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Chemistry Of Insulin

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Chemically Modified Insulin Is Available More Quickly

Chemically modified insulin is available more quickly Binding of the insulin analog (green) to the receptor (light blue). The receptors surface is shown in transparent gray. Credit: University of Basel, Department of Chemistry Replacing a hydrogen atom by an iodine atom in insulin, the hormone retains its efficacy but is available more rapidly to the organism. Researchers at the University of Basel were able to predict this effect based on computer simulations and then confirm it with experiments. The results have been published in the Journal of Biological Chemistry. Insulin is formed in the pancreas and regulates the blood glucose level . In the body, it is stored as a zinc-bound complex of six identical molecules, called a hexamer. However, the physiologically active form is a single insulin monomer. Only when the body requires insulin the hexamer divides into monomers available for blood sugar regulation. Researchers attempt to control this disassembly process by developing artificial insulin preparations, in order to optimize clinical treatment of diabetes mellitus. By means of chemical modifications, the release and availability of insulin can be improved. One possible appro Continue reading >>

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  1. jesse girl

    > walmart needs a prescription for box of syringes

    just went to walmart i am in southern California and went to pick up insulin and a box of syringes
    they brought back my insulin and 3 bags of syringes and said you would need a prescription to get a whole box
    they said people were abusing the policy but said you can come back every day and get 3 bags if you wanted without a prerscription
    the problem is you will pay more for the syringes per bag i think she said a $1.87 per bag so that would come out to $ 18.70 for a 100
    well as we know 3 bags will not cover a month of insulin injections if using two or more syringes a day
    the question is anybody getting a prescription for syringes and how are you doing it as far as refills could a prescription be wrote for a years worth of syringes or in most situations one refill then need new prescription
    i thought that was odd change any ideas is appreciated

  2. Cebe

    I have not run into this problem - yet. I get my syringes from Walgreens, because I cannot convince Walmart that 1/2 unit syringes exist.
    I would go to your vet and ask for the prescriptions - you could do a prescription for 1 box with 11 refills or you could ask the doctor to write out 12 monthly prescriptions. Or some version of this based on how many you use in a month (60 or 62).

  3. Judi

    YEP, I can buy one bag without otherwise I need a prescription. My vet calls it in for a year. Last time they screwed up and instead of putting 12 refills they put one. I ordered some syringes online because I didn't want to deal with it right now. But I like the Walmart syringes better

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Chemistry And Insulin-like Properties Of Vanadium(iv) And Vanadium(v) Compounds1

Get rights and content The chemistry of vanadium compounds that can be taken orally is very timely since a vanadium(IV) compound, KP-102, is currently in clinical trials in humans, and the fact that human studies with inorganic salts have recently been reported. VO(acac)2 and VO(Et-acac)2 (where acac is acetylacetonato and Et-acac is 3-ethyl-2,4-pentanedionato) have long-term in vivo insulin mimetic effects in streptozotocin induced diabetic Wistar rats. Structural characterization of VO(acac)2 and two derivatives, VO(Me-acac)2 and VO(Et-acac)2, in the solid state and solution have begun to delineate the size limits of the insulin-like active species. Oral ammonium dipicolinatooxovanadium(V) is a clinically useful hypoglycemic agent in cats with naturally occurring diabetes mellitus. This compound is particularly interesting since it represents the first time that a well-characterized organic vanadium compound with the vanadium in oxidation state five has been found to be an orally effective hypoglycemic agent in animals. Continue reading >>

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  1. mslayla

    i am desperately trying to figure out how to dind my dosage and how much to inject and how much to mix...and one of the things i need to know is if im gonna do 200iu, or even 175iu or 150iu, how do you measure that on an insulin syringe that only has units on it, starting at 10-100? i found this on here:
    Water
    1,500 IU - 5 ml bac water
    2,000 IU - 7 ml bac water
    5,000 IU - 19 ml bac water
    10,000 IU - 39 ml bac water
    Dose
    125 IU dose = .50 ml, or 50 on an insulin needle
    150 IU dose = .60 ml, or 60 on an insulin needle
    175 IU dose = .70 ml, or 70 on an insulin needle
    200 IU dose = .80 ml, or 80 on an insulin needle
    but im not sure how many units that is because if i actually did 50 units, thats like almost half of the syringe....surely that cant be right....someone know how much i inject of the units??

  2. bouscher

    I'm anxious for the answer! Just told hubby I may be playing with needles, syringes and measuring spoons/cups one of these days to find the right answer! LOL
    First round I used 50 unit insulin syringes, 1/2 cc...I went to 20 units for 200 iu's, 15 units for 150iu's etc.
    This time I have a 20 unit insulin syringe, still 1/2 cc syringe!!

  3. bouscher

    bump

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Insulin Chemistry | Springerlink

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 92) Major aims of insulin chemistry are the large-scale production of the hormone for the treatment of diabetes mellitus as well as laboratory-scale syntheses of analogs for structure-function studies, of radioactive tracers, and of tailormade special derivatives. Further, one should include the detection and isolation of new native insulins and related compounds. The total synthesis, accomplished 25 years ago by the groups of ZAHN (MEIENHOFER et al. 1963), KATSOYANNIS (1964), and in China marked the advent of a new era in pep tide and protein chemistry. Remarkable progress has since been achieved through refinement of synthetic and semisynthetic procedures, the advances in recombinant DNA techniques, and high pressure liquid chromatography (HPLC). Insulin ReceptorHigh Pressure Liquid ChromatographyHuman InsulinInsulin AnaloguePorcine Insulin These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access Unable to display preview. Download preview P Continue reading >>

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  1. DeathVan

    DIY Pet Euthanasia

    Well my old fat buddy is starting to crap out, Kitty Diabetes (he's slipped into one coma already, but was nursed back to life)
    The one vet in town has monopoly on putting pets down and charges what I deem to be an exorbitant, and unnecessary, fee for this procedure.
    So it got me thinking: What other ways could I help Frostee reach the afterlife?
    -I want the procedure to be quick and painless, and relatively inexpensive.
    -I am also not bothered by any moral or ethical issues.
    So far I have:
    1) Overdose of Heroin (note: I've never purchased nor done heroin, but I imagine he'd get pretty fucking high on the way out)
    -issue: could lead to legal problems in the procurement of said drug, and a new and unwanted addiction
    2) Samurai Sword Head Removal (Pretty awesome way to go, and I would get to practice on a watermelon or another cat-like object)
    -issue: the lunatic I know that owns the sword might decide to kill me in a blood rage
    3) Two Taps to the Dome (Old school mob-land style hit)
    -issue: looking him in the eyes and telling him he betrayed me for the last time
    here's a picture of Frostee when he was in his prime, (he's not, how do you say, "smart", but is very friendly)
    What ideas do you have to help him pass into the light?
    -I appreciate your time, this is very difficult and serious for me

  2. Flyoverland Captive

    We took out our last two cats with a single pellet to the brain; quick and painless.
    Is he on insulin? If so, can't you just overdose him?
    And what the hell is wrong with your vet; our local vet puts family pets down for free. She wants to encourage folks to not let their pets linger; by doing it free, she makes sure that cost doesn't factor into pet owner's decisions.

  3. mud

    Sorry about Frostee.
    Considering his size maybe pull a Garfield, death by lasagna.

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