Pregnancies Following Use Of Metformin For Ovulation Induction In Patients Withpolycystic Ovary Syndrome.
Pregnancies following use of metformin for ovulation induction in patients withpolycystic ovary syndrome. Heard MJ(1), Pierce A, Carson SA, Buster JE. (1)Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Baylor College of Medicine, Houston, Texas 77030, USA. Comment in Fertil Steril. 2002 Oct;78(4):890; author reply 890-1. OBJECTIVE: To assess pregnancy outcome in anovulatory infertility patientsdiagnosed with polycystic ovary syndrome (PCOS) who were treated with metformin.DESIGN: Case series.SETTING: Outpatient.PATIENT(S): Anovulatory patients (n = 48) with a diagnosis of PCOS based onclinical, diagnostic, and laboratory evaluations were enrolled in the study over a 15-month period.INTERVENTION(S): Metformin was started at 500 mg b.i.d. for 6 weeks and thenincreased to 500 mg t.i.d. if no ovulation occurred. Clomiphene citrate (CC; 50mg) was added if no ovulatory response occurred after 6 weeks.MAIN OUTCOME MEASURE(S): Resumption of menses, presumptive ovulation, andpregnancy.RESULT(S): Nineteen of 48 (40%) patients resumed spontaneous menses followingtreatment and showed presumptive evidence of ovulation with metformin alone;15/48 Continue reading >>