Could Serum Uric Acid Levels Predict Progression To Diabetic Kidney Disease?
This study assessed the association between serum uric acid levels and progression to chronic kidney disease in type 2 diabetes. Type 2 diabetes is associated with the development of many complications, including diabetic nephropathy (kidney disease or damage), which often leads to chronic kidney disease. Uric acid is a byproduct of many metabolic pathways, and is typically filtered in the kidneys and removed from the body through the urine. Higher levels of uric acid in the blood (referred to as serum uric acid) often indicates kidney damage, and several studies has suggested that serum uric acid may be used as a marker of progressive diabetic kidney damage. The aim of this study was to determine whether serum uric acid levels could predict the development of chronic kidney disease among patients with type 2 diabetes mellitus and preserved kidney function at the beginning of the study. The study evaluated 512 type 2 diabetic patients with normal uric acid levels (less than or equal to 8 mg/dL). Patients were classified into four groups based on their serum uric acid levels. Group 1 was composed of 137 patients with uric acid levels of less than or equal to 3.8 mg/dL. Group 2 was c Continue reading >>