Exercise And Insulin Sensitivity—where Do We Stand? You’d Better Run!
The prevalence of insulin-resistant conditions—such as obesity, the metabolic syndrome, and type 2 diabetes—is on the increase, affecting all age groups and both sexes.1 A sedentary lifestyle lies at the core of these disorders; therefore, increased physical activity is considered an integral part of lifestyle modification for the prevention and treatment of insulin resistance.2,3 There is a wealth of epidemiological evidence indicating that high levels of habitual physical activity are associated with lower incidences of obesity, the metabolic syndrome, and type 2 diabetes.2,3 This article will review current knowledge regarding exercise and insulin sensitivity, focusing on factors that determine the response to exercise, such as acute versus chronic exercise, the mode and amount of exercise, duration, and intensity, as well as other parameters that may modify this response. Definition of Insulin Resistance and Measurement of Insulin Sensitivity Broadly, insulin resistance can be defined as a subnormal biological response to normal insulin concentrations;4 therefore, it pertains to many different actions of insulin in the many different tissues of the body. Typically, however, Continue reading >>