg down after a big meal you would get a spike after phase 1 or phase 2 response (after all the food was digested). You pancreas would go into positive feedback.

    Does the liver respond to low levels of insulin one way and high levels of insulin another way, absolutely not. I think that is the question/comment with which you started the thread, no?

    I think it does, for two reasons:
    1) There are many cells in the liver, when insulin runs low, some cells will get an insulin input other won't and would be subject to the slightest stress hormone. So as insulin levels go low, not all liver cells would be turned off to producing glucose.
    2) In the presence insulin resistance the effect is more pronounced, since less cells get an insulin "turn off " signal at a lower amount of insulin, keep in mind that in the presense of insulin resistance you need more insulin to generate a "Turn Off" signal. That is why some people have to a larger amount of insulin to turn the liver off.
    So when insulin is low, some of the cells are getting a "turn on signal" and some are getting a "turn off signal", that is supported by the fact that again, that some people have to take a large amount of insulin to FULLY TURN OFF THE LIVER.
    If low levels of insulin caused the pancreas produce large amounts of glucogen to be generated then you would see large amount of glucogen with morning DP, most of those hormones are stress hormones.
    Oh and I forgot to mention, the liver does respond to low levels of insulin one way andl high levels another in the presense of insulin resistance. By definition when you are inuslin resistant you need more insulin to do the same work. It's like needing more current to get the same brightness out of a light bulb.

  2. dlabbee

    Here is an explanation of how the pancreas works. http://www.mydr.com.au/gastrointesti...as-and-insulin

  3. furball64801

    Originally Posted by dlabbee
    Here is an explanation of how the pancreas works. http://www.mydr.com.au/gastrointesti...as-and-insulin Thanks for the link it explains it very well.

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