Weight Gain And Janumet Xr (sitagliptin And Metformin Hcl Extended-release) Tablets
JANUMET tablets contain 2 prescription medicines: sitagliptin (JANUVIA®) and metformin. Once-daily prescription JANUMET XR tablets contain sitagliptin (the medicine in JANUVIA®) and extended-release metformin. JANUMET or JANUMET XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JANUMET or JANUMET XR should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUMET or JANUMET XR. Selected Risk Information About JANUMET and JANUMET XR Metformin, one of the medicines in JANUMET and JANUMET XR, can cause a rare but serious side effect called lactic acidosis (a buildup of lactic acid in the blood), which can cause death. Lactic acidosis is a medical emergency that must be treated in a hospital. Call your doctor right away if you get any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet; feel dizzy or lightheaded; have a slow or irregular heartbeat; feel very weak or tired; have unusualonScreenDetect (not normal) muscle pain; have trouble breathing; feel sleepy or drowsy; have stomach pains, nausea, or vomiting. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance of getting lactic acidosis with JANUMET or JANUMET XR if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye; have liver problems; drink alcohol very often, or drink a lot of alcohol in short-term “b Continue reading >>
Why Metformin (glucophage) Causes Weight Loss And Reduced Appetite Despite Stimulating Ampk?
In regard to weight loss, Metformin provides two primary benefits. First, it significantly improves glycemic control. This stabilizes your blood sugar, and makes you less likely to experience the up-and-down rollercoaster experience that often comes along with dieting. The second benefit of Metformin (partially a result of the first benefit) is suppressed appetite. Users typically note a measurable improvement from their usual cravings for food. By simply not desiring as much food, and still feeling normal despite eating less (due to the improved glycemic control), the result can be profound weight loss. That’s the good news, but you can’t just take the pill and expect everything to change on its own. Weight loss just doesn’t work that way. Metformin won’t work for you – rather, it will work with you. Continue reading >>
Metformin (glucophage) For Weight Loss
After you eat, sugar goes from your intestines into your bloodstream, and then immediately into your liver. Then your liver releases sugar back into your bloodstream to cause your blood sugar level to rise. To keep blood sugar levels from rising too high, your pancreas release insulin into your bloodstream. Insulin makes you hungry all the time and causes your liver to convert extra calories to fat and it constricts arteries to cause heart attacks. You need insulin to keep blood sugar levels from rising too high to cause diabetes, nerve damage, heart attacks, strokes and kidney damage. Glucophage reduces sugar release from your liver to prevents blood sugar levels from rising too high, so your body doesn't need to produce as much insulin that makes you hungry and causes your liver to make fat (3,13,14). Glucophage lowers insulin levels (4), prevents many of the side effects of diabetes and can be used by people who want to lose weight. However, Glucophage is not effective when your blood is acidic from excess lactic acid and recent research shows that exercise, which raises lactic acid, does not cause blood acid levels to rise enough to reduce Glucophage's benefits (5). Glucophage, itself, does not raise blood lactate levels and is therefore considerably safer than doctors originally thought. Since Glucophage lowers insulin, diabetics should be placed on Glucophage to lower their requirements for all other medications used to treat diabetes (6). A common cause of obesity in women is called polycystic ovary syndrome, which is caused by having high blood levels of insulin. Glucophage helps these women to lose weight (7-12). See the report on Polycystic Ovary Syndrome (PCOS) in the Women's Health section. Glucophage is a safe medication that prevents blood sugar levels fro Continue reading >>
3 Things You Need To Know About Metformin
September 30, 2015 by Dr. Brooke in Be Better , Eat Better , pcos 3 Things You Need To Know About Metformin Metformin is recommended by doctors for women with PCOS that want to loose weight or otherwise manage their PCOS and insulin resistance. But there are 3 very important things that you need to know about it including the fact that it's not the only option! Let me first say, I dont hate Metformin for women with PCOS . For some women it really does help spur ovulation, control blood sugar and help with some weight management but.its not without its share of issues. And its definitely not the magic bullet for weight loss although its usually presented that way. How Metformin (or its generic form: Glucophage) Works Metformin is typically given with meals throughout the day, or more commonly now the extended release version is given once with dinner or at bedtime. While only having to pop a pill one time per day is always appealing, this once a day dosing (especially at bedtime) is where I see the most problems with my patients. It lowers both fasting and post meal glucose levels by decreasing the glucose absorption in your intestines after a meal; as well as decreasing the amount of glucose your liver makes for later use. It also does help improve insulin sensitivity by increasing glucose movement into a cell. All sounds good so far right? Not so fast, here are the most common issues I see in women using Metformin: Metformin is notorious for causing sometimes severe digestive issues including stomach pain or upset, nausea, vomiting, diarrhea and even a sense of body weakness or metallic taste in the mouth in some. And it is touted as not causing low blood sugar as many older blood sugar lowering drugs did, however I see it every day in my practice that Metformin can m Continue reading >>
Does Metformin Cause Weight Loss? What To Know Before You Take It
If you’re managing type 2 diabetes with metformin (Glucophage), you might be well acquainted with unwanted side effects of this drug — namely, upset stomach, diarrhea, muscle aches, and sleepiness. These can be a figurative and literal pain, but you might welcome one side effect of metformin with open arms, particularly if you’ve struggled to lose weight. Metformin isn’t a weight loss drug, but researchers have found a link between the drug and weight loss. In fact, a long-term study published in April 2012 in the journal Diabetes Care that was conducted by the Diabetes Prevention Program (DPP) concluded that the drug could serve as a treatment for excess body weight, although more studies are needed. What Is Metformin and How Does It Work? “[Metformin] has been considered a first-line medication in the treatment of type 2 diabetes, and it mainly acts by lowering the amount of glucose released by the liver,” says Minisha Sood, MD, an endocrinologist at Lenox Hill Hospital in New York City. “It also helps a hormone called insulin to work better by helping muscles use glucose in a more efficient manner. When insulin works better (and insulin sensitivity improves), a person’s insulin levels are lower than they would be otherwise.” There’s no cure for type 2 diabetes, but the right combination of medication and healthy lifestyle can stabilize blood sugar levels, which, of course, is the end goal of any diabetes treatment. As the medication helps your body properly metabolize food and restores your ability to respond to insulin, you’ll not only feel better, you can potentially avoid complications of high blood sugar, such as heart disease, kidney damage, nerve damage (diabetic neuropathy), and eye damage (retinopathy). Why Does Metformin Cause Weight Lo Continue reading >>
Metformin, Weight Loss & Pcos – Does It Actually Work?
Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). But one simple question r Continue reading >>
Metformin (glucophage) And Weight Loss
Tweet Metformin, a generic diabetes treatment usually sold under the brand name Glucophage, may help people with diabetes to lose weight by lowering their appetites. Insulin makes people overweight by acting on the brain to cause hunger, making the liver manufacture fat and fill fat cells in the stomach. Avoiding obesity is a matter of avoiding foods high in blood sugar, and taking medication that prevents blood sugar levels from climbing too high. Glucophage function The function of diabetes drug Glucophage is to reduce the release levels of sugar from your liver. This stops blood glucose levels from rising too high, and means that the body does not have to produce as much insulin. Therefore, the patient is not as hungry. Type 2 diabetes drug Metformin (Glucophage) may be used successfully as a medication for type 2 diabetes. Lowers insulin levels It lowers insulin levels, helps to prevent diabetes complications, and helps people with diabetes to lose weight. Losing weight whilst taking Metformin (Glucophage) means also eating a healthy diet. Eating lots of foods that boost blood sugar levels will counteract the effects of Metformin. Most doctors prescribe 500mg of Metformin (Glucophage) before eating. Tweet Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body: Being ineffective at using the insulin it has produced; also known as insulin resistance and/or Being unable to produce enough insulin Type 2 diabetes is characterised by the body being unable to metabolise glucose (a simple sugar). This leads to high levels of blood glucose which over time may damage the organs of the body. From this, it can be understood that for someone with diabetes something that is food for ordinary people can become a s Continue reading >>
Metformin Hcl? - 3 Fat Chicks On A Diet Weight Loss Community
I'm pre-diabetic, and my doctor put me on Metformin HCL. I take it everyday, and she said it will heighten my resistance to insulin and help me lose weight. Hopefully it will help, because before, my weight didn't budge no matter what I did. ..Does anyone else take Metformin HCL? Have you been able to lose weight? I've taken it. I am PCOS/IR. I am back on it at a lower dose. While it helps some to lose, for me it did not. What it did do is stop weight grain creeping up further, which was a relief. Thanks for the info! I just want to get healthy haha I am on it, but I'm so bad about consistently taking medication. When I was consistently taking it I didn't get that boost of anything that other people talk about. However, what I felt it did do is assist in the weight loss when I actually tried to lose weight. For years anything I did didn't make a damn difference. It was so discouraging. So I gave up for awhile. But then I was diagnosed with hasimotos and then declared to have type II diabetes. I think the hasimotos was a blocker for me. So I'm now on some thyroid medications as well as 1000 mg. of metformin. I feel like I've got as much help as I can get. But the weight didn't just fall off of me. It just seemed to come off a little when I was really trying to exercise and eat well which it hadn't ever before. Unfortunately I'm my own worst enemy and still have problems with bingeing and not exercising which has inhibted the weight loss. Hopefully metformin will help you out, but I wouldn't think of it as a wonder drug. Sweat Pea from Sucker Punch - "Who honors those we love with the very life we live? Who sends monsters to kill us, and at the same time sings that we'll never die? Who teaches us what's real, and how to laugh at lies? Who decides why we live, and what we Continue reading >>
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Pcos Weight Gain Causes And Treatments
Many of these conditions can lead to heart disease . In fact, women with PCOS are four to seven times more likely to have a heart attack than women of the same age without the condition. Experts think weight gain also helps trigger PCOS symptoms, such as menstrual abnormalities and acne . What can I do to lose weight if I have polycystic ovary syndrome? Losing weight not only cuts your risk for many diseases, it can also make you feel better.When you have PCOS, shedding just 10% of your body weight can bring your periods back to normal. It can also help relieve some of the symptoms of polycystic ovary syndrome. Weight loss can improve insulin sensitivity. That will reduce your risk of diabetes , heart disease, and other PCOS complications. To lose weight, start with a visit to your doctor. The doctor will weigh you and check your waist size and body mass index. Body mass index is also called BMI, and it is the ratio of your height to your weight. Your doctor may also prescribe medication. Several medications are approved for PCOS, including birth control pills and anti-androgen medications. The anti-androgen medications block the effects of male hormones. A few medications are used specifically to promote weight loss in women with PCOS. These include: Metformin ( Glucophage ). Metformin is a diabetes drug that helps the body use insulin more efficiently. It also reduces testosterone production. Some research has found that it can help obese women with PCOS lose weight. Thiazolidinediones. These should be used with contraception . The drugs pioglitazone ( Actos ) and rosiglitazone ( Avandia ) also help the body use insulin. In studies, these drugs improved insulin resistance. But their effect on body weight is unclear. All patients using Avandia must review and fully un Continue reading >>
Can Metformin Help With Weight Loss?
Metformin is a drug prescribed to manage blood sugar levels in people with type 2 diabetes. You may have heard that metformin can also help you lose weight. But is it true? The answer is a resounding maybe. Here’s what you should know about what metformin can do for weight loss, as well as why your doctor may prescribe it for you. According to research, metformin can help some people lose weight. However, it’s not clear why metformin may cause weight loss. One theory is that it may prompt you to eat less by reducing your appetite. It may also change the way your body uses and stores fat. Although studies have shown that metformin may help with weight loss, the drug is not a quick-fix solution. According to one long-term study, the weight loss from metformin tends to occur gradually over one to two years. The amount of weight lost also varies from person to person. In the study, the average amount of weight lost after two or more years was four to seven pounds. Taking the drug without following other healthy habits may not lead to weight loss. Individuals who follow a healthy diet and exercise while taking metformin tend to lose the most weight. This may be because metformin is thought to boost how many calories you burn during exercise. If you don’t exercise, you likely won’t have this benefit. In addition, any weight loss you have may only last as long as you take the medication. That means if you stop taking metformin, there’s a good chance you will return to your original weight. And even while you’re still taking the drug, you may slowly gain back any weight you’ve lost. In other words, metformin may not be the magic diet pill some people have been waiting for. It has been shown to reduce weight in some, but not others. One of the benefits of metformin Continue reading >>
The Truth About Metformin And Weight Loss
The Truth About Metformin And Weight Loss The Truth About Metformin And Weight Loss Did you know that metformin and weight loss are closely related? I will explain what metformin is and what its side effects might be. I will also answer the million dollar question, can it help people lose weight? Almost a hundred years ago it was discovered that meformin reduces blood sugar levels , although it wasn’t until the last few decades that it really became popular in treating patients suffering from diabetes . Metformin is now the best and most popular drug in the world for treating type 2 diabetes, especially for obese and overweight persons with normally functioning kidneys. It is sold under many different trade names – including Glucophage, Carbophage and Gluformin – and it is orally administered either as tablets or in the form of liquid. Tablets are available in three different versions: SR and XR were developed to milden side effects while maintaining the effectiveness of the IR. The tablets are for sale in different strengths, from 500 mg to 1000 mg , and they consist of metformin hydrochloride (also called metformin HCl). The short explanation of how this drug works is this: Metformin hydrochloride reduces the liver’s production of glucose (by roughly a third), which then lowers the level of blood sugar in the body. A longer explanation would also include metformin’s ability to decrease the oxidation of fatty acids, increase insulin sensitivity which will make you feel less hungry, as well as several other positive effects. It would really take an entire article (or even more) to describe all the different aspects of how it works. I just prefer to think of it as a lowered glucose production in the liver. Time for the million dollar question. Can treatm Continue reading >>
Information On Metformin Hcl Er 500 Mg For Weight Loss
If you have high blood glucose levels, you may take metformin hydrochloride, an oral anti-hyperglycemic medication that lowers blood sugar. Metformin may also help you lose weight in some cases by decreasing your appetite. Clinical studies have not proven that metformin helps you lose weight if you don't have Type 2 diabetes or other metabolic disorders that cause insulin resistance. It may help prevent weight gain or cause modest weight loss if you're taking antipsychotic drugs that cause weight gain. Metformin comes in several doses, including a 500-milligram extended release form, which you may find easier to take. Video of the Day Metformin might help you lose weight if you have metabolic syndrome or polycystic ovary disease, both associated with insulin resistance. The pancreas releases insulin in response to glucose in your bloodstream. Insulin helps cells remove glucose from the bloodstream. When you eat large amounts of high-carb foods, the pancreas may overproduce insulin to keep up. Eventually, your cells stop responding to the insulin and your blood glucose levels rise. Because your cells feel starved for energy, you feel hungry all the time and may crave carbohydrates. Metformin helps cells respond better to insulin, so you don't feel as hungry. Insulin can also cause your liver to convert extra calories to fat. Metformin decreases the amount of glucose your liver produces, and also decreases the amount of glucose absorbed in your intestines. Decreased amounts of glucose in your bloodstream results in less glucose absorbed by your cells. When you absorb less glucose, you lose weight. An Indian study published in the March 2011 "British Journal of Clinical Pharmacology" reported that metformin increased weight loss in people taking olanzapine, an antipsychoti Continue reading >>
Metformin Decreases Food Consumption And Induces Weight Loss In Subjects With Obesity With Type Ii Non-insulin-dependent Diabetes.
Abstract Metformin often promotes weight loss in patients with obesity with non-insulin-dependent diabetes mellitus (NIDDM). The mechanism may be attributed to decreased food intake. This study has tested the effect of metformin on satiety and its efficacy in inducing weight loss. Twelve diet-treated NIDDM women with obesity were randomly given two dose levels (850 mg or 1700 mg) of metformin or placebo at 0800 for three consecutive days followed by a meal test on the third day on three occasions using a 3x3 Latin square design. The number of sandwich canapes eaten in three consecutive 10-minute periods beginning at 1400 hours was used to quantitate food intake, and the level of subjective hunger was rated just before the sandwich meal with a linear analogue hunger rating scale at 1400 after a 6-hour fast. The prior administration of metformin produced a reduction in calorie intake after each of the two doses of metformin treatment. The 1700-mg metformin dose had the most marked appetite suppressant action. Similarly, hunger ratings were significantly lowered after metformin, and the effect was most pronounced after the administration of 1700 mg of metformin. To assess the efficacy of metformin in reducing bodyweight, 48 diet-treated NIDDM women with obesity who had failed to lose weight by diet therapy were first placed on a 1200-kcal ADA (American Diabetes Association) diet before being randomized to receive either metformin (850 mg) or placebo twice daily in a double-blind fashion for 24 weeks. A 4-week single-blind placebo lead-in period preceded and a 6-week single-blind placebo period followed the 24-week double-blind treatment period. Subjects treated with metformin continued to lose weight throughout 24 weeks of treatment; their mean maximum weight loss was 8 kg Continue reading >>
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Metformin 850mg Tablets
1. WHAT METFORMIN IS AND WHAT IT IS USED FOR The name of this medicine is Metformin 500mg or 850mg Tablets (called metformin in this leaflet). It belongs to a group of medicines called biguanides (a type of oral hypoglycaemic). Metformin is used for the sort of diabetes called Type 2 diabetes or non-insulin-dependent diabetes mellitus. In type 2 diabetes, there is too much sugar (glucose) in your blood. This is because your body does not make enough insulin or because it makes insulin that does not work properly. Insulin is a hormone that allows your body tissue to take glucose from the blood and use it for energy or for storage for future use. Metformin works by improving the sensitivity of your body to insulin. It helps your body to use glucose in the normal way again This medicine is given when diet and exercise alone has not been able to control your blood sugar levels. Metformin can be given on its own. However, sometimes it is given with other medicines for diabetes or with insulin. In patients who are overweight, long-term use of metformin also helps to lower the risk of any problems related to diabetes you are allergic (hypersensitive) to metformin or any of the other ingredients in this liquid (see section 6: Further information). An allergic reaction can include a rash, itching or shortness of breath. you have recently had a heart attack or any other heart problems you have severe circulation problems or difficulty in breathing you have had serious problems with your diabetes in the past called diabetic ketoacidosis. When you have this you lose weight quickly, feel sick (nausea) or are sick (vomiting). See also in Section 4: Possible side effects you have recently had a severe infection, injury or trauma (shock) you are going to have an X-ray where you will b Continue reading >>
Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
