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Fastest Acting Insulin

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Strong Early Results For Eli Lilly's Fast-acting Insulin Formulation

Illustration of BioChaperone formulation of insulin--Courtesy of Adocia Eli Lilly ($LLY) reported strong Phase I results of its BioChaperone Lispro ultrarapid formulation of insulin, which it in-licensed from Lyon, France's Adocia for $50 million upfront and up to $520 million in milestone payments. The candidate is designed to enable injections before, during or after meals due to its fast-acting nature. The study compared Lispro to Lilly's Humalog on postprandial glycemic control relative to solid standardized meals in 36 Type 1 diabetes patients, according to a release. In the 14-day study, patients were injected with either Lispro or Humalog at the time of, 15 minutes before, or 15 minutes after a test meal. The trial had a crossover design, meaning all patients received both medications for two consecutive weeks, or a total of 28 days. That way each patient is his or her own control. At the beginning of the study, Lispro achieved a statistically significant 31% reduction in blood glucose over the first two hours compared to Humalog, and a statistically significant 42% reduction on day 14, according to a release. The meal tolerance test was carried out on days 1-3 of the study, Continue reading >>

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Popular Questions

  1. kel varnsen

    expired insulin

    does anyone HONESTLY think humalog with an expiration of 02.2008 is not good for use? not even as a backup emergency supply? it has been keep in a fridge. my friend's brother is type 1 and he is now playing pro sports in Italy. he left about 40 - 50 full pens. i have had them for a year myself and just kept refilling my own prescriptions. i never asked why he had so many. i only get a box of 5 at one time. could be black market Italian mafia.

  2. poodlebone

    Just a couple of months ago I finally finished a vial of Humalog that expired November 2007. Last year I discovered a bunch of expired Humalog in my fridge, all with the Nov 2007 date. I used them all. That last vial was one I had been carrying around, opened, in my daily kit. When it was down to the last 100 units and wasn't enough to fill my pump reservoir, I put it in the fridge at work, just in case. I did use it a few times when my BG went high and I wanted to make sure I didn't have a problem with my infusion set. That bottle worked great down to the last drop, more than a year expired, opened for months, in & out of the fridge.

  3. hhinma

    Originally Posted by poodlebone
    Just a couple of months ago I finally finished a vial of Humalog that expired November 2007. Last year I discovered a bunch of expired Humalog in my fridge, all with the Nov 2007 date. I used them all. That last vial was one I had been carrying around, opened, in my daily kit. When it was down to the last 100 units and wasn't enough to fill my pump reservoir, I put it in the fridge at work, just in case. I did use it a few times when my BG went high and I wanted to make sure I didn't have a problem with my infusion set. That bottle worked great down to the last drop, more than a year expired, opened for months, in & out of the fridge. The general rule i follow here is that the expiration date does NOT mean it wont be any good after the expiration date, it means that the manufacturer is telling you
    Dont assume it will be. It will either work or it wont, if it doesnt, try another one. But dont under any circumstances have expired insulin as your one and only emergency last resort. That will probably be one of the times it doesnt work....

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