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A Newer, Faster-acting Insulin? (faster Than Novolog!)

New findings from phase 3a trials show that a faster-acting insulin aspart by Novo Nordisk reduced A1c levels and improved after meal blood sugars in people with type 1 and 2 diabetes compared with NovoLog. These findings were presented at the 76th annual Scientific Sessions of the American Diabetes Association (ADA) in New Orleans. Novolog (also marketed as Novorapid) is a fast-acting insulin aspart. The trial involves 2,100 people with type 1 and 2 diabetes and an even faster-acting insulin aspart. The trial consisted of 26 weeks of randomized therapy using a faster-acting insulin aspart which showed statistically significantly improved A1c in adults with type 1 diabetes when dosed at mealtime compared with Novolog. A similar result in A1c improvement was found when the insulin aspart was dosed 20 minutes after a meal compared with Novolog. What is Faster-Acting Insulin Aspart? Faster-acting insulin aspart is a fast acting bolus or mealtime insulin in investigation stages developed by Novo Nordisk. It is also insulin aspart like Novolog (or Novorapid) but in a new formulation which includes a vitamin and an amino acid intended to increase the initial absorption rate and provide a Continue reading >>

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  1. RacetrackReject

    I was just in Wal-mart and they had signs up saying they now carry pet insulin and had a price listed as $24.88. I'm not sure if this is any cheaper than the vet, but I thought I would pass it along in case it was.

  2. Bacardi1

    I didn't even realize there WAS such a thing as pet insulin. When I had a diabetic cat a number of years ago, vet prescribed human insulin. If I remember correctly, the price was in the $20's, & since the cat's injection only used a tiny bit, the bottle lasted in the fridge a LONG time.

  3. mvp

    Sounds dirt cheap!
    Hate WallyWorld. Small animal vets hate me. Between a rock and a hard place in terms of my personal politics.

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New Faster-acting Insulin Fiasp Now Available In The Uk

A new fast-acting insulin called Fiasp has been launched in the UK for adults with type 1 diabetes or type 2 diabetes. Fiasp received European approval on 10 January this year, and will now be made available to the NHS at no additional cost compared to NovoRapid (insulin aspart). Fiasp, developed by Novo Nordisk, can help improve blood sugar levels after meals by working twice as quickly in the bloodstream following injection. This faster absorption therefore helps people with diabetes achieve lower blood glucose levels after meals. "Today we are very pleased to make available a new and improved mealtime insulin option," said Avideh Nazeri, Director of Clinical, Medical and Regulatory, UK/IRE, Novo Nordisk. "Fast-acting insulin aspart will address the unmet need for those who struggle to keep their blood sugar levels in a healthy range around mealtimes. "This is an important step to help the achievement of optimal mealtime glucose control and ultimately may lead to meaningful health benefits." Clinical trials have shown Fiasp to outperform NovoRapid in helping people with type 1 diabetes achieve better diabetes control after meals and overall. The results were even more pronounced Continue reading >>

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  1. Habib Fanny

    OMG, kid. Chill out.
    The most important thing you can do right now is to be well-rounded.
    Read. Broaden your horizons. Learn some linguistics and history and politics. Become familiar with philosophy and psychology. Enjoy your adolescence; it won’t last forever. Play some tennis and go swimming. Learn about girls. Learn about people; they’re the ones you’ll be treating someday. A good doctor can read people. Does this person need a little more time today because they’re stressed out? You might want to find out. There’s little point in prescribing an insulin regimen to a person who’s not educated enough to be able to follow it. There’s no benefit in prescribing a medication someone won’t be able to afford. Will the patient in front of you need the help of a social worker to help them access daycare services so they can make it to their appointments? Do they have transportation issues that will make them unable to follow-up with you? If they do, you’ll have a hard time getting them better.
    At this point, you shouldn’t stress out too much. The best things you can do for yourself are the following:
    be a good, kindhearted person: it will make a difference for your patients someday.
    develop good study habits: it’s not so much what you study as how that matters right now. If you are diligent about studying every day, doing your assignments on time, not skipping class, etc, you’ll likely do well in med school. Success in med school doesn’t depend on raw smarts but on discipline and regular study habits.
    be intellectually curious: this will enable you to think outside the box someday when dealing with complicated cases
    you don’t have to take any particular AP subjects in high school. Hell, I’d recommend you take all the AP classes you can get away with. If nothing else, it’d be a great preparation for college. That said, the science classes can make your undergrad time a bit shorter, if you’re in a hurry: biology, chemistry, physics, etc.

    unless you’re trying to become a professor of medicine at Harvard, it doesn’t really matter where you go. Get good grades in college (no one gives a damn about your high school grades), do well on the MCAT, and go to your local state school. Save money.

    That’s my advice.

  2. Sivakesavam O

    Hari om , you are asking a question as to : " I am going to go to 8th grade.What should I do if I want to be a doctor?."
    First let me congratulate you to have chosen medical profession as your future career. Medicine is a noble profession. By being a doctor , you can do service to humanity - which is the essence of human life.By being a doctor , you will be in a position to relieve pain & sufferage of fellow humans.
    But , you will have to be prepared to sacrifice from your side - your personal comforts & conveniences as a doctor. If you are not having that service orientation , better not to go to medical profession.
    You have 5 years from now to join your professional course.
    Study :
    biology , (compusary)
    botony , (compulsary)
    zoology ( compulsarily) , &
    physics , (optional)
    chemistry (optional), &

    mathematics ( optional ).
    Depending on your interest you can study other optionals.
    Getting a seat in medicine is not that easy as aspirants will be in almost a lakh & above , while seats are in a few thousands only.
    So work studiously from now on wards to realise your chosen career. God bless you. Hari om.

  3. Aditya Sharma

    You're still small, enjoy yar, play, roam enjoy, give time to yourself.

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Fiasp® (insulin Aspart Injection) 100 U/ml Indications And Usage

Fiasp® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Fiasp® or one of its excipients. Never share a Fiasp® FlexTouch® Pen between patients, even if the needle is changed. Patients using Fiasp® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, manufacturer, type, or method of administration may affect glycemic control and predispose to hypoglycemia or hyperglycemia. These changes should be made cautiously under close medical supervision and the frequency of blood glucose monitoring should be increased. Fiasp® (insulin aspart injection) 100 U/mL is a rapid-acting insulin analog indicated to improve glycemic control in adults with diabetes mellitus. Fiasp® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Fiasp® or one of its excipients. Never share a Fiasp® FlexTouch® Pen between patients, even if the needle is changed. Patients using Fiasp® vials must never share needles or syringes with another person. Sharing poses a risk for transmission of blood-borne pathogens. Changes in insulin strength, Continue reading >>

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  1. Gondwanaland

    People who eat lots of vegetables should eat them with enough fat (methyl donors) such as extra virgin olive oil on the leafy greens or butter to broil vegetables.
    J Nutr. 2011 Mar;141(3):531-4. doi: 10.3945/jn.110.130369. Epub 2011 Jan 26.
    Nutritional genomics: defining the dietary requirement and effects of choline
    It is important to recognize differences in dietary requirements for choline in women, because during pregnancy, maternal dietary choline modulates fetal brain development in rodent models. Because choline metabolism and folate metabolism intersect at the methylation of homocysteine, manipulations that limit folate availability also increase the use of choline as a methyl donor. The supplement folic acid is a synthetic, inactive form that requires more methyl donors to be activated than food folate.
    Having said that, an experiment on rats showed that high dose folic acid (without the needed accompanying methyl donors) during pregnancy caused insulin resistance in the offspring.
    Journal of Endocrinology
    Excess perigestational folic acid exposure induces metabolic dysfunction in post-natal life
    The results of this work indicate that perigestational high folic acid exposure the affects long-term metabolic phenotype of the offspring, predisposing them to an insulin-resistant state.
    J Nutr. 2010 Jun;140(6):1162-6. doi: 10.3945/jn.110.122044. Epub 2010 Apr 14.
    Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain
    In mice, maternal dietary folate, a cofactor in 1-carbon metabolism, modulates neurogenesis and apoptosis in the fetal brain. Similarly, maternal dietary choline, an important methyl-donor, also influences these processes. Choline and folate are metabolically interrelated, and we determined whether choline supplementation could reverse the effects of folate deficiency on brain development A study in humans showed that folate and B12 supplementation reversed metabolic syndrome, improving insulin sensitivity and lowering homocysteine
    Eur J Endocrinol. 2004 Oct;151(4):483-9.
    Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia
    Folate and vitamin B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with metabolic syndrome, suggesting that folic acid has several beneficial effects on cardiovascular disease risk factors I think that the insulin sensitivity has been completely overlooked on this forum, along with blood cell synthesis. People take huge amounts on folate and B12 ignoring that it can cause hypoglycemia and acidosis, plus it will promote the recruitment of other B vitamins and minerals for blood cell synthesis. Additionally, the B vitamins and minerals which can be quickly depleted by an unbalanced supplementation are involved in hormonal and neurotransmitter balance.
    A study has been posted by someone else before showing that unmetabolized folic acid can build up, blocking the use of active folate.
    This causes or worsens B12 deficiency and insulin resistance, causing epigenetic changes and predisposing the offspring to IR and obesity.
    © 2008 American Society for Clinical Nutrition
    Is folic acid good for everyone?
    In humans, increased folic acid intake leads to elevated blood concentrations of naturally occurring folates and of unmetabolized folic acid. High blood concentrations of folic acid may be related to decreased natural killer cell cytotoxicity, and high folate status may reduce the response to antifolate drugs used against malaria, rheumatoid arthritis, psoriasis, and cancer. In the elderly, a combination of high folate levels and low vitamin B-12 status may be associated with an increased risk of cognitive impairment and anemia and, in pregnant women, with an increased risk of insulin resistance and obesity in their children. In my personal interpretation, excess of methylfolate intake can have the following adverse outcomes in regards to insulin resistance:
    - first methyfolate can make one who doesn't have IR hypoglycemic, causing panick attacks, acidosis, mood swings etc
    - secondly, excess methyfolate will build up and create/worsen insulin resistance, leading to a huge need for potassium (and B1, choline and magnesium).
    J Physiol Biochem. 2015 Dec 3. [Epub ahead of print]
    The role of dietary potassium in hypertension and diabetes
    ...
    Furthermore, accumulating epidemiological evidence from, especially, the last decade relates low dietary potassium intake or serum potassium levels to an increased risk for insulin resistance or diabetes.
    ... I will be happy to discuss it.
    PS to check for IR one needs the blood tests of fasting insulin, fasting glucose, insulinemic curve and HbA1c

  2. Gondwanaland

    Also, I would like to add that some sites for diabetics have warnings about high homocysteine, which will be raised by insulin resistance. High homocysteine has a series of implications, especially cardiovascular. I had a vein rupture followed by thormbosis and from the several doctors I saw back then no one asked for homocysteine or insulin blood tests. I am sure I had diabetis insipidus at some point, even though I described my symptoms to Gyn, Endo, Vascular, Hematologist, they never bothered to make a diagnosis from what I described.

  3. Gondwanaland

    BTW Niacin helps because it antagonizes methyl groups by increasing insulin resistance
    Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B
    Also
    https://examine.com/supplements/vitamin-b3/
    Niacin is an essential B-vitamin. Supplementation results in improved cholesterol and triglyceride levels. However, since a side-effect of supplementation is increased insulin resistance, niacin supplementation only provides benefits for cardiovascular health if precautions are taken.

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