Can Metformin Help With Weight Loss?
Bottom Line: Yes. About 2 to 9 kg (4 to 20 pounds) according to the studies and this fits my clinical experience. I want to give my patients the best shot possible when trying to lose weight (and keep it off). This may or may not include giving them medicines along the way. Our bodies are working against us so we must work against them (as safely as possible). Most approved weight loss medicines work in the brain to help us control our appetites. They can be pricey (unless generic, which are approved for short-term) and their long-term effects are unknown. There is one medicine that has been prescribed by weight loss doctors and used by bodybuilders for years despite not being approved for weight loss with a very strong safety record. That medicine is metformin. (Or as my Siri has written in the past, Matt Foreman). How to take it: Start with 500 mg tablet with breakfast (some say start with dinner). If you tolerate it after about a week or two, try 500 mg with breakfast and dinner. After another week or two go to 1000 mg with breakfast and dinner. Who takes it?: It is the first-line drug treatment approved for type 2 diabetes. However, it is also commonly used in PCOS (polycystic ovarian syndrome), prediabetes (and those with insulin resistance), those taking antipsychotics looking to minimize weight gain, and adolescents/adults looking to lose weight some weight loss. There are anecdotal reports of athletes and bodybuilders taking it as well. How does it work?: Metformin helps your muscles take in sugar (increases insulin sensitivity) and slows your liver’s sugar production (decreased hepatic gluconeogenesis). The mechanism is likely a peripheral activation of AMPK (AMP-activated protein kinase) and alteration of the gut microbiome and increases in GLP-1. You can re Continue reading >>
Why Metformin Is A Bad Idea For Weight Loss In Pcos
Home / Polycystic Ovarian Syndrome / Why Metformin Is A Bad Idea For Weight Loss In PCOS Why Metformin Is A Bad Idea For Weight Loss In PCOS Take Your First Step to a PCOD-Free Life! This program is available only in India, for now Know More Human anatomy is all about balance. It is all related. One has to attain the harmony between various facets of the body to keep it disease-free. The balance between your hormones plays the important role here as it drives your metabolism and thereby your blood sugar levels. The backstory of PCOD is elevated insulin levels. Almost 70% of women with PCOS have insulin resistance in their body. Which means the blood glucose levels continue to be high. This elevation eventually causes ovaries to produce more testosterone, upsetting the balance of hormones in the body. Excess testosterone leads to hair fall, cystic acne, irregular periods and stubborn weight gain. The weight gain typically happens in the abdominal area. To help women combat PCOS symptoms they are often prescribed metformin -a drug used to lower sugar levels. For those who are new to sugar-inflated world, Metformin is a first-line medication for Type 2 diabetes mellitus. Metformin comes from a drug group named Biguanides. It is an insulin-sensitizing drug (ISD) which works by lowering the production of glucose in the liver. Taking metformin restores the ability of the body to respond to insulin, metabolizing food better and managing blood sugar levels. The human body does not tolerate sugar in the blood for too long and it starts damaging cells. This excess sugar is generally taken by the liver and converted into fat. Metformin seemingly improves liver function. And so women are recommended this drug as an easy way to weight loss. Unfortunately, this dalliance of metformi Continue reading >>
Does Metformin Help With Weight Loss? (the Answer Is Yes & Here’s Why)
Metformin may be one of the cheapest and most underused weight loss medications out there. Metformin is traditionally reserved for those with diabetes or insulin resistance, but many studies show that it can be effective in overweight or obese patients without diabetes. The only problem? You wouldn't know about it unless you do the research yourself! Use this post to learn everything you need to know about using metformin (both if you have diabetes or if you are simply just overweight): Metformin & How it May Help With Weight Loss Does metformin help with weight loss? The answer is more complex than just a standard "yes" or "no", instead the correct answer is more of a "maybe". What do I mean? Well metformin is a medication that falls into the class of biguanides. The most popular of these medications is metformin (and the topic of our discussion today) which is being used by at least 120 million people worldwide. Classically, metformin is used to treat blood sugar issues, insulin resistance and type II diabetes. It was found a long time ago, that if used for these conditions, metformin does indeed help some patients lose weight. Studies have shown that patients who take metformin with insulin resistance do tend to lose weight - most studies showing a "modest" amount to the tune of around 5-10 pounds. Because these studies have been favorable to some patients (especially those with the conditions listed above), it's normal to ask if it also works for patients who don't have type II diabetes. In order to understand that, we need to understand how metformin works. As it relates to weight loss metformin has powerful actions in 2 main areas: In the mitochondria respiratory chain complex: Activating the mitochondrial pathway is a powerful way to increase energy production an Continue reading >>
Effectiveness Of Metformin On Weight Loss In Non-diabetic Individuals With Obesity.
Abstract OBJECTIVE: The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results. Moreover, the effectiveness in a real-life outpatient setting has not been tested until today. In this study we aimed to examine the effectiveness of metformin as a weight reducing drug in obese and overweight patients with regard to their degree of insulin resistance. DESIGN AND PATIENTS: We treated 154 consecutive patients with a body mass index ≥27 kg/m(2) in an outpatient setting over 6 months with metformin up to a dosage of 2,500 mg per day. Additionally, we included 45 untreated patients as controls. Patients were monitored for weight changes over 6 months. Before metformin treatment was started insulin sensitivity was determined in all patients by calculating HOMA index and Matsuda index after a 75 g oral glucose tolerance test. RESULTS: The mean weight loss in the metformin treated group was 5.8±7.0 kg (5.6±6.5%). Untreated controls gained 0.8±3.5 kg (0.8±3.7%) on average. Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive patients. The percentage of weight loss was independent of age, sex or BMI. CONCLUSION: Metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. Continue reading >>
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Must I Increase My Dose Of Metformin To Lose Weight?
Weight loss is an integral aspect of improving Polycystic Ovarian Syndrome, or PCOS, in women who are overweight. Carrying extra weight can cause the condition’s symptoms to become more severe, and can even increase the level of Insulin Resistance (IR) that a woman experiences.1 IR occurs when the body’s cells become desensitized to insulin, preventing the hormone from turning glucose into energy. This results in high blood sugar and, in some cases, diabetes. For this reason, Metformin, a popular diabetes medication, is also used to improve PCOS. Aside from regulating blood sugar levels, this pharmaceutical, also known as Glucophage, contributes to weight loss. How Metformin Encourages PCOS Weight Loss Insulin is a hormone that triggers both hunger and the production of fat cells. Therefore, by reducing insulin, women can reduce the amount of food they eat as well as the amount of fat cells that their bodies produce.2 Metformin’s primary function is to reduce insulin, so it is only natural that this medication contributes to weight loss. How Much Medication Is Necessary? Dosage is determined by several factors; healthcare professionals consider medical history, body type, and severity of symptoms when coming to the proper dosage. Metformin comes in three different sized pills: 500 mg, 850 mg, and 1,000 mg.2 Generally, individuals are prescribed between 850 and 1,000 mg two times per day, with 850 mg three times per day being the maximum amount of the medication safe to consume.2 Typically, doctors will prescribe a low dose to gauge the body’s reaction to the medication.2 If the body needs more, physicians will alter the dosage until the right amount is achieved. Because so many factors contribute to the proper dosage, many women who are prescribed different amou Continue reading >>
3 Things You Need To Know About Metformin
September 30, 2015 by Dr. Brooke in Be Better , Eat Better , pcos 3 Things You Need To Know About Metformin Metformin is recommended by doctors for women with PCOS that want to loose weight or otherwise manage their PCOS and insulin resistance. But there are 3 very important things that you need to know about it including the fact that it's not the only option! Let me first say, I dont hate Metformin for women with PCOS . For some women it really does help spur ovulation, control blood sugar and help with some weight management but.its not without its share of issues. And its definitely not the magic bullet for weight loss although its usually presented that way. How Metformin (or its generic form: Glucophage) Works Metformin is typically given with meals throughout the day, or more commonly now the extended release version is given once with dinner or at bedtime. While only having to pop a pill one time per day is always appealing, this once a day dosing (especially at bedtime) is where I see the most problems with my patients. It lowers both fasting and post meal glucose levels by decreasing the glucose absorption in your intestines after a meal; as well as decreasing the amount of glucose your liver makes for later use. It also does help improve insulin sensitivity by increasing glucose movement into a cell. All sounds good so far right? Not so fast, here are the most common issues I see in women using Metformin: Metformin is notorious for causing sometimes severe digestive issues including stomach pain or upset, nausea, vomiting, diarrhea and even a sense of body weakness or metallic taste in the mouth in some. And it is touted as not causing low blood sugar as many older blood sugar lowering drugs did, however I see it every day in my practice that Metformin can m Continue reading >>
How To Take Metformin As A Weight-loss Pill
Metformin, or glucophage, is an oral diabetes medication that is commonly prescribed to control blood sugar levels. This medication makes it easier for your body to absorb available glucose in the bloodstream. Metformin is generally a safe medication; however, some patients may experience lactic acidosis, which results in muscle pain, difficulty breathing, slow or uneven heart rate, weakness, dizziness and stomach pain. In addition, metformin may cause weight loss as a side effect, which can be beneficial if you are trying to lose weight. Video of the Day Schedule and appointment with your physician to determine is metformin is an appropriate medication for control of diabetes and weight loss. Be sure to let your doctor know of other medications you are taking, in particular the medications related to diabetes. Bring in at least a week's worth of before and after-meal blood sugar recordings. Take metformin with a meal, whether it is prescribed once per day or twice per day. Avoid eating high-calorie, fatty foods while taking metformin. Focus on consuming more fruits, vegetables, whole grains and nuts. Check your blood sugar levels after eating. Drink a full glass of water each time you take metformin. It will also make you feel full and reduce your cravings to eat. Continue reading >>
'can I Take Metformin If I Want To Lose Weight?'
'Can I Take Metformin If I Want To Lose Weight?' Some doctors are now prescribing this diabetes drug for weight loss. But is it safe? Metformin is a drug designed to treat patients with Type 2 diabetes, but it comes with an interesting side effect: weight loss . And Reddit is filled with stories from people who have lost weight on the drug. Was trying to lose weight for a long time with no success, one person wrote of being prescribed metformin. Im on 1000 mg a day and am down 10 pounds. I saw weight loss at first with 500 mg twice per day, another wrote. The difference was almost immediate. While some people say the drug didnt do much for them, others swear by iteven those that dont have Type 2 diabetes, saysFatima Cody Stanford, M.D., an instructor of medicine and pediatrics at Harvard Medical School and obesity medicine physician at Massachusetts General Hospital. In fact, Cody Stanford says that she often prescribes the medication to overweight or obese people who don't have Type 2 diabetes. Heres what you need to know about the drug. (Hit the reset buttonand burn fat like crazy with The Body Clock Diet !) Metformin causes a decrease in the release of glucose from a persons liver. This helps to lower a persons blood sugar when its too high and restore the way someone uses food to make energy, according to the Mayo Clinic . " Weight loss can occur because it decreases appetite in some people who take it," says women's health expert Jennifer Wider , M.D. In order for the prescription to work effectively, the amount of metformin you take must be balanced against your diet and exercise because it helps level out your blood sugar, the clinic says. For that reason, if you change your diet or exercise, you doctor may need to change the amount of metformin you take. Check Continue reading >>
Metformin For Weight Loss How It Works, Benefits, And Side Effects
For adults, Metformin tablets can be taken 2-3 times a day. For children and teenagers, 1 Metformin tablet per day is recommended. It is not allowed for children under 10 years of age. The maximum daily dose is 1000 3000 mg metformin per day (divide the doses into 2 or 3 smaller doses). Your doctor will start with the lowest dose, and after a week or two, depending on your bodys response to the previous dose, he/she may increase the dose. Do not stop taking it until your doctor tells you to do so. But, what happens if you miss a dose? Find out next. You should be extra careful when you take Metformin for weight loss. There is nothing to worry about if you miss a dose. However, if you remember it very close to the time for your next dose, do not take the pill. If not, you can safely take the missed dose as soon as possible. Make sure to eat something along. Metformin overdose can be fatal. Do not try to take too many pills to lose weight quickly. Overdosing yourself will not lead to weight loss, but you may experience fast breathing, chills, stomach ache, nausea, headache, and lactic acidosis. Make sure to go to your nearest hospital to get help. Now, the next big question is, how much weight loss can you expect and in how much time. Lets find out. How Much Weight Loss Is Expected From Metformin? There have been many studies regarding Metformin-induced weight loss in type 2 diabetic patients and obese people. Many of these studies lasted from 4 to 7 months. The results concluded that the immediate weight loss experienced due to Metformin ranged from 1 to 4 kg. Experts say that the real weight reduction begins only after taking the medication for 4 to 6 weeks in total. So, is it really safe to take Metformin for such a long period for weight loss? Find out in the next se Continue reading >>
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Does Metformin Cause Weight Loss? What To Know Before You Take It
If you’re managing type 2 diabetes with metformin (Glucophage), you might be well acquainted with unwanted side effects of this drug — namely, upset stomach, diarrhea, muscle aches, and sleepiness. These can be a figurative and literal pain, but you might welcome one side effect of metformin with open arms, particularly if you’ve struggled to lose weight. Metformin isn’t a weight loss drug, but researchers have found a link between the drug and weight loss. In fact, a long-term study published in April 2012 in the journal Diabetes Care that was conducted by the Diabetes Prevention Program (DPP) concluded that the drug could serve as a treatment for excess body weight, although more studies are needed. What Is Metformin and How Does It Work? “[Metformin] has been considered a first-line medication in the treatment of type 2 diabetes, and it mainly acts by lowering the amount of glucose released by the liver,” says Minisha Sood, MD, an endocrinologist at Lenox Hill Hospital in New York City. “It also helps a hormone called insulin to work better by helping muscles use glucose in a more efficient manner. When insulin works better (and insulin sensitivity improves), a person’s insulin levels are lower than they would be otherwise.” There’s no cure for type 2 diabetes, but the right combination of medication and healthy lifestyle can stabilize blood sugar levels, which, of course, is the end goal of any diabetes treatment. As the medication helps your body properly metabolize food and restores your ability to respond to insulin, you’ll not only feel better, you can potentially avoid complications of high blood sugar, such as heart disease, kidney damage, nerve damage (diabetic neuropathy), and eye damage (retinopathy). Why Does Metformin Cause Weight Lo Continue reading >>
Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>
Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
Metformin (glucophage) And Weight Loss
Tweet Metformin, a generic diabetes treatment usually sold under the brand name Glucophage, may help people with diabetes to lose weight by lowering their appetites. Insulin makes people overweight by acting on the brain to cause hunger, making the liver manufacture fat and fill fat cells in the stomach. Avoiding obesity is a matter of avoiding foods high in blood sugar, and taking medication that prevents blood sugar levels from climbing too high. Glucophage function The function of diabetes drug Glucophage is to reduce the release levels of sugar from your liver. This stops blood glucose levels from rising too high, and means that the body does not have to produce as much insulin. Therefore, the patient is not as hungry. Type 2 diabetes drug Metformin (Glucophage) may be used successfully as a medication for type 2 diabetes. Lowers insulin levels It lowers insulin levels, helps to prevent diabetes complications, and helps people with diabetes to lose weight. Losing weight whilst taking Metformin (Glucophage) means also eating a healthy diet. Eating lots of foods that boost blood sugar levels will counteract the effects of Metformin. Most doctors prescribe 500mg of Metformin (Glucophage) before eating. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being unable to produce enough insulin Type 2 diabetes is characterised by the body being unable to metabolise glucose (a simple sugar). This leads to high levels of blood glucose which over time may damage the organs of the body. From this, it can be understood that for someone with diabetes something that is food for ordinary people can become a s Continue reading >>
Metformin: Use, Action, Dose, Side-effects And Brands Available
Controlling blood sugar levels inadults, adolescents and children aged 10 years and over with type 2 diabetes . Metformin is usedwhen diet alone has failed to fully control blood sugar. It may be used on its own, in combination with other oral antidiabetic medicines, or with insulin. Polycystic ovary syndrome (PCOS). This is an off-licence use of metformin, so you won't find it mentioned in the information leaflets that come with the medicine. However, metforminis awidely used and established treatmentoptionfor this condition. In type 2 diabetes the cells in the body, particularly muscle, fat and liver cells, become resistant to the action of insulin.Insulin is the main hormone responsible for controlling the level of sugar (glucose)in the blood. It makes cells in the body remove sugar from the blood. When the cells are resistant to insulin this makes blood sugar levels rise too high. Metformin hydrochlorideis a type of antidiabetic medicine called a biguanide. It works in a number of ways to lower blood sugar levels in people with type 2 diabetes. Firstly,it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively.Secondly,it reduces the amount of sugar produced by cells in the liver.Finally, it delays the absorption of sugar from the intestines into the bloodstream after eating so that there is less of a spike in blood sugar levels after meals. Metformin is taken regularly every day to help controlblood sugar levels both between and directly after meals. In polycystic ovary syndrome or PCOSmanywomen have high insulin levels, and as a result their cells become resistant to the action ofinsulin. The high insulin levels also cause an increase in the male hormonetestosterone. Both problems cancause som Continue reading >>
Can You Take Metformin For Weight Loss? A Look At The Numbers
Metformin is a medication said to cause weight loss, but is it true? Should you be worried if you are underweight, or should you use it if you want a slimmer waistline? This article takes a looks at the current evidence and if you can take metformin for weight loss. What is Metformin? Metformin belongs to the class of medications called “oral hypoglycemics.” This means it’s taken by mouth to help reduce blood sugar (glucose) levels. For this reason, metformin is commonly used for the management of type 2 diabetes. How Does Metformin Work? The way metformin works isn’t fully understood yet. However, what is known is that it reduces the production of sugar by liver cells (1). Metformin also improves insulin sensitivity and influences the bacterial community in the gut. It may have anti-inflammatory effects that could be beneficial for metabolic health too (2, 3). Metformin may also cause weight loss by reducing food intake and blocking gastrointestinal absorption of glucose, at least in theory (4). Summary: Commonly prescribed for type 2 diabetes, metformin is a medication that influences the metabolism and absorption of sugar. What is Metformin Used For? Metformin has been approved for treating type 2 diabetes. This medication is also sometimes prescribed for the following: Research continues on other uses for metformin including: Anti-aging or anti-cancer effects (8) Helping manage type 1 diabetes (9) Reducing the risk of heart disease (10). Summary: Metformin has been approved for the management of type 2 diabetes. It is sometimes prescribed for other conditions that involve abnormal blood sugar, such as diabetes during pregnancy. Can You Take Metformin For Weight Loss? Metformin helps manage type 2 diabetes, a health condition associated with being overweight. Continue reading >>