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Fastest Acting Insulin

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Pharmacokinetic Properties Of Fast-acting Insulin Aspart Administered In Different Subcutaneous Injection Regions

Go to: Abstract Fast-acting insulin aspart (faster aspart) is insulin aspart set in a new formulation with faster initial absorption after subcutaneous administration. This study investigated the pharmacokinetic properties, including the absolute bioavailability, of faster aspart when administered subcutaneously in the abdomen, upper arm or thigh. In a randomised, open-label, crossover trial, 21 healthy male subjects received a single injection of faster aspart at five dosing visits: 0.2 U/kg subcutaneously in the abdomen, upper arm and thigh, intramuscularly in the thigh and 0.02 U/kg intravenously. Blood sampling for pharmacokinetics was performed pre-dose and frequently thereafter until 12 h post-dose (8 h after intravenous administration). Onset of appearance (~3 min), time to 50% of maximum concentration (t Early 50% Cmax; ~20 min) and time to maximum concentration (t max; ~55 min) were all similar between injection regions. Early exposure within the first 2 h after injection (AUCIAsp,0–1h and AUCIAsp,0–2h) as well as maximum concentration (C max) were comparable for the abdomen and upper arm, but were ~25% lower for the thigh as seen previously for other mealtime insulin Continue reading >>

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Popular Questions

  1. Robanny

    Hey everyone,
    I have a few questions about units of insulin.
    I've only just started caring about my diabetes after 10 years. I'm 19 and have suffered from depression since the age of approx' 11/12 (Though am happy to say that I've turned over a new leaf and am finally coming out of it), so just blocked everything out and ignored all the information given to me, etc. I want to get my diabetes under control and have finally decided that coming to a forum with other diabetics can help me.
    I decided to start by asking this:
    I am on Novo Rapid fast-acting insulin and Lantus long-acting insulin.
    I was wondering if anybody could give me advice on how many units of insulin I should be doing in relation to my blood glucose reading?
    For example:
    How many units of novo rapid should I do if my blood sugar is... 9.0, 10.0, 11.0... etc, all the way up to being in the 30s 40s (which happens a lot due to my lack of control).
    Is there a formula I could work with?
    Like X amount of insulin units for X amount of 1.0s (cant think of a better name..) you want to reduce your sugars by? (For example: 1 unit of insulin to reduce my blood sugar by 1.5... or so on).
    Also:
    Is there a set amount of insulin to take after meals?
    For example: If I had a normal sized plate of chips and pizza for dinner (though I don't usually, I'm quite a healthy veggie teenager! Ha-ha!) then is there an amount of insulin I should be taking? Is there a dose of insulin that would cover me for all normal-sized meals? And would this just be halved/quatered in relation to snacks, etc? Or am I going to have to start counting fat and carbohydrates etc in order to calculate every insulin dose? (See? I really have no idea! )
    I've been working with blind knowledge for so long, I have no idea how much insulin to do in relation to my readings. I've always just guessed, and it's never helped as I've NEVER had constant, normal readings - they're almost always high or low.
    I'm trying to start taking care of myself, and feel like I need this information to get started.
    Any help would be appreciated!
    Thanks a lot everybody,
    Robyn
    x

  2. dipsticky

    Come on you guys, 'bout time you was all up. This person needs some answers fast. Where's all you T1's ?
    D.

  3. totsy

    hya robyn,
    im glad u are starting to take control, im on the same meds, do u carb count?? if not it will help if u learn,
    we are all different i inject 1 unit per 10g carb and as a correction dose if im say 8 or 9 b4 a meal i find if i take an extra unit it takes me down 3mmol, can u give me an idea what a days food and readings look like and i will try and help

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