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Gestational Diabetes Pills Vs Insulin

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Oral Hypoglycemic Agents Vs Insulin In Management Of Gestational Diabetes: A Systematic Review And Metaanalysis

Sheffield Teaching Hospitals NHS Foundation Trust The objective of this review was to provide pooled estimates of randomized controlled trials comparing the effects of oral hypoglycemic agents with insulin in achieving glycemic control and to study the maternal and perinatal outcomes in gestational diabetes mellitus.A protocol for the study was developed. All metaanalyses were performed using Stats Direct statistical software (Stats Direct Ltd, Cheshire, UK).Six studies comprising 1388 subjects were analyzed. No significant differences were found in maternal fasting (weighted mean difference [WMD], 1.31; 95% confidence interval [CI], 0.81-3.43) or postprandial (WMD, 0.80; 95% CI, -3.26 to 4.87) glycemic control. Use of oral hypoglycemic agents (OHAs) was not associated with risk of neonatal hypoglycemia (odds ratio [OR], 1.59; 95% CI, 0.70-3.62), increased birthweight (WMD, 56.11; 95% CI, -42.62 to 154.84), incidence of caesarean section (OR, 0.91; 95% CI, -0.68 to 1.22), or incidence of large-for-gestational-age babies (OR, 1.01; 95% CI, 0.61-1.68).Our study demonstrates that there are no differences in glycemic control or pregnancy outcomes when OHAs were compared with insulin. Continue reading >>

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Popular Questions

  1. lindsings

    My doc prescribed this to me today-I'm only taking half a pill at night to help my fasting numbers. She said this drug is perfectly safe for the baby.

  2. Sdh040916

    I started insulin tonight. The doctor came in yesterday and had a prescription in hand for glyburide without am talking to me first. I asked why she was choosing it over insulin. She said that insulin is the "gold standard" for GD but many people don't like injections. I told her I wanted whatever was the safest and best for me and my baby, and she ripped up the prescription and wrote me one for insulin repeating that it was the "gold standard".

    I just gave myself my first injection and honestly I couldn't feel the needle go in. It's a personal choice but I didn't feel comfortable taking something that isn't FDA labeled for GD and had questionable safety for babies. I just read a study stating mothers taking glyburide were more likely to have babies with respiratory distress requiring NICU, low BS after birth, etc versus mothers taking insulin. Decision made for me!

  3. aw0811

    Good for you for asking! And yeah, that's how I felt too. The study did say that they couldn't say whether the relationship was cause and effect (i.e., maybe the people on glyburide in the study weren't following the diet), but I felt, better safe than sorry. Also, I only started injections at 31 weeks, so won't have to do it for long...

  4. -> Continue reading
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Glibenclamide, Metformin, And Insulin For The Treatment Of Gestational Diabetes: A Systematic Review And Meta-analysis

Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis BMJ 2015; 350 doi: (Published 21 January 2015) Cite this as: BMJ 2015;350:h102 Montserrat Balsells, registrar in endocrinology and nutrition 1 , Apolonia Garca-Patterson, registrar in endocrinology and nutrition 2 , Ignasi Gich, associate researcher 5 6 7 , Rosa Corcoy, assistant professor in endocrinology and nutrition 2 8 9 1Department of Endocrinology and Nutrition, Hospital Universitari Mtua de Terrassa, Terrassa 8821, Spain 2Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, Barcelona 08025, Spain 3Iberoamerican Cochrane Centre, Hospital de la Santa Creu i Sant Pau, Barcelona 4Institute of Biomedical Research (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau Barcelona 5CIBER Epidemiologa y Salud Pblica (CIBERESP), Instituto de Salud Carlos III, Madrid 28029, Spain 6Department of Epidemiology, Hospital de la Santa Creu i Sant Pau, Barcelona 7Department of Clinical Pharmacology and Therapeutics, Universitat Autn Continue reading >>

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Popular Questions

  1. lindsings

    My doc prescribed this to me today-I'm only taking half a pill at night to help my fasting numbers. She said this drug is perfectly safe for the baby.

  2. Sdh040916

    I started insulin tonight. The doctor came in yesterday and had a prescription in hand for glyburide without am talking to me first. I asked why she was choosing it over insulin. She said that insulin is the "gold standard" for GD but many people don't like injections. I told her I wanted whatever was the safest and best for me and my baby, and she ripped up the prescription and wrote me one for insulin repeating that it was the "gold standard".

    I just gave myself my first injection and honestly I couldn't feel the needle go in. It's a personal choice but I didn't feel comfortable taking something that isn't FDA labeled for GD and had questionable safety for babies. I just read a study stating mothers taking glyburide were more likely to have babies with respiratory distress requiring NICU, low BS after birth, etc versus mothers taking insulin. Decision made for me!

  3. aw0811

    Good for you for asking! And yeah, that's how I felt too. The study did say that they couldn't say whether the relationship was cause and effect (i.e., maybe the people on glyburide in the study weren't following the diet), but I felt, better safe than sorry. Also, I only started injections at 31 weeks, so won't have to do it for long...

  4. -> Continue reading
read more close
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Gestational Diabetes - Medications

Most women can treat gestational diabetes by changing the way they eat and exercising more often. If these changes do not keep your blood sugar level within a target range , you may need to take diabetes medicine, for example glyburide , insulin , or metformin . You may also need to take insulin if your doctor thinks that your baby is getting too large. If you need to take insulin , you will learn how to give yourself an insulin shot. Gestational Diabetes: Giving Yourself Insulin Shots Insulin is the primary medicine used to treat gestational diabetes. Insulin is only used if you cannot control your blood sugar level by eating well and exercising regularly. How much insulin you need depends on how much you weigh and on how close you are to your due date . Some women need more insulin as they get closer to their delivery date, because the placenta makes more and more hormones that make it harder and harder for insulin to do its job. In rare cases, a woman with gestational diabetes has to stay in the hospital for a short time to get her blood sugar level within a target range. This information is not intended to replace the advice of a doctor.Healthwise disclaims any liability for t Continue reading >>

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Popular Questions

  1. lindsings

    My doc prescribed this to me today-I'm only taking half a pill at night to help my fasting numbers. She said this drug is perfectly safe for the baby.

  2. Sdh040916

    I started insulin tonight. The doctor came in yesterday and had a prescription in hand for glyburide without am talking to me first. I asked why she was choosing it over insulin. She said that insulin is the "gold standard" for GD but many people don't like injections. I told her I wanted whatever was the safest and best for me and my baby, and she ripped up the prescription and wrote me one for insulin repeating that it was the "gold standard".

    I just gave myself my first injection and honestly I couldn't feel the needle go in. It's a personal choice but I didn't feel comfortable taking something that isn't FDA labeled for GD and had questionable safety for babies. I just read a study stating mothers taking glyburide were more likely to have babies with respiratory distress requiring NICU, low BS after birth, etc versus mothers taking insulin. Decision made for me!

  3. aw0811

    Good for you for asking! And yeah, that's how I felt too. The study did say that they couldn't say whether the relationship was cause and effect (i.e., maybe the people on glyburide in the study weren't following the diet), but I felt, better safe than sorry. Also, I only started injections at 31 weeks, so won't have to do it for long...

  4. -> Continue reading
read more close

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