Pcos - Metformin And Losing Weight Before Trying Clomid
I am almost in the same boat. My BMI isn't great, and I've packed on over 40 lbs since last year's miscarriage. The doctor and I discussed at length what we would do. He believes sincerely that my weight gain is the source of a lot of my issues. The plan now is to treat me with Clomid, while simultaneously working on weight management. I do feel a tremendous amount of guilt, because I know my weight is likely the source of most of my fertility troubles. I'm no longer a spring chicken, so I'm moving forward with this treatment plan. Ideally, if I was younger, I would have given myself a year or two to slim down. If you are under 35, you have time on your side. At a very moderate weight loss rate of 1.5 pounds a week, that will be almost 80 pounds lost in a year. When you start at a higher weight, you can even safely lose more. That will make amajor difference for you in the long run. Best of luck to you in whatever you decide. I have to chime in as well. I've been TTC #2 with PCOS for over 3 years - and I've been working on my weight for longer. The downside of PCOS is that you can diet and exercise all you want, but it's not going to make the same kind of difference you might see in someone else. I'm a huge fan of being very careful of what you eat - just know that hopping on Metformin and the treadmill won't necessarily get you a drastic drop in weight. If you are committed to getting exercise as a way of life, and you have a healthy diet (or make the changes needed to get there) you can be healthy even if you are not "thin". My BMI is 30 and ideally, I'dbe in a healhty range if I lost 35 lbs, but I swear to you I have the healthiest diet among anyone I know. Just don't beat yourself up too badly. I've been there, and it sucks. Also, make sure you are being monitored Continue reading >>
Weight Loss With Pcos: Why Is It So Hard?
How many times have you been to the doctor only to be told to lose weight to improve your Polycystic Ovarian Syndrome symptoms? Easier said than done, right! We know that weight gain and difficulty with weight loss with PCOS is part and parcel of the condition and we seem to be fighting a constant battle with the scale. But, why is it so darn hard to lose weight? Just what is it about PCOS that makes weight loss seem virtually impossible? Let’s have a look at what is happening in our bodies and what some of the research says about weight loss and PCOS. Insulin Resistance and the Role of Insulin in PCOS Insulin is an important hormone that is responsible for metabolizing glucose or dealing with sugar in our blood stream. It transports sugar to the muscles and if the body has more glucose than is needed, insulin is involved in the process of storing it as fat should we need it later (1). Research shows that women with PCOS have some kind of dysfunction in the cells responsible for secreting insulin (Beta cells). It seems that these cells are responsible for detecting sugar in the blood stream and may over react, producing more insulin than is needed. This means that more glucose is stored as fat (2). Also, many, but not all, women with PCOS also have insulin resistance (3). This means that your body needs more insulin than normal to deal with sugar in your blood stream. High levels of insulin cause your body to store more fat and also causes your ovaries to make more testosterone, making the symptoms of PCOS worse (4). Unfortunately, Insulin and Insulin resistance is only one piece of this puzzle and isn’t the only reason that we struggle to lose weight… Slow Metabolism Women with PCOS have also been found to have a slower metabolic rate. Basal metabolic rate is the Continue reading >>
Metformin Treatment Is Effective In Obese Teenage Girls With Pcos
Metformin treatment is effective in obese teenage girls with PCOS To whom correspondence should be addressed at: Institute of Obstetrics and Gynecology, University of Siena, Policlinico Le Scotte, Via Bracci, 53100 Siena, Italy. E-mail: [email protected] Search for other works by this author on: Department of Pediatrics, Obstetrics and Reproductive Medicine, Institute of Obstetrics and Gynecology, University of Siena, Siena, Italy Search for other works by this author on: Human Reproduction, Volume 21, Issue 9, 1 September 2006, Pages 22522256, Vincenzo De Leo, M.C. Musacchio, G. Morgante, P. Piomboni, F. Petraglia; Metformin treatment is effective in obese teenage girls with PCOS, Human Reproduction, Volume 21, Issue 9, 1 September 2006, Pages 22522256, BACKGROUND: Polycystic ovary syndrome (PCOS) is the most frequent cause of menstrual disorders in teenage girls. Little information is available about the effects of metformin in adolescent girls with PCOS and its dose and its efficacy in regulating menstrual cyclicity and hyperandrogenic symptoms. We evaluated the effects of metformin treatment on ovulatory function, hirsutism, acne, hormonal patterns and body weight in adolescent girls with PCOS. METHODS: Eighteen girls, ranging in age from 15 to 18 years, were enrolled in the study. Clinical diagnosis of PCOS was based on the consensus criteria for PCOS accepted in May 2003 at Rotterdam. All subjects received 1700 mg/day metformin as tablets continuously for 6 months. They were then followed up for 6 months. RESULTS: Two patients complained of side effects for >2 weeks and interrupted treatment; they were not evaluated. All the others showed an improvement in menstrual cyclicity. Menstrual periods were ovulatory, with progesterone levels up to 6 ng/ml in luteal phase a Continue reading >>
Does Glucophage/metformin Cause Weight Loss?
Does Glucophage/Metformin cause weight loss? Does Glucophage/Metformin cause weight loss? Brand new to pre-d. I got diagnosed in March. Spent a couple of months in denial and continuing to eat whatever I wanted. Then I started getting fasting numbers over 100 so I snapped out of denial. My endo who treats my hypothyroidism runs an A1c annually because of my age (49) and my father's diabetes. The number has slowly been creeping up. Last year's was 5.9 which endo said was "normal" and this years was 6.3 to which he said was pre-diabetes and that I should start lowering my carb intake. He said he could prescribe glucophage if I wanted it. I know nothing about it so I said no. I had been complaining to him about how in the past an increase in my thyroid med dose would make me drop 10 lbs without trying and asked him why my latest increase (to 50 mcg) did not do anything. He said it was due to my age and being post-menopausal which is when he said "if you want to lose weight I can put you on glucophage" I have a lot of trouble swallowing even small pills and both glucophage and metformin are horse pills so I would have to go with riomet (sp?) liquid. My question: I've seen on PCOS boards that glucophage/metoformin causes dramatic weight loss but I haven't seen much of this on diabetes boards. For anyone taking this, what has been your experience? I lost about 40 pounds over a few months with metformin. The problem with metformin is that it can cause major gastrointestinal distress in some people. they should start you out on a low does to see how you do if you do decide to take medicine A1C December 6= 8.1 put on MDI Pumping Madtronic 4-4-13 My metformin is a round pill, so ask your Pharmacist to order a smaller version. I did lose weight on metformin, about 32 pounds but I Continue reading >>
Metformin, Weight Loss & Pcos – Does It Actually Work?
Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). But one simple question r Continue reading >>
Metformin (glucophage) For Weight Loss
After you eat, sugar goes from your intestines into your bloodstream, and then immediately into your liver. Then your liver releases sugar back into your bloodstream to cause your blood sugar level to rise. To keep blood sugar levels from rising too high, your pancreas release insulin into your bloodstream. Insulin makes you hungry all the time and causes your liver to convert extra calories to fat and it constricts arteries to cause heart attacks. You need insulin to keep blood sugar levels from rising too high to cause diabetes, nerve damage, heart attacks, strokes and kidney damage. Glucophage reduces sugar release from your liver to prevents blood sugar levels from rising too high, so your body doesn't need to produce as much insulin that makes you hungry and causes your liver to make fat (3,13,14). Glucophage lowers insulin levels (4), prevents many of the side effects of diabetes and can be used by people who want to lose weight. However, Glucophage is not effective when your blood is acidic from excess lactic acid and recent research shows that exercise, which raises lactic acid, does not cause blood acid levels to rise enough to reduce Glucophage's benefits (5). Glucophage, itself, does not raise blood lactate levels and is therefore considerably safer than doctors originally thought. Since Glucophage lowers insulin, diabetics should be placed on Glucophage to lower their requirements for all other medications used to treat diabetes (6). A common cause of obesity in women is called polycystic ovary syndrome, which is caused by having high blood levels of insulin. Glucophage helps these women to lose weight (7-12). See the report on Polycystic Ovary Syndrome (PCOS) in the Women's Health section. Glucophage is a safe medication that prevents blood sugar levels fro Continue reading >>
Can You Take Metformin For Weight Loss? A Look At The Numbers
Metformin is a medication said to cause weight loss, but is it true? Should you be worried if you are underweight, or should you use it if you want a slimmer waistline? This article takes a looks at the current evidence and if you can take metformin for weight loss. What is Metformin? Metformin belongs to the class of medications called “oral hypoglycemics.” This means it’s taken by mouth to help reduce blood sugar (glucose) levels. For this reason, metformin is commonly used for the management of type 2 diabetes. How Does Metformin Work? The way metformin works isn’t fully understood yet. However, what is known is that it reduces the production of sugar by liver cells (1). Metformin also improves insulin sensitivity and influences the bacterial community in the gut. It may have anti-inflammatory effects that could be beneficial for metabolic health too (2, 3). Metformin may also cause weight loss by reducing food intake and blocking gastrointestinal absorption of glucose, at least in theory (4). Summary: Commonly prescribed for type 2 diabetes, metformin is a medication that influences the metabolism and absorption of sugar. What is Metformin Used For? Metformin has been approved for treating type 2 diabetes. This medication is also sometimes prescribed for the following: Research continues on other uses for metformin including: Anti-aging or anti-cancer effects (8) Helping manage type 1 diabetes (9) Reducing the risk of heart disease (10). Summary: Metformin has been approved for the management of type 2 diabetes. It is sometimes prescribed for other conditions that involve abnormal blood sugar, such as diabetes during pregnancy. Can You Take Metformin For Weight Loss? Metformin helps manage type 2 diabetes, a health condition associated with being overweight. Continue reading >>
Polycystic Ovary Syndrome (pcos) And Weight Gain
Most women at some point have to contend with weight gain. But for women with polycystic ovary syndrome (PCOS), losing weight can become a constant struggle. PCOS is the most common hormonal disorder in women of childbearing age and can lead to issues with fertility. Women who have PCOS have higher levels of male hormones and are also less sensitive to insulin or are "insulin-resistant." Many are overweight or obese. As a result, these women can be at a higher risk of diabetes, heart disease, sleep apnea, and uterine cancer. If you have PCOS, certain lifestyle changes can help you shed pounds and reduce the disease's severity. Why does polycystic ovary syndrome cause weight gain? PCOS makes it more difficult for the body to use the hormone insulin, which normally helps convert sugars and starches from foods into energy. This condition -- called insulin resistance -- can cause insulin and sugar -- glucose -- to build up in the bloodstream. High insulin levels increase the production of male hormones called androgens. High androgen levels lead to symptoms such as body hair growth, acne, irregular periods -- and weight gain. Because the weight gain is triggered by male hormones, it is typically in the abdomen. That is where men tend to carry weight. So, instead of having a pear shape, women with PCOS have more of an apple shape. Abdominal fat is the most dangerous kind of fat. That’s because it is associated with an increased risk of heart disease and other health conditions. What are the risks associated with PCOS-related weight gain? No matter what the cause, weight gain can be detrimental to your health. Women with PCOS are more likely to develop many of the problems associated with weight gain and insulin resistance, including: Endometrial cancer Many of these condit Continue reading >>
Metformin And Weight Loss In Obese Women With Polycystic Ovary Syndrome: Comparison Of Doses
Context: Metformin treatment of women with polycystic ovary syndrome (PCOS) is widespread, as determined by studies with diverse patient populations. No comparative examination of weight changes or metabolite responses to different doses has been reported. Objective: The aim of this study was to determine whether different doses of metformin (1500 or 2550 mg/ d) would have different effects on body weight, circulating hormones, markers of inflammation, and lipid profiles. Design: The study included prospective cohorts randomized to two doses of metformin. Setting: The study was performed at a university teaching hospital with patients from gynecology/endocrinology clinics. Patients: The patients studied were obese (body mass index, 30 to <37 kg/m2; n = 42) and morbidly obese (body mass index, ≥37 kg/m2; n = 41) women with PCOS. Intervention: Patients were randomized to two doses of metformin, and parameters were assessed after 4 and 8 months. Main Outcome Measures: The main outcome measures were changes in body mass, circulating hormones, markers of inflammation, and lipid profiles. Results: Intention to treat analyses showed significant weight loss in both dose groups. Only the obese subgroup showed a dose relationship (1.5 and 3.6 kg in 1500- and 2550-mg groups, respectively; P = 0.04). The morbidly obese group showed similar reductions (3.9 and 3.8 kg) in both groups. Suppression of androstenedione was significant with both metformin doses, but there was no clear dose relationship. Generally, beneficial changes in lipid profiles were not related to dose. Conclusion: Weight loss is a feature of protracted metformin therapy in obese women with PCOS, with greater weight reduction potentially achievable with higher doses. Additional studies are required to determine wh Continue reading >>
Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
Pcos -- Metformin- Weight Loss
My doc has put me on metformin because i have PCOS.She has refered me to a OBGYN to get looked at better. I am in the weight wise program here in canada and since i started .. i have lost 14 pounds... in 2 months. Ihave made some suttle changes to what i eat .. at my dietians request.. and im just wondering... is the weight loss ... from METFORMIN.. or from the little bit i have changed... changing from 2 % to 1%milk..Started Eating breakfast, no more pop, food journaling, recording my steps. I was on Metformin and from what I know, is it kind of curbs your appetite. Or makes you feel a little sick so you aren't hungry. And that's why you lose weight. Thats what I noticed it did for me. I was basically sick or just not hungry. I can't say I lost weight from it, but it made me feel sick in the beginning of taking it. On April 13, 2010 at 8:03 AM Pacific Time, Julia23 wrote: I was on Metformin and from what I know, is it kind of curbs your appetite. Or makes you feel a little sick so you aren't hungry. And that's why you lose weight. Thats what I noticed it did for me. I was basically sick or just not hungry. I can't say I lost weight from it, but it made me feel sick in the beginning of taking it. I agree with Julia. You either feel sick or simply not hungry. Metformin does help with weight loss. It does this through several mechanisms but the primary one is that it increases muscle cells sensitivity to insulin. The insulin resistance you had was contributing to weight gain and the metformin helps to reverse that. Metformin works best when you are on a low carb diet. I am sure your eating better and being mindful of your health is a major contributing factor to your weight loss as well. Generally the weight loss with the metformin will happen during the first 3 months, Continue reading >>
Role Of Metformin In The Management Of Polycystic Ovary Syndrome
Go to: Background Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder affecting 4–12% of women [Diamanti-Kandarakis et al. 1999; Farah et al. 1999; Knochenhauer et al. 1998]. It has also been the most controversial medical condition and every aspect has received a lot of attention from the nomenclature to the management. Several descriptions of similar conditions took place in the 20th century and it was named Stein—Leventhal Syndrome in 1935 after the authors who described polycystic ovarian morphology in patients suffering from hirsutism, amenorrhoea and infertility [Leventhal, 1958; Stein and Leventhal, 1935]. PCOS was also called polycystic ‘ovarian’ syndrome implying that the primary pathology lies in or triggered by the ovary. Others have called it polycystic ovary disease (PCOD), which is the least used term for obvious reasons. Currently, PCOS refers to a disorder with a combination of reproductive and metabolic characteristics. This has evolved over time with controversy over the definition culminating in the latest consensus [ESHRE/ASRM, 2004] which instead of solving the issue created more controversy [Azziz et al. 2006]. In the European Society of Human Reproduction and Embryology/American Society of Reproductive Medicine (ESHRE/ASRM) consensus, at least two of the following features are needed to make the diagnosis; oligo/anovulation, hyperandrogenism, and polycystic features on ultrasound scan [ESHRE/ASRM, 2004]. The Androgen Excess Society, however, recommended that androgen excess should remain a constant feature of PCOS irrespective of the ovulatory status and morphological features of the ovaries [Azziz et al. 2006]. For almost three decades, PCOS has been regarded as a life course disease which besides its reproductiv Continue reading >>
Metformin And Weight Loss?
I started Metformin for PCOS on Friday - and I've been doing Weight Watchers since the Wednesday before. Anyone experience weight loss with Metformin after a PCOS diagnosis? if so, how much? I'm a big girl to begin with but I'm down 10lbs since last Wednesday and wondering if I should be excited or concerned! @luvdgame hey there. started metformin 500mg in may and going to gym 3 to 5 days a wk. lost a few lbs and then dh and i cut out all eating out and have dropped enough so ppl are starting to notice. also think i ovulated for 1st time since january...am in the tww hopefully 10dpo so we will see... Good job girls!!!! My body is messed up!!!!! Meteformin made my tummy really upset. I did Jenny for a month and only lost a pound. I'm on another weight loss pill it's making me have tummy issues again too but it's suposed to!!! Please let me know how WW goes!!!! I want to know from a PCOS sister how it goes. It sucks hey!!!! I feel like my body has betrayed me. I feel bad that I'm the one that's making me lose our babies. I just got out of the hospital after having massive blood loss and huge clots... Sorry TMI.... They said I don't have any cysts and I just have an abnormally thick uterus (great..... What does that even mean hey!!! Lol) but I'm soooo happy I don't have any cysts!!!!! Wooty wooty!!! Anyways I think WTE should have a PCOS board cause I don't feel like I belong in any others really..... Sorry to hijack!!! Good luck girls!!!!!!!! Sticky baby dust. :) @Whycarts? Metformin can make you lose weight which is fantastic. For me I have to take it and really kick my a$$ to lose any weight. I work out hard lift weights and everything but in a month I lost 6 inches all over and 5 lbs. So slowly but surely. Sounds like WW is a good idea. There really should be a PCOS b Continue reading >>
Pcos And Metformin:how Long Before You Started Losing Weight?
PCOS and Metformin:How long before you started losing weight? If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. PCOS and Metformin:How long before you started losing weight? For the rest of you girls who are as blessed as me to have PCOS, =( and went on MetFormin, how long did it take you to start losing weight, how much did you lose, and what dosage did they start you on, how much overweight were you? Sorry for all the questions but I got diagnosed a couple weeks ago and got my prescription for MetFormin today... I just wanted to know how all of you guys benefited from the medicine!! Lost about 4 pounds right away. Cycle started about a week or so into taking met. Continuoulsy loosing I am about 260, 262 5'3 but lots of muscles, and major problem belly fat. Cycles are 32 days right on time past two months. I am in indy as well. Currently not ttc but I haven't ovulated yet. If you don't stand for something...you will fall for anything. good to see you here. I answered your question on that other board [I'm medicmamm over there] I never lost any weight on metformin and I have been taking it for a year or so. I have lost 15 pounds but that was by excercising and changing my eating habits. I guess I was not one of the lucky ones! Darn! I guess I weighed about 168 to 172 when I was first put on met. and that is how much I still weighed up until 2 months ago when I got sick of being curvy and changed my lifestyle. Met. did not make me O on my own, but it did help regulate my cycles a bit. I've been taking metformin for about 2-3 weeks now...and even though my mood Continue reading >>
Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>