Platelet Function In Patients With Diabetes Mellitus: From A Theoretical To A Practical Perspective
Platelet Function in Patients with Diabetes Mellitus: From a Theoretical to a Practical Perspective 1Johns Hopkins University School of Medicine, and Johns Hopkins Hospital Division of Cardiovascular Disease, Baltimore, MD 21287-073, USA Received 27 April 2011; Accepted 22 June 2011 Copyright 2011 Nicholaos Kakouros et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation compared to healthy controls. We review the pathophysiology of platelet hyperreactivity in DM patients and its implications in clinical practice, with particular focus on acute coronary syndromes, percutaneous coronary intervention, and novel antiplatelet agents. Diabetes mellitus, that affects over 25 million people in the US and an estimated 285 million worldwide, is associated with a significant burden of cardiovascular disease [ 1 , 2 ]. Patients with type 2 diabetes mellitus (DM2) have a 2- to 4-fold increased risk of premature cerebral, coronary, and peripheral vascular disease that together constitute the leading cause of death in these patients [ 3 , 4 ]. Unlike the diabetes-specific microvasculopathy, neuropathy, nephropathy, and retinopathy, the macroangiopathic process in patients with diabetes represents an accelerated but pathophysiolog Continue reading >>
Can I Give Blood, Even Though I Have Diabetes?
I am 42 years old, and I have diabetes. Can I donate blood or become an organ donor? — Annette, New Jersey How wonderful it is that you are thinking about donating blood or an organ. It is a constant struggle for the blood banks and transplant centers to maintain an adequate supply. The answer to your question is not the same for both organ and blood donation, so I will first address blood donation. Yes, you can donate blood, if you meet the following criteria: Your sugar level is controlled. You are in good health. Your blood pressure is below 180/100. You are not anemic (low red blood cells). The blood banks usually check for donor eligibility through a series of other questions and tests, so keep in mind that you might still be disqualified. For example, if you have received bovine (beef) insulin since 1980, you may not be eligible to donate. That's because some bovine insulin was made from cattle in the United Kingdom and might carry Creutzfeldt-Jakob (or "mad cow") disease. If you are eligible to donate, make sure you have an adequate meal, drink extra fluids to replace the volume being removed, and stay away from caffeinated beverages on the day of your donation. Around that date, it's important to eat iron-rich foods (such as spinach, kale, and lean red meat). And as always, stay away from fatty foods, which might affect some of the tests done to determine eligibility. Regarding organ donation, let me give you some general information. There are various organs and tissues in the human body that can be transplanted to save lives or cure illnesses. The heart, lungs, kidneys, pancreas, liver, and intestines can be donated. Besides organs, we can donate tissues such as skin, cartilage, tendons, corneas, veins, and heart valves. The donation of an organ can be life Continue reading >>
Factors Contributing To Increased Platelet Reactivity In People With Diabetes
Factors Contributing to Increased Platelet Reactivity in People With Diabetes From the Cardiology Unit, Department of Medicine, Cardiovascular Research Institute, University of Vermont, Burlington, Vermont. Corresponding author: David J. Schneider, [email protected] . Received 2008 Oct 14; Accepted 2008 Nov 8. Copyright 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. This article has been cited by other articles in PMC. People with diabetes, particularly those with type 2 diabetes, exhibit increased platelet reactivity. Hyperglycemia contributes to greater platelet reactivity through direct effects and by promoting glycation of platelet proteins. Hypertriglyceridemia increases platelet reactivity. Both insulin resistance and insulin deficiency increase platelet reactivity. Insulin antagonizes activation of platelets. Thus, relative or absolute deficiency of insulin would be expected to increase platelet reactivity. Diabetes is associated with oxidative stress and inflammation. Resultant endothelial dysfunction promotes activation of platelets by decreasing production of nitric oxide (NO) that attenuates platelet reactivity. Oxidative stress accentuates this effect by attenuating activity of NO and promoting platelet activation. Inflammation and platelet activation are reciprocally related. Inflammation promotes platelet activation that, in turn, promotes inflammation. Accordingly, improved metabolic control achieved with regimens that improve insulin sensitivity and preserve pancreatic -cell function is likely to decrease platelet reactivity and enhance effects of antiplatelet agents. Platelets from subjects with Continue reading >>
Who Can Donate Blood?
Anyone diagnosed with Babesiosis isnot eligibleto donate. Anyone withthe following types of cancermay donate:SquamousorBasal Cell Carcinomaof the skin, and those withMelanoma may be eligibleafter evaluation by our Medical Director. Persons with other forms of cancermay donate one (1) yearafter recovery. Individuals with Blood Cancer(leukemia or lymphoma) are not eligible to donate. Any individual who has tested positive for Chagas Disease isnot eligibleto donate blood. Potential donors with Diabetes are eligible, as long as it is controlled with oral medication. Those who have taken bovine insulin are not eligible to donate. Persons receiving electrolysis or acupuncture treatmentare eligibleto donate. Anyone who has lived with, or had sexual contact with a person with Hepatitis ,may not donate. Those with heart or lung disease who have symptoms or activity restrictionsshould not donate. However, youmay be eligible if you have recovered from cardiac, pulmonary (lung) or vascular surgery, and have no physical restrictions. Medical clearance from your physician may be required. Any individual who has HIV/AIDS ,or has tested positivefor HIV/AIDS,is not eligibleto donate blood. Potential donors who have had sexual contact in the past 12 months with anyone who has HIV/AIDS, or has had a positive test for the HIV/AIDS, virusisdeferred for 366 daysfrom the date of last sexual contact. Anyone who has used needles to take drugs, steroids, or anythingNOTprescribed by a doctor, even once,is not eligible. Potential donors who have been diagnosed with Lyme Disease areeligible to donate 30 days after diagnosis, and after they have completed antibiotic treatment. Persons taking antibiotics areeligible to donatethe day afterthe last dose, if recovered from the condition for which it wa Continue reading >>
Platelet Proteome Changes Associated With Diabetes And During Platelet Storage For Transfusion
Platelet proteome changes associated with diabetes and during platelet storage for transfusion 2 School of Electrical engineering and Computer Science, Washington State University Tri-Cities, 2710 University Drive, Richland, WA 99352 3 Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 2 School of Electrical engineering and Computer Science, Washington State University Tri-Cities, 2710 University Drive, Richland, WA 99352 3 Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 4 Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 4 Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 5 Environmental Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 4 Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 6 Pathology, Environmental Medicine, Medicine and Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 1 Fundamental Science Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland WA 99352, USA 2 School of Electrical engineering and Computer Science, Washington State University Tri-Cities, 2710 University Drive, Richland, WA 99352 3 Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester NY 14642, USA 4 Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester N Continue reading >>
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Blood Donation Eligibility Requirements | American Red Cross
This page uses Javascript. Your browser either doesn't support Javascript or you have it turned off. This list is not complete. Specially trained technical staff are available at each blood collection center and details of each donor's health and activities are discussed in a confidential setting prior to blood donation. The majority of donor eligibility rules are specified by the Food and Drug Administration for every collection center in the country. Other rules are determined by the medical professionals at specific blood centers, or with other regulatory bodies. Therefore, these rules may differ between programs. Donor eligibility rules are intended to protect the health and safety of the donor as well as the patient who will receive the transfusion. The criteria listed below are provided as guidelines to assist you in determining whether you may be eligible to be a blood donor. The final determination of eligibility is made at the time of donation. The guidelines listed below were last revised on 08/31/09. There may have been some changes to these criteria since the last revision date. The most up to date eligibility information can be obtained by contacting the American Red Cross blood donation center nearest you. To ensure the safety of blood donation for both donors and recipients, all volunteer blood donors must be evaluated to determine their eligibility to give blood. The final determination will be made on the day of the donation at the blood drive or blood donation center. If you were deferred from donating in the past, you may be able to donate again. The Red Cross recommends that females wait until the age of 19 or older to donate power reds. Please note higher requirements may apply in certain cases. Check with your donor center to confirm. Other aspect Continue reading >>
Can I Still Donate Blood If I Have Diabetes?
20 Books People with Diabetes Should Read Your diabetes should be under controlled before you donate blood To donate blood with diabetes, your blood sugar needs to be in your target range . Your A1C should be less than 7%, as recommended by the American Diabetes Association. If your blood sugars and diabetes are not well controlled, you shouldnt donate blood. Its up to you to let the Red Cross know. If you are unsure about the condition of your diabetes, discuss your concerns with your healthcare provider. They will be able to help you decide if giving blood is a good idea, or if you should wait until your diabetes is better managed. You should be in good overall health before you donate blood with diabetes Besides having your blood sugars in control, you should also have other conditions under control. For example, your blood pressure should be less than 180/100 mmHg to give blood, which is higher than 140/90 mmHg that is the recommended blood pressure for people with diabetes. Conversely, if your blood pressure is less than 90/50 mmHg, you wont be able to donate blood. Besides diabetes, they will also ask you about other conditions, and medications which you may be taking. Diabetes medications generally wont keep you from giving blood in the US, but there is a Red Cross list of other medications that shouldnt be taken if you are donating blood, including blood thinners. The Red Cross representative will screen you for conditions and medications which may affect your ability to donate blood with diabetes and related health conditions. Another thing to know is that if you plan to donate platelets, you should not take aspirin or blood thinners for several days prior to your donation. 1 If you have heart complications from your diabetes, there are some things that you ne Continue reading >>
Plasma Donor Eligibility Guidelines
This page lists a number of medical conditions that may affect your donation eligibility. It is designed to help answer some of your questions prior to contactingor visiting your local Biotest Plasma Center. This is not a complete list and in some instances, documentation may be required from your personal physician to confirm the diagnosis and treatment, along with their consent for you to donate. If you are not feeling well and / or have allergy, cold or flu-like symptoms, you should not donate. If you have mild allergies and taking medication for this condition, generally you are eligible to donate provided you are symptom-free on your donation days. If you have food allergies, you should be eligible to donate. Depending on the typeand reason for the anemia will determine if you are eligible to donate. Your blood test result will need to be within our established guidelines. Depending on the type of arthritis and the severity of the condition will determine if you are eligible to donate. Documentation may be required from your personal physician to confirm the diagnosis, treatment along with their consent for you to donate. Depending on the medication prescribed and the severity of the condition will determine if you are eligible to donate. You must also be symptom-free on your donation days. Depending on the type of cancer, you may be eligible to donate. Documentation may be required from your personal physician to confirm the diagnosis, treatment along with their consent for you to donate. Depending on the medical condition will determine if you are eligible to donate. If you have a hiatel hernia or GERD (gastoesophageal reflux disease), you should be eligible to donate. Depending on the type and the severity of the condition, you may be eligible to donate. Docume Continue reading >>
Can Diabetic People Donate Blood?
In the United States, the Food and Drug Administration does not have any regulatory restrictions against diabetics donating blood other than if the individual has received bovine source insulin since 1980. The concern here is not the diabetes but rather the bovine spongiform encephalopathy. As bovine source insulins were not widely available in the US, the diabetic would have had to specifically import it from Europe. (Of note, the FDA regulations require that is the donor answers that they are not certain whether they received bovine source insulin, they are deferred. Many donors answer "I do not know" and are therefore deferred when in reality they have not been exposed as it was not available in the US.) Donors may mistake this deferral as being due to their having diabetes. Here is the FDA guidance (Each blood collection center in the US can have criteria more stringent that either the FDA and AABB so there is some variability among blood centers. At the collection center where I work, we allow donors with diabetes, whether controlled with diet, oral hypoglycemics, or insulin, to donate. The only instance where I can think where diabetes would have a negative affect on blood product and therefore an adverse effect on the patient would be in the rare instances where we collect granulocytes. If the donor had poor glucose control, this could impair neutrophil function. Since granulocyte donors are usually stimulated with corticosteroids, which would worsen glucose control, diabetics are deferred from granulocyte donation at my institution so this is not an issue. Continue reading >>
Can People With Diabetes Give Blood?
Tweet When it comes to giving blood, there are a number of conditions that can make you ineligible. Unfortunately, people with diabetes won't, in most cases, be eligible to give blood. At least, not in the UK. This is because NHS Blood and Transplant (NHSBT) maintain a policy of refusing blood donations from anybody who may be placed at risk by giving blood. In many cases, this includes people with diabetes. Prediabetes and giving blood People who have been diagnosed with prediabetes are eligible to give blood, as long as they haven't had any heart problems. Insulin and blood donation People who take insulin are not allowed to give blood, which excludes both people with type 1 diabetes and people with type 2 diabetes who are insulin-dependent. The affect of blood donations on insulin levels is considered a risk to the donor's health. Because of this, people who are dependent on insulin are not permitted to give blood. This applies to both regular insulin injections and insulin pump therapy. Diabetes medication and giving blood People who take diabetes medication can give blood, as long as their medication hasn't changed in the last four weeks. Medication changes include changes in dosage, as well as the type of medication taken. If your medication has changed recently, the effect on your blood glucose means that your health would be at risk should you give blood. Diabetes, the heart, and giving blood People with diabetes who have experienced heart problems are, in most cases, ineligible to give blood. This includes people who have: Experienced faintness or giddiness as a result of heart problems Experienced heart failure Had surgery for blocked or narrowed arteries (including amputation) Conditions for giving blood There are a number of conditions that may prevent you f Continue reading >>
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Nhsbt - Who Can Donate Blood Platelets
You can become a platelet donor if you are generally in good health Aged 17 to 65 (if you have not donated before) If you are over 65 and have given blood before Or if you are over 70 you must have given a full donation in the last 2 years You do not have to have given blood before - you need to give a small sample of blood to determine if you have a high enough platelet count. Your sample is assessed which takes a couple of weeks, during which time we can determine your blood group. We will also need to know your gender, height and weight to see if you have a large enough blood volume to give 2 transfusions of platelets. Currently we are particularly looking to boost our recruitment of A negative group donors as their donations can be given to patients with blood groups other than their own. We look forward to welcoming you as a donor, whether is it giving platelets or whole blood - both of which help to save lives. Hopefully, this website has explained the urgent need for platelets, as well as the issues we face about the location and eligibility of people who can donate. If you think platelet donation is for you, please give us a call, and we'll answer any questions you have. We'll take your details, and the next step will be for your local centre's Platelet Donor Manager to contact you and arrange a visit to see if platelet donation is for you. Hopefully, this video has explained the urgent need for platelets, as well as about the location and eligibility of people who can donate. If you think platelet donation is for you, please register your interest online or call us on 0300 123 23 23, and we'll answer any questions you have. Once we have your details, we can arrange an appointment to see if platelet donation is suitable for you. We would like to emphasise again Continue reading >>
Platelet Donation (pheresis)
What are your platelets used for and why are they important? Platelets are cells produced in the bone marrow that are needed to prevent bleeding. Donation of these cells is important, as certain patients need transfusions of only platelets to survive. Although a single whole blood donation does yield about one tablespoon of platelets, eight to ten times that amount is needed for one platelet transfusion. Platelets are a very precious component of blood. Donations are needed frequently as these cells only have a shelf life of five days. To help keep the supply up, donors can safely give as frequently as every two weeks. Step 1: Call the donor recruiter at 314-362-1253 to schedule an appointment. Step 2: Come to the Pheresis Center at Barnes-Jewish Hospital. Be sure to bring a photo ID. Step 3: A registered nurse will ask you confidential qualifying questions and will conduct a complete medical screening. Your temperature, pulse and blood pressure will be taken along with one tube of blood for analysis. If your hemoglobin (iron-rich cells) and platelet count are high enough, you will be moved to the donation area. Step 4: Donating is safe, simple and relaxing. For the next 90 minutes, sit back in the cushy chair and put your feet up while the pheresis machine does all of the work. During the time it takes to complete your donation, you can read, watch television, use your computer and even make phone calls. The nurses in the Pheresis Center also can provide you with refreshments at your request. The donation: One sterile single-use needle is used in the donation process, through which whole blood leaves your body. Some of the platelets are removed, and then the blood is returned to your body. An anticoagulant will flow through the sterile tubing attached to the needle, s Continue reading >>
Can I Donate Blood If I Have Diabetes?
Donating blood is a selfless way to help others. Blood donations help people who need transfusions for many types of medical conditions, and you may decide to donate blood for a variety of reasons. A pint of donated blood may help up to three people. Although you’re allowed donate blood if you have diabetes, there are a few requirements that you’ll need to meet. If you have diabetes and want to donate blood, it’s generally safe for you to do so. People with type 1 and type 2 diabetes are eligible to give blood donations. You should have your condition under control and be in otherwise good health before you donate blood. Having your diabetes under control means that you maintain healthy blood sugar levels. This requires you to be vigilant about your diabetes on a daily basis. You need to be aware of your blood sugar levels throughout each day and make sure you eat a proper diet and exercise sufficiently. Living a healthy lifestyle will contribute to keeping your blood sugar levels in a healthy range. Your doctor may also prescribe certain medications to help manage your diabetes. These medications shouldn’t impact your ability to donate blood. If you want to donate blood but are concerned about your diabetes, talk to your doctor before your donation. They can answer any questions you may have and help you determine whether this is the best option for you. Health screening Blood donation centers have a screening process that requires you to disclose any preexisting health conditions. It’s also a time where a certified Red Cross professional will evaluate you and measure your basic vital statistics, such as your temperature, pulse, and blood pressure. They will take a small blood sample (likely from a finger prick) to determine your hemoglobin levels as well. If Continue reading >>
Can One Donate Blood With Diabetes, Cholesterol, Controlled Blood Pressure And After Cured Tuberculosis?
Medical Conditions and blood donation As per the Drugs and Cosmetics Act and guidelines from national blood transfusion council the medical conditions mentioned for deferral is vague and incomplete and hence the medical officer has got the discretion to take or defer donation based on recent developments in modern medicine. According to Dr Sunder Periyavan, Additional Professor, Officer in charge, Transfusion Medicine Center, NIMHANS, Bangalore - Diabetes with medication: A. Type I diabetes who is on Insulin (Injection) are to be deferred. This is because these patients can have extreme levels of blood glucose with or without insulin. Lower levels of blood glucose will have effect on blood donation because blood removal will further bring down the glucose level to bring about symptomatic hyplogycemia which is dangerous. And type I diabetes will have higher chance skin infection at the site of needle prick. B. Type II diabetes who is on oral diabetic drug can donate blood. This is because the blood glucose levels are not that extreme and even with 350/450 ml of blood with drawls will not cause symptomatic hypoglycemia. Since their blood levels are fairly maintained the chances of skin infection is less. Diabetes without medication: Since we do not know the blood glucose levels-high or low and at the camp site we do not test for glucose levels it is better to avoid bleeding the donor. High Cholesterol: high cholesterol is an abnormal condition for the donor. If blood 350/450 ml of blood is drawn from the donor and transfused it gets diluted in patients’ blood and the level will not be that high. And the patient can metabolize it brings down the level original level. It is as if the patient has taken a fatty meal. Hence blood donation is acceptable. And if the donor repe Continue reading >>
Donor Eligibility | Roswell Park Comprehensive Cancer Center
The following is general donation criteria. This is not a complete list. The information below serves only as a guideline to donor eligibility. Please contact The Donor Center at Roswell Park at 716-845-8275 if you have any questions. If you plan to schedule a plateletdonation and have not donated at the Donor Center since mid-July 2016 have a history of pregnancy, please contact the Donor Center before scheduling your appointment online. Recent regulatory requirements have resulted in a change to the eligibility criteria for some female platelet donors, and we would like the opportunity to speak with you over the phone before scheduling your appointment. Please call (716) 845-8275 Must be in general good health (not experiencing any active cold or flu symptoms, headaches, cold sore or infections at time of donation) Must not have donated whole blood within the last 56 days. *Please be sure to eat a substantial meal before your donation. Antibiotics: A donor with an infection may not be eligible to donate. Reason for antibiotic use must be assessed and a deferral period may be necessary after completing an antibiotic medication. Aspirin: Acceptable for whole blood donations. A platelet donor must wait 72 hours from the date of their last dose of aspirin or medications containing aspirin. (Please consult with your physician before discontinuing aspirin that has been medically prescribed). Blood Pressure: Acceptable limits are: Systolic (first number) 180 or below and diastolic (second number) 100 or below at the time of donation. Most blood pressure medications are acceptable. Surgery-please alert the collections specialist to any surgeries you have had that are less than 12 months from the date of your donation (including dental surgeries). A deferral period may or may Continue reading >>
