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Is Metformin Good For Losing Weight?

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Effectiveness Of Metformin On Weight Loss In Non-diabetic Individuals With Obesity.

Abstract OBJECTIVE: The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results. Moreover, the effectiveness in a real-life outpatient setting has not been tested until today. In this study we aimed to examine the effectiveness of metformin as a weight reducing drug in obese and overweight patients with regard to their degree of insulin resistance. DESIGN AND PATIENTS: We treated 154 consecutive patients with a body mass index ≥27 kg/m(2) in an outpatient setting over 6 months with metformin up to a dosage of 2,500 mg per day. Additionally, we included 45 untreated patients as controls. Patients were monitored for weight changes over 6 months. Before metformin treatment was started insulin sensitivity was determined in all patients by calculating HOMA index and Matsuda index after a 75 g oral glucose tolerance test. RESULTS: The mean weight loss in the metformin treated group was 5.8±7.0 kg (5.6±6.5%). Untreated controls gained 0.8±3.5 kg (0.8±3.7%) on average. Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive patients. The percentage of weight loss was indepen Continue reading >>

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Popular Questions

  1. BeantownMatt

    Metformin and weight loss

    newbie question here...
    Recently diagnosed but not on any meds yet. The doc has mentioned first step will be Metformin. I see a few posts of people losing weight. My curious brain would like to hear success stories of people losing weight from it?
    Also, need to read more about this but does Any one have an idea of what the drug does to help lose weight? Is it the controlling of BG that helps you lose? Does it have other affects like speed up your metabolism ( just an example)?
    Matt

  2. jwags

    Metformin works in the liver and the gut. In the liver it helps stop the liver from converting stored glycogen and turning it into glucose. It also works in the gut, so you tend to feel full sooner. I have to eat very small meals on Metformin. It also causes GI distress in some people. So I think the weight loss comes from eating smaller meals. I lost around 40 pounds over 3-4 years on the max of Metformin. I also was doing very low carb diet and doing tons of exercise. I got back to my HS weight of 110-115.

  3. furball64801

    Met helps many lose weight but also many lower carb intake and walk. It really has not made me lose weight but we are all very different. What Jeanne said covers it pretty well, also when people go on a med and know they are D will make changes and those changes with walking or exercise can cause the weight loss.

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